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1. 发明申请

WO2008060415A1 PHOTONIC CRYSTAL SENSORS WITH INTEGRATED FLUID CONTAINMENT STRUCTURE 审中-公开
标题翻译：具有集成流体容纳结构的光电晶体传感器
公开(公告)号：WO2008060415A1
公开(公告)日：2008-05-22
申请号：PCT/US2007/023408
申请日：2007-11-06
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , CHOI, Charles
发明人： CUNNINGHAM, Brian, T. , CHOI, Charles
IPC分类号： B01L3/00 , G01N21/25
CPC分类号： B01L3/5085 , B01L3/5027 , B01L2300/0636 , B01L2300/0654 , B82Y20/00 , G01N21/253 , G02B2006/1213
摘要： Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.
摘要翻译：描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

2. 发明申请

WO2008008247A3 NEAR ULTRAVIOLET-WAVELENGTH PHOTONIC-CRYSTAL BIOSENSOR WITH ENHANCED SURFACE TO BULK SENSITIVITY RATIO 审中-公开
公开(公告)号：WO2008008247A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/015448
申请日：2007-07-02
申请人： The Board of Trustees of the University of Illinois , SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , BLOCK, Ian, D. , GANESH, Nikhil
发明人： CUNNINGHAM, Brian, T. , BLOCK, Ian, D. , GANESH, Nikhil
IPC分类号： G01N21/47 , G01N21/25 , G02B5/18 , G01N33/551 , B01L3/00 , G01N33/552
摘要： Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

3. 发明申请

WO2012018364A1 MULTI-COLOR FLUORESCENCE ENHANCEMENT FROM A PHOTONIC CRYSTAL SURFACE 审中-公开
标题翻译：来自光子晶体表面的多色荧光增强
公开(公告)号：WO2012018364A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/001155
申请日：2011-06-28
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , SRU BIOSYSTEMS, INC. , LU, Meng , SHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , POKHRIYAL, Anusha
发明人： LU, Meng , SHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , POKHRIYAL, Anusha
IPC分类号： G01N21/64 , G01N21/77
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/7743
摘要： A photonic crystal substrate exhibiting resonant enhancement of multiple fluorophores has been demonstrated. The device, which can be fabricated uniformly from plastic materials over a ∼3x5 in 2 surface area by nanoreplica molding, features a 1 -D periodic grating structure; (16, 18) which utilizes two distinct resonant modes to enhance electric field stimulation of a. first dye excited by a first laser (31) (e.g., λ=632.8 nm laser exciting cyantne-5) and a second dye excited by a second laser (32) (e.g., λ=532 nm laser exciting cyanine-3). The first and second lasers could be replaced by a single variable wavelength (tunable) laser. Resonant coupling of the laser excitation to the photonic crystal surface is obtained for each wavelength at a distinct incident angle θ. The photonic crystal is capable of amplifying the output of any fluorescent dye with an excitation wavelength in a given wavelength range (e.g., the range 532 nm
摘要翻译：已经证明了表现出多个荧光团的共振增强的光子晶体衬底。该器件可以通过纳米尺寸成型在〜3×5平方的表面积上由塑料材料均匀制成，具有1-D周期性光栅结构; （16,18），其利用两种不同的谐振模式来增强a的电场刺激。由第一激光器（31）激发的第一染料（例如，λ= 632.8nm的激光激发光子-5）和由第二激光器（32）激发的第二染料（例如，λ= 532nm激光花青-3）。第一和第二激光器可以由单个可变波长（可调谐）激光器代替。以不同的入射角θ对每个波长获得激光激发与光子晶体表面的共振耦合。光子晶体能够通过选择适当的入射角来放大具有给定波长范围（例如，532nm <λ<660nm）范围内的激发波长的任何荧光染料的输出。该装置可用于在单个成像区域内利用多种荧光染料的生物测定法，例如基因表达微阵列。

