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1. 发明申请

WO2014066383A1 APPARATUS AND METHOD FOR TARGETING A BODY TISSUE 审中-公开
标题翻译：装置和方法来达到身体组织
公开(公告)号：WO2014066383A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066173
申请日：2013-10-22
申请人： THE CLEVELAND CLINIC FOUNDATION , BAVARIA MEDICAL TECHNOLOGY, CANADA INC.
发明人： KAPADIA, Samir , BERRADA, Marwane , FUENTES-ORTEGA, Cesar , MOK, Daniel Wing Fai
IPC分类号： A61B17/34 , A61B19/00
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member, when deployed into an expanded condition, has a framing member body which includes a three-dimensionally bulbous portion defining a maximum body footprint in a lateral dimension and has longitudinally spaced proximal and distal body ends which are both longitudinally spaced from the maximum body footprint. The proximal body end is attached to the target catheter. A protrusion has a diameter which is smaller than the maximum body footprint diameter. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway is substantially spaced apart from the framing member body.
摘要翻译：用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。框架构件在展开状态时具有框架构件主体，该框架构件主体包括三维球形部分，其在侧向尺寸上限定最大身体足迹，并且具有纵向间隔开的近端和远侧主体端部，身体足迹。近端体端部附接到目标导管。突起具有比最大身体足迹直径小的直径。至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。至少一个目标通路连接至至少一个目标点。目标通路的至少一部分与框架构件主体基本间隔开。

2. 发明申请

WO2014066389A1 APPARATUS AND METHOD FOR TARGETING A BODY TISSUE 审中-公开
标题翻译：装置和方法来达到身体组织
公开(公告)号：WO2014066389A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066182
申请日：2013-10-22
申请人： THE CLEVELAND CLINIC FOUNDATION , BAVARIA MEDICAL TECHNOLOGY, CANADA INC.
发明人： KAPADIA, Samir , BERRADA, Marwane , FUENTES-ORTEGA, Cesar , MOK, Daniel Wing Fai
IPC分类号： A61B17/34 , A61B19/00
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. A framing member has a collapsed condition and an expanded condition. The framing member has a framing member body which includes a bulbous portion defining a maximum body footprint having proximal and distal body ends which are both longitudinally spaced from the maximum body footprint. The framing member is comprised of a plurality of framing member beams. At least three framing member beam arrays of framing member beams are arranged in non-overlapping longitudinal sequence to form at least a portion of the framing member. The framing member beams that make up the framing member substantially each have a width-to-thickness fractional ratio in the range of 0.6-3.0.
摘要翻译：用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。框架构件具有折叠状态和扩展状态。框架构件具有框架构件主体，该框架构件包括限定最大身体足迹的球形部分，其具有近端和远端本体端部，其与最大身体足迹纵向间隔开。框架构件由多个框架构件梁组成。框架构件梁的至少三个框架构件梁阵列以不重叠的纵向顺序布置以形成框架构件的至少一部分。构成框架构件的框架构件基本上各自具有在0.6-3.0的范围内的宽度 - 厚度分数比。

3. 发明申请

WO2014066397A1 APPARATUS AND METHOD FOR TARGETING A BODY TISSUE 审中-公开
标题翻译：装置和方法来达到身体组织
公开(公告)号：WO2014066397A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066192
申请日：2013-10-22
申请人： THE CLEVELAND CLINIC FOUNDATION , BAVARIA MEDICAL TECHNOLOGY, CANADA INC.
发明人： KAPADIA, Samir , BERRADA, Marwane , FUENTES-ORTEGA, Cesar , MOK, Daniel Wing Fai
IPC分类号： A61B17/34 , A61B19/00
CPC分类号： A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
摘要： An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member has a longitudinal framing member core defining a central framing member axis. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. The framing member comprises a plurality of longitudinally extending multi-segment framing strands.
摘要翻译：用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。框架构件具有限定中央框架构件轴线的纵向框架构件芯部。至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。框架构件包括多个纵向延伸的多段框架线。

4. 发明申请

WO2022035728A1 APPARATUSES AND METHODS FOR AT LEAST PARTIALLY SUPPORTING A VALVE LEAFLET OF A REGURGITANT HEART VALVE 审中-公开
公开(公告)号：WO2022035728A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045153
申请日：2021-08-09
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAVIA, Jose , KAPADIA, Samir , HOVEST, Torey , GEOFFRION, Richard , FARNAN, Robert
IPC分类号： A61F2/24
摘要： An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

