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1. 发明申请

WO2016168609A1 APPARATUS AND METHODS FOR DELIVERY, REPOSITIONING, AND RETRIEVAL OF TRANSCATHETER PROSTHETIC VALVES 审中-公开
标题翻译：交通运输预报阀的交付，报告和检索的装置和方法
公开(公告)号：WO2016168609A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027770
申请日：2016-04-15
申请人： TENDYNE HOLDINGS, INC. , EKVALL, Craig A. , LE, Khoi , OTTE, John F. , TEGELS, Zachary J. , VIDLUND, Robert M.
发明人： EKVALL, Craig A. , LE, Khoi , OTTE, John F. , TEGELS, Zachary J. , VIDLUND, Robert M.
IPC分类号： A61F2/24
CPC分类号： A61F2/2433 , A61B2017/00292 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2/2466 , A61F2002/9517 , A61F2002/9522 , A61F2220/0016 , A61F2230/0023 , A61F2230/005 , A61F2250/0039 , A61M25/0102 , A61M2025/0681
摘要： Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve into a heart. In some embodiments, an apparatus includes a catheter assembly, a valve holding tube and a handle assembly. The valve holding tube is releasably couplable to a proximal end portion of the catheter assembly and to a distal end portion of the handle assembly. The handle assembly includes a housing and a delivery rod. The delivery rod is configured to be actuated to move distally relative to the housing to move a prosthetic heart valve disposed within the valve holding tube out of the valve holding tube and distally within a lumen of the elongate sheath of the catheter assembly. The catheter assembly is configured to be actuated to move proximally relative to the housing such that the prosthetic valve is disposed outside of the lumen of the elongate sheath.
摘要翻译：本文描述的装置和方法用于将二次瓣膜递送和部署到心脏中。在一些实施例中，装置包括导管组件，阀保持管和手柄组件。阀保持管可释放地联接到导管组件的近端部分和手柄组件的远端部分。手柄组件包括壳体和输送杆。输送杆构造成被致动以相对于壳体向远侧移动，以将设置在瓣膜保持管内的假体心脏瓣膜移出阀保持管并远离地在导管组件的细长护套的内腔内。导管组件构造成被致动以相对于壳体向近侧移动，使得假体瓣膜设置在细长护套的内腔的外侧。

2. 发明申请

WO2016126942A2 EXPANDABLE EPICARDIAL PADS AND DEVICES AND METHODS FOR DELIVERY OF SAME 审中-公开
标题翻译：可扩展的EPICARDIAL PADS和装置及其传送方法
公开(公告)号：WO2016126942A2
公开(公告)日：2016-08-11
申请号：PCT/US2016/016567
申请日：2016-02-04
申请人： VIDLUND, Robert M. , KOVALSKY, Igor , TEGELS, Zachary J. , EKVALL, Craig A.
发明人： VIDLUND, Robert M. , KOVALSKY, Igor , TEGELS, Zachary J. , EKVALL, Craig A.
IPC分类号： A61F2/24 , A61B17/04
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/0443 , A61B2017/3425 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/2457 , A61F2220/0016 , A61F2220/0041 , A61F2220/0075 , A61F2220/0083 , A61F2230/0093 , A61F2250/0039 , A61F2250/0063 , A61F2250/0098
摘要： Apparatus and methods are described herein for use in the delivery of a prosthetic mitral valve. In some embodiments, a method includes after deploying a prosthetic mitral valve within a mitral annulus of a heart, inserting a delivery sheath into the patients body and disposing a distal end near the apex of the heart. A tissue dilator device can be inserted through a lumen of the delivery sheath and used to dilate tissue near the apex of the heart to create space for an epicardial pad device. After dilating the tissue, the tissue dilator device can be removed and an epicardial pad device can be attached to a tether extending from the prosthetic valve. The pad can be secured at the apex of the heart to secure the prosthetic valve and tether in a desired position. In some embodiments, the epicardial pad device can be an expandable epicardial pad device.
摘要翻译：本文描述了用于递送假性二尖瓣的装置和方法。在一些实施例中，一种方法包括在将心脏的二尖瓣环内部署假体二尖瓣之后，将输送护套插入患者体内并将远端设置在心脏顶点附近。组织扩张器装置可插入穿过输送护套的内腔，并用于扩张心脏顶点附近的组织以产生心外膜垫装置的空间。在扩张组织之后，可以去除组织扩张器装置，并且将心外膜垫装置连接到从假肢瓣延伸的系绳。垫可以固定在心脏的顶点以将假体瓣膜和系绳固定在期望的位置。在一些实施例中，心外膜垫装置可以是可扩张心外膜垫装置。

