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1. 发明申请

WO2015168152A1 SYSTEM AND METHOD FOR SPECTRAL CHARACTERIZATION OF SLEEP 审中-公开
标题翻译：睡眠光谱特征的系统与方法
公开(公告)号：WO2015168152A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028046
申请日：2015-04-28
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PRERAU, Michael, J. , PURDON, Patrick, L.
IPC分类号： A61B5/04
CPC分类号： A61B5/4812 , A61B3/113 , A61B5/0205 , A61B5/048 , A61B5/0488 , A61B5/0533 , A61B5/08 , A61B5/11 , A61B5/14542 , A61B5/4815 , A61B5/7278
摘要： A system and method for identifying sleep states of a subject are provided. In some aspects, the method includes acquiring physiological data from a subject over a sleep period using sensors positioned about the subject, and assembling the physiological data into time-series datasets. The method also includes selecting a temporal window in which signals associated with the time-series datasets are substantially stationary, computing a time bandwidth product based on a selected spectral resolution and the selected temporal window, and determining a number of tapers using the computed time bandwidth product. The method further includes computing a spectrogram using the determined number of tapers and the time-series datasets, analyzing the spectrogram to identify signatures of sleep in the subject, and generating, using the identified signatures, a report indicative of sleep states of the subject.
摘要翻译：提供了一种用于识别受试者的睡眠状态的系统和方法。在一些方面，该方法包括使用位于对象周围的传感器在休眠期间从受试者获取生理数据，以及将生理数据组装成时间序列数据集。该方法还包括选择时间窗口，其中与时间序列数据集相关联的信号基本上是固定的，基于所选择的频谱分辨率和所选择的时间窗口计算时间带宽积，以及使用所计算的时间带宽确定多个锥度产品。该方法还包括使用确定数量的锥度和时间序列数据集来计算频谱图，分析频谱图以识别对象中睡眠的签名，以及使用所识别的签名生成指示对象的睡眠状态的报告。

2. 发明申请

WO2006121469A1 APPARATUSES AND METHODS FOR ELECTROPHYSIOLOGICAL SIGNAL DELIVERY AND RECORDING DURING MRI 审中-公开
标题翻译： MRI中电生理信号传递和记录的装置和方法
公开(公告)号：WO2006121469A1
公开(公告)日：2006-11-16
申请号：PCT/US2005/042401
申请日：2005-11-21
申请人： THE GENERAL HOSPITAL CORPORATION , BONMASSAR, Giorgio , PURDON, Patrick, L.
发明人： BONMASSAR, Giorgio , PURDON, Patrick, L.
IPC分类号： A61B5/0478
CPC分类号： A61B5/6814 , A61B5/0478 , A61B5/1102 , A61B5/721
摘要： Methods, systems and arrangements are provided for obtaining electroencephalograph ("EEG") EEG signals from a patient e.g., during a concurrent EEG/MRI examination of the patient. The methods, systems and arrangements include a cap made of conductive inks with sensor positions for attaching a plurality of sensors to the patient's head. The sensors can include electrodes as well as motion sensors for improving EEG signal quality and MRI image quality in the presence of motion noise and other artifacts within the MRI environment. The electrodes may be composed of conductive inks, and can be used in high magnetic fields due to a weak interaction with the RF fields generated by the MRI scanner. The exemplary methods, systems and arrangements can achieve lower SAR and lower temperature increase, as compared to conventional electrodes.
摘要翻译：提供了用于从患者获得脑电图（EEG））EEG信号的方法，系统和布置，例如在患者的并行EEG / MRI检查期间。所述方法，系统和布置包括由导电油墨制成的盖，其具有用于将多个传感器附接到患者头部的传感器位置。传感器可以包括电极以及运动传感器，用于在存在运动噪声和MRI环境中的其他伪影的情况下改善EEG信号质量和MRI图像质量。电极可以由导电油墨组成，并且由于与MRI扫描仪产生的RF场的弱相互作用，可以用于高磁场。与常规电极相比，示例性方法，系统和布置可以实现更低的SAR和更低的温度升高。

