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1. 发明申请

WO2012167133A2 INHIBITORS OF ANANDAMIDE TRANSPORT AND THEIR THERAPEUTIC USES 审中-公开
标题翻译： ANANDAMIDE运输的抑制剂及其治疗用途
公开(公告)号：WO2012167133A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040531
申请日：2012-06-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , IIT - ISTITUTO ITALIANO DI TECNOLOGIA , PIOMELLI, Daniele , FU, Jin , BOTTEGONI, Giovanni , CAVALLI, Andrea , BANDIERA, Tiziano
发明人： PIOMELLI, Daniele , FU, Jin , BOTTEGONI, Giovanni , CAVALLI, Andrea , BANDIERA, Tiziano
IPC分类号： A61K31/502 , A61K31/495 , A61P29/00 , A61P25/00
CPC分类号： C07D237/34 , A61K31/495 , A61K31/502 , C07K14/435 , C12N15/11 , G01N33/5008
摘要： Nucleic acid and polypeptide sequences corresponding to FLAT, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (FAAH-1), are provided. FLAT lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells. A chemical scaffold for the inhibition of anandamide transport is identified. Compositions of the invention prevent anandamide internalization in vitro, interrupt anandamide deactivation in vivo, and cause profound CB1 cannabinoid receptor-mediated analgesia in a mouse model of inflammatory pain. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the modulation of anandamide transport would be of benefit.
摘要翻译：提供了对应于FLAT，细胞内anandamide降解酶的部分胞质变体，脂肪酸酰胺水解酶-1（FAAH-1）的核酸和多肽序列。 FLAT没有酰胺酶活性，但是结合内源性抗生素Aandamide并促进其转运到细胞中。鉴定了用于抑制anandamide转运的化学支架。本发明的组合物在体外阻止氨酰胺内化，在体内中断anandamide失活，并在炎症性疼痛的小鼠模型中引起严重的CB1大麻素受体介导的镇痛。因此，本发明还提供了用于治疗其中调节anandamide转运有益的病症的方法和药物组合物。

2. 发明申请

WO2005002524A2 COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES OF OLEOYLETHANOLAMIDE-LIKE COMPOUNDS AND MODULATORS OF PPARα 审中-公开
标题翻译：化合物，组合物和治疗用途的乙酰氨基酚类化合物和PPARα的调节剂
公开(公告)号：WO2005002524A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/021394
申请日：2004-07-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , FU, Jin , GAETANI, Silvana , PIOMELLI, Daniele
发明人： FU, Jin , GAETANI, Silvana , PIOMELLI, Daniele
IPC分类号： A61K
CPC分类号： A61K31/20
摘要： The present invention provides compounds, compositions, and methods for the treatment of disorders and conditions mediated by PPARa. The invention relates to the surprising discovery that oleoylethanolamide (OEA) is an endogenous high affinity and selective ligand of PPARa. The compounds of the invention include, but are not limited to, specific PPARa agonists sharing the receptor binding properties of OEA and fatty acid alkanolamides and their homologs which also are PPARa agonists. Such OEA-like compounds include, but are not limited to, compounds of the following formula: in which n is from 0 to 5, the sum of a and b can be from 0 to 4; Z is a member selected from the group consisting of -C(O)N(Ro) ; (Ro)NC(O) ; OC(O) ; (O)CO ; O; NRo; and S; and wherein Ro and R2 are members independently selected from the group consisting of unsubstituted or unsubstituted alkyl, hydrogen, C1 -C6 alkyl, and lower (C1-C6) acyl, and wherein up to eight hydrogen atoms are optionally substituted by methyl or a double bond, and the bond between carbons c and d may be unsaturated or saturated, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了用于治疗由PPARα介导的病症和病症的化合物，组合物和方法。本发明涉及令人惊奇的发现，即油基乙醇酰胺（OEA）是PPARα的内源性高亲和力和选择性配体。本发明的化合物包括但不限于分享了OEA和脂肪酸链烷醇酰胺及其同系物的受体结合性质的特异性PPARα激动剂，它们也是PPARα激动剂。这种OEA类化合物包括但不限于下式的化合物：其中n为0至5，a和b的和可以为0至4; Z是选自-C（O）N（Ro）; （Ro）NC（O）; OC（O）; （O）CO; O; NRO; 和S; 并且其中R a和R 2是独立地选自未取代或未取代的烷基，氢，C 1 -C 6烷基和低级（C 1 -C 6）酰基的成员，并且其中多达8个氢原子任选地被甲基或双碳和c之间的键可以是不饱和的或饱和的，或其药学上可接受的盐。

