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1. 发明申请

WO2014011724A1 SYSTEM AND METHOD FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开
标题翻译：用于监控和处理主体表面的系统和方法
公开(公告)号：WO2014011724A1
公开(公告)日：2014-01-16
申请号：PCT/US2013/049847
申请日：2013-07-10
申请人： THE GENERAL HOSPITAL CORPORATION , EVANS, Conor, L. , APIOU, Gabriela , BIRNGRUBER, Reginald , NICHOLS, Alexander, J. , ROUSAKIS, Emmanouil , LI, Zongxi
发明人： EVANS, Conor, L. , APIOU, Gabriela , BIRNGRUBER, Reginald , NICHOLS, Alexander, J. , ROUSAKIS, Emmanouil , LI, Zongxi
IPC分类号： G01N21/64 , G01N21/65 , A61B5/1455
CPC分类号： A61B5/6832 , A61B5/0022 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/443 , A61B5/4839 , A61B5/6833 , A61B5/743 , A61B90/39 , A61B2562/12 , A61F2013/0097 , A61K49/0015 , C07D487/22
摘要： A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte.
摘要翻译：提供了一种系统和方法，用于设计和组装包括传感器能力的装置以及并入敷料中的相容的基质材料。该传感器能够检测分析物，如分子氧，二氧化碳，一氧化氮，等离子体中溶解的分析物和氢离子，基质至少部分可渗透分析物。当传感器在分析物存在下被激发时，该装置发出可检测的信号。

2. 发明申请

WO2015006015A1 COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开
标题翻译：用于监测和处理主体表面的化合物，系统和方法
公开(公告)号：WO2015006015A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/042377
申请日：2014-06-13
申请人： THE GENERAL HOSPITAL CORPORATION , EVANS, Conor, L. , APIOU, Gabriela , NICHOLS, Alexander, J. , ROUSAKIS, Emmanouil , LI, Zongxi
发明人： EVANS, Conor, L. , APIOU, Gabriela , NICHOLS, Alexander, J. , ROUSAKIS, Emmanouil , LI, Zongxi
IPC分类号： G01N21/64 , C07F15/00
CPC分类号： A61K49/0015 , A61B5/14556 , A61B5/6833 , A61L15/56 , C07D487/22 , G01N21/6408
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.
摘要翻译：提供化合物，系统和方法用于非侵入性分析物感测敷料的设计和组装。敷料可以治疗。敷料包括传感器和矩阵。该传感器能够检测分析物，如分子氧，二氧化碳，一氧化氮，溶解在等离子体中的分析物和氢离子。基质至少部分可渗透分析物。当传感器在分析物存在下被激发时，该装置发出可检测的信号。在一种版本的敷料中，传感器包括对氧敏感的中等非取代的金属卟啉。当以第一波长照射时，可以激发金属化卟啉，随后在第二波长处发射磷光，其强度可以用作氧浓度的指标。

3. 发明申请

WO2015163957A3 SYSTEM AND METHOD FOR PHOTOLUMINESCENCE DETECTION 审中-公开
标题翻译：光致发光检测系统和方法
公开(公告)号：WO2015163957A3
公开(公告)日：2015-10-29
申请号：PCT/US2015/014065
申请日：2015-02-02
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： LI, Zongxi , EVANS, Conor, L. , NICHOLS, Alexandr, J.
IPC分类号： A61B5/1477 , G01N21/64
摘要： In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.
摘要翻译：在一个方面，本公开提供了一种系统A系统，其包括光源，检测器以及与光源和检测器电通信的控制器。控制器被配置为执行存储在控制器中的程序以触发光源发射具有用于照射目标的第一脉冲持续时间的第一光脉冲，在第一脉冲持续时间之后的第一延迟时间之后致动检测器，光开始在第一检测时间检测来自目标的第一信号，并且重复触发光源并致动检测器至少一次的步骤，对于每次重复改变第一脉冲持续时间，第一延迟时间和第一次检测时间。

4. 发明申请

WO2012009448A2 CATIONIC POLYMER COATED MESOPOROUS SILICA NANOPARTICLES AND USES THEREOF 审中-公开
标题翻译：阳离子聚合物涂覆的介孔二氧化硅纳米粒子及其用途
公开(公告)号：WO2012009448A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/043874
申请日：2011-07-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ZINK, Jeffrey I. , NEL, Andre E. , XIA, Tian , JI, Zhaoxia , MENG, Huan , LI, Zongxi , LIONG, Monty
发明人： ZINK, Jeffrey I. , NEL, Andre E. , XIA, Tian , JI, Zhaoxia , MENG, Huan , LI, Zongxi , LIONG, Monty
IPC分类号： B82B1/00 , B82B3/00 , A61K47/30 , B82Y40/00
CPC分类号： B82Y40/00 , A61K9/50 , A61K9/5146 , B82Y30/00
摘要： A submicron structure having a silica body defining a plurality of pores and a cationic polymer on the surface of said silica body is described. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
摘要翻译：描述了在所述二氧化硅体的表面上具有限定多个孔和阳离子聚合物的二氧化硅主体的亚微米结构。亚微米结构可进一步包括寡核苷酸并用于将寡核苷酸递送至细胞。亚微米结构可进一步包括治疗剂并用于将治疗剂递送至细胞。寡核苷酸和治疗剂可以一起使用。例如，当寡核苷酸是siRNA时，通过降低抗性基因的翻译，组合物可用于降低对治疗剂的细胞抗性。

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