3. 发明申请

WO2015168151A1 SYSTEM AND METHOD FOR TRACKING SLEEP DYNAMICS USING BEHAVIORAL AND PHYSIOLOGICAL INFORMATION 审中-公开
标题翻译：使用行为和生理信息跟踪睡眠动态的系统和方法
公开(公告)号：WO2015168151A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028039
申请日：2015-04-28
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PRERAU, Michael, J. , PURDON, Patrick, L.
IPC分类号： A61B5/16 , A61M21/02 , G06F11/34 , G06F19/12
CPC分类号： A61B5/4812 , A61B3/113 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/0476 , A61B5/048 , A61B5/0488 , A61B5/0496 , A61B5/0533 , A61B5/08 , A61B5/0816 , A61B5/11 , A61B5/1118 , A61B5/14542 , A61B5/4848 , A61B5/681 , A61B5/6825 , A61B5/6898 , A61B5/7246 , A61B5/7264 , G06F11/34 , G06F19/00 , G06K9/00335 , G06K9/00536 , G16H40/63 , G16H50/30 , G16H50/50
摘要： A system and method is provided for tracking sleep dynamics in a subject. In one aspect, a method includes acquiring physiological data using sensors positioned about the subject, and acquiring behavioral data using input provided by the subject. The method also includes generating a statistical model of wakefulness by combining information obtained from the acquired physiological data and behavior data, and estimating a probability indicative of a degree to which the subject is awake at each point in time during sleep onset using the statistical model. The method further includes generating a report indicative of sleep onset in the subject.
摘要翻译：提供了用于跟踪受试者中的睡眠动态的系统和方法。一方面，一种方法包括使用位于对象周围的传感器来获取生理数据，以及使用由对象提供的输入来获取行为数据。该方法还包括通过组合从所获取的生理数据和行为数据获得的信息，并且使用统计模型来估计在睡眠开始期间的每个时间点对象睡眠的程度的概率来产生觉醒的统计模型。该方法还包括产生指示受试者睡眠开始的报告。

4. 发明申请

WO2014169100A1 REMOVING ELECTROPHYSIOLOGIC ARTIFACTS FROM A MAGNETIC RESONANCE IMAGING SYSTEM 审中-公开
标题翻译：从磁共振成像系统中去除电生理学文献
公开(公告)号：WO2014169100A1
公开(公告)日：2014-10-16
申请号：PCT/US2014/033619
申请日：2014-04-10
申请人： THE GENERAL HOSPITAL CORPORATION , KRISHNASWAMY, Pavitra , PURDON, Patrick, L.
发明人： KRISHNASWAMY, Pavitra , PURDON, Patrick, L.
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/05 , A61B5/055
CPC分类号： A61B5/7203 , A61B5/024 , A61B5/0476 , A61B5/055 , A61B5/1102 , A61B5/16 , A61B5/4064 , A61B2576/026
摘要： Systems and a method for reducing periodic artifacts in an electrophysiologic signal are provided. The method includes receiving a time-series electrophysiologic signal acquired from a subject and providing a regression model that defines an interference signal caused by periodic artifacts using a harmonic representation. The method also includes applying the regression model using the time-series electrophysiologic signal to define a cost function and performing an iterative optimization process to estimate regression parameters that minimize the cost function. The method further includes determining, using the regression parameters, the interference signal, and generating a corrected time-series electrophysiologic signal by reducing the interference signal.
摘要翻译：提供了用于减少电生理信号中的周期性伪像的系统和方法。该方法包括接收从对象获取的时间序列电生理信号，并提供使用谐波表示定义由周期性伪像引起的干扰信号的回归模型。该方法还包括使用时间序列电生理信号应用回归模型来定义成本函数，并执行迭代优化过程来估计使成本函数最小化的回归参数。该方法还包括使用回归参数确定干扰信号，并通过减少干扰信号来产生经校正的时间序列电生理信号。

5. 发明申请

WO2014059418A1 SYSTEM AND METHOD FOR MONITORING AND CONTROLLING A STATE OF A PATIENT DURING AND AFTER ADMINISTRATION OF ANESTHETIC COMPOUND 审中-公开
标题翻译：用于监测和控制麻醉药物治疗期间和之后的患者状态的系统和方法
公开(公告)号：WO2014059418A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/064852
申请日：2013-10-14
申请人： THE GENERAL HOSPITAL CORPORATION , BROWN, Emery, N. , PURDON, Patrick, L.
发明人： BROWN, Emery, N. , PURDON, Patrick, L.
IPC分类号： A61B5/04 , A61B5/0476 , G06F19/00
CPC分类号： A61B5/4821 , A61B5/0476 , A61B5/4839 , A61B5/7235 , G06F19/00
摘要： A system and method for monitoring and controlling the administration of at least one drug having anesthetic properties are provided. The method includes arranging a plurality of sensors configured to acquire physiological data from a patient and reviewing the physiological data from the plurality of sensors and an indication from a user interface. The method also includes assembling the physiological data into sets of time-series data and analyzing the sets of time-series data to determine signature profiles consistent with the administration of at least one drug. The method further includes identifying, using signature profiles, at least one of a current state and a predicted future state of the patient, controlling the administration of the least one drug to attain the predicted future state, and then generating a report including information regarding at least one of the current state and the predicted future state of the patient induced by the drug.
摘要翻译：提供了用于监测和控制至少一种具有麻醉性质的药物的给药的系统和方法。所述方法包括布置多个传感器，所述多个传感器被配置为从患者获取生理数据并且从所述多个传感器检查生理数据以及来自用户界面的指示。该方法还包括将生理数据组合成一组时间序列数据并分析时间序列数据集以确定符合至少一种药物施用的特征谱。该方法还包括识别，使用签名简档，患者的当前状态和预测未来状态中的至少一个，控制至少一种药物的管理以达到预测的未来状态，然后生成包括关于目前的状态中最少的一个和由药物引起的患者的预测未来状态。