3. 发明申请

WO2004034968A2 COMBINATION THERAPY FOR CONTROLLING APPETITES 审中-公开
标题翻译：用于控制提示的组合治疗
公开(公告)号：WO2004034968A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/025760
申请日：2003-08-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PIOMELLI, Daniele , DE FONSECA, Fernando, Rodriguez , FU, Jin , GAETANI, Silvana
发明人： PIOMELLI, Daniele , DE FONSECA, Fernando, Rodriguez , FU, Jin , GAETANI, Silvana
IPC分类号： A61K
CPC分类号： A61K31/415 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： The invention provides methods and pharmaceutical compositions for administering a PPARα agonist (e.g., OEA-like agonist, OEA-like compound), an OEA-like appetite reducing compound, or a FAAH inhibitor and a CB1 cannabinoid receptor antagonist to a subject in order to reduce the consumption or ingestion of food, ethanol or other appetizing substances as well as in treating appetency disorders related to the excess consumption of food, ethanol, and other appetizing substances. The combination therapy can also be useful for reducing body fat or body weight and modulating lipid metabolism.
摘要翻译：本发明提供了用于向受试者施用PPARα激动剂（例如，OEA样激动剂，OEA样化合物），类似OEA的食欲降低化合物或FAAH抑制剂和CB1大麻素受体拮抗剂的方法和药物组合物，以便减少食物，乙醇或其他开胃物质的消耗或摄入，以及治疗与食物，乙醇和其他开胃物质过量消费有关的食欲障碍。联合治疗也可用于减少体脂肪或体重并调节脂质代谢。

4. 发明申请

WO2013095382A1 WIRELESS WIDE AREA NETWORK (WWAN) ASSISTED PROXIMITY WIRELESS LOCAL AREA NETWORK (WLAN) PEER-TO-PEER (P2P) CONNECTION AND OFFLOADING 审中-公开
标题翻译：无线宽带网络（WWAN）辅助无线无线局域网（WLAN）对等（P2P）连接和卸载
公开(公告)号：WO2013095382A1
公开(公告)日：2013-06-27
申请号：PCT/US2011/066160
申请日：2011-12-20
申请人： INTEL CORPORATION , YIN, Hujun , YANG, Rongzhen , FU, Jin
发明人： YIN, Hujun , YANG, Rongzhen , FU, Jin
IPC分类号： H04W76/02 , H04W92/18 , H04W88/06
CPC分类号： H04W4/005 , H04W4/70 , H04W12/06 , H04W76/14 , H04W84/12 , H04W88/06
摘要： A system and method for wireless wide area network (WWAN) assisted proximity wireless local area network (WLAN) peer-to-peer (P2P) connection and offloading is disclosed. The method includes the operation of identifying a first wireless device and a second wireless device between which a WLAN P2P connection is desired. Each wireless device can have a WWAN radio and a WLAN radio. WLAN information can be sent for at least one of the first and second wireless devices via the WWAN to a P2P configuration server. A WLAN P2P configuration can be received from the P2P configuration server at the first and second wireless devices via the WWAN for WLAN P2P communication between the first and second wireless devices. A WLAN P2P connection can be set up between the first and second wireless devices using the WLAN P2P configuration. The first and the second wireless devices can communicate using the WLAN P2P connection.
摘要翻译：公开了一种用于无线广域网（WWAN）辅助接近无线局域网（WLAN）对等（P2P）连接和卸载的系统和方法。该方法包括识别第一无线设备和在其间期望WLAN P2P连接的第二无线设备的操作。每个无线设备可以具有WWAN无线电和WLAN无线电。可以经由WWAN将第一和第二无线设备中的至少一个的WLAN信息发送到P2P配置服务器。可以经由WWAN在第一和第二无线设备处的P2P配置服务器接收WLAN P2P配置，用于第一和第二无线设备之间的WLAN P2P通信。可以使用WLAN P2P配置在第一和第二无线设备之间建立WLAN P2P连接。第一和第二无线设备可以使用WLAN P2P连接进行通信。

