专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006040334A1 MALARIA PRIME/BOOST VACCINES 审中-公开
标题翻译： MALARIA PRIME / BOOST VACCINES
公开(公告)号：WO2006040334A1
公开(公告)日：2006-04-20
申请号：PCT/EP2005/055209
申请日：2005-10-13
申请人： CRUCELL HOLLAND B.V. , GLAXOSMITHKLINE BIOLOGICALS, S.A. , WALTER REED ARMY INSTITUTE OF RESEARCH , PAU, Maria Grazia , GOUDSMIT, Jaap , COHEN, Joseph, D. , DUBOIS, Patrice, M. , STEWART, V. Ann , HEPPNER, Donald
发明人： PAU, Maria Grazia , GOUDSMIT, Jaap , COHEN, Joseph, D. , DUBOIS, Patrice, M. , STEWART, V. Ann , HEPPNER, Donald
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , Y02A50/412
摘要： The invention relates to novel vaccine regimens in which specific prime/boost regimens are applied using low-neutralized recombinant adenoviral vectors harboring nucleic acids encoding antigens from Plasmodium falciparum and purified recombinant protein vaccines such as RTS,S, in the context of appropriate adjuvants.
摘要翻译：本发明涉及新颖的疫苗方案，其中使用含有编码来自恶性疟原虫的抗原的核酸的低中和重组腺病毒载体和在合适佐剂的情况下使用纯化的重组蛋白疫苗如RTS，S应用特异性初始/加强方案。

2. 发明申请

WO2005012360A3 BINDING MOLECULES AGAINST SARS-CORONAVIRUS AND USES THEREOF 审中-公开
标题翻译：绑定分子抗SARS-CORONAVIRUS及其用途
公开(公告)号：WO2005012360A3
公开(公告)日：2005-09-29
申请号：PCT/EP2004051568
申请日：2004-07-21
申请人： CRUCELL HOLLAND BV , TER MEULEN JAN HENRIK , DE KRUIF CORNELIS ADRIAAN , VAN DEN BRINK EDWARD NORBERT , GOUDSMIT JAAP
发明人： TER MEULEN JAN HENRIK , DE KRUIF CORNELIS ADRIAAN , VAN DEN BRINK EDWARD NORBERT , GOUDSMIT JAAP
IPC分类号： A61P31/14 , C07K14/165 , C12N15/13 , C07K16/10 , A61K39/215 , C12N5/10 , C12N15/63 , G01N33/68
CPC分类号： G01N33/56983 , A61K2039/505 , C07K14/005 , C07K16/10 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C12N7/00 , C12N2770/20022 , C12N2770/20061 , G01N2333/165
摘要： The present invention provides binding molecules that specifically bind to SARS-CoV, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules are capable of specifically binding to SARS-CoV and can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from SARS-CoV.
摘要翻译：本发明提供了特异性结合SARS-CoV的结合分子，编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。结合分子能够特异性结合SARS-CoV，可用于诊断，预防和/或治疗由SARS-CoV引起的病症。

