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1. 发明申请

WO2006107900A3 MONITORING BY MEANS OF AN ON-LINE SENSOR AND FLUIDIC OPERATIONS INVOLVING UNIT SEPARATION AND REACTION OPERATIONS 审中-公开
公开(公告)号：WO2006107900A3
公开(公告)日：2006-10-12
申请号：PCT/US2006/012374
申请日：2006-03-31
申请人： SYMYX TECHNOLOGIES, INC. , CYPES, Stephen , UHRICH, Mark , CARLSON, Eric, D. , KOLOSOV, Oleg , PADOWITZ, David , BENNETT, James , MATSIEV, Leonid
发明人： CYPES, Stephen , UHRICH, Mark , CARLSON, Eric, D. , KOLOSOV, Oleg , PADOWITZ, David , BENNETT, James , MATSIEV, Leonid
IPC分类号： G01N29/02 , G01N29/036 , G01N29/22 , G01N9/00 , G01N11/10 , G01N27/00
摘要： Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

2. 发明申请

WO2005017502A1 PARALLEL INFRARED SPECTROSCOPY APPARATUS AND METHOD 审中-公开
标题翻译：并行红外光谱仪和方法
公开(公告)号：WO2005017502A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/024146
申请日：2004-07-28
申请人： SYMYX TECHNOLOGIES, INC. , CONG, Peijun , GUAN, Shenheng , CYPES, Stephen , WELLS, Jason , BERGH, H., Sam
发明人： CONG, Peijun , GUAN, Shenheng , CYPES, Stephen , WELLS, Jason , BERGH, H., Sam
IPC分类号： G01N21/35
CPC分类号： G01N21/253 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01L3/5027 , C40B30/08 , C40B40/18 , G01N21/0303 , G01N21/05 , G01N21/3577 , G01N35/028 , G01N2021/0346 , G01N2035/00237
摘要： A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.
摘要翻译：以适于使用红外（IR）光谱法进行成像的条件提供材料样品库。将样品提供给一个或多个检测细胞，每个细胞包括或包含反射表面。优选地，对于成像，能量源（例如，红外辐射源）向检测单元提供能量以与样品相互作用。此后，基于相互作用创建与样本相关的图像（例如，光谱）。

3. 发明申请

WO2007033334A3 TESTING COMPOSITIONS IN A CORROSIVE ENVIRONMENT 审中-公开
公开(公告)号：WO2007033334A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/035872
申请日：2006-09-14
申请人： SYMYX TECHNOLOGIES, INC , BERGH, H., Sam , CYPES, Stephen , HAJDUK, Damian , HOGAN, Zach , TIEDE, Richard
发明人： BERGH, H., Sam , CYPES, Stephen , HAJDUK, Damian , HOGAN, Zach , TIEDE, Richard
IPC分类号： G01N35/08
摘要： Methods, apparatus and systems implementing techniques for screening compositions in a test environment. Test samples are exposed to one or more test fluids under controlled conditions. The test samples and/or test fluids are analyzed to detect an effect of the exposure.

4. 发明申请

WO2007033335A1 MICROSCALE FLASH SEPARATION OF FLUID MIXTURES 审中-公开
标题翻译：液体混合物的微观闪烁分离
公开(公告)号：WO2007033335A1
公开(公告)日：2007-03-22
申请号：PCT/US2006/035873
申请日：2006-09-14
申请人： SYMYX TECHNOLOGIES, INC. , CYPES, Stephen , BERGH, Sam, H. , HAJDUK, Damian
发明人： CYPES, Stephen , BERGH, Sam, H. , HAJDUK, Damian
IPC分类号： B01D17/12
CPC分类号： B01D3/065 , B01L3/5027 , G01N2001/4033
摘要： Systems, methods and apparatus implementing techniques for separating and/or analyzing fluid mixtures. The techniques employ microfluidic separation devices that include an inlet port for receiving a fluid feed stream, a microscale fluid flow channel in fluid communication with the fluid inlet port, a phase equilibrium control region located along the fluid flow channel for controlling conditions including temperature and/or pressure to provide a thermal equilibrium, a capillary network in the temperature control region, a first outlet port in indirect fluid communication with the fluid flow channel through the capillary network, and a second outlet port in direct fluid communication with the fluid flow channel. A plurality of microfluidic separation devices can be coupled in fluidic communication to provide for separation of complex mixtures. The systems, methods and apparatus can be used to characterize fluid mixtures.
摘要翻译：用于分离和/或分析流体混合物的系统，方法和设备实施技术。该技术使用微流体分离装置，其包括用于接收流体进料流的入口端口，与流体入口端口流体连通的微流体流动通道，沿着流体流动通道定位的相位平衡控制区域，用于控制包括温度和/ 或压力以提供热平衡，温度控制区域中的毛细管网络，与通过毛细管网络的流体流动通道间接流体连通的第一出口端口和与流体流动通道直接流体连通的第二出口端口。多个微流体分离装置可以流体连通地联接以提供复杂混合物的分离。系统，方法和装置可用于表征流体混合物。

5. 发明申请

WO2005020920A2 NOVEL CRYSTALLINE FORMS OF A PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR 审中-公开
标题翻译：脯氨酸-IV抑制剂的磷酸盐的新型晶体形式
公开(公告)号：WO2005020920A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027983
申请日：2004-08-27
申请人： MERCK & CO., INC. , WENSLOW, Robert, M. , ARMSTRONG, Joseph, D., III , CHEN, Alex, M. , CYPES, Stephen , FERLITA, Russell, R. , HANSEN, Karl , LINDEMANN, Christopher, M. , SPARTALIS, Evangelia
发明人： WENSLOW, Robert, M. , ARMSTRONG, Joseph, D., III , CHEN, Alex, M. , CYPES, Stephen , FERLITA, Russell, R. , HANSEN, Karl , LINDEMANN, Christopher, M. , SPARTALIS, Evangelia
IPC分类号： A61K
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline anhydrate polymorphs of the dihydrogenphosphate salt of (2 R )-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8 H )-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a process for their preparation, pharmaceutical compositions containing these novel forms, and methods of use of the novel forms and pharmaceutical compositions for the treatment of diabetes, obesity, and high blood pressure. The invention also concerns novel crystalline solvates of the dihydrogenphosphate salt of (2 R )-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8 H )-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a crystalline desolvated polymorph and their use for the preparation of the anhydrate polymorphs of the present invention.
摘要翻译：本发明涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-α]二氢磷酸盐的晶体无水物多晶型物，吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺以及它们的制备方法，含有这些新形式的药物组合物，以及使用这些新形式的方法以及用于治疗糖尿病，肥胖症和高血压的药物组合物。本发明还涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪的磷酸二氢盐的新结晶溶剂合物 -7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺以及晶体脱溶化的多晶型物及其用于制备本发明的无水物多晶型物的用途。

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