5. 发明申请

WO2014134109A1 APPARATUS FOR DELIVERING A STRUCTURE TO A DESIRED TARGET SITE 审中-公开
标题翻译：将结构传递给所需目标站点的设备
公开(公告)号：WO2014134109A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018532
申请日：2014-02-26
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KAPADIA, Samir
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2439 , A61F2/2466 , A61F2220/0091 , A61F2250/0096 , A61F2250/0098
摘要： An apparatus (100) for delivering an implanted structure (102) to a desired target site within a body lumen of a patient includes a catheter (104) having a longitudinally extending catheter lumen (106) and adapted to provide access to the body lumen. A framing member (108) has a collapsed and an expanded condition. At least one target point (114) is carried by the framing member and is adapted for placement adjacent the desired target site. A holding mechanism (118) is carried by the framing member and is adapted to releasably grasp the implanted structure. At least one target pathway (116) is attached to at least one target point. At least a portion of the target pathway extends through the catheter lumen.
摘要翻译：用于将植入结构（102）递送到患者的体腔内的期望目标部位的装置（100）包括具有纵向延伸的导管腔（106）并适于提供对体腔的通路的导管（104）。框架构件（108）具有折叠和膨胀状态。至少一个目标点（114）由框架构件承载并适于邻近所需目标位置放置。保持机构（118）由框架构件承载并且适于可释放地抓住植入结构。至少一个目标路径（116）附接到至少一个目标点。目标通路的至少一部分延伸穿过导管内腔。

6. 发明申请

WO2007025028A1 PERCUTANEOUS ATRIOVENTRICULAR VALVE AND METHOD OF USE 审中-公开
公开(公告)号：WO2007025028A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/033052
申请日：2006-08-24
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KAPADIA, Samir , YADAV, Jay , TUZCU, E., Murat
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B2017/00243 , A61F2/2409 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2230/0065 , A61F2230/0071 , A61F2230/0076
摘要： An apparatus for percutaneously replacing a diseased cardiac valve includes an expandable support member for positioning in an atrial chamber. The expandable support member includes at least one anchoring portion for anchoring in at least one opening that extends from the atrial chamber and a main body portion located adjacent the at least one anchoring portion. The main body portion has a cage-like structure and is adapted to conform to a size and shape of the atrial chamber. An expandable ring is selectively connected to the main body portion. The expandable ring is adapted to engage an annulus of the diseased cardiac valve. A prosthetic valve is attached to the expandable ring. The prosthetic valve is adapted to replace the diseased cardiac valve. A method for percutaneously replacing a diseased cardiac valve is also described.
摘要翻译：用于经皮置换患病心脏瓣膜的装置包括用于定位在心房中的可扩张支撑构件。可扩张支撑构件包括至少一个锚固部分，用于锚固在从心房延伸的至少一个开口中，以及主体部分，邻近于至少一个锚定部分。主体部分具有笼状结构并且适于符合心房的尺寸和形状。可膨胀环选择性地连接到主体部分。可膨胀环适于接合患病心脏瓣膜的环。假肢瓣附接到可扩张环。人造瓣膜适于替换患病的心脏瓣膜。还描述了用于经皮置换患病心脏瓣膜的方法。

7. 发明申请

WO2013016618A3 APPARATUS, SYSTEM, AND METHOD FOR TREATING A REGURGITANT HEART VALVE 审中-公开
公开(公告)号：WO2013016618A3
公开(公告)日：2013-01-31
申请号：PCT/US2012/048499
申请日：2012-07-27
申请人： THE CLEVELAND CLINIC FOUNDATION , KAPADIA, Samir
发明人： KAPADIA, Samir
IPC分类号： A61F2/24
摘要： An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes a lollipop-shaped body member having a proximal end portion, a distal end portion, and an intermediate portion extending between the end portions. The intermediate portion includes an expandable occluding member having an adjustable diameter so that, during at least a portion of the cardiac cycle, at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve. The proximal end portion is physically connected to the occluding member and includes a connecting mechanism for operably mating with an adjustment member for adjusting the position and diameter of the occluding member within the diseased heart valve. The distal end portion includes an anchoring member for securing the ' apparatus in a heart chamber containing the diseased heart valve.

