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1. 发明申请

WO2020092928A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS OF CARDIOVASCULAR DISEASE 审中-公开
公开(公告)号：WO2020092928A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059433
申请日：2019-11-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , GONEN, Ayelet , TSIMIKAS, Sotirios , WITZTUM, Joseph, L.
IPC分类号： C07K16/18 , G01N33/92
摘要： Provided herein are new diagnostic biomarkers for cardiovascular disease, antibodies for detecting said diagnostic biomarkers, and immunoassays, imaging agents, and therapeutics based therefrom.

2. 发明申请

WO2014193822A1 COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS 审中-公开
标题翻译：用于调节血管生成和胆固醇并治疗氯吡格雷的组合物和方法，ATHEROSCLEROSIS，癌症和炎症条件
公开(公告)号：WO2014193822A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/039549
申请日：2014-05-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , FANG, Longhou
IPC分类号： A61K38/00 , A61P3/06 , A61P9/00 , C07K14/515
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1761 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/3233
摘要： The invention provides pharmaceutical compounds and formulations comprising nucleic acids and polypeptides for regulating (including upregulating or inhibiting) the expression of ApoA-l Binding Protein (APOAIBP, AIBP, or AI-BP), and methods for making and using them. In alternative embodiments, APOAIBP-inhibiting pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to stimulate tissue revascularization, e.g., supporting or stimulating revascularization of heart tissue, e.g., after a cardiac ischemia. In alternative embodiments, pharmaceutical compositions and formulations of the invention that comprise APOAIBP nucleic acids and polypeptides or result in an increase in expression or activity of APOAIBP nucleic acids and polypeptides are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate a dyslipidemia, e.g., to treat, prevent, reverse and/or ameliorate conditions responsive to increasing cholesterol efflux from cells, including cardiovascular disease and atherosclerosis.
摘要翻译：本发明提供包含用于调节（包括上调或抑制）ApoA-1结合蛋白（APOAIBP，AIBP或AI-BP）的表达的核酸和多肽的药物化合物和制剂及其制备和使用方法。在替代实施方案中，本发明的APOAIBP抑制药物组合物和制剂以足以刺激组织血运重建的量给予有此需要的个体，例如支持或刺激心脏组织的血运重建，例如在心脏缺血后。在替代实施方案中，包含APOAIBP核酸和多肽或导致APOAIBP核酸和多肽的表达或活性增加的本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善血脂异常，例如，治疗，预防，逆转和/或改善对增加胆固醇从细胞外溢（包括心血管疾病和动脉粥样硬化）的反应。

3. 发明申请

WO2022046919A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR NEUROINFLAMMATION 审中-公开
公开(公告)号：WO2022046919A2
公开(公告)日：2022-03-03
申请号：PCT/US2021/047569
申请日：2021-08-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , CHOI, Soo-Ho , JU, Wonkyu
IPC分类号： A61K38/00 , A61K38/17 , A61P29/00 , A61P3/06 , C12N15/86
摘要： Provided herein are products of manufacture, kits, and methods, for: treating, ameliorating, protecting against, reversing or decreasing the severity or duration of neuroinflammation in the eye, as for example, during glaucomatous neurodegeneration by administration of a polypeptide composition or a nucleic acid composition encoding a polypeptide composition, wherein the polypeptide composition is, or is comprised of, an ApoA-I Binding Protein.

4. 发明申请

WO2022198073A1 COMPOSITIONS AND METHODS FOR TARGETING INFLAMMATORY OR ARCTIVATED CELLS AND TREATING OR AMELIORATING INFLAMMATORY CONDITIONS AND PAIN 审中-公开
公开(公告)号：WO2022198073A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020991
申请日：2022-03-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , CHOI, Soo-Ho
IPC分类号： A61P25/00 , C07K14/47
摘要： Provided are methods for modification of amino acid sequence and increasing levels of expression of ApoA-I Binding Protein to treat: a neuropathic pain, a CNS inflammation, an allodynia, a post nerve injury pain, a post-surgical pain, a chemotherapeutic-induced peripheral neuropathy, a neurodegeneration, including for example, a neurodegenerative disease or condition such as Alzheimer's disease, a hyperalgesia, primary headaches such as migraines and cluster headaches, glaucoma or other inflammatory diseases of the eye, lung inflammation, asthma, HIV infection, vascular inflammation, atherosclerosis and cardiovascular disease. Provided are methods comprising administering pharmaceutical compositions comprising a recombinantly modified APOA1BP polypeptide to treat a neuropathic pain, an allodynia, a hyperalgesia, a neurodegenerative disease, a primary headache such as a migraine, glaucoma, lung inflammation and asthma, acute respiratory distress syndrome (ARDS), sepsis, viral infection, including influenza, coronavirus (for example, COVID-19) or HIV infection, or its comorbidities, and/or vascular inflammation, atherosclerosis and cardiovascular disease.

5. 发明申请

WO2017100125A1 COMPOSITIONS AND METHODS FOR TREATING OR AMELIORATING NEUROINFLAMMATION, NEURODEGENERATION, NEUROPATHIC PAIN, AND MIGRAINE 审中-公开
标题翻译：用于治疗或改善神经性疼痛，神经退化，神经性疼痛和偏头痛的组合物和方法
公开(公告)号：WO2017100125A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/064938
申请日：2016-12-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , YAKSH, Tony L.
IPC分类号： A61K38/00 , A61K38/17 , A61P25/02 , C07K14/47 , C07K14/515 , C07K16/18
CPC分类号： C12Y501/99006 , A61K38/52 , A61K48/00 , A61P25/28 , A61P29/00 , C07K14/00 , C12N9/90
摘要： This invention generally relates to medicine, pain control and cell biology. In particular, provided are methods for increasing levels of and/or upregulating the expression of ApoA-1 Binding Protein (APOA1 BP, AIBP, or A1-BP) to treat, ameliorate, prevent, reverse, decrease the severity and/or duration of: a neuropathic pain, a CNS inflammation, an allodynia, a post nerve injury pain, a post-surgical pain, a chemotherapeutic-induced peripheral neuropathy (CIPN) a neurodcgeneration. In alternative embodiments, provided are methods comprising administering formulations and pharmaceutical compositions comprising an APOA1 BP polypeptide, a peptidomimetic or a synthetic APOA1 BP thereof, to treat, ameliorate prevent, reverse, decrease the severity of a neuropathic pain, an allodynia, a hyperalgesia, a neurodegenerative disease or condition such as Alzheimer's disease, and/or a primary headache such as a migraine. In alternative embodiments, provided are kits comprising a formulation or a pharmaceutical composition used in a method or use as provided herein.
摘要翻译：本发明一般涉及药物，疼痛控制和细胞生物学。具体而言，提供了用于增加和/或上调ApoA-1结合蛋白（APOA1BP，AIBP或A1-BP）表达水平和/或上调治疗，改善，预防，逆转，降低严重性和/或持续时间：神经性疼痛，CNS炎症，异常性疼痛，后神经损伤疼痛，术后疼痛，化疗诱导的周围神经病变（CIPN），神经再生。在替代实施方案中，提供了包括施用包含APOA1BP多肽，其拟肽或合成APOA1BP的制剂和药物组合物以治疗，改善预防，逆转，降低神经性疼痛的严重性，异常性疼痛，痛觉过敏，神经退行性疾病或病症如阿尔茨海默氏病，和/或原发性头痛如偏头痛。在替代实施方案中，提供了包含在本文提供的方法或用途中使用的制剂或药物组合物的试剂盒。

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