6. 发明申请

WO2016029226A1 SYSTEM AND METHOD FOR ADMINISTERING, MONITORING AND CONTROLLING BIOMIMETIC SLEEP 审中-公开
标题翻译：用于管理，监测和控制生物睡眠的系统和方法
公开(公告)号：WO2016029226A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/046602
申请日：2015-08-24
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PURDON, Patrick, L. , BROWN, Emery, N. , VAN DORT, Christa, J. , AKEJU, Olewaeseun
IPC分类号： A61M21/02 , A61B5/0205 , A61N1/36
CPC分类号： A61M21/02 , A61B5/0205 , A61B5/04012 , A61B5/0476 , A61B5/4812 , A61B5/4821 , A61B5/4836 , A61B5/4839 , A61M2021/0077 , A61M2205/3561 , A61M2205/3592 , A61M2205/502 , A61M2230/06 , A61M2230/10 , A61M2230/14 , A61M2230/18 , A61M2230/205 , A61M2230/30 , A61M2230/65
摘要： Systems and methods for inducing natural sleep in a subject is provided. In some aspects, the method includes inducing a first sleep state; monitoring a first plurality of characteristics of a brain of the subject to verify the subject is in the first sleep state; inducing a second sleep state after the subject has been in the first sleep state for a predetermined amount of time; and monitoring a second plurality of characteristics of the brain of the subject to verify the subject is in the second sleep state.
摘要翻译：提供了用于在受试者中诱导自然睡眠的系统和方法。在一些方面，该方法包括诱导第一睡眠状态; 监测所述对象的脑的第一多个特征以验证所述对象处于所述第一睡眠状态; 在所述对象已经处于所述第一睡眠状态预定时间量之后引起第二睡眠状态; 以及监测所述对象的大脑的第二多个特征以验证所述对象处于所述第二睡眠状态。

7. 发明申请

WO2015168154A1 SYSTEM AND METHOD FOR MONITORING BEHAVIOR DURING SLEEP ONSET 审中-公开
标题翻译：系统和方法在睡眠过程中监测行为
公开(公告)号：WO2015168154A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028049
申请日：2015-04-28
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PRERAU, Michael, J. , PURDON, Patrick, L.
IPC分类号： A61B5/00
CPC分类号： A61B5/4812 , A61B3/113 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/0476 , A61B5/048 , A61B5/0488 , A61B5/0496 , A61B5/0533 , A61B5/08 , A61B5/0816 , A61B5/11 , A61B5/1118 , A61B5/14542 , A61B5/4848 , A61B5/681 , A61B5/6825 , A61B5/6898 , A61B5/7246 , A61B5/7264 , G06F11/34 , G06F19/00 , G06K9/00335 , G06K9/00536 , G16H40/63 , G16H50/30 , G16H50/50
摘要： A system and method are provided for monitoring subject behavior during sleep onset. In some aspects, a system includes one or more sensors configured to acquire behavioral data from a subject using input provided during sleep onset. The system also includes a processor programmed to at least assemble a time-series of behavioral responses using the behavioral data acquired using the one or more sensors, and estimate an instantaneous probability of response using the time-series of behavioral responses. The processor is also programmed to generate a statistical model of wakefulness using the instantaneous probability of response, and estimate, using the model, a probability indicative of a degree to which the subject is awake at each point in time during the sleep onset process. The processor is further configured to generate a report indicative of sleep onset in the subject. The system also includes an output for displaying the report.
摘要翻译：提供了一种用于在睡眠发作期间监测受试者行为的系统和方法。在一些方面，系统包括一个或多个传感器，其被配置为使用在睡眠开始期间提供的输入从对象获取行为数据。该系统还包括处理器，其被编程为使用使用一个或多个传感器获取的行为数据来至少组装时间序列的行为响应，并且使用时间序列的行为响应来估计瞬时响应概率。处理器还被编程为使用瞬时响应概率来生成清醒的统计模型，并且使用该模型来估计在睡眠开始过程期间每个时间点对象被清醒的程度的概率。处理器还被配置为产生指示对象睡眠开始的报告。该系统还包括用于显示报告的输出。