4. 发明申请

WO2008136812A2 FLUORESCENCE DETECTION ENHANCEMENT USING PHOTONIC CRYSTAL EXTRACTION 审中-公开
标题翻译：使用光子晶体提取的荧光检测增强
公开(公告)号：WO2008136812A2
公开(公告)日：2008-11-13
申请号：PCT/US2007/024234
申请日：2007-11-19
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , CUNNINGHAM, Brian, T. , GANESH, Nikhil , MATHIAS, Patrick, C. , BLOCK, Ian, D.
发明人： CUNNINGHAM, Brian, T. , GANESH, Nikhil , MATHIAS, Patrick, C. , BLOCK, Ian, D.
CPC分类号： G01N21/648 , B82Y15/00 , B82Y20/00 , G01N21/6428 , G01N33/54373 , G01N33/582 , G01N2021/7786 , G02B2006/1213
摘要： Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.
摘要翻译：描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

5. 发明申请

WO2009089006A1 LABEL-FREE BIOSENSORS BASED UPON DISTRIBUTED FEEDBACK LASER 审中-公开
标题翻译：基于分布式反馈激光器的无标签生物传感器
公开(公告)号：WO2009089006A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/000073
申请日：2009-01-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , CUNNINGHAM, Brian, T. , LU, Meng
发明人： CUNNINGHAM, Brian, T. , LU, Meng
IPC分类号： C12M1/34
CPC分类号： G01N21/7743 , G01N2021/7709
摘要： A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two- dimensional dielectric grating coated with a laser dye-doped polymer as the gain medium. A sensor is also described in which the grating layer and the active layer are combined into a single layer. DFB lasers using an inorganic or organic thin film with alternating regions of high and low index of refraction as the active layer are also disclosed. The sensor actively generates its own narrowband high intensity light output without stringent requirements for coupling alignment, thereby resulting in a simple, robust illumination and detection configuration.
摘要翻译：公开了一种基于垂直发射分布反馈（DFB）激光器的生物传感器。在一种配置中，DFB激光器包括涂覆有激光染料掺杂聚合物作为增益介质的复制模制的一维或二维介质光栅。还描述了传感器，其中光栅层和有源层被组合成单层。还公开了使用具有高折射率和低折射率的交替区域的无机或有机薄膜作为活性层的DFB激光器。传感器主动产生自己的窄带高强度光输出，无需对耦合对准的严格要求，从而产生简单，鲁棒的照明和检测配置。

6. 发明申请

WO2008123927A1 BIOSENSORS WITH POROUS DIELECTRIC SURFACE FOR FLUORESCENCE ENHANCEMENT AND METHODS OF MANUFACTURE 审中-公开
标题翻译：用于荧光增强的多孔介电表面生物传感器及其制造方法
公开(公告)号：WO2008123927A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/003854
申请日：2008-03-24
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHANG, Wei , CUNNINGHAM, Brian, T.
发明人： ZHANG, Wei , CUNNINGHAM, Brian, T.
IPC分类号： C12Q1/00
CPC分类号： G01N21/648 , B82Y15/00 , B82Y20/00 , G01N21/7743 , G01N2021/7726 , G02B6/1226
摘要： Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO2. In one example the porous, thin film is in the form of a multitude of sub-micron sized rod-like structures ("nanorods") projecting therefrom. In one embodiment, the biosensor is in the form of a photonic crystal biosensor. The approach of depositing a thin film of dielectric nanorods may be applied to any enhanced fluorescence biosensor surface structure, including 1 -dimensional photonic crystals, 2-dimensional photonic crystals, 3-dimensional photonic crystals, surface plasmon resonance surfaces, planar waveguides, and grating-coupled waveguides. The dielectric nanorod structures can be fabricated on the surface of a biosensor by the glancing angle deposition technique (GLAD).
摘要翻译：公开了生物传感器，其包括以多孔的电介质材料薄膜（例如TiO 2）的形式将样品分子结合到生物传感器的表面。在一个示例中，多孔薄膜是从其突出的多个亚微米尺寸的棒状结构（“纳米棒”）的形式。在一个实施例中，生物传感器是光子晶体生物传感器的形式。沉积电介质纳米棒薄膜的方法可以应用于任何增强的荧光生物传感器表面结构，包括1维光子晶体，2维光子晶体，3维光子晶体，表面等离子体共振表面，平面波导和光栅耦合波导。介电纳米棒结构可以通过扫眼角沉积技术（GLAD）在生物传感器的表面上制造。