5. 发明申请

WO2013091147A1 METHOD AND APPARATUS FOR WIRELESS LOCATION TRACKING 审中-公开
标题翻译：无线定位跟踪的方法和装置
公开(公告)号：WO2013091147A1
公开(公告)日：2013-06-27
申请号：PCT/CN2011/002170
申请日：2011-12-23
申请人： INTEL CORPORATION , FU, Jin , YANG. Rongzhen , YIN, Hujin
发明人： FU, Jin , YANG. Rongzhen , YIN, Hujin
IPC分类号： H04L12/28
CPC分类号： H04W4/025 , G01S5/0252 , H04W4/029 , H04W4/043 , H04W64/00
摘要： A method and apparatus for wireless location tracking by a wireless device. In one embodiment of the invention, the wireless device has logic to determine the information of a plurality of specific location points and to determine the location of the wireless device based on the information of the plurality of specific location points. The specific location points are selected from a target area where the wireless device is located. By selecting the specific location points in the target area, it allows hidden Access Points (APs) or Base Stations (BSs) to be detected and measured and it increases the accuracy of the tracking of the wireless device.
摘要翻译：一种无线设备进行无线定位跟踪的方法和装置。在本发明的一个实施例中，无线设备具有确定多个特定位置点的信息并基于多个特定位置点的信息来确定无线设备的位置的逻辑。从无线设备所在的目标区域中选择特定的位置点。通过选择目标区域中的特定位置点，允许检测和测量隐藏的接入点（AP）或基站（BS），并提高无线设备的跟踪精度。

6. 发明申请

WO2013071485A1 SCHEDULING THREAD EXECUTION BASED ON THREAD AFFINITY 审中-公开
标题翻译：基于线程调度螺纹执行
公开(公告)号：WO2013071485A1
公开(公告)日：2013-05-23
申请号：PCT/CN2011/082215
申请日：2011-11-15
申请人： INTEL CORPORATION , CHEN, Feng , HAO, Yan , FU, Jin
发明人： CHEN, Feng , HAO, Yan , FU, Jin
IPC分类号： G06F9/46
CPC分类号： G06F9/46 , G06F9/4881 , G06F9/5033 , G06T15/00
摘要： In accordance with some embodiments, spatial and temporal locality between threads executing on graphics processing units may be analyzed and tracked in order to improve performance. In some applications where a large number of threads are executed and those threads use common resources such as common data, affinity tracking may be used to improve performance by reducing the cache miss rate and to more effectively use relatively small-sized caches.
摘要翻译：根据一些实施例，可以分析和跟踪在图形处理单元上执行的线程之间的空间和时间局部性，以便提高性能。在一些执行大量线程并且这些线程使用公共资源（例如公共数据）的应用中，可以使用亲和度跟踪来降低高速缓存未命中率并更有效地使用相对小尺寸的高速缓存。

7. 发明申请

WO2013006200A1 ACCURATE UPLINK POWER CONTROL FOR COMP AND C-RAN 审中-公开
标题翻译： COMP和C-RAN的精确上挂电源控制
公开(公告)号：WO2013006200A1
公开(公告)日：2013-01-10
申请号：PCT/US2011/067936
申请日：2011-12-29
申请人： YANG, Rongzhen , FU, Jin , NIU, Huaning , YIN, Hujun
发明人： YANG, Rongzhen , FU, Jin , NIU, Huaning , YIN, Hujun
IPC分类号： H04W52/24 , H04J11/00
CPC分类号： H04W72/042 , H04B7/0697 , H04B15/00 , H04L1/0025 , H04L1/0038 , H04L1/0041 , H04L1/0045 , H04L1/06 , H04L5/0037 , H04L5/14 , H04L27/34 , H04L27/362 , H04W4/70 , H04W8/02 , H04W24/00 , H04W24/08 , H04W52/0209 , H04W52/0212 , H04W52/0251 , H04W52/0258 , H04W52/143 , H04W52/242 , H04W52/244 , H04W52/325 , H04W72/02 , H04W72/04 , H04W72/0446 , H04W72/082 , H04W72/1215 , H04W72/1278 , H04W76/19 , H04W76/28 , H04W84/042 , H04W88/06 , Y02D70/00 , Y02D70/1224 , Y02D70/1226 , Y02D70/1242 , Y02D70/1244 , Y02D70/1262 , Y02D70/1264 , Y02D70/142 , Y02D70/144 , Y02D70/146 , Y02D70/164 , Y02D70/168 , Y02D70/21 , Y02D70/23 , Y02D70/24 , Y02D70/444
摘要： A user equipment (UE) is arranged to send an uplink power reference signal to an enhanced Node B (eNB) associated with multiple reception points (RPs), to receive identification of an RP set and a downlink reference signal power level, to determine a path loss estimate for each downlink reference signal received from RPs of the RP set, to determine an uplink power level that is a function of the path loss estimates determined for the downlink signals received from the RPs of the RP set, and to use the determined uplink power level during communication with the multiple RPs.
摘要翻译：用户设备（UE）被配置为向与多个接收点（RP）相关联的增强型节点B（eNB）发送上行链路功率参考信号，以接收RP集合的标识和下行链路参考信号功率电平，以确定确定从RP集合的RP接收的下行链路信号确定的路径损耗估计的函数的上行链路功率电平，并使用确定的路径损耗估计与多个RP通信期间的上行功率电平。

