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1. 发明申请

WO1990011298A1 A PEPTIDE, IMMUNOGENIC COMPOSITION AND VACCINE OR MEDICINAL PREPARATION; A METHOD OF IMMUNISING A MAMMAL AGAINST LHRH, AND A METHOD OF IMPROVING THE MEAT QUALITY OF PIGS 审中-公开
标题翻译：肽，免疫组合物和疫苗或药物制剂; 免疫对LHRH的杀虫剂的方法和改善皮重的肉质量的方法
公开(公告)号：WO1990011298A1
公开(公告)日：1990-10-04
申请号：PCT/NL1990000037
申请日：1990-03-22
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , MELOEN, Robert, Hans , WENSING, Cornelis, Johannes, Gerardus
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C07K07/20
CPC分类号： C07K7/23 , A61K39/0006 , A61K2039/55566 , A61K2039/6081 , A61K2039/627 , A61K2039/64
摘要： This invention relates to a peptide suitable for vaccination of mammals, such as pigs, against the hormone LHRH and comprising at least two LHRH sequences in tandem.
摘要翻译：本发明涉及一种适合于哺乳动物如猪的免疫接种针对激素LHRH并且包含至少两个LHRH序列的肽。

2. 发明申请

WO1989003391A1 OLIGOPEPTIDES AND THEIR USE FOR DIAGNOSTIC AND VACCINATION PURPOSES FOR AIDS AND ARC 审中-公开
标题翻译：寡核苷酸及其用于艾滋病和ARC的诊断和疫苗用途
公开(公告)号：WO1989003391A1
公开(公告)日：1989-04-20
申请号：PCT/NL1988000040
申请日：1988-10-07
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN ... , GOUDSMIT, Jaap , MELOEN, Robert, Hans
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN ...
IPC分类号： C07K07/06
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： The invention relates to oligopeptides having utility in diagnosis of, or vaccination against AIDS and ARC, and to antibodies raised against such oligopeptides. The oligopeptides have a length of 8 to 17 amino acids. The amino acid sequence corresponds to a sequence occurring in the V3 region of gp120 and comprises the beta-turn sequence GPG(R) at the positions 312-314 (315), or a variant beta-turn sequence, and flanking sequences of at least one and preferably at least two amino acids on both sides of the beta-turn sequence.

3. 发明申请

WO1992002542A1 PEPTIDES AND PHARMACEUTICAL COMPOSITIONS HAVING GLYCOPROTEIN HORMONE AGONISTIC OR ANTAGONISTIC ACTIVITY 审中-公开
标题翻译：具有糖蛋白激素激动剂或拮抗活性的肽和药物组合物
公开(公告)号：WO1992002542A1
公开(公告)日：1992-02-20
申请号：PCT/NL1991000139
申请日：1991-07-26
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , HAGE-VAN NOORT, Marjolein , PUIJK, Wouter, Cornelis , MELOEN, Robert, Hans
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C07K07/02
CPC分类号： C07K14/59 , A61K38/00 , A61K39/00 , C07K16/26
摘要： A peptide having a glycoprotein hormone (ant)agonistic activity, comprising at least 2 partial peptides selected from (1) a partial peptide having an amino acid sequence comprising TDSDS based on the amino acids (92, 88, 89, 90 and 91) of the beta -chain of the glycoprotein hormone hFSH or a corresponding sequence of another glycoprotein hormone and/or another animal species, (2) a partial peptide having an amino acid sequence occurring in the alpha -chain of glycoprotein hormones and comprising SRAY, (3) a partial peptide having an amino acid sequence comprising TRDL based on the amino acids (34-37) of the beta -chain of the glycoprotein hormone hFSH or a corresponding sequence of another glycoprotein hormone and/or another animal species, and (4) a partial peptide having an amino acid sequence comprising AHASTA, derived from the amino acids (82 - 87) of the alpha -chain of the human glycoprotein hormones by replacing the cysteines by alanines, or a corresponding sequence of a glycoprotein hormone of another animal species, which partial peptides can be linked together by bridge groups, and variants and derivatives having a glycoprotein hormone agonistic or antagonistic activity.
摘要翻译：一种具有糖蛋白激素（蚂蚁）激动活性的肽，其包含至少2种选自（1）部分肽的部分肽，所述部分肽具有包含基于氨基酸（92,88,89,90和91）的氨基酸（92,88,89,90和91）的氨基酸序列的氨基酸序列糖蛋白激素hFSH的β-链或另一种糖蛋白激素和/或其他动物物种的相应序列，（2）具有氨基酸序列的部分肽，其存在于糖蛋白激素的α-链中并且包含SRAY，（3 ）具有基于糖蛋白激素hFSH的β-链的氨基酸（34-37）或另一种糖蛋白激素和/或另一种动物物种的相应序列的包含TRDL的氨基酸序列的部分肽，和（4）或由相应的糖基序列组成的具有氨基酸序列的部分肽，该氨基酸序列衍生自人类糖蛋白激素的α-链的氨基酸（82-87）另一种动物物种的蛋白激素，部分肽可以通过桥接基团连接在一起，以及具有糖蛋白激素激动或拮抗活性的变体和衍生物。