7. 发明申请

WO2007008440A2 PHOTONIC CRYSTAL BIOSENSOR STRUCTURE AND FABRICATION METHOD 审中-公开
标题翻译：光电晶体生物传感器结构与制造方法
公开(公告)号：WO2007008440A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/025400
申请日：2006-06-29
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , CUNNINGHAM, Brian, T. , BLOCK, Ian , CHAN, Leo Li-Ying
发明人： CUNNINGHAM, Brian, T. , BLOCK, Ian , CHAN, Leo Li-Ying
IPC分类号： B01L3/00 , G01N21/25 , G01N21/47
CPC分类号： G01N21/7743 , B82Y20/00 , C12M23/20 , C12M41/36 , G01N2021/7776 , G02B6/1225
摘要： The invention provides sensor compositions and method of making sensors.
摘要翻译：本发明提供了传感器组成和制造传感器的方法。

8. 发明申请

WO2022169926A1 PHOTONIC RESONATOR INTERFEROMETRIC SCATTERING MICROSCOPY 审中-公开
公开(公告)号：WO2022169926A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015023
申请日：2022-02-03
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： CUNNINGHAM, Brian, T. , LI, Nantao , CANADY, Taylor, D. , HUANG, Qinglan , WANG, Xing
IPC分类号： G02B1/02 , G02B5/18 , G02B5/20 , G02B6/14
摘要： Disclosed herein are methods and systems that use a photonic crystal (PC) for interference scattering microscopy. Incident light is directed onto a surface of the PC and couples into a photonic crystal guided resonance (PCGR) mode of the PC such that less than 1% of the incident light is transmitted through the PC as transmitted light. One or more particles adjacent to the surface of the PC scatter a portion of the light coupled into the PCGR mode as scattered light. An image comprising a pattern of constructive and destructive interference between the transmitted light and the scattered light is formed, and an image sensor may capture one or more image frames of the image. Imaging processing of the one or more image frames can be used to identify at least one scattering center corresponding to at least one particle of the one or more particles.

9. 发明申请

WO2022147340A1 SPECIFIC DETECTION OF NUCLEIC ACID SEQUENCES USING ACTIVATE CLEAVE & COUNT (ACC) TECHNOLOGY 审中-公开
公开(公告)号：WO2022147340A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/065804
申请日：2021-12-31
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： CUNNINGHAM, Brian, T. , GANGULI, Anurup , CANADY, Taylor, D. , LI, Nantao , XIONG, Ying , GHOSH, Shreya , XIONG, Yanyu , AKIN, Lucas, D.
IPC分类号： B01L3/00 , C12N9/22 , C12N9/96 , C12N15/09 , C12N15/10 , C12N15/11
摘要： The current disclosure provides a simple single-step room temperature Activate Cleave and Count (ACC) assay coupled to Photonic Resonator Absorption Microscopy (PRAM) in an amplification-free approach. The assay, and associated system and method disclosed herein allow for detection of viral and bacterial pathogens as well disease such as cancer at the point of care.

10. 发明申请

WO2019067822A1 MOBILE BIOSENSING INSTRUMENT CAPABLE OF MULTIPLE DETECTION MODALITIES 审中-公开
公开(公告)号：WO2019067822A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/053277
申请日：2018-09-28
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： CUNNINGHAM, Brian, T. , LONG, Kenneth, D.
IPC分类号： B01L3/00 , G01J3/00 , G01J3/28 , G01N21/00 , G01N21/25
摘要： A smartphone is optically coupled to an apparatus that can operate in multiple modes to perform transmission, reflectance, intensity, or scattered light spectroscopy on a sample provided, in an appropriately configured sample cartridge. The apparatus includes a first illumination optical path for illuminating the sample, with light from a light source, on the smartphone for transmission, reflectance, and scattered light spectroscopy. The apparatus also includes a second illumination optical path for illuminating the sample with light from a laser diode for intensity spectroscopy. The apparatus farther includes a collection optical path for collecting light from the sample in each of the modes. An image sensor on the smartphone receives the collected light via a diffraction grating to obtain a spectrum image. The first illumination optical path is substantially parallel to the collection optical path, whereas the second illumination optical path is substantially orthogonal to the collection path.

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