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1. 发明申请

WO2014179760A1 CYCLIC DI-NUCLEOTIDE INDUCTION OF TYPE I INTERFERON 审中-公开
标题翻译：循环二核苷酸诱导I型干扰素
公开(公告)号：WO2014179760A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/036685
申请日：2014-05-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BURDETTE, Dara
发明人： BURDETTE, Dara , VANCE, Russell E. , HAMMOND, Ming C. , DINER, Elie J. , WILSON, Stephen C.
IPC分类号： C07H19/00 , C07K14/555 , C12P21/00
CPC分类号： C07H21/02 , A61K31/7084
摘要： Methods and compositions are provided for increasing the production of a type I interferon (IFN) in a cell. Aspects of the methods include increasing the level of a 2'-5' phosphodiester linkage comprising cyclic-di-nucleotide in a cell in a manner sufficient to increase production of the type I interferon (IFN) by the cell. Also provided are compositions and kits for practicing the embodiments of the methods.
摘要翻译：提供了用于增加细胞中I型干扰素（IFN）产生的方法和组合物。方法的方面包括以足以增加细胞产生I型干扰素（IFN）的方式增加细胞中包含环状二核苷酸的2'-5'磷酸二酯键的水平。还提供了用于实施方法的实施方案的组合物和试剂盒。

2. 发明申请

WO2017218358A1 FLUORESCENT BIOSENSOR FOR 2', 3'-cGAMP 审中-公开
标题翻译：荧光生物传感器2'，3'-cGAMP
公开(公告)号：WO2017218358A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/036859
申请日：2017-06-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： HAMMOND, Ming C. , SU, Yichi , BOSE, Debojit
IPC分类号： A61K31/7125 , A61K31/713 , C12N15/113 , C12N15/115 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/115 , C12N2310/16 , C12N2320/10 , C12Q1/6825
摘要： A single stranded nucleic acid biosensor for 2', 3'-cGAMP is provided. The single stranded nucleic acid may include a 2', 3'-cGAMP-binding riboswitch domain comprising a transducer stem and a dye-binding aptamer domain that is operably connected to the transducer stem. A 2', 3'-cGAMP-binding riboswitch domain can be a GEMM-II riboswitch domain. The dye-binding aptamer domain can be a Spinach2 aptamer. The 2', 3'-cGAMP biosensor may further include a signaling chromophore specifically bound to the Spinach2 aptamer domain, where the sensor is configured to fluorescently activate the signaling chromophore upon specific binding of 2', 3'-cGAMP to the 2', 3'-cGAMP-binding riboswitch domain. Also provided are methods in which the subject 2', 3'-cGAMP biosensors find use including methods for determining the level of cGAS activity in a sample or a cell. Nucleic acid constructs and host cells including the same are also provided.
摘要翻译：提供了用于2'，3'-cGAMP的单链核酸生物传感器。单链核酸可包括2'，3'-cGAMP-结合核糖开关结构域，其包含可操作地连接至换能器茎的换能器茎和染料结合适体结构域。 2'，3'-cGAMP结合核糖开关结构域可以是GEMM-II核糖开关结构域。染料结合适体结构域可以是Spinach2适体。 2'，3'-cGAMP生物传感器可以进一步包括与Spinach2适体结构域特异性结合的信号发色团，其中传感器被配置为在2'，3'-cGAMP与2'，3'-cGAMP特异性结合后荧光激活信号发色团， 3'-cGAMP-结合核糖开关结构域。还提供了其中受试者2'，3'-cGAMP生物传感器的使用方法，包括用于确定样品或细胞中cGAS活性水平的方法。还提供了核酸构建体和包括它们的宿主细胞。

3. 发明申请

WO2018119117A1 METHODS OF PRODUCING CYCLIC DINUCLEOTIDES 审中-公开
公开(公告)号：WO2018119117A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/067669
申请日：2017-12-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： HAMMOND, Ming C. , WRIGHT, Todd A.
IPC分类号： C07H19/207 , C12N15/09 , C12N15/10 , C12N15/52 , C12N15/79 , C12N15/80 , C12N15/81
CPC分类号： C12P19/36 , C12N9/1241 , C12N15/09 , C12N15/10 , C12N15/52 , C12N15/79 , C12N15/80 , C12N15/81
摘要： The present disclosure provides cyclic dinucleotides (CDNs), and methods of preparing and using the same. The subject methods can include contacting a CDN producing-enzyme with a precursor of a CDN under conditions sufficient to convert the precursor into a CDN. In some embodiments, the CDN producing-enzyme is a Hypr GGDEF enzyme. The methods can be performed in vitro or in a genetically modified host cell. Also provided are CDN compositions that find use in a variety of applications. Methods of modulating an immune response in an individual and methods of inhibiting a bacterial biofilm in an industrial system are also provided.

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