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1. 发明申请

WO2003100390A2 HIGH THROUGHPUT MICROBALANCE AND METHODS OF USING SAME 审中-公开
标题翻译：高通量微波和使用它的方法
公开(公告)号：WO2003100390A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/012503
申请日：2003-04-23
申请人： SYMYX TECHNOLOGIES, INC. , CARLSON, Eric, D. , KOLOSOV, Oleg , MATSIEV, Leonid , MAZZOLA, Laura, T. , SPITKOVSKY, Mikhail , GALLIPEO, John
发明人： CARLSON, Eric, D. , KOLOSOV, Oleg , MATSIEV, Leonid , MAZZOLA, Laura, T. , SPITKOVSKY, Mikhail , GALLIPEO, John
IPC分类号： G01N19/00
CPC分类号： G01N29/036 , B01J2219/00689 , B01J2219/00707 , G01G3/13 , G01N5/045 , G01N33/15 , G01N2291/0257
摘要： A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate a system (100) including one resonator, or a plurality of resonators in a resonator array (110), adapted to monitor the response of a sample to a change in environmental condition, and correlating the response with mass change in the samples.
摘要翻译：用于测量小样品量的质量的方法和装置。该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。该方法和装置考虑了包括谐振器阵列（110）中的一个谐振器或多个谐振器的系统（100），其适于监测样品对环境条件变化的响应，并且将响应与质量变化相关联样品。

2. 发明申请

WO2003050174A1 CATALYTIC PGM MIXTURE FOR HYDROSILYLATION 审中-公开
标题翻译：催化PGM混合物用于氢化
公开(公告)号：WO2003050174A1
公开(公告)日：2003-06-19
申请号：PCT/EP2001/015413
申请日：2001-12-11
申请人： RHODIA CHIMIE , SYMYX TECHNOLOGIES, INC , BRUMMER, Oliver , CARLSON, Eric, D. , CREVIER, Thomas , GIRAUD, Yves , LA POINTE, Anne-Marie , STERIN, Sébastien
发明人： BRUMMER, Oliver , CARLSON, Eric, D. , CREVIER, Thomas , GIRAUD, Yves , LA POINTE, Anne-Marie , STERIN, Sébastien
IPC分类号： C08K5/00
CPC分类号： C08K5/3432 , C08G77/12 , C08G77/20 , C08G77/24 , C08G77/70 , C08K5/0091 , C08L83/04 , C08L83/00 , C08L2666/28
摘要： This invention relates to a one part mixture based on a PGM catalyst, a PGM inhibitor thereof and a ligand, convenient for the catalysis of hydrosilylation reactions and to polyaddition-curable polyorganosiloxane compositions including such a mixture
摘要翻译：本发明涉及一种基于PGM催化剂，其PGM抑制剂和配体的一部分混合物，其方便催化氢化硅烷化反应，以及包括这种混合物的可加聚固化的聚有机硅氧烷组合物

3. 发明申请

WO2003021251A1 METHODS FOR CHARACTERIZATION OF POLYMERS USING MULTI-DIMENTIONAL LIQUID CHROMATOGRAPHY 审中-公开
标题翻译：用多维液相色谱法表征聚合物的方法
公开(公告)号：WO2003021251A1
公开(公告)日：2003-03-13
申请号：PCT/US2002/027629
申请日：2002-08-28
申请人： SYMYX TECHNOLOGIES, INC. , PETRO, Miroslav , NGUYEN, Son, Hoai , CARLSON, Eric, D.
发明人： PETRO, Miroslav , NGUYEN, Son, Hoai , CARLSON, Eric, D.
IPC分类号： G01N30/88
CPC分类号： G01N30/463 , B01D15/1878 , B01D15/265 , B01D15/325 , B01D15/34 , B01D15/424 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00389 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00736 , G01N30/02 , G01N30/20 , G01N30/46 , G01N30/461 , G01N30/8651 , G01N33/44 , G01N2030/027 , G01N2030/324 , G01N30/16
摘要： Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
摘要翻译：公开了在全面的直接偶联的多维液相色谱系统中表征聚合物样品并且在优选实施方案中表征聚合物样品的文库的方法和装置。第一和第二尺寸优选为高效液相色谱法尺寸，例如适合于确定组合物的第一尺寸，例如，适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等）和适用于确定分子量或粒度（例如，适用于尺寸排阻色谱法，包括凝胶渗透色谱法）的第二维度。 p>