3. 发明申请

WO2005012337A2 ANTIGENIC PEPTIDES OF SARS CORONAVIRUS AND USES THEREOF 审中-公开
标题翻译：非典型肺炎克雷伯病毒的抗原肽及其用途
公开(公告)号：WO2005012337A2
公开(公告)日：2005-02-10
申请号：PCT/EP2004/051498
申请日：2004-07-15
申请人： CRUCELL HOLLAND B.V. , TER MEULEN, Jan, Henrik , GOUDSMIT, Jaap , SLOOTSTRA, Jelle Wouter , TIMMERMAN, Peter , DE KRUIF, Cornelis Adriaan , VAN DEN BRINK, Edward Norbert
发明人： TER MEULEN, Jan, Henrik , GOUDSMIT, Jaap , SLOOTSTRA, Jelle Wouter , TIMMERMAN, Peter , DE KRUIF, Cornelis Adriaan , VAN DEN BRINK, Edward Norbert
IPC分类号： C07K14/165
CPC分类号： A61K39/215 , A61K39/00 , A61K39/12 , C07K14/005 , C07K16/10 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C12N2770/20022 , C12N2770/20034 , G01N33/56983 , G01N2333/165 , G01N2469/10 , G01N2469/20
摘要： The present invention pertains to antigenic peptides of SARS-CoV and their use in diagnostic test methods and in the treatment of condition resulting from SARS-CoV. Furthermore, this invention provides antibodies capable of specifically recognizing the peptides of the invention. The antibodies can also advantageously be used in diagnostic test methods and in the treatment of condition resulting from SARS-CoV.
摘要翻译：本发明涉及SARS-CoV的抗原肽及其在诊断试验方法中的用途以及SARS-CoV引起的病症的治疗。此外，本发明提供能够特异性识别本发明的肽的抗体。抗体也可有利地用于诊断测试方法和治疗由SARS-CoV引起的病症。

4. 发明申请

WO2006051091A1 COMPOSITIONS AGAINST SARS-CORONAVIRUS AND USES THEREOF 审中-公开
标题翻译：组合物对抗SARS-CORONAVIRUS及其用途
公开(公告)号：WO2006051091A1
公开(公告)日：2006-05-18
申请号：PCT/EP2005/055876
申请日：2005-11-10
申请人： CRUCELL HOLLAND B.V. , TER MEULEN, Jan, Henrik , VAN DEN BRINK, Edward Norbert , DE KRUIF, Cornelis Adriaan , GOUDSMIT, Jaap
发明人： TER MEULEN, Jan, Henrik , VAN DEN BRINK, Edward Norbert , DE KRUIF, Cornelis Adriaan , GOUDSMIT, Jaap
IPC分类号： A61K39/42 , A61P31/12
CPC分类号： C07K16/10 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76
摘要： The present invention provides compositions of binding molecules specifically binding to a coronavirus such as SARS-CoV and capable of neutralizing an infection caused by the virus. The compositions are suitable for diagnosing, preventing and/or treating a condition resulting from a coronavirus such as SARS-CoV.
摘要翻译：本发明提供了特异性结合冠状病毒如SARS-CoV的结合分子的组合物，并且能够中和由病毒引起的感染。该组合物适用于诊断，预防和/或治疗冠状病毒如SARS-CoV引起的病症。

5. 发明申请

WO2006037038A1 OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES 审中-公开
标题翻译：优化疫苗提供针对EBOLA和其他病毒的保护
公开(公告)号：WO2006037038A1
公开(公告)日：2006-04-06
申请号：PCT/US2005/034798
申请日：2005-09-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CRUCELL HOLLAND B.V. , SULLIVAN, Nancy , CHAKRABARTI, Bimal , YANG, Zhi-Yong , PAU, Maria, Grazia , GOUDSMIT, Jaap , NABEL, Gary, J.
发明人： SULLIVAN, Nancy , CHAKRABARTI, Bimal , YANG, Zhi-Yong , PAU, Maria, Grazia , GOUDSMIT, Jaap , NABEL, Gary, J.
IPC分类号： C07K14/08 , C07K16/10 , C12N15/861 , A61K39/12
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译：本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，所述修饰的病毒糖蛋白（GP）具有位于所述GP的相对保守区中的至少一个氨基酸改变，