3. 发明申请

WO2018005779A1 PROSTHETIC HEART VALVES AND APPARATUS AND METHODS FOR DELIVERY OF SAME 审中-公开
标题翻译：人造心脏瓣膜和装置及其递送方法
公开(公告)号：WO2018005779A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039972
申请日：2017-06-29
申请人： TEGELS, Zachary J. , VIDLUND, Zach , VIDLUND, Robert M.
发明人： TEGELS, Zachary J. , VIDLUND, Zach , VIDLUND, Robert M.
IPC分类号： A61F2/24
摘要： Apparatus and methods are described herein for various embodiments of a prosthetic heart valve, delivery apparatus and delivery methods for delivering a prosthetic heart valve to a heart of a patient via a transapical or transvascular delivery approach. In some embodiments, a prosthetic heart valve includes an outer frame coupled to an inner frame and the outer frame is movable between a first configuration relative to the inner frame and a second inverted configuration relative to the inner frame. The valve can be delivered to a heart using an apparatus that includes a delivery sheath that defines a lumen that can receive the prosthetic heart valve therein when the outer frame is in the inverted configuration. Actuation wires are releasably coupled to the outer frame and can be used to help revert the outer frame after the valve is deployed outside of the delivery sheath and within the heart.
摘要翻译：这里描述了用于假体心脏瓣膜的各种实施例的装置和方法，递送装置和递送方法，用于经由经心尖或经血管递送方法将人造心脏瓣膜递送到患者的心脏。在一些实施例中，人造心脏瓣膜包括耦合到内部框架的外部框架，并且外部框架可相对于内部框架在第一构造和相对于内部框架的第二颠倒构造之间移动。使用包括输送护套的装置可以将瓣膜输送到心脏，所述输送护套限定当外框架处于倒置构造时可以将人造心脏瓣膜容纳在其中的管腔。驱动线可释放地连接到外部框架，并且可以用于在瓣膜部署在输送护套外部并且在心脏内部之后帮助恢复外部框架。

4. 发明申请

WO2017156333A1 SYSTEMS AND METHODS FOR TREATING EYE DISEASES USING RETROGRADE BLOOD FLOW 审中-公开
标题翻译：用逆向血流治疗眼部疾病的系统和方法
公开(公告)号：WO2017156333A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021673
申请日：2017-03-09
申请人： J.D. FRANCO & CO. , CALHOUN, Michael , FRANCO, Jeff , VIDLUND, Robert M.
发明人： CALHOUN, Michael , FRANCO, Jeff , VIDLUND, Robert M.
IPC分类号： A61M27/00
CPC分类号： A61F9/007 , A61B17/12109 , A61B17/12136 , A61F2/856 , A61F2/966 , A61F9/00781 , A61F2002/821 , A61M1/10 , A61M1/1086 , A61M25/104 , A61M27/00 , A61M2025/1052
摘要： A method, device, or system for treating eye disorders or conditions, comprising restoring or increasing blood flow or blood flow rate in an artery that supplies blood to or in the eye, thereby increasing the amount of nutrient(s) that reaches the eye or a portion thereof. The invention also includes methods, devices, or systems for treating eye disorders or conditions which use reverse flow or retrograde flow structures and systems during the treatment of the eye disease.
摘要翻译：用于治疗眼病或病症的方法，装置或系统包括恢复或增加将血液供应到眼内或眼内的动脉中的血流或血流速度，由此增加营养物的量（s）到达眼睛或其一部分。本发明还包括用于治疗在治疗眼病过程中使用逆流或逆流结构和系统的眼病或病症的方法，装置或系统。