4. 发明申请

WO1992021751A1 BOVINE HERPESVIRUS TYPE 1 DELETION MUTANTS, VACCINES BASED THEREON, DIAGNOSTIC KITS FOR DETECTION OF BOVINE HERPESVIRUS TYPE 1 审中-公开
标题翻译：牛肝病毒1型删除突变体，基于其的疫苗，用于检测牛肝病毒1型的诊断试剂盒
公开(公告)号：WO1992021751A1
公开(公告)日：1992-12-10
申请号：PCT/NL1992000097
申请日：1992-06-05
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , RIJSEWIJK, Franciscus, Antonius, Maria , VAN OIRSCHOT, Johannes, Theodorus , MAES, Roger, Kamiel
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/265 , A61K2039/5254 , A61K2039/552 , C07K16/087 , C07K2319/00 , C12N15/86 , C12N2710/16722 , C12N2710/16732 , C12N2710/16734 , C12N2710/16743
摘要： Deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene. The mutant may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene. Recombinant nucleic acid which comprises the gE-gene or a part thereof. Glycoprotein gE, peptides based thereon and complexes of the glycoproteins gE and gI, and antibodies against them. Vaccines and diagnostic kits comprising any one of these materials.
摘要翻译：牛疱疹病毒1型的缺失突变体，其在糖蛋白gE基因中具有缺失。突变体还可以在胸苷激酶基因和/或糖蛋白gI基因中具有缺失，或者具有异源基因的插入。包含gE基因或其一部分的重组核酸。糖蛋白gE，基于其的肽和糖蛋白gE和gI的复合物，以及针对它们的抗体。包括任何一种这些材料的疫苗和诊断试剂盒。

5. 发明申请

WO1992021375A1 CAUSATIVE AGENT OF THE MYSTERY SWINE DISEASE, VACCINE COMPOSITIONS AND DIAGNOSTIC KITS 审中-公开
标题翻译：神经疾病的原因，疫苗组合物和诊断试剂盒
公开(公告)号：WO1992021375A1
公开(公告)日：1992-12-10
申请号：PCT/NL1992000096
申请日：1992-06-05
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , WENSVOORT, Gert , TERPSTRA, Catharinus , POL, Joannes, Maria, Anthonis , MOORMANN, Robertus, Jocobus, Maria , MEULENBERG, Johanna, Jacoba, Maria
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12Q1/6883 , C12Q1/6888 , Y10S424/815 , Y10S435/975
摘要： Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
摘要翻译：由活的，减毒，死亡或重组形式或其部分或部分组成的包含神秘猪疾病的致病因子，Lelystad药剂的物质组成。疫苗组合物和基于其的诊断试剂盒。包含Lelystad特异性核苷酸序列的重组核酸。包含Lelystad特异性氨基酸序列的肽。 Lelystad特异性抗体。

