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1. 发明申请

WO2010085539A1 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN 审中-公开
标题翻译：基于SHIGA毒素2型蛋白的方法和组合
公开(公告)号：WO2010085539A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021610
申请日：2010-01-21
申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. , O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
发明人： O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
摘要翻译：本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。本发明还具有产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法表位或使用本发明的方法开发的抗Stx2抗体。此外，本发明的特征在于使用使用本发明的方法开发的抗体检测样品中的Stx2。

2. 发明申请

WO2007003931A1 DEVICE FOR PICKING THE STRINGS OF A MUSICAL INSTRUMENT 审中-公开
标题翻译：拍摄音乐仪器的设备
公开(公告)号：WO2007003931A1
公开(公告)日：2007-01-11
申请号：PCT/GB2006/002459
申请日：2006-07-03
申请人： SINCLAIR, James
发明人： SINCLAIR, James
IPC分类号： G10D3/16
CPC分类号： G10D3/163
摘要： A device for picking the strings of a stringed musical instrument, the said device comprising a mounting portion for mounting on a finger; and a picking portion for manipulation against the strings; wherein the picking portion and the mounting portion are adapted to be connected together during use in such a manner that one can move with respect to the other.
摘要翻译：一种用于拾取弦乐器的琴弦的装置，所述装置包括用于安装在手指上的安装部分; 以及用于操纵琴弦的拾取部分; 其中拾取部分和安装部分适于在使用期间以可相对于另一个移动的方式连接在一起。

3. 发明申请

WO2004040422A2 TRADING SYSTEM 审中-公开
标题翻译：交易系统
公开(公告)号：WO2004040422A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/034402
申请日：2003-10-29
申请人： ELECTRONIC BROKING SERVICES LIMITED , SINCLAIR, James , O'HAGAN, James , HOWORKA, Edward, R. , JAIN, Neena
发明人： SINCLAIR, James , O'HAGAN, James , HOWORKA, Edward, R. , JAIN, Neena
IPC分类号： G06F
CPC分类号： G06Q40/04 , G06Q30/0601
摘要： An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.
摘要翻译：一个匿名的交易系统包括一个主要的经纪人设施，允许第三方代表一个机构进行交易。第三方与对方之间签订协议，再由第三方与其交易的代理方签订进一步协议。第二笔交易可能与第一笔交易相同，或可能被更改，以包括第三方进行第一笔交易的费用。第三方的客户可以通过第三方在其交易终端上显示的交易获得价格。客户认为，通过第三方可以获得更好的价格，而不是直接交易，并通过第三方进行交易。

4. 发明申请

WO2011046746A1 WIRELESS MONITORING OF LABORATORY ANIMALS 审中-公开
标题翻译：实验动物无线监测
公开(公告)号：WO2011046746A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/050732
申请日：2010-09-29
申请人： VERTEX PHARMACEUTICALS, INC. , SALZMANN, Phillip , NGUYEN, Trang , SINCLAIR, James
发明人： SALZMANN, Phillip , NGUYEN, Trang , SINCLAIR, James
IPC分类号： G01S5/02 , A01K29/00
CPC分类号： G01N27/028 , A01K1/031 , A01K11/006 , A01K29/005
摘要： Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
摘要翻译：用于监测实验室动物的系统和方法包括标签，其包括电感元件和连接到实验室动物的一部分的电容元件。通过监视标签对具有不同频率，一个接近标签共振的时变磁场和一个远离标签共振的时变磁场来检测该部分的位置。

5. 发明申请

WO2004012119A1 AUTOMATED TRADING SYSTEM 审中-公开
标题翻译：自动交易系统
公开(公告)号：WO2004012119A1
公开(公告)日：2004-02-05
申请号：PCT/US2003/021206
申请日：2003-07-07
申请人： ELECTRONIC BROKING SERVICES LIMITED , SETZ, Karen, Ilse , MALKIN, Snezhana , RIORDAN, Tracey , HOWORKA, Edward, R. , MAH, Leong, Fai , SCULLY, Steven, J. , SINCLAIR, James
发明人： SETZ, Karen, Ilse , MALKIN, Snezhana , RIORDAN, Tracey , HOWORKA, Edward, R. , MAH, Leong, Fai , SCULLY, Steven, J. , SINCLAIR, James
IPC分类号： G06F17/60
CPC分类号： G06Q40/04 , G06Q20/10 , G06Q40/00 , G06Q40/06
摘要： A computerized trading system (2) for trading instruments between counter parties of the type in which quotes to bid or offer instruments are matched with orders to buy or sell instruments. A quote screening function (24) is configured to accept quotes specifying a quote amount and a price where the quote amount is greater than a minimum quote amount to produce screened quote messages and to reject quotes specifying a quote amount less than the minimum quote amount. A market view generator (28) generates market views from the quotes which specifies an amount greater than or equal to the minimum quote amount. An order screening function (32) is configured to only accept orders specifying an amount less than a maximum transaction amount submitted in response to the market views to produce screen order messages. A transaction processor (30) is configured to receive screened quote messages and screened order messages and to match the screened order messages with the appropriate screened quote messages. The minimum quote amount is substantially equal to or greater than the maximum transaction amount, whereby a screened order message can be matched entirely with one screened quote message.
摘要翻译：一种电子交易系统（2），用于交易双方之间的交易工具，其中报价或报价工具的报价与买卖手段的订单相匹配。报价筛选功能（24）被配置为接受报价指定报价金额和报价金额大于最低报价金额的报价，以产生筛选报价信息，并拒绝指定低于最低报价金额的报价单的报价。市场视图生成器（28）根据报价产生市场观点，其中指定的金额大于或等于最低报价金额。订单筛选功能（32）被配置为仅接受指定小于根据市场视图提交的最大交易金额的数量以产生屏幕订单消息的订单。交易处理器（30）被配置为接收筛选的报价消息和筛选的订单消息，并且将筛选的订单消息与适当的筛选报价消息相匹配。最小报价金额基本上等于或大于最大交易金额，从而筛选的订单消息可以完全与一个已筛选的报价消息相匹配。

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