5. 发明申请

WO2011084888A1 METHOD AND SYSTEM FOR SEALING PERCUTANEOUS PUNCTURES 审中-公开
标题翻译：用于密封刺痛的方法和系统
公开(公告)号：WO2011084888A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/000022
申请日：2011-01-06
申请人： ST. JUDE MEDICAL, INC. , VIDLUND, Robert M. , KILLION, Douglas P.
发明人： VIDLUND, Robert M. , KILLION, Douglas P.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/12136 , A61B2017/00601 , A61B2017/00623 , A61B2017/0065 , A61B2017/00654 , A61B2017/00898 , A61B2017/22042 , A61B2017/22067
摘要： A puncture closure device operable to seal closed a vessel puncture in a vessel. The puncture closure device includes a delivery member insertable through a tissue tract to the vessel puncture, a sealing material, and an expandable member. The sealing material is deliverable through the delivery member to the vessel puncture and configured to seal closed the vessel puncture from outside the vessel. The expandable member is positionable within the vessel through a vessel access distinct from the vessel puncture and is operable to temporarily seal closed the vessel puncture from within the vessel to restrict passage of the sealing material into the vessel.
摘要翻译：穿刺封闭装置，其可操作以密封容器中的血管穿刺。穿刺闭合装置包括可通过组织管道插入到血管穿刺的输送构件，密封材料和可扩张构件。密封材料可通过输送构件输送到血管穿刺并且被构造成密封容器从容器外部穿刺。可膨胀构件可通过与血管穿刺不同的血管通道在容器内定位，并且可操作以临时密封容器内的血管穿刺以限制密封材料进入血管的通道。

6. 发明申请

WO2015138306A2 DEVICES AND METHODS FOR POSITIONING AND MONITORING TETHER LOAD FOR PROSTHETIC MITRAL VALVE 审中-公开
标题翻译：用于定位和监测预制阀门的负载的装置和方法
公开(公告)号：WO2015138306A2
公开(公告)日：2015-09-17
申请号：PCT/US2015/019418
申请日：2015-03-09
申请人： TENDYNE HOLDINGS, INC.
发明人： VIDLUND, Robert M. , EKVALL, Craig A.
IPC分类号： A61B17/04
CPC分类号： A61F2/2487 , A61B90/06 , A61B2090/064 , A61F2/2418 , A61F2/2427 , A61F2/2457 , A61F2/2466
摘要： Apparatus and methods are described herein for positioning an epicardial anchor device and measuring the load of a tether extending from a prosthetic heart valve and coupled to the epicardial anchor device. In some embodiments, an apparatus includes a handle assembly coupled to an elongate member and a docking member coupled to a distal end of the elongate member. The docking member can be releasably coupled to an epicardial anchor device configured to secure a tether extending from a prosthetic heart valve implanted with a heart at a location on an exterior of a ventricular wall of the heart. A force sensor device is coupled to the handle assembly and can measure a force exerted on the force sensor device. The force is associated with a tension of the tether extending through the elongate member and handle assembly.
摘要翻译：本文描述了用于定位心外膜锚装置并测量从假体心脏瓣膜延伸并连接到心外膜锚定装置的系绳的负载的装置和方法。在一些实施例中，装置包括联接到细长构件的手柄组件和联接到细长构件的远端的对接构件。对接构件可以可释放地联接到心外膜锚定装置，所述心外膜锚定装置构造成固定从在心脏的心室壁的外部的位置处植入心脏的假体心脏瓣膜延伸的系绳。力传感器装置联接到手柄组件并且可以测量施加在力传感器装置上的力。该力与延伸穿过细长构件和手柄组件的系绳的张力相关联。