6. 发明申请

WO1992004446A1 CLONING OF CHICKEN ANAEMIA DNA 审中-公开
标题翻译：克隆鸡血清DNA
公开(公告)号：WO1992004446A1
公开(公告)日：1992-03-19
申请号：PCT/NL1991000165
申请日：1991-09-11
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , RIJKSUNIVERSITEIT TE LEIDEN , NOTEBORN, Matheus, Hubertus, Maria , DE BOER, Gerben, Foppe
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C12N15/35
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C12N15/86 , C12N2750/10022 , C12N2750/10043 , C12N2830/00 , C12N2830/008 , C12N2830/60 , G01N33/56983 , G01N33/574 , Y10S424/816 , Y10S435/81
摘要： Recombinant genetic information (DNA or RNA), comprising a Chicken Anaemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production. Recombinant CAV protein and the use thereof for diagnostics, vaccination or production of CAV-specific antibodies. The use of CAV-specific antibodies thus obtained.
摘要翻译：包含鸡贫血病毒（CAV）特异性核苷酸序列的重组遗传信息（DNA或RNA）及其用于诊断，疫苗接种或蛋白质生产的用途。重组CAV蛋白及其用于诊断，接种或产生CAV特异性抗体的用途。使用由此获得的CAV特异性抗体。

7. 发明申请

WO1991004986A1 OLIGOPEPTIDES/EXPRESSION PRODUCTS OF THE AUJESZKY'S DISEASE VIRUS, AND RECOMBINANT POLYNUCLEOTIDES CODING THEREFOR 审中-公开
标题翻译：奥昔布病毒的寡核苷酸/表达产物及其编码的重组多核苷酸
公开(公告)号：WO1991004986A1
公开(公告)日：1991-04-18
申请号：PCT/NL1990000143
申请日：1990-09-28
申请人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , VAN OIRSCHOT, Johannes, Theodorus , MELOEN, Robbert, Hans
发明人： STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C07K15/14
CPC分类号： C07K14/005 , A61K39/00 , C07K16/087 , C12N2710/16722
摘要： The invention relates to novel oligopeptides/expression products derived from glycoprotein I of the Aujeszky's disease virus, to their use for diagnostic purposes or for producing polyclonal or monoclonal antibodies, and to recombinant genetic information coding for the novel oligopeptides/expression products.
摘要翻译：本发明涉及衍生自Aujeszky病病毒的糖蛋白I的新型寡肽/表达产物，其用于诊断目的或用于产生多克隆或单克隆抗体，以及编码新型寡肽/表达产物的重组遗传信息。

8. 发明申请

WO1988005464A1 PhoE PROTEIN WITH AN INSERTED ANTIGENIC DETERMINANT 审中-公开
标题翻译： Phoe蛋白与插入的抗原决定因子
公开(公告)号：WO1988005464A1
公开(公告)日：1988-07-28
申请号：PCT/NL1988000002
申请日：1988-01-20
申请人： RIJKSUNIVERSITEIT UTRECHT , STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT , TOMMASSEN, Johannes, Petrus, Maria
发明人： RIJKSUNIVERSITEIT UTRECHT , STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C07K14/245 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N2770/32122 , Y02A50/466 , Y02A50/472
摘要： Recombinant DNA comprising the genetic information for PhoE protein of Enterobacteriaceae bacteria and, in a part thereof coding for a region of the PhoE protein localized at the cell surface, the genetic information for a foreign antigenic determinant. Enterobacteriaceae bacteria containing and expressing such recombinant DNA contain in their outer membrane PhoE with a cell-surface exposed foreign antigenic determinant. Such bacteria or the modified PhoE protein recovered therefrom can be used as a diagnostic aid or as a vaccine.
摘要翻译：包含肠杆菌科细菌的PhoE蛋白的遗传信息的重组DNA，并且在编码位于细胞表面的PhoE蛋白的区域的一部分中，是外源抗原决定簇的遗传信息。含有和表达这种重组DNA的肠杆菌科细菌在其外膜PhoE中含有细胞表面暴露的外源抗原决定簇。这样的细菌或从其回收的经修饰的PhoE蛋白质可以用作诊断辅助剂或疫苗。

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