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1. 发明申请

WO03066023A9 A STABLE PHARMACEUTICAL FORMULATION COMPRISING TORSEMIDE MODIFICATION II 审中-公开
标题翻译：一种包含TORSEMIDE修饰的稳定的药物制剂II
公开(公告)号：WO03066023A9
公开(公告)日：2003-11-20
申请号：PCT/US0303701
申请日：2003-02-07
申请人： TEVA PHARMA , TEVA PHARMA , LEIBOVICI MINUTZA , TENENGAUZER RUTH , KOPEL MIRA , ARONHIME JUDITH , KORDOVA MARKO
发明人： LEIBOVICI MINUTZA , TENENGAUZER RUTH , KOPEL MIRA , ARONHIME JUDITH , KORDOVA MARKO
IPC分类号： A01N43/40 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/44 , A61K31/4409 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/38 , A61P9/00 , A61P9/12 , C07D213/70 , C07D213/74
CPC分类号： C07D213/74 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： Novel, stable pharmaceutical formulations for the oral administration of high purity torsemide modification II are disclosed. These formulations release high purity torsemide modification II in water at a constant and high purity rate, and the high purity torsemide modification II therein does not rearrange to torsemide modification I over time. Methods for their manufacture are also disclosed.
摘要翻译：公开了用于口服给予高纯度托拉塞米变体II的新型稳定药物制剂。这些制剂以恒定且高纯度的速率在水中释放高纯度托拉塞米改性剂II，其中高纯度托拉塞米改性剂II随时间不重排为托拉塞米改性剂I. 它们的制造方法也被公开。

2. 发明申请

WO2007018588A8 STABLE PHARMACEUTICAL COMPOSITION COMPRISING LINEZOLID FORM IV 审中-公开
标题翻译：包含LINEZOLID形式的稳定的药物组合物IV
公开(公告)号：WO2007018588A8
公开(公告)日：2008-05-08
申请号：PCT/US2006001514
申请日：2006-01-17
申请人： TEVA PHARMA , TEVA PHARMA , TENENGAUZER RUTH , LEIBOVICI MINUTZA , SOLOMON BEN-ZION
发明人： TENENGAUZER RUTH , LEIBOVICI MINUTZA , SOLOMON BEN-ZION
IPC分类号： A61K9/20 , A61K31/421
CPC分类号： A61K31/421 , A61K9/2004 , A61K9/2009 , A61K9/2018 , A61K9/2077 , A61K31/5377
摘要： A method of formulating a pharmaceutical composition comprising Form IV substantially free of linezolid Form II and methods of treating a condition responsive to linezolid in a patient comprising administering to the patient a solid pharmaceutical composition comprising linezolid form IV substantially free of linezolid Form II.
摘要翻译：配制包含基本上不含利奈唑胺形式II的形式IV的药物组合物的方法和治疗患者中对利奈唑胺有反应的病症的方法，包括向患者施用包含基本上不含利奈唑胺形式II的利奈唑胺形式IV的固体药物组合物。

3. 发明申请

WO03032922A3 STABILIZED AZITHROMYCIN COMPOSITIONS 审中-公开
标题翻译：稳定的阿奇霉素组合物
公开(公告)号：WO03032922A3
公开(公告)日：2003-10-16
申请号：PCT/US0233339
申请日：2002-10-18
申请人： TEVA PHARMA , TEVA PHARMA , TENENGAUZER RUTH , SCHWARZ JOSEPH , HRAKOVSKY JULIA , LESSEN TANIA , KHONDO LEV , MATHIVANAN MATHI , SINGER CLAUDE , PESACHOVICH MICHAEL
发明人： TENENGAUZER RUTH , SCHWARZ JOSEPH , HRAKOVSKY JULIA , LESSEN TANIA , KHONDO LEV , MATHIVANAN MATHI , SINGER CLAUDE , PESACHOVICH MICHAEL
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/353 , A61K31/375 , A61K31/70 , A61K31/7048 , A61K31/7052 , A61K47/10 , A01N43/04
CPC分类号： A61K9/1617 , A61K9/0095 , A61K9/145 , A61K9/2077 , A61K31/7052
摘要： Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin compositions and methods of making such formulations are also described.
摘要翻译：描述了稳定阿奇霉素组合物的组合物和方法。稳定的阿奇霉素组合物包含阿奇霉素和稳定有效量的抗氧化剂的紧密混合物以改善阿奇霉素对降解的抗性。阿奇霉素和抗氧化剂的共沉淀或共研磨是获得均匀混合物的特别优选的手段。还描述了包含稳定的阿奇霉素组合物的药物制剂以及制备该制剂的方法。

