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    • 6. 发明申请
    • FUNGICIDES
    • 杀菌剂
    • WO2004048315A1
    • 2004-06-10
    • PCT/GB2003/004832
    • 2003-11-10
    • SYNGENTA LIMITEDSALMON, RogerCROWLEY, Patrick, JelfBACON, David, Philip
    • SALMON, RogerCROWLEY, Patrick, JelfBACON, David, Philip
    • C07C235/20
    • C07D249/08A01N39/04C07C235/20C07C255/30C07C317/28C07C323/41
    • Fungicidal compounds of the general formula (1): wherein X, Y and Z are independently H, halogen, C l-4 alkyl, halo(C 1-4 )alkyl, C 2-4 alkenyl, halo(C 2 - 4 )alkenyl, C24 alkynyl, halo(C 2-4 )alkynyl, C 1 _ 4 alkoxy, halo(C 1-4 )alkoxy, -S(O) n (C 1-4 )alkyl where n is 0, 1 or 2 and the alkyl group is optionally substituted with fluoro, -OS0 2 (C 1-4 )alkyl where the alkyl group is optionally substituted with fluoro, cyano, nitro, C, 1-4 alkoxycarbonyl, -CONR'R", -COR', -NR'COR" or -NR'COOR"' where R' and R" are independently H or C 1-4 alkyl and R"' is C l-4 alkyl, provided that at least one of X and Z is other than H; R 1 is C l - 4 alkyl, C 2-4 alkenyl or C 2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms, with a cyano group, with a C 1-4 alkylcarbonyl group, with a C 1-4 alkoxycarbonyl group or with a hydroxy group; R 2 is H, C 1-4 alkyl, C 1-4 alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with CI-4 alkoxy; R 3 and R 4 are independently H, C 1-3 alkyl, C 2-3 alkenyl or C 2-3 alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or R 3 and R 4 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one 0, S or N atom and optionally substituted with halo or C 1-4 alkyl; and R 5 is unsubstituted C 3-4 alkyl, unsubstituted C 3-6 cycloalkyl or C l-4 alkyl or C 3-6 cycloalkyl in which the alkyl and cycloalkyl groups are substituted with halo, hydroxy, C 1-6 alkoxy, cyano, C 1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C 1 _ 4 )alkylaminocarbonyloxy, -S(O)"(C 1-6 )alkyl where n is 0, 1 or 2, triazolyl, tri(C 1-4 )alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienyl-methoxy, in which the optionally substituted phenyl and thienyl rings of phenoxy, thienyloxy, benzyloxy and thienylmethoxy are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C1-4 alkoxy, C 2-4 alkenyloxy, C 2-4 alkynyloxy, halo(C 1-4 )­alkyl, halo(C 1-4 )alkoxy, C 1-4 alkylthio; halo(C 1-4 )alkylthio, hydroxy(C 1-4 )alkyl, C 1-4 alkoxy(C 1-4 )alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR - R', -NHCOR m , -NHCONR m R", -CONRmR", -S02R m , -OS02R m , -COR M , -CR'=NR" or -N=CR m R", in which R"' and R" are independently hydrogen, CI-4 alkyl, halo(C 1-4 )alkyl, C1-4 alkoxy, halo(C 1-4 )alkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy.
