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1. 发明申请

WO2012158226A2 A BIOMEDICAL IMPLANT WITH A MONOLITHIC TIMING CONTROL BASED RECTIFIER FOR MULTIVOLTAGE FOR BIOMEDICAL APPLICATIONS 审中-公开
标题翻译：具有用于生物医学应用的多功能时间控制的整流器的生物医学植入物
公开(公告)号：WO2012158226A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/025389
申请日：2012-02-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANTA CRUZ , LIU, Wentai , LO, Yi-kai
发明人： LIU, Wentai , LO, Yi-kai
CPC分类号： H02M7/217 , H02J1/08 , H02J5/005 , H02J7/025 , H02J17/00 , H02J50/05 , H02J50/10 , H02J2001/008 , H02M1/36 , H02M3/33561 , Y10T307/406
摘要： A biomedical implant is provided for simultaneously generating multiple voltages for digital and analog circuits. Two AC voltages induced from an external single AC source located externally to the biomedical implant are used as input to a multi-voltage rectifier. The multi-voltage rectifier has a rectifier circuitry for simultaneously generating: (i) both low positive and negative voltages and (ii) both high positive and negative voltages. A startup circuitry is designed to stabilize both low positive and negative voltages prior to stabilizing both high positive and negative voltages. A timing control circuitry is used to prevent reverse leakage currents from loading capacitors to input for efficiency enhancement. The biomedical implant, by virtue of the multi-voltage timing control rectifier, achieves high power transfer efficiency greater than 85%.
摘要翻译：提供生物医学植入物，用于同时为数字和模拟电路产生多个电压。从位于生物医学植入物外部的外部单个AC电源引起的两个AC电压被用作多电压整流器的输入。多电压整流器具有整流电路，用于同时产生：（i）低正电压和负电压，以及（ii）高正电压和负电压。启动电路设计用于在稳定高正电压和负电压之前稳定低正电压和负电压。定时控制电路用于防止反向泄漏电流从负载电容器输入以提高效率。通过多电压定时控制整流器，生物医学植入物实现高于85％的高功率传输效率。

2. 发明申请

WO2012177654A2 NEURON RECORDING SYSTEM 审中-公开
标题翻译：神经记录系统
公开(公告)号：WO2012177654A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043173
申请日：2012-06-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LO, Yi-kai , LIU, Wentai
发明人： LO, Yi-kai , LIU, Wentai
CPC分类号： A61B5/04001 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/7203 , A61B5/7225 , H03F3/45192 , H03F3/45475 , H03F3/45928 , H03F2200/165 , H03F2200/168 , H03F2200/171 , H03F2200/408 , H03F2203/45362 , H03F2203/45512 , H03F2203/45528 , H03F2203/45544 , H03F2203/45631 , H03F2203/45686 , H03F2203/45726
摘要： A neuron recording system was provided. By using the gain-boosted topology, the amplifier input impedance can be increased while simultaneously reducing the noise. The system can be configured to record local field potentials (LFPs) and neuron spikes, respectively, with low-power consumption. With the flexible digital controller module (DCM), any subset of the recording channels can be activated for recording with independent sampling rate at each channel. A wireless interface to transmit recorded neuron data and an on-chip neuron processor to perform real-time signal processing can be incorporated in the system.
摘要翻译：提供神经元记录系统。通过使用增益升压拓扑，可以增加放大器输入阻抗，同时降低噪声。该系统可以配置为分别以低功耗记录局部场电位（LFP）和神经元峰值。使用灵活的数字控制器模块（DCM），可以激活记录通道的任何子集，以便在每个通道上以独立的采样率进行记录。用于发送记录的神经元数据的无线接口和用于执行实时信号处理的片上神经元处理器可以并入系统中。

