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1. 发明申请

WO2004042086A1 GAS JET PROCESS AND APPARATUS FOR HIGH-SPEED AMPLIFICATION OF DNA 审中-公开
标题翻译：气体喷射方法和用于高速扩增DNA的装置
公开(公告)号：WO2004042086A1
公开(公告)日：2004-05-21
申请号：PCT/US2002/035138
申请日：2002-11-01
申请人： MEGABASE RESEARCH PRODUCTS , WHITNEY, Scott, E. , NELSON, R., Michael , QUINTANAR, Andre , VILJOEN, Hendrik, J. , PADHYE, Nisha, V.
发明人： WHITNEY, Scott, E. , NELSON, R., Michael , QUINTANAR, Andre , VILJOEN, Hendrik, J. , PADHYE, Nisha, V.
IPC分类号： C12Q1/68
CPC分类号： B01L7/52 , B01L2300/0867 , B01L2300/1838
摘要： Processes and apparatus for performing fast, precise, and reliable gas jet thermocycling on a sample using of pressurized gases delivered to a thermostated reaction chamber at high velocity using computer controlled electronic multiport valves are disclosed. Apparatus for achieving these processes are also disclosed.
摘要翻译：公开了一种用于使用计算机控制的电子多端口阀以高速输送到恒温反应室的加压气体在样品上进行快速，精确和可靠的气体热循环的方法和装置。还公开了用于实现这些方法的装置。

2. 发明申请

WO2012166913A1 RAPID THERMOCYCLER SYSTEM FOR RAPID AMPLIFICATION OF NUCLEIC ACIDS AND RELATED METHODS 审中-公开
标题翻译：用于快速放大核酸的快速热分解系统及相关方法
公开(公告)号：WO2012166913A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040201
申请日：2012-05-31
申请人： STRECK, INC. , TERMAAT, Joel, R. , WHITNEY, Scott, E. , VILJOEN, Hendrik, J. , KREIFELS, Matthew, R.
发明人： TERMAAT, Joel, R. , WHITNEY, Scott, E. , VILJOEN, Hendrik, J. , KREIFELS, Matthew, R.
IPC分类号： C12Q1/68 , G01N35/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0627 , B01L2300/0858 , B01L2300/1805 , B01L2300/1822 , C12Q1/6844 , G01N2035/00366
摘要： A thermocycling device (10) and method of operating in which at least one first temperature sensor (1060) monitors a first temperature condition within the sample holder (64) and is adapted to provide a first electrical signal corresponding with the first temperature condition. In addition, at least one second temperature sensor (87) monitors a second temperature condition of a component external of the sample holder and is adapted to provide a second signal corresponding with the second temperature condition. At least one control device is adapted to interface with a power supply (1010) to control the delivery of power to a first thermal cycling element (60) and a second thermal cycling element (62), (both of which may sandwich a sample holder) and optionally an air mover (54); adapted to be in signaling communication with the first temperature sensor and the second temperature sensor; is configured for analysis of signals from the first temperature sensor and the second temperature sensor and; is configured such that, based upon such analysis, the at least one control device alters the power that is delivered to one or more of the first thermal cycling element and second thermal cycling element, and/or the air mover. The device Is controllably operated to account for thermal inertia effects.
摘要翻译：一种热循环装置（10）和操作方法，其中至少一个第一温度传感器（1060）监测样品保持器（64）内的第一温度条件，并适于提供对应于第一温度条件的第一电信号。此外，至少一个第二温度传感器（87）监测样品保持器外部的部件的第二温度条件，并且适于提供对应于第二温度条件的第二信号。至少一个控制装置适于与电源（1010）接口，以控制向第一热循环元件（60）和第二热循环元件（62）的输送，（两者都可以夹持样品架）和任选的鼓风机（54）; 适于与第一温度传感器和第二温度传感器进行信令通信; 被配置用于分析来自第一温度传感器和第二温度传感器的信号; 被配置为使得基于这种分析，所述至少一个控制装置改变被输送到第一热循环元件和第二热循环元件和/或鼓风机中的一个或多个的功率。该装置可控地操作以考虑热惯性效应。

3. 发明申请

WO2012145662A1 IMPROVED SAMPLE TUBE HAVING PARTICULAR UTILITY FOR NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：具有特异性实用性的改良样品管用于核酸放大
公开(公告)号：WO2012145662A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034506
申请日：2012-04-20
申请人： STRECK, INC. , VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , KREIFELS, Matthew, Robert
发明人： VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , KREIFELS, Matthew, Robert
IPC分类号： B01L3/00
CPC分类号： B01L3/50825 , B01L7/52 , B01L2300/022 , B01L2300/043 , B01L2300/123 , B01L2300/168
摘要： An improved tube (10) including a closure portion (12), a strap (18) integrally connected to the closure portion (12) and being configured for defining a living hinge, a body portion (20) having a longitudinal axis and an outer wall generally circumscribing the longitudinal ax is, and being integrally and hingedly connected with the closure portion (12) by way of the strap (18), the body portion (20) including a head portion (13) that has an opening (26) through which a sample is dispensed, and a sample portion (28) having a first outer wall dimension (OWD1) and including a closed distal end (30) and a wall structure (32) that includes an outer wall (34) and an inner wall structure (36) that defines a hollow cavity (38) within which the sample resides as a sample volume after is dispensed through the head portion (13), the sample portion (28) being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wail dimension (OWD1) of the sample portion (28) reduces to a smaller second outer wall dimension (OWD2).
摘要翻译：一种改进的管（10），包括封闭部分（12），一体地连接到封闭部分（12）并且构造成用于限定活动铰链的带子（18），具有纵向轴线的外部部分（20）所述主体部分（20）包括具有开口（26）的头部（13），所述头部（13）具有开口（26），所述主体部分通过其分配样品和具有第一外壁尺寸（OWD1）并包括封闭的远端（30）的样品部分（28）和包括外壁（34）和内壁（34）的壁结构壁结构（36），其限定空心空腔（38），在所述中空空腔（38）中，所述样品部分（28）沿着所述纵向轴线大致伸长，所述样品部分（28）在所述中空空腔（38）中被分配通过所述头部部分（13）弹性变形沿其长度的一部分，包括在a 方向，其通常横向于纵向轴线，使得壁结构的至少一部分压缩和弹性变形并且接合限定聚合酶链式反应放大装置的样品块中的开口的壁，并且与第一外壁尺寸（OWD1 ）减小到较小的第二外壁尺寸（OWD2）。

