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1. 发明申请

WO1998008980A1 METHOD FOR DETECTING CELL PROLIFERATIVE DISORDERS 审中-公开
标题翻译：检测细胞增殖性疾病的方法
公开(公告)号：WO1998008980A1
公开(公告)日：1998-03-05
申请号：PCT/US1997015286
申请日：1997-08-28
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , SIDRANSKY, David
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to the detection of a cell proliferative disorder associated with alterations of microsatellite DNA in a sample. The microsatellite DNA can be contained within any of a variety of samples, such as urine, sputum, bile, stool, cervical tissue, saliva, tears or cerebral spinal fluid. The invention is a method to detect an allelic imbalance by assaying microsatellite DNA. Allelic imbalance is detected by observing an abnormality in an allele, such as an increase or decrease in microsatellite DNA which is at or corresponds to an allele. An increase can be detected as the appearance of a new allele. In practicing the invention, DNA amplification methods, particularly polymerase chain reactions, are useful for amplifying the DNA. DNA analysis methods can be used to detect such a decrease or increase. The invention is also a method to detect genetic instability of microsatellite DNA. Genetic instability is detected by observing an amplification or deletion of the small, tandem repeat DNA sequences in the microsatellite DNA which is at or corresponds to an allele. The invention is also a kit for practicing these methods.
摘要翻译：本发明涉及与样品中微卫星DNA的改变相关的细胞增殖性病症的检测。微卫星DNA可以包含在各种样品中，例如尿液，痰液，胆汁，粪便，宫颈组织，唾液，眼泪或脑脊髓液中。本发明是通过测定微卫星DNA检测等位基因不平衡的方法。通过观察等位基因的异常来检测等位基因不平衡，例如与等位基因处于或对应的微卫星DNA的增加或减少。可以检测到增加作为新等位基因的出现。在实施本发明时，DNA扩增方法，特别是聚合酶链式反应，可用于扩增DNA。 DNA分析方法可用于检测这种减少或增加。本发明也是检测微卫星DNA遗传不稳定性的方法。通过观察微卫星DNA中位于或对应于等位基因的小的串联重复DNA序列的扩增或缺失来检测遗传不稳定性。本发明也是用于实施这些方法的试剂盒。

2. 发明申请

WO1998006746A2 MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME 审中-公开
标题翻译： MELANOMA细胞系表达共享的免疫抑制剂MELANOMAA抗原及其使用方法
公开(公告)号：WO1998006746A2
公开(公告)日：1998-02-19
申请号：PCT/US1997012868
申请日：1997-08-04
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , PARDOLL, Drew, M. , JAFFEE, Elizabeth, M. , ADLER, Adam , TOPALIAN, Suzanne, L. , ROSENBERG, Steven, A.
IPC分类号： C07K14/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
摘要翻译：本发明涉及治疗或保护黑色素瘤的方法，其包括（a）获得表达一种或多种共同免疫显性黑素瘤抗原的黑素瘤细胞系，（b）修饰黑素瘤细胞系以使其能够产生增加的水平相对于未修饰的细胞系的citokyne，和（c）将黑色素瘤细胞系施用于具有黑素瘤或具有发展黑素瘤风险的哺乳动物宿主。优选地，黑素瘤细胞系是同种异体的并且不与宿主MHC匹配。

3. 发明申请

WO1996002559A1 GROWTH DIFFERENTIATION FACTOR-12 审中-公开
标题翻译：生长差异因子-12
公开(公告)号：WO1996002559A1
公开(公告)日：1996-02-01
申请号：PCT/US1995008745
申请日：1995-07-12
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , LEE, Se-Jin , ESQUELA, Aurora, F.
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
IPC分类号： C07H21/04
CPC分类号： C07K14/475 , A61K38/00
摘要： Growth differentiation factor-12 (GDF-12) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-12 polypeptide and polynucleotide sequences.
摘要翻译：公开了生长分化因子-12（GDF-12）及其多核苷酸序列和氨基酸序列。还公开了使用GDF-12多肽和多核苷酸序列的诊断和治疗方法。

4. 发明申请

WO1995001802A1 GROWTH DIFFERENTIATION FACTOR-7 审中-公开
标题翻译：生长差异因子-7
公开(公告)号：WO1995001802A1
公开(公告)日：1995-01-19
申请号：PCT/US1994007799
申请日：1994-07-08
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , LEE, Se-Jin , HUYNH, Thanh
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
IPC分类号： A61K37/36
CPC分类号： C07K14/475 , A61K38/00 , C07K14/51
摘要： Growth differentiation factor-7 (GDF-7) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-7 polypeptide and polynucleotide sequences.
摘要翻译：公开了生长分化因子-7（GDF-7）及其多核苷酸序列和氨基酸序列。还公开了使用GDF-7多肽和多核苷酸序列的诊断和治疗方法。

5. 发明申请

WO1991009958A1 METHOD OF DELIVERING MOLECULES INTO EUKARYOTIC CELLS 审中-公开
标题翻译：将分子递送到真核细胞中的方法
公开(公告)号：WO1991009958A1
公开(公告)日：1991-07-11
申请号：PCT/US1990007607
申请日：1990-12-21
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , FRANKEL, Alan , PABO, Carl
IPC分类号： C12N15/87