4. 发明申请

WO2004078131A3 EVALUATING EFFECTS OF EXPOSURE CONDITIONS ON DRUG SAMPLES OVER TIME 审中-公开
标题翻译：暴露条件对药物样品的影响评估时间
公开(公告)号：WO2004078131A3
公开(公告)日：2005-01-20
申请号：PCT/US2004006327
申请日：2004-03-01
申请人： SYMYX TECHNOLOGIES INC , CARLSON ERIC D , DESROSIERS PETER J , SONG LI
发明人： CARLSON ERIC D , DESROSIERS PETER J , SONG LI
IPC分类号： A61K20060101 , B01J19/00 , G01N33/15 , G01N33/53 , G01N33/543 , G01N35/00
CPC分类号： G01N33/15 , B01J2219/00599 , B01J2219/00686 , B01J2219/00702 , B01J2219/00756 , C40B60/12
摘要： The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.
摘要翻译：本发明涉及药物制剂的研究领域。更具体地，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在多种药物组合物中进行平行合成和筛选以确保稳定性和相容性的装置和方法。一方面，本发明包括测试病症对药物样品的影响的方法。该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的一段时间内的第一受控状态，以及第一次评估多个暴露的药物样品并且第二次使用非破坏性测试来确定条件是否随着时间对一种或多种药物样品产生影响。所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

5. 发明申请

WO2003051996A1 CATALYTIC PALLADIUM MIXTURE 审中-公开
标题翻译：催化聚氯乙烯混合物
公开(公告)号：WO2003051996A1
公开(公告)日：2003-06-26
申请号：PCT/EP2001/015422
申请日：2001-12-19
申请人： RHODIA CHIMIE , SYMYX TECHNOLOGIES, INC , LA POINTE, Anne-Marie , CARLSON, Eric, D. , CREVIER, Thomas , GIRAUD, Yves , STERIN, Sébastien
发明人： CARLSON, Eric, D. , CREVIER, Thomas , GIRAUD, Yves , STERIN, Sébastien
IPC分类号： C08L83/04
CPC分类号： C08K5/0091 , C08G77/08 , C08G77/12 , C08G77/20 , C08G77/24 , C08G77/70 , C08K5/3442 , C08L83/04 , C08L83/00 , C08L2666/52
摘要： This invention relates to the use of an effective amount of a composition based on a palladium catalyst for preparing a polyaddition heat type curable polyorganosiloxane elastomer. It is also directed to a polyaddition heat type curable polyorganosiloxane elastomer.
摘要翻译：本发明涉及有效量的基于钯催化剂的组合物用于制备加聚热固化型聚有机硅氧烷弹性体的用途。它还涉及加聚热固化聚有机硅氧烷弹性体。

6. 发明申请

WO2003014732A1 APPARATUSES AND METHODS FOR CREATING AND TESTING PRE-FORMULATIONS AND SYSTEMS FOR SAME 审中-公开
标题翻译：用于创建和测试其预配制和系统的装置和方法
公开(公告)号：WO2003014732A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/016962
申请日：2002-05-24
申请人： SYMYX TECHNOLOGIES, INC. , CARLSON, Eric, D. , CONG, Peijun , CHANDLER, William, H., Jr. , CHAU, Henry, K. , DANIELSON, Earl , DESROSIERS, Peter, J. , DOOLAN, Robert, D. , WU, Luping
发明人： CARLSON, Eric, D. , CONG, Peijun , CHANDLER, William, H., Jr. , CHAU, Henry, K. , DANIELSON, Earl , DESROSIERS, Peter, J. , DOOLAN, Robert, D. , WU, Luping
IPC分类号： G01N33/48
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G06F19/703 , G06F19/709 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.
摘要翻译：本发明提供了用于进行候选药物的盐和多形态的高通量制备和筛选的方法，装置和系统。本发明旨在增强用于药物开发的预配制发现过程。特别地，提供了确定基本上发现可以从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。

7. 发明申请

WO2006107900A3 MONITORING BY MEANS OF AN ON-LINE SENSOR AND FLUIDIC OPERATIONS INVOLVING UNIT SEPARATION AND REACTION OPERATIONS 审中-公开
公开(公告)号：WO2006107900A3
公开(公告)日：2006-10-12
申请号：PCT/US2006/012374
申请日：2006-03-31
申请人： SYMYX TECHNOLOGIES, INC. , CYPES, Stephen , UHRICH, Mark , CARLSON, Eric, D. , KOLOSOV, Oleg , PADOWITZ, David , BENNETT, James , MATSIEV, Leonid
发明人： CYPES, Stephen , UHRICH, Mark , CARLSON, Eric, D. , KOLOSOV, Oleg , PADOWITZ, David , BENNETT, James , MATSIEV, Leonid
IPC分类号： G01N29/02 , G01N29/036 , G01N29/22 , G01N9/00 , G01N11/10 , G01N27/00
摘要： Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