8. 发明申请

WO2018204335A1 SYSTEMS AND METHODS FOR TREATING A REGURGITANT HEART VALVE 审中-公开
公开(公告)号：WO2018204335A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/030409
申请日：2018-05-01
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KAPADIA, Samir
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2220/0008 , A61F2250/0001 , A61F2250/001
摘要： A system for treating regurgitation of blood through a diseased heart valve having at least two leaflets can include an implantable, lollipop-shaped device and an adjustment mechanism. The device can have a proximal end portion, a distal end portion, and an intermediate portion extending therebetween. The intermediate portion can include an expandable occluding member having a selectively adjustable diameter and a biocompatible layer attached to at least a portion thereof. The distal end portion can include an anchoring member. The adjustment member can include a distal connecting end that is operatively connected to the proximal end portion of the device. Operation of the adjustment member, after implantation of the device, can cause the diameter of the occluding member to change so that at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve.

9. 发明申请

WO2014169097A1 APPARATUS FOR GUIDING A CATHETER 审中-公开
标题翻译：用于指导导管的装置
公开(公告)号：WO2014169097A1
公开(公告)日：2014-10-16
申请号：PCT/US2014/033612
申请日：2014-04-10
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： KAPADIA, Samir
IPC分类号： A61M25/01 , A61M25/09 , A61M25/00 , A61F2/06 , A61M25/10
CPC分类号： A61M25/09041 , A61M25/01 , A61M25/09 , A61M2025/0063 , A61M2025/0177 , A61M2025/018 , A61M2025/1045
摘要： An apparatus (100) for guiding a catheter within a patient's body, the apparatus comprising:a first wire (1 12 )having longitudinally spaced distal and proximal first wire ends (1 14,1 16)) separated by a first wire body; a catheter (102) having longitudinally spaced distal and proximal catheter ends (130,132) separated by a catheter body having a catheter lumen (136) extending longitudinally therethrough between the distal and proximal catheter ends, the catheter having a catheter aperture (138) extending substantially laterally through the catheter body at a location proximally adjacent to the distal catheter end; a second wire (120) having longitudinally spaced distal and proximal second wire ends (122,124) separated by a second wire body.
摘要翻译：一种用于在患者体内引导导管的装置（100），所述装置包括：具有由第一线体分开的纵向间隔开的远端和近端的第一线端（114,116）的第一线（112）导管（102），其具有纵向间隔开的远端和近侧导管末端（130,132），所述远端和近端导管末端（130,132）由具有在所述远端和近端导管末端之间纵向延伸穿过的导管内腔（136）分开的导管主体分开，所述导管具有基本上延伸的导管孔横向穿过导管主体在靠近远侧导管末端的位置; 第二线（120）具有由第二线体分开的纵向间隔开的远端和近端的第二线端（122,124）。

10. 发明申请

WO2018035105A1 APPARATUSES AND METHODS FOR AT LEAST PARTIALLY SUPPORTING A VALVE LEAFLET OF A REGURGITANT HEART VALVE 审中-公开
标题翻译：用于至少部分支撑回肠心瓣膜瓣膜的装置和方法
公开(公告)号：WO2018035105A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/046912
申请日：2017-08-15
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： NAVIA, Jose L. , KAPADIA, Samir , BERRADA, Marwane
IPC分类号： A61F2/24
摘要： An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
摘要翻译：用于部分支撑反流心脏瓣膜的瓣叶的设备包括至少一个瓣膜下装置，瓣膜装置包括瓣膜支撑部分，所述瓣膜支撑部分包括与相对朝向的下支撑表面纵向隔开的瓣叶接触上支撑表面。支撑物周壁在上支撑物表面和下支撑物表面之间纵向延伸，其中至少一部分接触与心脏瓣膜相邻的瓣下心脏壁。锚部分与上支撑表面相邻并且与上支撑表面纵向间隔开。锚部分包括与相反面向的上锚表面纵向间隔开的接触瓣叶的下锚表面。连接器颈部纵向地插入在上支撑件表面和下锚定件表面之间，并且直接连接到上支撑件表面和下锚定件表面。连接器颈部在制造的穿刺部位纵向穿过小叶的基部和心脏瓣膜的瓣环中的至少一个。

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