7. 发明申请

WO2017117109A1 ATRIAL POCKET CLOSURES FOR PROSTHETIC HEART VALVES 审中-公开
标题翻译：人工心脏瓣膜的房间封闭
公开(公告)号：WO2017117109A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068680
申请日：2016-12-27
申请人： TENDYNE HOLDINGS, INC.
发明人： VIDLUND, Zach , EVANS, Michael , VIDLUND, Robert M.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2250/0069
摘要： A prosthetic heart valve can include an outer frame (420) coupled to an inner frame (450) such that the outer frame can be moved between a first position and a second position in which the outer frame is inverted relative to the inner frame. The inner frame and the outer frame define between them an annular space, and a pocket closure (480) can bound the annular space to form a pocket in which thrombus can form and be retained. The pocket closure can include a stretchable pocket covering (480) that can move from a first position in which the pocket covering has a first length when the outer frame is in the first position relative to the inner frame and a second position in which the pocket covering has a second length greater than the first length when the outer frame is in the second position relative to the inner frame.
摘要翻译：假体心脏瓣膜可包括联接到内部框架（450）的外部框架（420），使得外部框架可在第一位置和第二位置之间移动，其中外部框架相对于内框倒立。内框架和外框架在它们之间限定了环形空间，并且袋闭合件（480）可以限制环形空间以形成其中可以形成和保持血栓的袋。该口袋闭合件可包括可伸展的口袋覆盖物（480），该口袋覆盖物能够从第一位置移动到第二位置，在第一位置中，当外部框架相对于内部框架处于第一位置时，口袋覆盖物具有第一长度，当外部框架相对于内部框架处于第二位置时，覆盖物具有大于第一长度的第二长度。

8. 发明申请

WO2016196933A1 APICAL CONTROL OF TRANSVASCULAR DELIVERY OF PROSTHETIC MITRAL VALVE 审中-公开
标题翻译：前列腺门静脉输送的临床控制
公开(公告)号：WO2016196933A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035719
申请日：2016-06-03
申请人： TENDYNE HOLDINGS, INC.
发明人： KOVALSKY, Igor , TEGELS, Zachary J. , VIDLUND, Robert M. , VIDLUND, Zach
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61B17/0401 , A61B17/3478 , A61B2017/00247 , A61B2017/00358 , A61B2017/0404 , A61B2017/3425 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2457 , A61F2002/9534 , A61F2002/9665 , A61F2210/0014 , A61F2220/0008 , A61F2220/0075 , A61F2230/0054
摘要： Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve. In some embodiments, after a prosthetic valve (1500) has been at least partially delivered from a delivery sheath into the left atrium of a heart, a valve positioning device can be used to engage with and position the prosthetic valve within the mitral annulus. The valve positioning device can include a alignment member (1576) configured to engage with a prosthetic valve such that the alignment member can control the distal, proximal, lateral and/or rotational movement of the prosthetic valve. The prosthetic valve can include a tether (1536) that can be inserted or threaded through the alignment member such that the alignment member can be moved along the tether into engagement with the prosthetic valve.
摘要翻译：本文描述的装置和方法用于递送和展开假体二尖瓣。在一些实施例中，在假体瓣膜（1500）至少部分地从输送护套输送到心脏的左心房之后，阀定位装置可以用于与二尖瓣环内的假体瓣接合并定位。瓣膜定位装置可以包括配置成与假性瓣膜接合的对准构件（1576），使得对准构件可以控制人造瓣膜的远侧，近侧，侧向和/或旋转运动。假体瓣膜可以包括可以插入或穿过对准构件的系绳（1536），使得对准构件可以沿着系绳移动以与假性瓣膜接合。

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