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1. 发明申请

WO2014025398A1 REAL-TIME OPTICAL SYSTEM FOR POLYMERASE CHAIN REACTION 审中-公开
标题翻译：用于聚合酶链反应的实时光学系统
公开(公告)号：WO2014025398A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/031910
申请日：2013-03-15
申请人： STRECK, INC.
发明人： KREIFELS, Matthew, R. , WHITNEY, Scott, E. , TERMAAT, Joel, R.
IPC分类号： G01N21/64
CPC分类号： C12Q1/686 , G01N21/645 , G01N21/6452 , G01N2021/6484 , G01N2201/0627 , G01N2201/0826 , G01N2201/0833
摘要： A device and system for facilitating polymerase chain reaction analysis including a light source (46), photodiodes (44), multi- branched waveguides (32), and filters (40) that occupy minimal space and allow reduced sample read time and rapid reading of multiple light wavelengths.
摘要翻译：用于促进聚合酶链反应分析的装置和系统，包括占据最小空间并允许缩短样品读取时间和快速读取的光源（46），光电二极管（44），多分支波导（32）和滤光器（40）多个光波长。

2. 发明申请

WO2015134053A1 IMPROVED SAMPLE TUBE WITH TRANSPARENT TIP HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：改进的样品管，具有明显的提示，具有用于核酸放大的特殊用途
公开(公告)号：WO2015134053A1
公开(公告)日：2015-09-11
申请号：PCT/US2014/044867
申请日：2014-06-30
申请人： STRECK, INC.
发明人： KREIFELS, Matthew, R. , WHITNEY, Scott, E. , DOWLING, James , JUST, Troy
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： B01L3/5082 , B01L7/52 , B01L2300/021 , B01L2300/022 , B01L2300/043 , B01L2300/0654 , B01L2300/0832 , B01L2300/0848 , B01L2300/0851 , B01L2300/123 , B01L2300/168 , C12Q1/686 , G01N21/03 , G01N2021/0364 , G01N2021/0382 , G01N2021/6482 , G01N2021/6484
摘要： An improved sample tube that includes a body portion having a longitudinal axis and a wall generally circumscribing the longitudinal axis. The body portion terminates in a distal tip having a dimple. The body portion includes at least one transparent portion (e.g., at the distal tip) that is adapted for transmitting light. The wail is configured for elastic deformation along at feast a portion of its length, including in a direction that is generally transverse to the longitudinal axis, so that it compressively and resiliently deforms and engages a wail defining an opening in a sample block of a PGR amplification instrument. The tube may be made by injection molding a polymeric material including a thermoplastic.
摘要翻译：一种改进的样品管，其包括具有纵向轴线的主体部分和通常围绕纵向轴线的壁。主体部分终止于具有凹坑的远端。主体部分包括适于透射光的至少一个透明部分（例如，在远端）。围栏被构造成沿着其长度的一部分包括在大致横向于纵向轴线的方向上的弹性变形，使得其压缩和弹性变形并且接合限定PGR的样品块中的开口的壁放大仪器。管可以通过注射模制包括热塑性塑料的聚合材料制成。

3. 发明申请

WO2012166913A1 RAPID THERMOCYCLER SYSTEM FOR RAPID AMPLIFICATION OF NUCLEIC ACIDS AND RELATED METHODS 审中-公开
标题翻译：用于快速放大核酸的快速热分解系统及相关方法
公开(公告)号：WO2012166913A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040201
申请日：2012-05-31
申请人： STRECK, INC. , TERMAAT, Joel, R. , WHITNEY, Scott, E. , VILJOEN, Hendrik, J. , KREIFELS, Matthew, R.
发明人： TERMAAT, Joel, R. , WHITNEY, Scott, E. , VILJOEN, Hendrik, J. , KREIFELS, Matthew, R.
IPC分类号： C12Q1/68 , G01N35/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0627 , B01L2300/0858 , B01L2300/1805 , B01L2300/1822 , C12Q1/6844 , G01N2035/00366
摘要： A thermocycling device (10) and method of operating in which at least one first temperature sensor (1060) monitors a first temperature condition within the sample holder (64) and is adapted to provide a first electrical signal corresponding with the first temperature condition. In addition, at least one second temperature sensor (87) monitors a second temperature condition of a component external of the sample holder and is adapted to provide a second signal corresponding with the second temperature condition. At least one control device is adapted to interface with a power supply (1010) to control the delivery of power to a first thermal cycling element (60) and a second thermal cycling element (62), (both of which may sandwich a sample holder) and optionally an air mover (54); adapted to be in signaling communication with the first temperature sensor and the second temperature sensor; is configured for analysis of signals from the first temperature sensor and the second temperature sensor and; is configured such that, based upon such analysis, the at least one control device alters the power that is delivered to one or more of the first thermal cycling element and second thermal cycling element, and/or the air mover. The device Is controllably operated to account for thermal inertia effects.
摘要翻译：一种热循环装置（10）和操作方法，其中至少一个第一温度传感器（1060）监测样品保持器（64）内的第一温度条件，并适于提供对应于第一温度条件的第一电信号。此外，至少一个第二温度传感器（87）监测样品保持器外部的部件的第二温度条件，并且适于提供对应于第二温度条件的第二信号。至少一个控制装置适于与电源（1010）接口，以控制向第一热循环元件（60）和第二热循环元件（62）的输送，（两者都可以夹持样品架）和任选的鼓风机（54）; 适于与第一温度传感器和第二温度传感器进行信令通信; 被配置用于分析来自第一温度传感器和第二温度传感器的信号; 被配置为使得基于这种分析，所述至少一个控制装置改变被输送到第一热循环元件和第二热循环元件和/或鼓风机中的一个或多个的功率。该装置可控地操作以考虑热惯性效应。

4. 发明申请

WO2018031903A1 MOLECULAR REFERENCE CONTROLS 审中-公开
标题翻译：分子参考控制
公开(公告)号：WO2018031903A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/046537
申请日：2017-08-11
申请人： STRECK, INC.
发明人： CONNELLY, Christopher , KREIFELS, Matthew, R. , SOBANSKY, Matthew
IPC分类号： C12Q1/18 , C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/18 , C12Q1/6876 , C12Q2600/166
摘要： Reference controls for use in downstream molecular technologies comprising a control composition including a sample base matrix, such as at least one biological fluid or biological fluid component, at least one condition component processed to be indicative of a condition, and at least one cross-linking agent.
摘要翻译：用于下游分子技术的参考对照包含对照组合物，所述对照组合物包含样品基质（例如至少一种生物流体或生物流体组分），至少一种条件组分被处理以指示病症，以及至少一种交联剂。

5. 发明申请

WO2014210593A1 DEVICES FOR REAL-TIME POLYMERASE CHAIN REACTION 审中-公开
标题翻译：用于实时聚合酶链反应的装置
公开(公告)号：WO2014210593A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044858
申请日：2014-06-30
申请人： STRECK, INC.
发明人： KREIFELS, Matthew, R. , WHITNEY, Scott, E. , WILDER, Gregg , FLANAGAN, John , DOWLING, James , HILL, Philip , TILLEMAN, Michael , JACKSON, Jeremie
IPC分类号： G01N21/64 , B01L7/00 , C12Q1/68
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/686 , C12Q2561/113 , C12Q2563/107 , G01N21/645 , G01N2201/062 , G01N2201/068
摘要： An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
摘要翻译：用于促进聚合酶链反应的改进的装置和系统，包括占据最小空间并促进静止样品检测的光源，检测器，波导和滤波器，减少的样本读取时间和同时读取多个光波长。

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