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1. 发明申请

WO1998023959A2 IMPROVED METHODS FOR THE DIAGNOSIS AND TREATMENT OF INSULIN-DEPENDENT DIABETES MELLITUS 审中-公开
标题翻译：胰岛素依赖性糖尿病的诊断和治疗的改进方法
公开(公告)号：WO1998023959A2
公开(公告)日：1998-06-04
申请号：PCT/US1997021846
申请日：1997-12-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , KAUFMAN, Daniel, L. , TIAN, Jide
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： G01N33/564
CPC分类号： G01N33/6854 , A61K38/00 , A61K39/0008 , G01N33/564 , G01N2800/042 , G01N2800/24 , G01N2800/245 , G01N2800/52 , Y10S424/81 , Y10S514/866
摘要： Methods for detecting the status of an insulin-dependent diabetes mellitus (IDDM)-associated autoimmune response in a mammal are provided. Specifically, the ratio of the frequency of T helper (1) cells to T helper (2) cells specific for a pancreatic beta -cell associated antigen is indicative of the status of the autoimmune response. The methods may be employed prior to the onset of the clinical symptoms of the disease, thereby allowing identification of those at risk for developing clinical symptoms of IDDM, or subsequent to pancreatic tissue transplantation, for example, to measure the efficacy of treatment directed to enhancing the lifetime of the tissue transplant. Methods for prolonging the survival of tissue transplants are also provided. Specifically, a tissue-associated antigen is administered to the mammal which serves to shift the pathogenic Th1 response associated with pathological immunity toward a protective Th2 response.
摘要翻译：提供了检测哺乳动物中胰岛素依赖性糖尿病（IDDM）相关自身免疫应答状态的方法。具体地，T辅助细胞（1）细胞与特异于胰腺β-细胞相关抗原的T辅助细胞（2）细胞的比率指示自身免疫反应的状态。该方法可以在该疾病的临床症状开始之前使用，从而允许识别处于IDDM临床症状或胰组织移植危险的患者，例如，以测量针对增强的治疗的功效组织移植的寿命。还提供了延长组织移植存活的方法。具体地，向哺乳动物施用组织相关抗原，其用于将与病理免疫相关的致病性Th1应答转移到保护性Th2应答。

2. 发明申请

WO1998039357A1 METHOD OF ALLEVIATING NEUROPATHIC PAIN 审中-公开
标题翻译：治疗神经痛疼痛的方法
公开(公告)号：WO1998039357A1
公开(公告)日：1998-09-11
申请号：PCT/US1997016062
申请日：1997-09-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , O'BRIEN, John, S.
IPC分类号： C07K04/00
CPC分类号： C07K14/475 , A61K38/00
摘要： The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
摘要翻译：本发明提供了一种减轻受试者神经性疼痛的方法，该方法是通过对受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供一种抑制受试者神经性疼痛发作的方法，该方法是向受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供了prosaposin受体激动剂和这些激动剂用于刺激神经突生长，抑制神经细胞死亡，促进髓鞘形成和抑制神经脱髓鞘的用途。此外，提供了通过使神经元细胞与包含有效抑制量的前列腺素受体激动剂的组合物接触来抑制感觉或运动神经病的方法。

3. 发明申请

WO1998030715A1 OPTICAL SENSORS OF CELL SIGNALING 审中-公开
标题翻译：细胞信号的光学传感器
公开(公告)号：WO1998030715A1
公开(公告)日：1998-07-16
申请号：PCT/US1997019453
申请日：1997-10-24
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SIEGAL, Micah, S. , ISACOFF, Ehud, Y.
发明人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12P21/04
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2267/0393 , C07K14/43595 , C07K14/705 , C07K2319/00
摘要： A chimeric protein sensor including an optically active polypeptide linked to a responsive polypeptide, or responsive fragment thereof, which undergoes a change in response to a cell signaling event, wherein an optical property of the sensor is altered in response to the change in the responsive polypeptide, or responsive fragment thereof is provided, as well as nucleic acid sequences encoding the chimeric protein sensor. The chimeric protein sensor includes an optically active polypeptide or fragment thereof, such as green fluorescent protein (GFP), for measuring cellular events in vivo.
摘要翻译：一种嵌合蛋白传感器，其包括与响应性多肽或其响应片段连接的光学活性多肽，其响应于细胞信号传导事件而发生变化，其中响应于响应性多肽的变化而改变传感器的光学性质，或其响应片段，以及编码嵌合蛋白传感器的核酸序列。嵌合蛋白质传感器包括用于测量体内细胞事件的光学活性多肽或其片段，例如绿色荧光蛋白（GFP）。

