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1. 发明申请

WO2014071398A1 MECHANICAL PHENOTYPING OF SINGLE CELLS: HIGH THROUGHPUT QUANTITATIVE DETECTION AND SORTING 审中-公开
标题翻译：单细胞的机械反应：高通量定量检测和分选
公开(公告)号：WO2014071398A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068571
申请日：2013-11-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： ROWAT, Amy , HOELZLE, David, J. , CHAN, Clara
IPC分类号： G01N35/08 , C12Q1/06 , C12Q1/24
CPC分类号： G01B7/22 , B01L3/5027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , C12M47/04 , G01L1/14 , G01N27/22 , G01N29/022 , G01N29/036 , G01N29/222 , G01N2291/02466 , G01N2291/02827
摘要： This invention provides methods and devices for the high-throughput characterization of the mechanical properties of cells or particles. In certain embodiments the devices comprise a micro fluidic channel comprising: an oscillating element on a first side of said channel; and a detecting element on a second side of said channel opposite said oscillating element, wherein said detecting element is configured to detect a force transmitted through a cell or microparticle by said oscillating element. In certain embodiments the devices comprise a microfluidic channel comprising an integrated oscillator and sensor element on one first side of said channel, wherein said sensor is configured to detect a force transmitted through a cell or microparticle by said oscillator.
摘要翻译：本发明提供用于高通量表征细胞或颗粒的机械性能的方法和装置。在某些实施例中，装置包括微流体通道，其包括：在所述通道的第一侧上的振荡元件; 以及在所述通道的与所述振荡元件相对的第二侧上的检测元件，其中所述检测元件被配置为检测由所述振荡元件传递通过电池或微粒的力。在某些实施例中，装置包括微流体通道，其包括在所述通道的一个第一侧上的集成振荡器和传感器元件，其中所述传感器被配置为检测由所述振荡器传递通过电池或微粒的力。

2. 发明申请

WO2013056253A1 HIGH THROUGHPUT INSTRUMENTATION TO SCREEN CELLS AND PARTICLES BASED ON THEIR MECHANICAL PROPERTIES 审中-公开
标题翻译：基于其机械性能的高电导率仪器筛选细胞和颗粒
公开(公告)号：WO2013056253A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/060297
申请日：2012-10-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： ROWAT, Amy , QI, Dongping
IPC分类号： C12Q1/24 , C12Q1/02 , B07B1/00
CPC分类号： G01N33/5091 , B07B1/46 , B07B13/04 , G01N33/5005 , G01N33/5011 , G01N33/5026 , G01N2500/10
摘要： A system for the high-throughput screening of mechanical properties of cells and/or particles is provided. In certain embodiments the system comprises a first structure comprising a plurality of sample receiving wells; a second structure comprising a plurality of exit ports; a porous structure disposed between said plurality of sample receiving wells and said plurality of exit ports and in communication with said plurality of sample receiving wells and in communication with said plurality of exit ports, and said first structure, said second structure and said porous structure are sealed or configured such that when sufficient pressure is applied to sample receiving wells in said first structure said cells or particles migrate through the porous structure into said exit ports, and wherein the mean or the median pore size of said porous structure is smaller than the mean or median cross-section of a cell or particle that is to be screened.
摘要翻译：提供了用于高通量筛选细胞和/或颗粒的机械性能的系统。在某些实施例中，系统包括包括多个样品接收孔的第一结构; 第二结构，包括多个出口; 设置在所述多个样品接收孔和所述多个出口之间并与所述多个样品接收阱连通并与所述多个出口连通的多孔结构，所述第一结构，所述第二结构和所述多孔结构是密封或构造使得当对所述第一结构中的样品接收孔施加足够的压力时，所述细胞或颗粒通过多孔结构迁移到所述出口中，并且其中所述多孔结构的平均孔径或中值孔径小于平均值或要筛选的细胞或颗粒的中间截面。

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