6. 发明申请

WO2004111081A3 ANTIGENIC PEPTIDES OF SARS CORONAVIRUS AND USES THEREOF 审中-公开
标题翻译：非典型肺炎克雷伯病毒的抗原肽及其用途
公开(公告)号：WO2004111081A3
公开(公告)日：2005-02-10
申请号：PCT/EP2004051102
申请日：2004-06-14
申请人： CRUCELL HOLLAND BV , TER MEULEN JAN HENRIK , GOUDSMIT JAAP , SLOOTSTRA JELLE WOUTER , TIMMERMAN PETER , PUIJK WOUTER CORNELIS
发明人： TER MEULEN JAN HENRIK , GOUDSMIT JAAP , SLOOTSTRA JELLE WOUTER , TIMMERMAN PETER , PUIJK WOUTER CORNELIS
IPC分类号： A61K39/00 , A61K39/215 , A61K39/42 , C07K14/165 , C07K16/10 , G01N33/569
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K39/42 , C07K16/10 , C07K2317/34 , C12N2770/20022 , C12N2770/20034 , G01N33/56983 , G01N2333/165 , G01N2469/20
摘要： The present invention pertains to antigenic peptides of SARS-CoV spike protein and their use in diagnostic test methods and in the treatment of condition resulting from SARS-CoV. Furthermore, this invention provides antibodies capable of specifically recognizing the peptides of the invention. The antibodies can also advantageously be used in diagnostic test methods and in the treatment of condition resulting from SARS-CoV.
摘要翻译：本发明涉及SARS-CoV刺突蛋白的抗原肽及其在诊断试验方法中的用途以及SARS-CoV引起的病症的治疗。此外，本发明提供能够特异性识别本发明的肽的抗体。抗体也可有利地用于诊断测试方法和治疗由SARS-CoV引起的病症。

7. 发明申请

WO2004042042A1 VACCINES AGAINST WEST NILE VIRUS 审中-公开
标题翻译：对抗西兰病毒的疫苗
公开(公告)号：WO2004042042A1
公开(公告)日：2004-05-21
申请号：PCT/EP2003/050806
申请日：2003-11-07
申请人： CRUCELL HOLLAND B.V. , UYTDEHAAG, Alphonsus, Gerardus, Cornelis, Maria , SCHOUTEN, Govert, Johan , GOUDSMIT, Jaap
发明人： UYTDEHAAG, Alphonsus, Gerardus, Cornelis, Maria , SCHOUTEN, Govert, Johan , GOUDSMIT, Jaap
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , Y02A50/394
摘要： The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived there from, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (El) gene product of an adenovirus. The cells are preferably cultured in suspension to very high densities and under serum-free conditions. Herein, it is disclosed that use of such cells results in high titers of West Nile Virus produced.
摘要翻译：本发明涉及在人细胞上产生的含有（全失活）西尼罗病毒和/或西尼罗病毒蛋白质的新疫苗，其中人细胞包含编码至少一个早期区域-1（E1）的序列，腺病毒的基因产物。细胞优选在悬浮液中以非常高的密度和无血清条件培养。在本文中，公开了使用这种细胞导致西尼罗病毒产生的高滴度。

