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1. 发明申请

WO1997038129A1 ASSAYS AND REAGENTS FOR IDENTIFYING ANTI-FUNGAL AGENTS, AND USES RELATED THERETO 审中-公开
标题翻译：用于鉴定抗真菌剂的测定剂和试剂及其相关用途
公开(公告)号：WO1997038129A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005929
申请日：1997-04-10
申请人： MITOTIX, INC. , THE JOHNS HOPKINS UNIVERSITY
发明人： MITOTIX, INC. , THE JOHNS HOPKINS UNIVERSITY , BERLIN, Vivian , DAMAGNEZ, Veronique , SMITH, Susan, E.
IPC分类号： C12Q01/18
CPC分类号： C07K16/14 , A61K38/00 , C07K14/40 , C12Q1/18 , C12Q1/48 , C12Q1/6895 , C12Q1/6897 , G01N33/573 , G01N2333/40 , G01N2333/91091 , G01N2333/91165
摘要： The present invention relates to rapid, reliable and effective assays for screening and identifying pharamceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
摘要翻译：本发明涉及用于筛选和鉴定特异性抑制真菌GTP酶蛋白的生物活性的特异性有效化合物的快速，可靠和有效的测定法，特别是涉及细胞壁完整性，菌丝形成和/或对发病机制至关重要的其它细胞功能的GTP酶。本发明的另一方面涉及新颖的念珠菌基因和基因产物。

2. 发明申请

WO1997008341A1 MONO-ALLELIC MUTATION ANALYSIS FOR IDENTIFYING GERMLINE MUTATIONS 审中-公开
标题翻译：用于识别GMLM突变的单声道突变分析
公开(公告)号：WO1997008341A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013477
申请日：1996-08-23
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , VOGELSTEIN, Bert , KINZLER, Kenneth, W. , PAPADOPOULOS, Nickolas
IPC分类号： C12Q01/68
CPC分类号： G01N33/68 , C12Q1/6827 , G01N33/5005 , C12Q2561/107
摘要： A diagnostic strategy for detection of inherited diseases caused by germline mutations is based on somatic cell hybridization. Each allele of a human gene involved in the inherited disease is isolated in a somatic cell hybrid. The products of the isolated human allele are then observed in the absence of the other allele of the human.
摘要翻译：用于检测由种系突变引起的遗传性疾病的诊断策略是基于体细胞杂交。参与遗传疾病的人类基因的每个等位基因被分离在体细胞杂交体中。然后在不存在人的其他等位基因的情况下观察分离的人等位基因的产物。

3. 发明申请

WO1997004104A2 TUMOR TYPE II HEXOKINASE TRANSCRIPTION REGULATORY REGIONS 审中-公开
标题翻译：肿瘤II型HEXOKINASE转录调节区
公开(公告)号：WO1997004104A2
公开(公告)日：1997-02-06
申请号：PCT/US1996011673
申请日：1996-07-12
申请人： THE JOHNS HOPKINS UNIVERSITY , PEDERSEN, Peter, Lynn , MATHUPALA, Saroj, P. , REMPEL, Annette
发明人： THE JOHNS HOPKINS UNIVERSITY
IPC分类号： C12N15/54
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to a tumor promoter involved in the regulation of glucose catabolism in neoplastic tissues. In particular, this promoter region contains numerous response elements that are involved in regulation of transcription of the Type II hexokinase gene in tumor cells. Such elements are of value for diagnostic and therapeutic applications, such as in controlling tumor growth. In addition, the entire promoter region (about 4.3 kbp) or regulatory segments (response elements) contained therein may be used for expression of naturally-occurring or foreign proteins. Such proteins may be derived from mammalian cells and expressed under the control of transcription factors that bind to specific response elements within the tumor Type II hexokinase promoter. Finally, the promoter is useful in gene therapeutic approaches to diseases including diabetes and cancer.
摘要翻译：本发明涉及参与肿瘤组织中葡萄糖分解代谢调控的肿瘤启动子。特别地，该启动子区域包含参与调节肿瘤细胞中II型己糖激酶基因转录的许多响应元件。这些元素对于诊断和治疗应用是有价值的，例如在控制肿瘤生长中。此外，其中包含的整个启动子区（约4.3kbp）或调节区（响应元件）可用于表达天然存在的或外来的蛋白质。这些蛋白质可以衍生自哺乳动物细胞，并在与II型己糖激酶启动子内的特异性应答元件结合的转录因子的控制下表达。最后，启动子可用于包括糖尿病和癌症在内的疾病的基因治疗方法。