    • 通式(1)的杀真菌化合物:其中X,Y和Z独立地为H,卤素,C 1-4烷基,卤代(C 1-4)烷基,C 2-4烯基,卤代(C 2-4)烯基,C 24炔基 ,卤素(C 2-4)炔基,C 1-4烷氧基,卤代(C 1-4)烷氧基,-S(O)n(C 1-4)烷基,其中n为0,1或2,烷基任选被氟取代, -OCO 2(C 1-4)烷基,其中烷基任选被氟,氰基,硝基,C 1-4烷氧基羰基,-CONR'R“,-COR',-NR'COR”或-NR'COOR“ 其中R'和R“独立地是H或C 1-4烷基,R”'是C 1-4烷基,条件是X和Z中的至少一个不是H; R 1是C 1-4烷基,C 2-4烯基 或C2-4炔基,其中烷基,烯基和炔基在其末端碳原子上任选被一个,两个或三个卤素原子与氰基,C 1-4烷基羰基和C 1-4烷氧基羰基 基团或羟基; R 2是H,C 1-4烷基,C 1-4烷氧基甲基或苄氧基甲基,其中苄基 部分任选被C 1-4烷氧基取代; R3和R4分别是H,C1-3烷基,C2-3烯基或C2-3炔基,条件是两者都不是H,当两者都不是H时,它们的总碳原子数不超过4,或者R3和R4 与它们所连接的碳原子一起形成任选含有一个O,S或N原子并任选被卤素或C 1-4烷基取代的3或4元碳环; R5是未取代的C3-4烷基,未取代的C3-6环烷基或C1-C4烷基或C3-6环烷基,其中烷基和环烷基被卤素,羟基,C1-6烷氧基,氰基,C1-4烷基羰基氧基, 氨基羰基氧基,单或二(C 1-4)烷基氨基羰基氧基,-S(O)“(C 1-6)烷基,其中n为0,1或2,三唑基,三(C 1-4)烷基甲硅烷氧基,任选取代的苯氧基,任选取代的噻吩氧基, 任选取代的苄氧基或任选取代的噻吩基 - 甲氧基,其中苯氧基,噻吩氧基,苄氧基和噻吩基甲氧基的任选取代的苯基和噻吩环任选被一个,两个或三个选自卤素,羟基,巯基,C 1-4烷基, C 2-4烷氧基,C 2-4烷氧基,C 2-4烷氧基,卤代(C 1-4)烷基,卤代(C 1-4)烷氧基,C 1-4烷硫基;卤代(C1- 4)烷硫基,羟基(C 1-4)烷基,C 1-4烷氧基(C 1-4)烷基,C 3-6环烷基,C 3-6环烷基(C 1-4)烷基,苯氧基,苄氧基,苯甲酰氧基,氰基, 异氰酸,硫氰酸酯,异硫氰酸酯,硝基,-NR'R',-NHCOR m,-NHCONR m R“,-CONRmR”,-SO 2 R m,-OSO 2 R m,-COR M >,-CR'= NR“或
    • 8. 发明申请
    • PYRIDYLOXYALKANOIC ACID AMIDE DERIVATIVES USEFUL AS FUNGICIDES
    • 作为杀菌剂有用的吡咯烷酮酸酰胺衍生物
    • WO2003048128A1
    • 2003-06-12
    • PCT/GB2002/005303
    • 2002-11-25
    • SYNGENTA LIMITEDSYNGENTA PARTICIPATIONS AGWHITTINGHAM, William, GuyLAWSON, Kevin, RobertWORTHINGTON, Paul, AnthonyRUSSELL, Charles, AdamSALMON, RogerMAY, Leslie, FrancisJORG, MarioPACHLATKO, Johannes, Paul
    • WHITTINGHAM, William, GuyLAWSON, Kevin, RobertWORTHINGTON, Paul, AnthonyRUSSELL, Charles, AdamSALMON, RogerMAY, Leslie, FrancisJORG, MarioPACHLATKO, Johannes, Paul
    • C07D213/65
    • C07D213/70A01N43/40C07D213/65C07D213/68C07D213/80C07D213/82C07D213/85
    • Fungicidal compounds of the general formula (I): wherein X and Y are independently H, halo, C 1-8 alkyl, C 3-6 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, nitro, amino, mono- or di-(C 1-6 )alkylamino, mono- or di-(C 2-6 )alkenylamino, mono- or di-(C 2-6 )alkynylamino, formylamino, C 1-4 alkyl(formyl)amino, C 1-4 alkylcarbonylamino, C 1-4 alkyl(C 1-4 alkylcarbonyl)amino, cyano, formyl, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl, aminocarbonyl, mono- or di-(C 1-4 )alkylaminocarbonyl, carboxy, C 1-4 alkylcarbonyloxy, aryl(C 1-4 )alkylcarbonyloxy, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, C 1-4 alkylsulphonyloxy, aryl, heteroaryl, aryloxy, arylthio, heteroaryloxy or heteroarylthio wherein any of the foregoing alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, groups or moieties are optionally substituted; R 1 is phenyl, cyano, C 1-4 alkyl, C 2-4 alkenyl or C 2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms, with a cyano group, with a C 1-4 alkylcarbonyl group, with a C 1-4 alkoxycarbonyl group or with a hydroxy group, or R 1 is alkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl or alkylsulphonylalkyl in which the total number of carbon atoms is 2 or 3; R 2 is H, C 1-4 alkyl, C 1-4 alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C 1-4 alkoxy; R 3 and R 4 are independently H, C 1-3 alkyl, C 2-3 alkenyl or C 2-3 alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or R 3 and R 4 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one O, S or N atom and optionally substituted with halo or C 1-4 alkyl; and R 5 is halo, C 1-4 alkyl or C 3-4 cycloalkyl in which the alkyl or cycloalkyl group is optionally substituted with halo, hydroxy, C 1-6 alkoxy, C 1-6 alkylthio, cyano, C 1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C 1-4 )alkylaminocarbonyloxy, or tri(C 1-4 )alkylsilyloxy. The compounds and compositions containing them are especially useful for combating fungal infections of plants.
    • 通式(I)的杀真菌化合物:其中X和Y独立地为H,卤素,C 1-8烷基,C 3-6环烷基,C 2-8链烯基,C 2-8 炔基,C> 1-8 <烷氧基,C 1-8烷基硫基,硝基,氨基,单 - 或二 - (C 1-6)烷基氨基,单 - 或二 - (C 2-6) 链烯基氨基,单 - 或二 - (C 2-6)炔基氨基,甲酰氨基,C 1-4烷基(甲酰基)氨基,C 1-4烷基羰基氨基,C 1-4烷基(C 1 -4 <烷基羰基)氨基,氰基,甲酰基,C 1-4烷基羰基,C 1-4烷氧基羰基,氨基羰基,一或二 - (C 1-4)烷基氨基羰基,羧基, 4 <烷基羰基氧基,芳基(C 1-4)烷基羰基氧基,C 1-4烷基亚磺酰基,C 1-4烷基磺酰基,C 1-4烷基磺酰氧基,芳基,杂芳基,芳氧基,芳硫基,杂芳氧基或杂芳硫基 其中任何前述烷基,环烷基,烯基,炔基,芳基,杂芳基,基团或部分任选被取代; R 1是苯基,氰基,C 1-4烷基,C 2-4链烯基或C 2-4炔基,其中烷基,烯基和炔基在其末端碳原子上任选被一个,两个或三个卤素原子取代, 具有C 1-4烷基羰基,C 1-4烷氧基羰基或羟基的氰基,或者R 1是烷基烷基或烷基磺酰基烷基,其中总碳原子数为2或3的烷氧基烷基,烷硫基烷基,烷基亚磺酰基烷基或烷基磺酰基烷基 ; R 2是H,C 1-4烷基,C 1-4烷氧基甲基或苄氧基甲基,其中苄基部分的苯环任选被C 1-4烷氧基取代; R 3和R 4独立地是H,C 1-3烷基,C 2-3烯基或C 2-3炔基,条件是两者都不是H,当两者都不是H时,它们的总碳原子数不超过 4或R 3和R 4与它们所连接的碳原子一起形成任选含有一个O,S或N原子并任选被卤素或C 1-4烷基取代的3或4元碳环 ; 羟基,C 1-6烷氧基,C 1-6烷硫基,氰基,C 1-4烷基羰基氧基,氨基羰基氧基,C 1-4烷氧基,C 1-4烷氧基, ,单或二(C 1-4)烷基氨基羰基氧基或三(C 1-4)烷基甲硅烷氧基。 含有它们的化合物和组合物特别可用于防治植物的真菌感染。