8. 发明申请

WO2012134531A1 UPLINK POWER CONTROL SCHEME FOR DISTRIBUTED RRH SYSTEMS WITH SAME CELL ID 审中-公开
标题翻译：用于具有相同小区ID的分布式RRH系统的上行功率控制方案
公开(公告)号：WO2012134531A1
公开(公告)日：2012-10-04
申请号：PCT/US2011/054274
申请日：2011-09-30
申请人： INTEL CORPORATION , YANG, Rongzhen , PAPATHANASSIOU, Apostolos , DAVYDOV, Alexei , ZHU, Yuan Y. , FU, Jin , ETEMAD, Kamran , YIN, Hujun , YANG, Xiangying , FWU, Jong-kae
发明人： YANG, Rongzhen , PAPATHANASSIOU, Apostolos , DAVYDOV, Alexei , ZHU, Yuan Y. , FU, Jin , ETEMAD, Kamran , YIN, Hujun , YANG, Xiangying , FWU, Jong-kae
IPC分类号： H04W52/18 , H04W52/14 , H04W52/08 , H04J11/00
CPC分类号： H04W48/10 , H04B7/0456 , H04B7/0486 , H04B7/0632 , H04B7/0639 , H04L5/003 , H04L5/0037 , H04L5/005 , H04L5/0094 , H04L25/0226 , H04L43/50 , H04L45/70 , H04L65/608 , H04L2025/03802 , H04W4/70 , H04W24/00 , H04W24/02 , H04W24/10 , H04W28/04 , H04W28/08 , H04W48/12 , H04W52/0216 , H04W52/146 , H04W52/18 , H04W52/242 , H04W52/40 , H04W72/00 , H04W72/0413 , H04W72/042 , H04W72/0453 , H04W88/02 , H04W88/08 , H04W92/20 , Y02D70/1224 , Y02D70/124 , Y02D70/1262 , Y02D70/142 , Y02D70/22 , Y02D70/444
摘要： Uplink power control in a macro cell in a wireless network comprises transmitting a reference signal from a base station device to at least one wireless device within the macro cell. The macro cell comprises the base station device and at least one radio transmitter device that is communicatively coupled to and remote from the base station device. The base station device and one or more radio transmitter devices could be selected to be a transmission point, a reception point or a combination thereof, for each wireless device. Information relating to a transmission power of the base station device is also transmitted to the at least one wireless device. An uplink signal is received from the at least one wireless device containing information relating to an uplink power determination that is based on the reference signal and the information relating to the transmission power of the base station device.
摘要翻译：在无线网络中的宏小区中的上行链路功率控制包括将参考信号从基站设备传送到宏小区内的至少一个无线设备。宏小区包括基站装置和至少一个通信地耦合到基站装置并远离基站装置的无线电发射装置。对于每个无线设备，可以将基站设备和一个或多个无线电发射机设备选择为传输点，接收点或其组合。与基站装置的发送功率有关的信息也被发送到至少一个无线装置。从至少一个无线装置接收到包含与基于参考信号的上行链路功率确定有关的信息和与基站装置的发送功率有关的信息的上行链路信号。

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