6. 发明申请

WO1990015076A2 MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE ADHESION RECEPTOR 'beta'-CHAIN, METHODS OF PRODUCING THESE ANTIBODIES AND USE THEREFORE 审中-公开
标题翻译：抗白念珠菌粘附受体β环的单克隆抗体，生产这些抗体的方法及其应用
公开(公告)号：WO1990015076A2
公开(公告)日：1990-12-13
申请号：PCT/US1990002979
申请日：1990-05-30
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , HILDRETH, James, E.
IPC分类号： C07K15/28
CPC分类号： C07K16/2845 , A61K38/00
摘要： Monoclonal antibodies and method for ameliorating an immune response disorder. The monoclonal antibodies are specific for an epitope present on the leukocyte adhesion receptor beta -chain.
摘要翻译：用于改善免疫应答障碍的单克隆抗体和方法。单克隆抗体对白细胞粘附受体β链上存在的表位是特异性的。

7. 发明申请

WO1996035708A1 FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR-1 (FHF-1) AND METHODS OF USE 审中-公开
标题翻译：纤维生长因子同源因子-1（FHF-1）及其使用方法
公开(公告)号：WO1996035708A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006664
申请日：1996-05-10
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , NATHANS, Jeremy , SMALLWOOD, Philip, M. , MACKE, Jennifer, P.
IPC分类号： C07K01/00
CPC分类号： C07K16/22 , A61K38/00 , C07K14/50 , C12Q1/6886 , C12Q2600/158
摘要： A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
摘要翻译：公开了一种新型蛋白质，成纤维细胞生长因子同源因子-1（FHF-1），编码FHF-1的多核苷酸序列和推定的氨基酸序列。还公开了使用FHF-1多肽和特异性结合FHF-1的多核苷酸序列和抗体的诊断和治疗方法。

8. 发明申请

WO1996023498A1 METHOD OF PREVENTING PROLIFERATION OF RETINAL PIGMENT EPITHELIUM BY RETINOIC ACID RECEPTOR AGONISTS 审中-公开
标题翻译：通过反义酸受体激动剂预防上皮细胞增殖的方法
公开(公告)号：WO1996023498A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001505
申请日：1996-01-31
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , CAMPOCHIARO, Peter, A. , WHEELER, Larry, A. , CHANDRARATNA, Roshantha, A. , NAGPAL, Sunil , DE JUAN, Eugene, Jr.
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
IPC分类号： A61K31/435
CPC分类号： A61K31/455 , A61K31/192 , Y10S514/912
摘要： Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is also a potent antagonist of AP1-dependent gene expression. Alternatively, the proliferation of retinal pigment epithelium is ameliorated with a therapeutic amount of an AP-1 antagonist, alone or in combination with an RAR agonist. The drug can be administered by bolus injection into the vitreous cavity using a dosage from about 50 to 150 mu g, or by slow release from liposomes or an oil tamponade injected into the vitreous cavity. Formulations for preventing proliferation of retinal pigment epithelium are also provided.
摘要翻译：通过使视网膜色素上皮细胞与治疗量的视黄酸受体（RAR）激动剂接触，可防止手术或创伤后视网膜色素上皮细胞增生或与脉络膜新生血管形成相关的眼部疾病如老年性黄斑变性和组织胞浆菌病综合征，优选具有视黄酸受体的比活性。优选地，RAR激动剂也是AP1依赖性基因表达的有效拮抗剂。或者，视网膜色素上皮的增殖用治疗量的AP-1拮抗剂单独或与RAR激动剂组合改善。药物可以通过使用约50至150μg的剂量或通过从注射到玻璃体腔中的脂质体或油栓塞缓慢释放而推注到玻璃体腔中来施用。还提供了用于防止视网膜色素上皮细胞增殖的制剂。

9. 发明申请

WO1996016668A1 NOVEL HEDGEHOG-DERIVED POLYPEPTIDES 审中-公开
标题翻译：新型HEDGEHOG衍生多糖
公开(公告)号：WO1996016668A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015923
申请日：1995-12-04
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF WASHINGTON
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF WASHINGTON , BEACHY, Philip, A. , MOON, Randall, T. , PORTER, Jeffrey, A.
IPC分类号： A61K38/17
CPC分类号： G01N33/5058 , A01K67/0339 , A01K2217/05 , A01K2227/40 , A01K2227/50 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/92 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G CF site recognized by the autoproteolytic domain in the native protein. Also provided are methods of use of the N and C fragments.
摘要翻译：本发明提供两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或分别在识别的G

10. 发明申请

WO1996009066A2 METHOD OF TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION 审中-公开
标题翻译：治疗人类免疫缺陷病毒（HIV）感染的方法
公开(公告)号：WO1996009066A2
公开(公告)日：1996-03-28
申请号：PCT/US1995011943
申请日：1995-09-19
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , CLEMENTS, Janice, E. , MURPHEY-CORB, Michael , ZINK, M., Christine
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , C07K16/1063 , C12N2740/15022
摘要： A method of treating a host prophylactically or therapeutically for infection with human immunodeficiency virus (HIV) is described. A simian immunodeficiency virus (SIV)-macaque monkey model shows that infection with a non-pathogenic, macrophage-tropic, recombinant SIV provides systemic immunity to the host by stimulation of production of neutralizing antibodies. Tests provided show that the neutralizing antibodies produced are broadly reactive with several heterologous strains of SIV. Also provided are pharmaceutical compositions useful for treatment of a subject prior to or following infection with HIV.
摘要翻译：描述了预防或治疗用于人类免疫缺陷病毒（HIV）感染的宿主的方法。猿猴免疫缺陷病毒（SIV） - 大麻猴模型显示，通过刺激中和抗体的产生，非致病性，巨噬细胞 - 转移重组SIV的感染为宿主提供了全身免疫。所提供的测试显示产生的中和抗体与SIV的几种异源株广泛反应。还提供了可用于在HIV感染之前或之后治疗受试者的药物组合物。

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