3. 发明申请

WO2007055726A3 DEVICES AND METHODS FOR STIMULATION OF TISSUE 审中-公开
公开(公告)号：WO2007055726A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/016812
申请日：2006-05-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , COCKERHAM, Kimberly, P. , FISHMAN, Harvey , LIU, Anthony , FITZGERALD, Alissa, M. , LIEPMANN, Dorian , CHUI, Benjamin, W. , MARMOR, Michael, F. , LIU, Wentai , SANTIAGO, Juan, Gabriel
发明人： COCKERHAM, Kimberly, P. , FISHMAN, Harvey , LIU, Anthony , FITZGERALD, Alissa, M. , LIEPMANN, Dorian , CHUI, Benjamin, W. , MARMOR, Michael, F. , LIU, Wentai , SANTIAGO, Juan, Gabriel
IPC分类号： A61N1/30
摘要： Devices, systems and methods are provided for directly stimulating tissues, particularly muscle tissues, to modulate muscle contractions (i.e. provide reanimation of the muscle or to suppress undesired muscle contractions). Reanimation of muscles may be desired when damage to the brain, nervous system or neuromuscular junctions have occurred, causing a muscle tissue to lack sufficient motor control. Suppression of muscle contractions may be desired in situations of pathologically hyperactive muscles, such as in conditions of muscle spasm (e.g. blepharospasm and hemifacial spasm) or muscle dystonia. Direct stimulation is achieved by delivering a chemical agent directly to the muscle tissue, particularly the motor end plate, bypassing the nerves and neuromuscular junctions which may be damaged or diseased. Implanted hybrid chemical and electromagnetic stimulation devices can modulate muscle contraction in response to signals from a controller.

4. 发明申请

WO2017091828A1 DISPOSABLE GASTROINTESTINAL IMPLANTABLE STIMULATOR 审中-公开
标题翻译：一次性胃肠道植入式刺激器
公开(公告)号：WO2017091828A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063886
申请日：2016-11-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, Yi-Kai , LIU, Wentai
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372 , H02J7/02 , A61N1/08
CPC分类号： A61N1/3787 , A61N1/3727 , H02J50/10
摘要： A disposable implant that may be positioned inside the gastrointestinal (GI) tract through laparotomy or laparoscopic surgery. The implant may be secured in place using a biodegradable glue or biodegradable suture and is naturally expelled from the body with bowel movement after a certain period of time. In one embodiment, GI implant comprises a coil that receives power from, and sends the recorded physiological information to, an external device through wireless inductive coupling.
摘要翻译：一次性植入物可以通过剖腹手术或腹腔镜手术定位在胃肠道（GI）内。植入物可以使用可生物降解的胶水或可生物降解的缝线固定在适当的位置，并且在一段时间后自然排便从身体排出。在一个实施例中，GI植入物包括线圈，其通过无线电感耦合从外部装置接收电力，并将记录的生理信息发送到外部装置。

5. 发明申请

WO2021151050A1 BIOMIMETIC STIMULATOR SYSTEM FOR NEURAL IMPLANT 审中-公开
公开(公告)号：WO2021151050A1
公开(公告)日：2021-07-29
申请号：PCT/US2021/014829
申请日：2021-01-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LIU, Wentai , CULACLII, Stanislav , WANG, Po-Min , LO, Yi-Kai
IPC分类号： A61N1/05 , A61N1/372 , A61N1/36
摘要： A neural stimulator system which generates stimulation from an implantable stimulator circuit which generates stimulation outputs which mimic biological signals. The user/operator can select stimulation generated from recorded waveforms, or by selecting the characteristics for generating stimulation based on randomized inter-pulse-intervals (IPI). A control unit controls the operation of the implantable stimulator circuit, and receives sets of stimulation parameters based on user input from a user input device executing application specific programming.

6. 发明申请

WO2017044433A1 ULTRA-DENSE ELECTRODE-BASED BRAIN IMAGING SYSTEM 审中-公开
标题翻译：超声电极基于脑的成像系统
公开(公告)号：WO2017044433A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050452
申请日：2016-09-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LIU, Wentai , LI, Ying , QIN, Jing , CHANG, Chi-Wei , LO, Yi-Kai
IPC分类号： A61B5/048 , A61B5/0478 , A61B5/04 , A61B5/00
CPC分类号： A61B5/048 , A61B5/04012 , A61B5/0478
摘要： An ultra-dense electrode-based brain imaging system with high spatial and temporal resolution. A Sparsity and Smoothness enhanced Method Of Optimized electrical TomograpHy (s-SMOOTH) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images is described. Also described is a graph Fractional-Order Total Variation (gFOTV) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images.
摘要翻译：具有高空间和时间分辨率的超致密电极脑成像系统。描述了一种稀疏和平滑度增强的优化电机重建技术（s-SMOOTH）的重建技术，以提高重建脑图像的空间分辨率和定位精度。还描述了基于分数阶总变异（gFOTV）的重建技术，以提高重建脑图像的空间分辨率和定位精度。

7. 发明申请

WO2018106843A1 OPTIMAL MULTI-ELECTRODE TRANSCUTANEOUS STIMULATION WITH HIGH FOCALITY AND INTENSITY 审中-公开
公开(公告)号：WO2018106843A1
公开(公告)日：2018-06-14
申请号：PCT/US2017/064970
申请日：2017-12-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LI, Ying , LIU, Wentai , LO, Yi-Kai
IPC分类号： A61B5/055 , A61B6/03 , A61N1/00 , A61N1/05 , A61N1/08 , A61N1/36 , G06F19/00
摘要： Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.