4. 发明申请

WO1996021026A1 POLYMERASE 'delta' MUTATIONS IN COLORECTAL TUMORS WITH REPLICATION ERRORS 审中-公开
标题翻译：具有复发错误的彩色肿瘤中的聚合酶三角体突变
公开(公告)号：WO1996021026A1
公开(公告)日：1996-07-11
申请号：PCT/US1996000005
申请日：1996-01-02
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , VOGELSTEIN, Bert , KINZLER, Kenneth, W.
IPC分类号： C12N15/54
CPC分类号： C12N9/1252 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The human pol delta gene, responsible for a replication error phenotype in some colorectal tumors, can be used for diagnostic and therapeutic purposes. It can be used to demonstrate the existence of germline or somatic mutations in replication error (RER ) tumor cells.
摘要翻译：在一些结肠直肠肿瘤中负责复制错误表型的人pol delta基因可用于诊断和治疗目的。它可用于证明复制错误（RER +）肿瘤细胞中种系或体细胞突变的存在。

5. 发明申请

WO1995019706A1 INHIBITORS OF FATTY ACID SYNTHESIS AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：作为抗微生物剂的脂肪酸合成抑制剂
公开(公告)号：WO1995019706A1
公开(公告)日：1995-07-27
申请号：PCT/US1995000544
申请日：1995-01-24
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , DICK, James, D. , KUHAJDA, Francis, P.
IPC分类号： A01N25/26
CPC分类号： A61K31/34 , A61K31/335
摘要： Fatty acid synthase (FAS) is overexpressed by certain infectious organisms that are resistant to most currently available antibiotics. Contrarywise, little FAS expression is identified in patient tissues. Inhibition of fatty acid synthesis is thus selectively toxic to invasive cells, while patient cells with low FAS activity are resistant. This invention provides a method of treating septic patients where fatty acid synthesis by invading cells is inhibited with resultant interruption of the disease process.
摘要翻译：脂肪酸合成酶（FAS）被某些对大多数现有抗生素具有抗性的感染性生物体过度表达。相反，在患者组织中鉴定出少量FAS表达。脂肪酸合成的抑制因此对侵入性细胞有选择性的毒性，而具有低FAS活性的患者细胞具有抗性。本发明提供一种治疗败血症患者的方法，其中通过侵入细胞的脂肪酸合成被抑制并导致疾病过程的中断。

6. 发明申请

WO1995014465A2 METHODS FOR AMELIORATION OF IMMUNODEFICIENCY VIRUS INDUCED NEURODEGENERATION BY COVERING NITRIC OXIDE OR SUPEROXIDE CONCENTRATION 审中-公开
标题翻译：通过覆盖氮氧化物或超氧化物浓度来增强免疫原性诱导的神经元化的方法
公开(公告)号：WO1995014465A2
公开(公告)日：1995-06-01
申请号：PCT/US1994013457
申请日：1994-11-22
申请人： THE JOHNS HOPKINS UNIVERSITY , THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE ADDICTION RESEARCH CENTER
发明人： THE JOHNS HOPKINS UNIVERSITY , THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE ADDICTION RESEARCH CENTER , DAWSON, Valina, L. , DAWSON, Ted, M. , UHL, George, R. , SNYDER, Solomon, H.
IPC分类号： A61K31/22
CPC分类号： A61K31/70 , A61K31/00 , A61K31/18 , A61K31/195 , A61K31/22 , A61K31/415 , A61K31/54 , A61K38/13
摘要： Methods are taught for amelioration of neurodegeneration which accompanies infection with an immunodeficiency virus. Agents are administered which reduce nitric oxide production by neurons (e.g. nitric oxide synthase inhibitors, calmodulin inhibitors, immunophilin binding drugs) or lower superoxide concentration (e.g. superoxide dismutase gene).
摘要翻译：教导了改善伴随感染免疫缺陷病毒的神经变性的方法。给予减少神经元（例如一氧化氮合酶抑制剂，钙调蛋白抑制剂，免疫亲和素结合药物）或较低超氧化物浓度（例如超氧化物歧化酶基因）产生一氧化氮的药剂。

7. 发明申请

WO1994028161A1 ANTIBODIES SPECIFIC FOR DCC GENE PRODUCT 审中-公开
标题翻译： DCC基因产品特异性抗体
公开(公告)号：WO1994028161A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005277
申请日：1994-05-18
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , BRUSKIN, Arthur , JAROSZ, David, E. , JOHNSON, Karen , KINZLER, Kenneth, W. , VOGELSTEIN, Bert , ZABRECKY, James, R.
IPC分类号： C12P21/08
CPC分类号： C07K14/70503 , C07K16/2803
摘要： Antibodies are disclosed which are able to detect the DCC protein in biological samples, despite the extremely low level of expression of DCC. Immunological methods for detecting DCC alterations are also disclosed. These reagents and methods allow detection of DCC mutations without the need to analyze this very large gene in individual test samples.
摘要翻译：公开了能够检测生物样品中的DCC蛋白质的抗体，尽管DCC的表达水平极低。还公开了用于检测DCC改变的免疫学方法。这些试剂和方法允许检测DCC突变，而不需要在单个测试样品中分析该非常大的基因。