8. 发明申请

WO2014210549A1 SYSTEMS AND METHODS FOR TRACKING NON-STATIONARY SPECTRAL STRUCTURE AND DYNAMICS IN PHYSIOLOGICAL DATA 审中-公开
标题翻译：追踪生理数据中非静态光谱结构与动力学的系统与方法
公开(公告)号：WO2014210549A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044720
申请日：2014-06-27
申请人： THE GENERAL HOSPITAL CORPORATION , PRERAU, Michael, J. , PURDON, Patrick, L. , EDEN, Uri
发明人： PRERAU, Michael, J. , PURDON, Patrick, L. , EDEN, Uri
IPC分类号： G01R23/16
CPC分类号： A61B5/04012 , A61B5/0402 , A61B5/048 , A61B5/0488 , A61B5/0496 , A61B5/0533 , A61B5/4806 , A61B5/4821 , A61B5/4839 , A61B5/725 , A61B5/7253
摘要： Systems and methods for tracking dynamic structure in physiological data are provided. In some aspects, the method includes providing physiological data, including electroencephalogram ("EEG") data, acquired from a subject and assembling a time-frequency representation of signals from the physiological data. The method also includes generating a dynamic model of at least one non-stationary spectral feature, such as at least one non-stationary spectral peak, using the time-frequency representation and a user indication, and applying a dynamic model of at least one non-stationary spectral feature in a parameter estimation algorithm to compute concurrent estimates of spectral parameters describing the at least one non-stationary spectral feature. The method also includes tracking the spectral parameters of the at least one spectral feature over time.
摘要翻译：提供了生理数据跟踪动态结构的系统和方法。在一些方面，该方法包括提供生理数据，包括从受检者获取的脑电图（“EEG”）数据，以及组合来自生理数据的信号的时间 - 频率表示。该方法还包括使用时间频率表示和用户指示来生成至少一个非平稳频谱特征（例如至少一个非平稳频谱峰值）的动态模型，以及应用至少一个非平稳频谱特征的动态模型， - 参数估计算法中的平稳光谱特征，以计算描述所述至少一个非平稳光谱特征的光谱参数的并发估计。该方法还包括随时间跟踪至少一个光谱特征的光谱参数。

9. 发明申请

WO2012154701A1 SYSTEM AND METHOD FOR TRACKING BRAIN STATES DURING ADMINISTRATION OF ANESTHESIA 审中-公开
标题翻译：在麻醉管理期间跟踪脑状态的系统和方法
公开(公告)号：WO2012154701A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036854
申请日：2012-05-07
申请人： THE GENERAL HOSPITAL CORPORATION , BROWN, Emery, N. , PURDON, Patrick, L.
发明人： BROWN, Emery, N. , PURDON, Patrick, L.
IPC分类号： A61B5/0476 , G06F19/00
CPC分类号： A61B5/0205 , A61B5/02 , A61B5/0476 , A61B5/048 , A61B5/04845 , A61B5/4821 , A61B5/7264 , G06K9/00496
摘要： A method and system for determining the state of a patients brain under anesthesia. The present invention recognizes that anesthesia compounds induce different signatures in physiological characteristics of the patient under anesthesia and aids interpretation of physiological characteristics and signatures therein based on a selected anesthesia compound. The present invention aids the monitoring and/or interpreting of the physiological characteristics to a state of the patient's brain.
摘要翻译：用于确定麻醉患者脑部状态的方法和系统。本发明认识到麻醉化合物在麻醉下诱导患者的生理特征不同的特征，并且基于选择的麻醉化合物帮助解释其中的生理特征和特征。本发明有助于将生理特征监测和/或解释为患者大脑的状态。

10. 发明申请

WO2017201455A1 SYSTEMS AND METHODS FOR DETERMINING RESPONSE TO ANESTHETIC AND SEDATIVE DRUGS USING MARKERS OF BRAIN FUNCTION 审中-公开
标题翻译：用脑功能标记确定对麻醉药和立体药的反应的系统和方法
公开(公告)号：WO2017201455A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033618
申请日：2017-05-19
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： PURDON, Patrick, L. , BROWN, Emery, N. , SHAO, Yu
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/4821 , A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/0533 , A61B5/4839 , G06K9/0053
摘要： Systems and methods for determining a response of a patient to the administration of at least one drug having anesthetic properties are provided. In one aspect, a method includes receiving physiological data acquired from a patient, and analyzing the physiological data to determine at least one indicator of brain function. The method also includes determining, based on the at least one indicator of brain function, a response of the patient to the administration of at least one drug having anesthetic properties, and generating a report indicative of the response.
摘要翻译：提供了用于确定患者对施用具有麻醉性质的至少一种药物的响应的系统和方法。在一个方面，一种方法包括接收从患者获取的生理数据，并分析生理数据以确定至少一个脑功能指标。该方法还包括基于脑功能的至少一个指标确定患者对具有麻醉性质的至少一种药物的施用的响应并且生成指示响应的报告。

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