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1. 发明申请

WO1997012057A1 CHEMOTHERAPEUTIC AGENTS FOR MYCOBACTERIUM 审中-公开
标题翻译： MYCOBACTERIUM的化学药剂
公开(公告)号：WO1997012057A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015303
申请日：1996-09-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HORWITZ, Marcus, A. , CLEMENS, Daniel, L. , LEE, Bai-Yu
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12Q01/58
CPC分类号： A61K31/664 , A61K31/00 , A61K31/16 , A61K31/17 , A61K31/4015 , A61K38/00 , C12N9/80 , C12N15/1137 , C12Q1/18 , C12Q1/58 , C12Y305/01005
摘要： A method for treating mammals who are infected with a mycobacterium wherein the mycobacterium produces a urease. The method involves treating the mammal with an anti-urease agent to reduce the production of urease by the mycobacterium and thereby reduce biological activity of the mycobacterium. Anti-urease agents include urease inhibitors and oligodeoxynucleotides anti-sense to the urease gene or messenger RNA derived therefrom which prevents expression of urease by the mycobacterium. Methods for screening compounds for potential use as anti-mycobacterial agents are also disclosed as is the identity of urease produced by M. tuberculosis. The urease provides a target to which anti-bacterial agents can be directed.
摘要翻译：用于治疗被分枝杆菌感染的哺乳动物的方法，其中分枝杆菌产生脲酶。该方法包括用抗脲酶试剂处理哺乳动物以减少分枝杆菌产生脲酶，从而降低分枝杆菌的生物活性。抗脲酶剂包括脲酶抑制剂和对脲酶基因反义的寡聚脱氧核苷酸或由其衍生的信使RNA，其防止分枝杆菌表达脲酶。筛选化合物作为抗分枝杆菌药物的潜在用途的方法也公开了由结核分枝杆菌产生的尿素酶的特性。脲酶提供可以引导抗细菌剂的靶标。

2. 发明申请

WO1996037219A1 ABUNDANT EXTRACELLULAR PRODUCTS AND METHODS FOR THEIR PRODUCTION AND USE 审中-公开
标题翻译：优质细胞产品及其生产和使用方法
公开(公告)号：WO1996037219A1
公开(公告)日：1996-11-28
申请号：PCT/US1996007781
申请日：1996-05-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HORWITZ, Marcus, A. , HARTH, Günter
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： A61K39/04
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/51
摘要： Vaccines based on one or more combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant extracellular products of a target pathogen are selected irrespective of their absolute molecular immunogenicity and used as vaccines to stimulate a protective immune response in mammalian hosts against subsequent infection by the target pathogen. The majorly abundant extracellular products may be characterized and distinguished by their respective N-terminal amino acid, amino acid, or DNA sequences. As the vaccines may comprise different combinations of the extracellular products, subunits thereof, or encoding nucleic acids, a broad range of effective immunotherapeutic compositions are provided by the present invention. In addition to other infectious agents, the vaccines so produced can be used to stimulate an effective immune response against intracellular pathogens and in particular Mycobacterium tuberculosis.
摘要翻译：提出了基于病原体主要丰富细胞外产物的一种或多种组合的疫苗及其使用和生产方法。选择目标病原体的最普遍或主要丰富的细胞外产物，而不管其绝对分子免疫原性如何，并且用作疫苗以在哺乳动物宿主中刺激保护性免疫应答，防止目标病原体随后感染。主要丰富的细胞外产物可以通过它们各自的N-末端氨基酸，氨基酸或DNA序列来表征和区分。由于疫苗可以包含细胞外产物，其亚基或编码核酸的不同组合，本发明提供了广泛的有效的免疫治疗组合物。除了其它感染因子之外，如此产生的疫苗可用于刺激针对细胞内病原体，特别是结核分枝杆菌的有效免疫应答。