8. 发明申请

WO1994027622A1 SURROGATE TOLEROGENESIS FOR THE DEVELOPMENT OF TOLERANCE TO XENOGRAFTS 审中-公开
标题翻译：用于发展XENOGRAFTS的发展趋势
公开(公告)号：WO1994027622A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005844
申请日：1994-05-24
申请人： THE JOHNS HOPKINS UNIVERSITY , BESCHORNER, William, E.
发明人： THE JOHNS HOPKINS UNIVERSITY
IPC分类号： A61K35/00
CPC分类号： A61K35/28 , A01K67/0271 , A61K35/15 , A61K35/26 , A61K39/001 , A61K2039/5154
摘要： This invention provides a method for developing immune tolerance in xenogeneic organ graft recipients, in which lympho-hematopoietic cells from an intended organ graft recipient are differentiated within a xenogeneic surrogate, such as a fetal animal. The figure illustrates one embodiment of the invention. After birth of the surrogate, the matured lympho-hematopoietic cells containing antigen specific regulatory cells, including suppressor cells, veto cells, select B cells, anti-idiotype antibodies, and other related factors responsible for antigen specific tolerance in a surrogate animal are reintroduced into the intended organ graft recipient, in conjunction with an organ transplant or a tissue transplant from the xenograft surrogate. The invention also provides an organ graft repopulated with cells from the intended organ graft recipient produced in a surrogate animal.
摘要翻译：本发明提供了用于在异种器官移植受体中发展免疫耐受的方法，其中来自预期器官移植受体的淋巴造血细胞在异种替代物（例如胎儿动物）内分化。该图示出了本发明的一个实施例。在替代物出生后，含有抗原特异性调节细胞的成熟淋巴造血细胞，包括抑制细胞，否决细胞，选择B细胞，抗独特型抗体以及其他在替代动物中负责抗原特异性耐受的相关因子被重新引入所述器官移植受体与器官移植物或异种移植物替代物的组织移植联合使用。本发明还提供了在替代动物中产生的来自预期器官移植受体的细胞重新填充的器官移植物。

9. 发明申请

WO1994016684A1 INHIBITION OF betaARK AND beta-ARRESTIN 审中-公开
标题翻译： β-ARK和β-ARRESTIN的抑制作用
公开(公告)号：WO1994016684A1
公开(公告)日：1994-08-04
申请号：PCT/US1994000516
申请日：1994-01-26
申请人： THE JOHNS HOPKINS UNIVERSITY , DUKE UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , DUKE UNIVERSITY , RONNETT, Gabriele, V. , DAWSON, Ted, M. , LEFKOWITZ, Robert, J.
IPC分类号： A61K31/00
CPC分类号： A61K31/715 , A61K31/00 , A61K39/395
摘要： beta -adrenergic receptor kinase ( beta ARK) and beta -arrestin function in the homologous or agonist-activated desensitization of G-protein coupled receptors. Both beta ARK-2 and beta -arrestin-2 isoforms are highly enriched in and localized to the cilia and dendritic knobs of the olfactory receptor neurons where the initial events of olfactory signal transduction occur as well as being localized to spermatids. Administration of neutralizing antibodies to beta ARK-2 and beta -arrestin-2 enhances the response to odorants and attenuates desensitization.
摘要翻译： β-肾上腺素能受体激酶（beta ARK）和β-arrestin功能在G蛋白偶联受体的同源或激动剂激活的脱敏作用。 βARK-2和β-arrestin-2同种型都被高度富集并定位于嗅觉受体神经元的纤毛和树突状旋钮，其中发生嗅觉信号转导的初始事件以及局限于精子细胞。对βARK-2和β-arrestin-2的中和抗体的施用增强了对气味剂的反应并减弱了脱敏作用。

10. 发明申请

WO1994002108A1 CHEMOTHERAPY FOR CANCER 审中-公开
标题翻译：癌症化疗
公开(公告)号：WO1994002108A1
公开(公告)日：1994-02-03
申请号：PCT/US1993007023
申请日：1993-07-26
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： THE JOHNS HOPKINS UNIVERSITY , KUHAJDA, Francis, P. , PASTERNACK, Gary, R.
IPC分类号： A61K31/00
CPC分类号： C12N9/1029 , A61K31/00 , A61K31/20 , A61K31/23 , A61K31/335 , A61K31/336 , A61K31/34 , C07K14/705 , C07K16/18 , C07K16/3015 , G01N33/57415 , G01N33/57488
摘要： Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues. Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.
摘要翻译：脂肪酸合成酶（FAS）在预后差的癌症中过表达，但在正常组织中鉴定出少量FAS表达。脂肪酸合成的抑制对癌细胞有选择性毒性，而FAS活性低的正常细胞具有抗性。本发明提供了一种治疗癌症患者的方法，其中抑制患者肿瘤细胞的脂肪酸合成，导致疾病过程的中断。

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