8. 发明申请

WO2016057244A1 REAL-TIME STIMULATION ARTIFACT SUPPRESSION FOR SIMULTANEOUS ELECTROPHYSIOLOGICAL ELECTRICAL STIMULATION AND RECORDING 审中-公开
标题翻译：实时刺激法同时抑制电刺激和记录电刺激
公开(公告)号：WO2016057244A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/052343
申请日：2015-09-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LIU, Wentai , LO, Yi-Kai
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0531 , A61B5/4238 , A61B5/4255 , A61B5/721 , A61B5/7225 , A61B5/7278 , A61B2560/0223 , A61N1/36125
摘要： A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus output, and then the artifact waveform calibrated during another stimulus output for accurately representing the actual artifact waveform received within each measured response to a stimulus. During actual stimulus generation and response recording, the calibrated artifact waveform is subtracted in at least one of the amplifier stages so that the artifacts are removed from the amplified response to the stimulus thus providing an accurate output without saturating the amplifiers.
摘要翻译：在执行电生理电刺激和记录时抑制刺激伪影的系统和方法。捕获与刺激输出相关联的伪像波形，然后在另一个刺激输出期间校准的伪影波形，以准确地表示在对刺激的每个测量的响应内接收到的实际伪像波形。在实际的刺激生成和响应记录期间，在至少一个放大器级中减去校准的伪影波形，使得伪像从放大的刺激中被去除，从而提供精确的输出而不使放大器饱和。

9. 发明申请

WO2016053902A1 FLEXIBLE AND STRETCHABLE ELECTRODES FOR GASTROINTESTINAL IMPLANTS 审中-公开
标题翻译：用于胃肠道植入物的柔性和可拉伸电极
公开(公告)号：WO2016053902A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052725
申请日：2015-09-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LIU, Wentai , DUNN, James C.Y. , WU, Benjamin M. , LO, Yi-Kai , CHANG, Chih-Wei , WAGNER, Justin
IPC分类号： A61F2/04 , A61F5/00
CPC分类号： A61N1/36007 , A61B5/4233 , A61B5/4238 , A61B5/4255 , A61F5/0026 , A61N1/0509 , A61N1/0517 , A61N1/08
摘要： A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
摘要翻译：一种胃肠刺激装置和方法，其具有电子控制器和具有中央分支和正交双侧分支的柔性和可伸展的电极阵列，其包围胃肠道的一部分并且可以适应道的重复收缩和松弛运动。阵列分支具有柔性弹簧结构，刺激电极，记录电极，由控制器控制的传感器和将分支固定到组织的粘附节点。电极阵列可以感测来自上游组织的正常蠕动，并产生刺激信号以刺激无能的肠段以产生刺激诱导的收缩。无能力肠段的电极可用于刺激或记录，来自无能肠段的记录信号可以发回电子部件，形成闭环控制系统。使用电流刺激的阻抗测量可用于捕获低频收缩信号。

10. 发明申请

WO2016033372A1 METHODS OF FABRICATING A MULTI-ELECTRODE ARRAY FOR SPINAL CORD EPIDURAL STIMULATION 审中-公开
标题翻译：制作脊髓脊索刺激多电极阵列的方法
公开(公告)号：WO2016033372A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047272
申请日：2015-08-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LIU, Wentai , CHANG, Chih-Wei
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0551 , A61N1/0456 , A61N1/0476 , B05D1/005 , C23C14/08 , C23C14/30 , C23C14/5826
摘要： In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
摘要翻译：在某些实施例中，提供了用于脊髓硬膜外刺激的电极阵列，其中所述阵列包括设置在柔性聚合物基底上的多个电极; 所述电极电连接到电连接器上的一个或多个引线和/或连接点; 其中所述阵列的电极结合到所述聚合物，使得电极可携带具有足以在体内或生理盐水溶液中提供脊髓和/或脑的硬膜外刺激的电压，频率和电流的电刺激信号，而不将电极的全部或一部分与聚合物基底分离。

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