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1. 发明申请

WO2017136497A1 DETECTION AND TREATMENT OF IL-17 AND IL-13 RELATED CONDITIONS 审中-公开
标题翻译：检测和治疗IL-17和IL-13相关病症
公开(公告)号：WO2017136497A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016127
申请日：2017-02-02
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： LI, Xiaoxia , BULEK, Katarzyna , LIU, Caini , ARONICA, Mark , HONG, Liz
IPC分类号： A61K39/395 , A61P11/06 , G01N33/53 , G01N33/68
CPC分类号： G01N33/68 , G01N33/53 , G01N33/6869 , G01N2800/122 , G01N2800/52
摘要： Provided herein are compositions, systems, and methods for detecting and treating IL-17 and/or IL-13 related conditions, such as asthma, autoimmune diseases, and cancer. In some embodiments, methods, compositions, and systems are provided for detecting elevated protein or RNA levels of IL-17 (and/or IL-13) and a second marker selected from: SAA, LCN2, and YKL-40, and treating the subject with an IL-17 (or IL-13) inhibitor or IL-17 (or IL-13) receptor inhibitor. In other embodiments, methods, compositions, and systems are provided for detecting a biomarker in a sample from a subject that has been treated with an IL-17 (or IL-13) inhibitor or IL-17 (or IL-13) receptor inhibitor, where the biomarker is SAA, LCN2, or YKL-40, and where at least one action is performed, such as identifying elevated levels of the biomarker in the biological sample and treating the subject with an IL-17 (or IL-13) inhibitor and/or IL-17 (or IL-13) receptor inhibitor.
摘要翻译：本文提供了用于检测和治疗IL-17和/或IL-13相关病症（例如哮喘，自身免疫性疾病和癌症）的组合物，系统和方法。在一些实施方案中，提供了用于检测IL-17（和/或IL-13）和选自SAA，LCN2和YKL-40的第二标志物升高的蛋白质或RNA水平的方法，组合物和系统，用IL-17（或IL-13）抑制剂或IL-17（或IL-13）受体抑制剂治疗。在其他实施方案中，提供了用于检测来自已经用IL-17（或IL-13）抑制剂或IL-17（或IL-13）受体抑制剂治疗的受试者的样品中的生物标志物的方法，组合物和系统，其中生物标志物是SAA，LCN2或YKL-40，并且其中执行至少一种作用，例如鉴定生物样品中生物标志物的升高水平和用IL-17（或IL-13）治疗受试者，抑制剂和/或IL-17（或IL-13）受体抑制剂。

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