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1. 发明申请

WO2014193822A1 COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS 审中-公开
标题翻译：用于调节血管生成和胆固醇并治疗氯吡格雷的组合物和方法，ATHEROSCLEROSIS，癌症和炎症条件
公开(公告)号：WO2014193822A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/039549
申请日：2014-05-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MILLER, Yury , FANG, Longhou
IPC分类号： A61K38/00 , A61P3/06 , A61P9/00 , C07K14/515
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1761 , C07K16/18 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/3233
摘要： The invention provides pharmaceutical compounds and formulations comprising nucleic acids and polypeptides for regulating (including upregulating or inhibiting) the expression of ApoA-l Binding Protein (APOAIBP, AIBP, or AI-BP), and methods for making and using them. In alternative embodiments, APOAIBP-inhibiting pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to stimulate tissue revascularization, e.g., supporting or stimulating revascularization of heart tissue, e.g., after a cardiac ischemia. In alternative embodiments, pharmaceutical compositions and formulations of the invention that comprise APOAIBP nucleic acids and polypeptides or result in an increase in expression or activity of APOAIBP nucleic acids and polypeptides are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate a dyslipidemia, e.g., to treat, prevent, reverse and/or ameliorate conditions responsive to increasing cholesterol efflux from cells, including cardiovascular disease and atherosclerosis.
摘要翻译：本发明提供包含用于调节（包括上调或抑制）ApoA-1结合蛋白（APOAIBP，AIBP或AI-BP）的表达的核酸和多肽的药物化合物和制剂及其制备和使用方法。在替代实施方案中，本发明的APOAIBP抑制药物组合物和制剂以足以刺激组织血运重建的量给予有此需要的个体，例如支持或刺激心脏组织的血运重建，例如在心脏缺血后。在替代实施方案中，包含APOAIBP核酸和多肽或导致APOAIBP核酸和多肽的表达或活性增加的本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善血脂异常，例如，治疗，预防，逆转和/或改善对增加胆固醇从细胞外溢（包括心血管疾病和动脉粥样硬化）的反应。

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