3. 发明申请

WO1998039357A1 METHOD OF ALLEVIATING NEUROPATHIC PAIN 审中-公开
标题翻译：治疗神经痛疼痛的方法
公开(公告)号：WO1998039357A1
公开(公告)日：1998-09-11
申请号：PCT/US1997016062
申请日：1997-09-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , O'BRIEN, John, S.
IPC分类号： C07K04/00
CPC分类号： C07K14/475 , A61K38/00
摘要： The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
摘要翻译：本发明提供了一种减轻受试者神经性疼痛的方法，该方法是通过对受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供一种抑制受试者神经性疼痛发作的方法，该方法是向受试者施用神经性疼痛缓解量的prosaposin受体激动剂。本发明还提供了prosaposin受体激动剂和这些激动剂用于刺激神经突生长，抑制神经细胞死亡，促进髓鞘形成和抑制神经脱髓鞘的用途。此外，提供了通过使神经元细胞与包含有效抑制量的前列腺素受体激动剂的组合物接触来抑制感觉或运动神经病的方法。

4. 发明申请

WO1998030715A1 OPTICAL SENSORS OF CELL SIGNALING 审中-公开
标题翻译：细胞信号的光学传感器
公开(公告)号：WO1998030715A1
公开(公告)日：1998-07-16
申请号：PCT/US1997019453
申请日：1997-10-24
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SIEGAL, Micah, S. , ISACOFF, Ehud, Y.
发明人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12P21/04
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2267/0393 , C07K14/43595 , C07K14/705 , C07K2319/00
摘要： A chimeric protein sensor including an optically active polypeptide linked to a responsive polypeptide, or responsive fragment thereof, which undergoes a change in response to a cell signaling event, wherein an optical property of the sensor is altered in response to the change in the responsive polypeptide, or responsive fragment thereof is provided, as well as nucleic acid sequences encoding the chimeric protein sensor. The chimeric protein sensor includes an optically active polypeptide or fragment thereof, such as green fluorescent protein (GFP), for measuring cellular events in vivo.
摘要翻译：一种嵌合蛋白传感器，其包括与响应性多肽或其响应片段连接的光学活性多肽，其响应于细胞信号传导事件而发生变化，其中响应于响应性多肽的变化而改变传感器的光学性质，或其响应片段，以及编码嵌合蛋白传感器的核酸序列。嵌合蛋白质传感器包括用于测量体内细胞事件的光学活性多肽或其片段，例如绿色荧光蛋白（GFP）。

5. 发明申请

WO1998026295A1 APPARATUS FOR AUTOMATED TESTING OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：自动测试生物样本的设备
公开(公告)号：WO1998026295A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022543
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N35/00
CPC分类号： G01N35/0092 , G01N35/0099 , G01N2035/00326 , G01N2035/0093 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for performing automated testing of infectious biological specimens is disclosed. The apparatus comprises a process controller for translating user commands into test instrument suite commands, and a test instrument suite comprising a means to treat the specimen to manifest an observable result, and a detector for measuring the observable result to generate specimen test results.
摘要翻译：公开了一种用于执行感染性生物样本的自动化测试的装置。该装置包括用于将用户命令转换为测试仪器套件命令的过程控制器，以及包括用于处理样本以显示可观察结果的装置的测试仪器套件，以及用于测量可观察结果以产生样本测试结果的检测器。

6. 发明申请

WO1998026290A1 APPARATUS FOR TESTING FOR INFECTION BY A RETROVIRUS 审中-公开
标题翻译：用于检测由RETROVIRUS感染的装置
公开(公告)号：WO1998026290A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022545
申请日：1997-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LAYNE, Scott, P. , BEUGELSDIJK, Tony, J.
IPC分类号： G01N33/569
CPC分类号： G01N33/56988 , G01N35/0092 , G01N35/0099 , G01N2035/00326 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/116664 , Y10T436/2575
摘要： An apparatus for testing specimens for infection by a retrovirus is described. The apparatus comprises a process controller including a communications module for translating user commands into test instrument suite commands and a means for communicating specimen test results to a user. The apparatus further comprises a test instrument suite including a means for treating the specimen to manifest an observable result and a detector for measuring the observable result.
摘要翻译：描述了用于测试由逆转录病毒感染的样品的装置。该装置包括一个过程控制器，该过程控制器包括用于将用户命令转换成测试仪器套件命令的通信模块和用于将样本测试结果传送给用户的装置。该装置还包括测试仪器套件，其包括用于处理样本以显示可观察结果的装置和用于测量可观察结果的检测器。