4. 发明申请

WO2010132756A2 SAMPLE PROCESSING CASSETTE, SYSTEM, AND METHOD 审中-公开
标题翻译：样品加工CASSETTE，系统和方法
公开(公告)号：WO2010132756A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034881
申请日：2010-05-14
申请人： STRECK, INC. , VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , FREIFELD, Alison , PIENAAR, Elsje
发明人： VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , FREIFELD, Alison , PIENAAR, Elsje
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/68 , B01F15/06 , B01F7/22
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.
摘要翻译：本发明提供了一种通过将源材料引入到样本容器中来收集生物或化学材料的处理和分析的方法和装置，将源材料转移到处理装置，并且热，化学和/或机械地处理源材料以改变源材料的至少一个构成特征并且从源材料释放或产生靶材料。

5. 发明申请

WO2011153244A1 SAMPLE PROCESSING METHOD AND DEVICE 审中-公开
标题翻译：样品处理方法和装置
公开(公告)号：WO2011153244A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038766
申请日：2011-06-01
申请人： STRECK, INC. , VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , FREIFELD, Alison , BOOTH, Christine , ZHAO, Xing
发明人： VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , FREIFELD, Alison , BOOTH, Christine , ZHAO, Xing
IPC分类号： B01L3/00 , C12Q1/68 , G01N1/40
CPC分类号： C12Q1/6806 , B01L3/5023 , B01L3/5029 , B01L3/505 , B01L2300/0825
摘要： The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.
摘要翻译：本发明提供一种用于处理和分析生物样本的方法和装置。将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。生物样品进一步与经处理的聚合材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。

6. 发明申请

WO2010132756A3 SAMPLE PROCESSING CASSETTE, SYSTEM, AND METHOD 审中-公开
标题翻译：样品加工CASSETTE，系统和方法
公开(公告)号：WO2010132756A3
公开(公告)日：2011-01-06
申请号：PCT/US2010034881
申请日：2010-05-14
申请人： STRECK INC , VILJOEN HENDRIK J , WHITNEY SCOTT E , TERMAAT JOEL R , FREIFELD ALISON , PIENAAR ELSJE
发明人： VILJOEN HENDRIK J , WHITNEY SCOTT E , TERMAAT JOEL R , FREIFELD ALISON , PIENAAR ELSJE
IPC分类号： B01L3/00 , B01F7/22 , B01F15/06 , B01J19/00 , C12Q1/68
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.
摘要翻译：本发明提供了一种通过将源材料引入到样本容器中来收集生物或化学材料的处理和分析的方法和装置，将源材料转移到处理装置，并且热，化学和/或机械地处理源材料以改变源材料的至少一个构成特征并且从源材料释放或产生靶材料。

7. 发明申请

WO2010132800A1 SPECIMEN CONTAINER, SYSTEM, AND METHOD 审中-公开
标题翻译：样品容器，系统和方法
公开(公告)号：WO2010132800A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034950
申请日：2010-05-14
申请人： STRECK, INC. , VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , FREIFIELD, Alison
发明人： VILJOEN, Hendrik, J. , WHITNEY, Scott, E. , TERMAAT, Joel, R. , FREIFIELD, Alison
IPC分类号： A61B10/00 , B01L3/00 , A61J1/10 , G01N1/18
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： A device for the collection and handling of biological or chemical specimens and a method for collecting and preparing the biological specimen from a patient selected from a population are disclosed. In particular, the device is particularly useful to collect a biological fluid specimen, such as sputum, to be used in downstream diagnostics tests. The device and method are particularly useful in reducing the handling and exposure of health-care workers to the sample by the use of a bag in which hermetic seals are utilized to separate sample aliquots while providing improved processing, testing and disposal thereof.
摘要翻译：公开了一种用于收集和处理生物或化学标本的装置以及从选自群体中的患者收集和制备生物标本的方法。特别地，该装置特别可用于收集用于下游诊断测试中的生物流体样本，例如痰液。该装置和方法特别可用于通过使用气密密封件来分离样品等分试样，同时提供改进的加工，测试和处理，来减少保健工作者对样品的处理和暴露。

8. 发明申请

WO2009105499A1 THERMOCYCLER AND SAMPLE VESSEL FOR RAPID AMPLIFICATION OF DNA 审中-公开
标题翻译：热释放器和样品容器用于快速扩增DNA
公开(公告)号：WO2009105499A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034446
申请日：2009-02-19
申请人： TERMAAT, Joel R. , VILJOEN, Hendrik J. , WHITNEY, Scott E.
发明人： TERMAAT, Joel R. , VILJOEN, Hendrik J. , WHITNEY, Scott E.
IPC分类号： C12P19/34 , B01J19/00
CPC分类号： B01L7/52 , B01L3/505 , B01L2300/043 , B01L2300/0627 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844
摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.
摘要翻译：用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间在热循环器的热电模块之间进行更快速的热传递。

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