8. 发明申请

WO03021251A9 METHODS FOR CHARACTERIZATION OF POLYMERS USING MULTI-DIMENTIONAL LIQUID CHROMATOGRAPHY 审中-公开
标题翻译：使用多种液相色谱法对聚合物进行表征的方法
公开(公告)号：WO03021251A9
公开(公告)日：2003-10-16
申请号：PCT/US0227629
申请日：2002-08-28
申请人： SYMYX TECHNOLOGIES INC , PETRO MIROSLAV , NGUYEN SON HOAI , CARLSON ERIC D
发明人： PETRO MIROSLAV , NGUYEN SON HOAI , CARLSON ERIC D
IPC分类号： B01D15/26 , B01D15/32 , B01D15/34 , B01J19/00 , G01N30/02 , G01N30/20 , G01N30/32 , G01N30/46 , G01N30/86 , G01N33/44 , G01N30/88
CPC分类号： G01N30/463 , B01D15/1878 , B01D15/265 , B01D15/325 , B01D15/34 , B01D15/424 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00389 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00736 , G01N30/02 , G01N30/20 , G01N30/46 , G01N30/461 , G01N30/8651 , G01N33/44 , G01N2030/027 , G01N2030/324 , G01N30/16
摘要： Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
摘要翻译：公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。第一和第二维度优选是高效液相色谱尺寸，例如，适于确定组合物的第一维度。适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），以及适用于测定分子量或粒度的第二维度（例如适用于尺寸排阻色谱法，包括凝胶渗透色谱法）。

9. 发明申请

WO2006107900A2 MONITORING AND OPERATIONS INVOLVING UNIT SEPARATION AND REACTION OPERATIONS 审中-公开
标题翻译：涉及单位分离和反应操作的监测和运行
公开(公告)号：WO2006107900A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012374
申请日：2006-03-31
申请人： SYMYX TECHNOLOGIES INC , CYPES STEPHEN , UHRICH MARK , CARLSON ERIC D , KOLOSOV OLEG , PADOWITZ DAVID , BENNETT JAMES , MATSIEV LEONID
发明人： CYPES STEPHEN , UHRICH MARK , CARLSON ERIC D , KOLOSOV OLEG , PADOWITZ DAVID , BENNETT JAMES , MATSIEV LEONID
IPC分类号： G01N29/02 , G01N9/00 , G01N11/10 , G01N27/00 , G01N29/036 , G01N29/22
CPC分类号： B01D5/009 , B01D3/00 , B01D3/06 , B01D3/14 , B01D3/22 , B01D3/322 , B01J19/0006 , B01J2219/00191 , G01N9/002 , G01N29/022 , G01N29/036 , G01N29/222 , G01N2291/0226 , G01N2291/0253 , G01N2291/0254 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0426 , G01N2291/0427 , G01N2291/101 , G01N2291/106
摘要： Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.
摘要翻译：公开了用于监测和/或控制流体系统中的蒸馏操作的流体传感器方法和系统，例如间歇式蒸馏操作或连续蒸馏操作。优选的实施方案涉及涉及终点确定蒸馏的单元操作的过程监控和/或过程控制，例如应用于液体成分切换操作（例如，溶剂切换操作），液 - 液分离操作溶质浓缩操作，分散相浓缩操作等。

10. 发明申请

WO2004078131A2 EVALUATING EFFECTS OF EXPOSURE CONDITIONS ON DRUG SAMPLES OVER TIME 审中-公开
标题翻译：暴露条件对药物样品的影响评估时间
公开(公告)号：WO2004078131A2
公开(公告)日：2004-09-16
申请号：PCT/US2004/006327
申请日：2004-03-01
申请人： SYMYX TECHNOLOGIES, INC. , CARLSON, Eric, D. , DESROSIERS, Peter, J. , SONG, Li
发明人： CARLSON, Eric, D. , DESROSIERS, Peter, J. , SONG, Li
IPC分类号： A61K
CPC分类号： G01N33/15 , B01J2219/00599 , B01J2219/00686 , B01J2219/00702 , B01J2219/00756 , C40B60/12
摘要： The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.
摘要翻译：本发明涉及药物制剂的研究领域。更具体地，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在多种药物组合物中进行平行合成和筛选以确保稳定性和相容性的装置和方法。一方面，本发明包括测试病症对药物样品的影响的方法。该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的一段时间内的第一受控状态，以及第一次评估多个暴露的药物样品并且第二次使用非破坏性测试来确定条件是否随着时间对一种或多种药物样品产生影响。所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

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