4. 发明申请

WO1998026295A1 APPARATUS FOR AUTOMATED TESTING OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：自动测试生物样本的设备
公开(公告)号：WO1998026295A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022543
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N35/00
CPC分类号： G01N35/0092 , G01N35/0099 , G01N2035/00326 , G01N2035/0093 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for performing automated testing of infectious biological specimens is disclosed. The apparatus comprises a process controller for translating user commands into test instrument suite commands, and a test instrument suite comprising a means to treat the specimen to manifest an observable result, and a detector for measuring the observable result to generate specimen test results.
摘要翻译：公开了一种用于执行感染性生物样本的自动化测试的装置。该装置包括用于将用户命令转换为测试仪器套件命令的过程控制器，以及包括用于处理样本以显示可观察结果的装置的测试仪器套件，以及用于测量可观察结果以产生样本测试结果的检测器。

5. 发明申请

WO1998026290A1 APPARATUS FOR TESTING FOR INFECTION BY A RETROVIRUS 审中-公开
标题翻译：用于检测由RETROVIRUS感染的装置
公开(公告)号：WO1998026290A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022545
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N33/569
CPC分类号： G01N33/56988 , G01N35/0092 , G01N35/0099 , G01N2035/00326 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for testing specimens for infection by a retrovirus is described. The apparatus comprises a process controller including a communications module for translating user commands into test instrument suite commands and a means for communicating specimen test results to a user. The apparatus further comprises a test instrument suite including a means for treating the specimen to manifest an observable result and a detector for measuring the observable result.
摘要翻译：描述了用于测试由逆转录病毒感染的样品的装置。该装置包括一个过程控制器，该过程控制器包括用于将用户命令转换成测试仪器套件命令的通信模块和用于将样本测试结果传送给用户的装置。该装置还包括测试仪器套件，其包括用于处理样本以显示可观察结果的装置和用于测量可观察结果的检测器。

6. 发明申请

WO1998026044A1 IN CULTURE PROLIFERATION OF HUMAN PANCREATIC ENDOCRINE CELLS 审中-公开
标题翻译：文化增殖人胰腺内皮细胞
公开(公告)号：WO1998026044A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022827
申请日：1997-12-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BEATTIE, Gillian, M. , HAYEK, Alberto
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12N05/00
CPC分类号： C12N5/0676 , C12N2502/30
摘要： Islets and islet-like cell clusters are proliferated in culture without loss of insulin-secreting function by incubation in a medium containing extracellular matrix of human bladder carcinoma cells, preferably the human bladder carcinoma cell line HTB-9.
摘要翻译：在含有人膀胱癌细胞，优选人膀胱癌细胞系HTB-9细胞外基质的培养基中孵育，胰岛和胰岛样细胞簇在培养物中增殖而不损失胰岛素分泌功能。

7. 发明申请

WO1998025701A1 MICROFABRICATED SLEEVE DEVICES FOR CHEMICAL REACTIONS 审中-公开
标题翻译：用于化学反应的微波清洗装置
公开(公告)号：WO1998025701A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023180
申请日：1997-12-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NORTHRUP, M., Allen
IPC分类号： B01L03/00
CPC分类号： B01L7/52 , B01J19/0046 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00936 , B01J2219/00945 , B01J2219/00952 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0654 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0421 , B01L2400/0439 , B01L2400/0487 , B81C3/00 , G01N21/0332 , G01N21/05 , G01N21/69 , G01N21/76 , G01N2021/0346
摘要： A silicon-based sleeve type chemical reaction chamber (50) that combines doped silicon heating elements (57) and bulk silicon convective cooling elements (51, 52). A critical ratio of silicon and non-silicon based materials provides the thermal properties desired. The reaction chamber may be used for any chemical reaction, especially synthetic, thermal-cycling-based reactions such as the polymerase chain reaction (PCR) or ligase chain reaction.
摘要翻译：组合掺杂硅加热元件（57）和体硅对流冷却元件（51,52）的硅基套管型化学反应室（50）。硅和非硅基材料的临界比提供了所需的热性质。反应室可用于任何化学反应，特别是合成的基于热循环的反应，如聚合酶链式反应（PCR）或连接酶链式反应。