4. 发明申请

WO2006078948A3 STABLE PHARMACEUTICAL FORMULATIONS OF ZONISAMIDE AND METHODS FOR THEIR MANUFACTURE 审中-公开
标题翻译： ZONISAMIDE的稳定的药物制剂及其制造方法
公开(公告)号：WO2006078948A3
公开(公告)日：2007-01-25
申请号：PCT/US2006002103
申请日：2006-01-20
申请人： TEVA PHARMA , TEVA PHARMA , HRAKOVSKY JULIA , TENENGAUZER RUTH
发明人： HRAKOVSKY JULIA , TENENGAUZER RUTH
IPC分类号： A61K9/16 , A61K9/14 , A61K31/423
CPC分类号： A61K9/1635 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/423
摘要： One of the embodiments of the present invention is directed toward a process for preparing a stable zonisamide pharmaceutical composition, comprising subjecting zonisamide to wet granulation with a granulation liquid to form a granulated mixture as the stable zonisamide pharmaceutical composition, wherein the granulation liquid is selected from purified water, alcohol and mixtures thereof. The stable zonisamide pharmaceutical composition can be used to fill capsule shells to prepare stable zonisamide capsules. Another embodiment of the invention concerns a for preparing a stable zonisamide pharmaceutical capsule, comprising (i) forming an intimate mixture with zonisamide powder and an effective amount of at least one pharmaceutically acceptable excipient by compressing, co-milling, co-micronization and/or co-compaction of the components, or subjecting the components to a similarly intensive process; and (ii) filling capsule shells with the intimate mixture to obtain the stable zonisamide pharmaceutical capsule.
摘要翻译：本发明的一个实施方案涉及用于制备稳定的唑尼沙胺药物组合物的方法，其包括用造粒液体对唑尼沙胺进行湿法制粒以形成作为稳定的唑尼拉唑药物组合物的粒化混合物，其中制粒液体选自纯化水，酒精及其混合物。稳定的唑尼沙胺药物组合物可用于填充胶囊壳以制备稳定的唑尼沙胺胶囊。本发明的另一个实施方案涉及用于制备稳定的唑尼沙胺药物胶囊的方法，该方法包括（i）通过压制，共研磨，共微粉化和/或与共溶化的粉末形成与唑尼沙胺粉末和有效量的至少一种药学上可接受的赋形剂的紧密混合物共同压实部件，或使部件经受类似的密集过程; 和（ii）用紧密混合物填充胶囊壳以获得稳定的唑尼沙胺药物胶囊。

5. 发明申请

WO2006078948B1 STABLE PHARMACEUTICAL FORMULATIONS OF ZONISAMIDE AND METHODS FOR THEIR MANUFACTURE 审中-公开
标题翻译：噻菌胺的稳定药用配方及其制造方法
公开(公告)号：WO2006078948B1
公开(公告)日：2007-03-01
申请号：PCT/US2006002103
申请日：2006-01-20
申请人： TEVA PHARMA , TEVA PHARMA , HRAKOVSKY JULIA , TENENGAUZER RUTH
发明人： HRAKOVSKY JULIA , TENENGAUZER RUTH
IPC分类号： A61K9/16 , A61K9/14 , A61K31/423
CPC分类号： A61K9/1635 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/423
摘要： One of the embodiments of the present invention is directed toward a process for preparing a stable zonisamide pharmaceutical composition, comprising subjecting zonisamide to wet granulation with a granulation liquid to form a granulated mixture as the stable zonisamide pharmaceutical composition, wherein the granulation liquid is selected from purified water, alcohol and mixtures thereof. The stable zonisamide pharmaceutical composition can be used to fill capsule shells to prepare stable zonisamide capsules. Another embodiment of the invention concerns a for preparing a stable zonisamide pharmaceutical capsule, comprising (i) forming an intimate mixture with zonisamide powder and an effective amount of at least one pharmaceutically acceptable excipient by compressing, co-milling, co-micronization and/or co-compaction of the components, or subjecting the components to a similarly intensive process; and (ii) filling capsule shells with the intimate mixture to obtain the stable zonisamide pharmaceutical capsule.
摘要翻译：本发明的一个实施方案涉及一种制备稳定的唑尼沙胺药物组合物的方法，其包括使唑胺与造粒液进行湿法制粒以形成作为稳定唑尼沙胺药物组合物的造粒混合物，其中造粒液体选自纯化水，醇及其混合物。稳定的唑尼沙胺药物组合物可用于填充胶囊壳以制备稳定的唑尼沙胺胶囊。本发明的另一个实施方案涉及制备稳定的唑尼沙胺药物胶囊，其包括（i）通过压缩，共研磨，共微粉化和/或形成与zonisamide粉末和有效量的至少一种药学上可接受的赋形剂形成紧密混合物组分的共同压实，或使组分经历类似的密集过程; 和（ii）用紧密混合物填充胶囊壳以获得稳定的唑尼沙胺药物胶囊。

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