8. 发明申请

WO1997037040A2 ISOLATION AND/OR AMPLIFICATION OF HEPATITIS C VIRUS (HCV) NUCLEIC ACIDS FROM SAMPLES SUSPECTED TO CONTAIN HCV 审中-公开
标题翻译：从包含HCV的样品中分离和/或扩增丙型肝炎病毒（HCV）核酸
公开(公告)号：WO1997037040A2
公开(公告)日：1997-10-09
申请号：PCT/NL1997000167
申请日：1997-04-03
申请人： AMSTERDAM SUPPORT DIAGNOSTICS B.V. , GOUDSMIT, Jaap , BELD, Marcellinus, Gualbertus, Hubertus, Maria , SOL, Cornelis, Johannes, Andreas , BOOM, Willem, René
发明人： AMSTERDAM SUPPORT DIAGNOSTICS B.V.
IPC分类号： C12Q01/68
CPC分类号： C12N15/1006 , C12Q1/707
摘要： The invention relates to methods for easily separating single stranded (HCV) nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at least one chaotropic agent, preferably a guanidine salt, at a selected concentration and other suitable conditions such as chelating agents, pH and the like it is possible to bind double stranded material to a solid phase such as silica particles, whereas single stranded material will not bind under those circumstances. By separating the silica particles from the sample the double stranded nucleic acid material is removed. It can easily be eluted from the silica particles. In a second step the single stranded HCV material may be bound to a solid phase by selecting a different set of conditions. The particles can again be separated from the sample and the single stranded material may now be eluted. For very efficient separations the process may be repeated. Following the separation of the two kinds of nucleic acid, either kind may be amplified. Methods of amplification are provided which do not need sequence data of the material to be amplified. In these methods a primer will be provided with an amplification motif and a random hybridization motif.
摘要翻译：本发明涉及在含有两者的样品中容易地从双链核酸材料分离单链（HCV）核酸材料的方法。通过选择浓度和其它合适条件如螯合剂，pH等的至少一种离液剂，优选胍盐的选择，可以将双链材料结合到固相如二氧化硅颗粒，而单链材料在这种情况下不会结合。通过从样品中分离二氧化硅颗粒，除去双链核酸材料。它可以容易地从二氧化硅颗粒中洗脱出来。在第二步中，通过选择不同的一组条件，单链HCV材料可以结合固相。颗粒可以再次与样品分离，单链材料现在可以被洗脱。为了非常有效的分离，可以重复该过程。在分离两种核酸后，可以扩增任一种。提供了不需要放大材料的序列数据的扩增方法。在这些方法中，引物将具有扩增基序和随机杂交基序。

9. 发明申请

WO2006037038B1 OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES 审中-公开
标题翻译：优化疫苗提供针对EBOLA和其他病毒的保护
公开(公告)号：WO2006037038B1
公开(公告)日：2006-08-03
申请号：PCT/US2005034798
申请日：2005-09-27
申请人： US GOV HEALTH & HUMAN SERV , CRUCELL HOLLAND BV , SULLIVAN NANCY , CHAKRABARTI BIMAL , YANG ZHI-YONG , PAU MARIA GRAZIA , GOUDSMIT JAAP , NABEL GARY J
发明人： SULLIVAN NANCY , CHAKRABARTI BIMAL , YANG ZHI-YONG , PAU MARIA GRAZIA , GOUDSMIT JAAP , NABEL GARY J
IPC分类号： C07K14/08 , A61K39/12 , C07K16/10 , C12N15/861
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitrocytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译：本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，其具有位于所述GP的相对保守区域中的至少一个氨基酸改变，其降低体外细胞毒性并与体外细胞毒性相比保留免疫原性，并且野生型病毒GP和相关修饰的病毒GP，质粒DNA，重组病毒，腺病毒，药物组合物，疫苗组合物，与修饰的病毒GP特异性反应的抗体的免疫原性及其制备和使用的相关方法。

10. 发明申请

WO2005023849A2 ANTIGENIC PEPTIDES OF RABIES VIRUS AND USES THEREOF 审中-公开
标题翻译： RABIES病毒的抗原性及其用途
公开(公告)号：WO2005023849A2
公开(公告)日：2005-03-17
申请号：PCT/EP2004/052043
申请日：2004-09-03
申请人： CRUCELL HOLLAND B.V. , BAKKER, Alexander, Berthold, Hendrik , MARISSEN, Willem, Egbert , GOUDSMIT, Jaap
发明人： BAKKER, Alexander, Berthold, Hendrik , MARISSEN, Willem, Egbert , GOUDSMIT, Jaap
IPC分类号： C07K14/14
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/205 , C07K16/10 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C12N7/00 , C12N2760/20121 , C12N2760/20122 , C12N2760/20134
摘要： The present invention pertains to antigenic peptides of rabies virus and their use in the detection, prevention and/or treatment of conditions resulting from rabies virus.
摘要翻译：本发明涉及狂犬病病毒的抗原肽及其在检测，预防和/或治疗由狂犬病病毒引起的病症中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式