9. 发明申请

WO1998020022A1 SOLUBLE PROTEINS 审中-公开
标题翻译：可溶性蛋白质
公开(公告)号：WO1998020022A1
公开(公告)日：1998-05-14
申请号：PCT/US1997006227
申请日：1997-04-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PRUSINER, Stanley, B. , COHEN, Fred, E. , MURAMOTO, Tamaki
IPC分类号： C07K01/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/47 , C07K16/18
摘要： The invention includes deleting codon segments from DNA expressing a native protein in order to obtain a shorter, soluble protein which mimics characteristics of an insoluble native protein. Soluble proteins of the invention are characterized by: (1) having less amino acids than the full length native protein; (2) having a higher degree of solubility than the native protein; (3) retaining the basic biological characteristics of the native protein such as (a) not being subject to enzymatic digestion and (b) causing disease. Soluble proteins of the invention are obtained by providing a DNA sequence which encodes a native protein and systematically removing codons, making copies of the shortened versions of DNA which are then expressed to provide the shortened proteins. The shortened proteins are then tested for solubility. Soluble proteins are then further tested to confirm that they retain the biological characteristics of the native protein.
摘要翻译：本发明包括从表达天然蛋白质的DNA中删除密码子片段，以获得模拟不溶性天然蛋白质特征的较短的可溶性蛋白质。本发明的可溶性蛋白质的特征在于：（1）具有比全长天然蛋白质少的氨基酸; （2）具有比天然蛋白质更高的溶解度; （3）保留天然蛋白质的基本生物学特性，如（a）不经酶消化和（b）引起疾病。通过提供编码天然蛋白质的DNA序列并系统地除去密码子，制备DNA的缩短形式的拷贝，然后进行表达以提供缩短的蛋白质，从而获得本发明的可溶性蛋白质。然后测试缩短的蛋白质的溶解度。然后进一步测试可溶性蛋白质以证实它们保留天然蛋白质的生物学特性。

10. 发明申请

WO1998018456A1 PROTEASE-ACTIVATED RECEPTOR 3 AND USES THEREOF 审中-公开
标题翻译： PROTEASE-ACTIVED RECEPTOR 3及其用途
公开(公告)号：WO1998018456A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019732
申请日：1997-10-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , COUGHLIN, Shaun, R. , ISHIHARA, Hiroaki , CONNOLLY, Andrew
IPC分类号： A61K31/00
CPC分类号： C07K14/705 , A61K38/00 , G01N33/6893 , G01N33/86 , G01N2333/705 , G01N2333/974 , G01N2500/00
摘要： Disclosed are cDNAs and genomic DNAs encoding protease-activated receptor 3 (PAR3) from mouse and human, and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the surface of cells are used in methods of screening candidate compounds for their ability to act as agonists or antagonists to the effects of interaction between thrombin and PAR3. Agonists are used as the therapeutics to treat wounds, thrombosis, atherosclerosis, restenosis, inflammation, and other thrombin-activated disorders. Antagonists are used as therapeutics to control blood coagulation and thereby treating heart attack and stroke. Antagonists mediate inflammatory and proliferative responses to injury as occur in normal wound healing and variety of diseases including atherosclerosis, restenosis, pulmonary inflammation (ARDS) and glomerulosclerosis. Antibodies specific for a protease-activated receptor 3 (or receptor fragment or analog) and their use as a therapeutic are also disclosed.
摘要翻译：公开了编码来自小鼠和人的蛋白酶活化受体3（PAR3）的cDNA和基因组DNA，以及从这些cDNA表达的重组多肽。在细胞表面表达的重组受体多肽，受体片段和类似物用于筛选候选化合物作为激动剂或拮抗剂对凝血酶和PAR3之间相互作用的作用的能力的方法。激动剂被用作治疗创伤，血栓形成，动脉粥样硬化，再狭窄，炎症和其他凝血酶活化障碍的治疗剂。拮抗剂用作治疗剂以控制血液凝固，从而治疗心脏病发作和中风。拮抗剂介导在正常伤口愈合和各种疾病（包括动脉粥样硬化，再狭窄，肺部炎症（ARDS）和肾小球硬化）中发生的损伤的炎症和增殖反应。还公开了对蛋白酶激活受体3（或受体片段或类似物）特异的抗体及其作为治疗剂的用途。

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