7. 发明申请

WO1998026044A1 IN CULTURE PROLIFERATION OF HUMAN PANCREATIC ENDOCRINE CELLS 审中-公开
标题翻译：文化增殖人胰腺内皮细胞
公开(公告)号：WO1998026044A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022827
申请日：1997-12-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BEATTIE, Gillian, M. , HAYEK, Alberto
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12N05/00
CPC分类号： C12N5/0676 , C12N2502/30
摘要： Islets and islet-like cell clusters are proliferated in culture without loss of insulin-secreting function by incubation in a medium containing extracellular matrix of human bladder carcinoma cells, preferably the human bladder carcinoma cell line HTB-9.
摘要翻译：在含有人膀胱癌细胞，优选人膀胱癌细胞系HTB-9细胞外基质的培养基中孵育，胰岛和胰岛样细胞簇在培养物中增殖而不损失胰岛素分泌功能。

8. 发明申请

WO1998025701A1 MICROFABRICATED SLEEVE DEVICES FOR CHEMICAL REACTIONS 审中-公开
标题翻译：用于化学反应的微波清洗装置
公开(公告)号：WO1998025701A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023180
申请日：1997-12-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NORTHRUP, M., Allen
IPC分类号： B01L03/00
CPC分类号： B01L7/52 , B01J19/0046 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00936 , B01J2219/00945 , B01J2219/00952 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0654 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0421 , B01L2400/0439 , B01L2400/0487 , B81C3/00 , G01N21/0332 , G01N21/05 , G01N21/69 , G01N21/76 , G01N2021/0346
摘要： A silicon-based sleeve type chemical reaction chamber (50) that combines doped silicon heating elements (57) and bulk silicon convective cooling elements (51, 52). A critical ratio of silicon and non-silicon based materials provides the thermal properties desired. The reaction chamber may be used for any chemical reaction, especially synthetic, thermal-cycling-based reactions such as the polymerase chain reaction (PCR) or ligase chain reaction.
摘要翻译：组合掺杂硅加热元件（57）和体硅对流冷却元件（51,52）的硅基套管型化学反应室（50）。硅和非硅基材料的临界比提供了所需的热性质。反应室可用于任何化学反应，特别是合成的基于热循环的反应，如聚合酶链式反应（PCR）或连接酶链式反应。

10. 发明申请

WO1998020022A1 SOLUBLE PROTEINS 审中-公开
标题翻译：可溶性蛋白质
公开(公告)号：WO1998020022A1
公开(公告)日：1998-05-14
申请号：PCT/US1997006227
申请日：1997-04-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PRUSINER, Stanley, B. , COHEN, Fred, E. , MURAMOTO, Tamaki
IPC分类号： C07K01/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/47 , C07K16/18
摘要： The invention includes deleting codon segments from DNA expressing a native protein in order to obtain a shorter, soluble protein which mimics characteristics of an insoluble native protein. Soluble proteins of the invention are characterized by: (1) having less amino acids than the full length native protein; (2) having a higher degree of solubility than the native protein; (3) retaining the basic biological characteristics of the native protein such as (a) not being subject to enzymatic digestion and (b) causing disease. Soluble proteins of the invention are obtained by providing a DNA sequence which encodes a native protein and systematically removing codons, making copies of the shortened versions of DNA which are then expressed to provide the shortened proteins. The shortened proteins are then tested for solubility. Soluble proteins are then further tested to confirm that they retain the biological characteristics of the native protein.
摘要翻译：本发明包括从表达天然蛋白质的DNA中删除密码子片段，以获得模拟不溶性天然蛋白质特征的较短的可溶性蛋白质。本发明的可溶性蛋白质的特征在于：（1）具有比全长天然蛋白质少的氨基酸; （2）具有比天然蛋白质更高的溶解度; （3）保留天然蛋白质的基本生物学特性，如（a）不经酶消化和（b）引起疾病。通过提供编码天然蛋白质的DNA序列并系统地除去密码子，制备DNA的缩短形式的拷贝，然后进行表达以提供缩短的蛋白质，从而获得本发明的可溶性蛋白质。然后测试缩短的蛋白质的溶解度。然后进一步测试可溶性蛋白质以证实它们保留天然蛋白质的生物学特性。

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