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1. 发明申请

WO2006045308A2 CHLAMYDIA TRACHOMATIS ANTIGENS FOR VACCINE AND DIAGNOSTIC USE 审中-公开
标题翻译： CHLAMYDIA TRACHOMATIS用于疫苗和诊断用途的抗生素
公开(公告)号：WO2006045308A2
公开(公告)日：2006-05-04
申请号：PCT/DK2005/000651
申请日：2005-10-11
申请人： STATENS SERUM INSTITUT , THEISEN, Michael , OLSEN, Anja , LEAH, Robert , FOLLMANN, Frank , JENSEN, Klaus , ANDERSEN, Peter
发明人： THEISEN, Michael , OLSEN, Anja , LEAH, Robert , FOLLMANN, Frank , JENSEN, Klaus , ANDERSEN, Peter
IPC分类号： A61K39/118 , C07K14/295 , C12Q1/68 , G01N33/569 , C07K16/12
CPC分类号： C07K14/295 , A61K39/118
摘要： The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are useful in vaccines but also as diagnostic compositions.
摘要翻译：本发明涉及来自沙眼衣原体的抗原，其被来自感染衣原体的个体的特异性抗体识别或可以诱导来自相同个体的T细胞分泌γ-干扰素。 T细胞反应性抗原存在于全细胞裂解物中，并且通过SDS-PAGE测定具有5-12,16-20,25-35和58-74kDa的表观分子量。本发明的抗原可用于疫苗，但也可用作诊断组合物。

2. 发明申请

WO2004043488A1 MALARIA VACCINE 审中-公开
公开(公告)号：WO2004043488A1
公开(公告)日：2004-05-27
申请号：PCT/DK2003/000759
申请日：2003-11-06
申请人： STATENS SERUM INSTITUT , THEISEN, Michael , JEPSEN, Søren
发明人： THEISEN, Michael , JEPSEN, Søren
IPC分类号： A61K39/015
CPC分类号： C07K14/445 , A61K39/015 , C07K2319/00 , Y02A50/412
摘要： A fusion protein, derived from P. falciparum Glutamate-rich protein (GLURP) genetically coupled to P. falciparum Merozoite surface protein 3 (MSP3) was produced in Lactococcus lactis as a secreted recombinant GLURP-MSP3 hybrid protein and experiments showed that the GLURP-part of the hybrid increased the overall antibody response. Immunizations with the hybrid protein consistently generated a stronger antibody response against the individual GLURP and MSP3 domains than a mixture of the two recombinant molecules injected at one site or the individual recombinant molecules injected simultaneously at two different sites. The difference was most pronounced for the MSP3-specific antibody response suggesting that T cell epitopes located in the GLURP RO-region provide help for B-cell epitopes in the MSP3 region. Moreover, when the animals were injected with a mixture of GLURP and MSP3, individual mice tended to mount a predominant antibody response against either molecule: in some animals GLURP was immunodominant whereas in other animals MSP3 was the dominant immunogen. Additionally, the hybrid was also more antigenic than the individual recombinant proteins since the ELISA-titer of naturally occurring IgG antibodies, in clinically immune African adults, against the hybrid protein was higher than the titers against the individual recombinant proteins. The hybrid protein was also demonstrated to be a potential protective antigen as mouse anti-GLURP-MSP3 IgG antibodies were able to inhibit parasite-growth in vitro in a monocyte-dependent manner.
摘要翻译：在乳酸乳球菌中作为分泌型重组GLURP-MSP3杂交蛋白产生了源自恶性疟原虫富含谷氨酸的蛋白质（GLURP）基因上与恶性疟原虫裂殖子表面蛋白3（MSP3）偶联的融合蛋白，实验表明，GLURP- 混合物的一部分增加了整体抗体反应。与在一个位点注射的两个重组分子或在两个不同位点同时注射的单个重组分子的混合物相比，杂交蛋白的免疫连续产生针对个体GLURP和MSP3结构域的更强的抗体应答。 MSP3特异性抗体反应的差异最明显，表明位于GLURP RO区域的T细胞表位为MSP3区域中的B细胞表位提供了帮助。此外，当动物注射了GLURP和MSP3的混合物时，单个小鼠倾向于对任一分子施加主要的抗体应答：在一些动物中，GLURP是免疫显性的，而在其他动物中，MSP3是显性免疫原。另外，杂交体也比单独的重组蛋白质具有更高的抗原性，因为针对杂交蛋白质的临床免疫非洲成年人中天然存在的IgG抗体的ELISA滴度高于针对各个重组蛋白的滴度。也证明杂交蛋白是潜在的保护性抗原，因为小鼠抗GLURP-MSP3 IgG抗体能够以单核细胞依赖性方式在体外抑制寄生虫生长。

3. 发明申请

WO2020201191A1 MULTIVALENT MALARIA TRANSMISSION-BLOCKING VACCINES 审中-公开
公开(公告)号：WO2020201191A1
公开(公告)日：2020-10-08
申请号：PCT/EP2020/058906
申请日：2020-03-30
申请人： STATENS SERUM INSTITUT , KØBENHAVNS UNIVERSITET
发明人： SINGH, Susheel Kumar , THEISEN, Michael
IPC分类号： A61K39/015 , A61P33/06 , C07K14/00
摘要： The present invention relates to a method for recombinant production of a fusion protein comprising multiple malaria antigens for inducing immune responses comprising a combination of antibodies. In particular, the fusion proteins of the present invention comprise fragments of both Pfs 230 and Pfs 48/45 to lower the required threshold of functional antibodies and to reduce the risk of escape mutations. Thus, the fusion proteins of the present invention are suitable for use in a multivalent malaria vaccine.

4. 发明申请

WO2013050034A1 PRODUCTION OF A CYSTEINE RICH PROTEIN 审中-公开
标题翻译：生产大量蛋白质的蛋白质
公开(公告)号：WO2013050034A1
公开(公告)日：2013-04-11
申请号：PCT/DK2012/000108
申请日：2012-10-03
申请人： STATENS SERUM INSTITUT
发明人： THEISEN, Michael , ANDERSEN, Gorm
IPC分类号： A61K39/015 , C07K14/445 , C12N15/30
CPC分类号： C07K14/445 , A61K39/015 , C07K14/4718 , C07K2319/055 , C12N15/62 , C12N15/746 , C12P21/02 , Y02A50/412
摘要： The present invention relates to a method for the production of correctly folded Pfs48/45. This is achieved in the lactococcus lactis when Pfs48/45 or fractions thereof are fused genetically to a glutamate rich protein, e.g. GLURP from Plasmodium falciparum .
摘要翻译：本发明涉及生产正确折叠的Pfs48 / 45的方法。当Pfs48 / 45或其部分在遗传上与富含谷氨酸的蛋白质融合时，这在乳酸乳球菌中实现。来自恶性疟原虫的GLURP。

5. 发明申请

WO2013064147A1 GENETIC VARIANTS ASSOCIATED WITH CEREBRAL MALARIA 审中-公开
标题翻译：与疟疾相关的遗传变异
公开(公告)号：WO2013064147A1
公开(公告)日：2013-05-10
申请号：PCT/DK2012/000117
申请日：2012-10-24
申请人： STATENS SERUM INSTITUT
发明人： THEISEN, Michael , CHRISTIANSEN, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156
摘要： The present invention relates to an in vitro method for diagnosing a genetic predisposition or susceptibility for cerebral malaria, a severe condition of a Plasmodium falsiparum infection characterized by sequestration of parasitized red blood cells (PRBCs) and non- PRBCs (NPRBCs) in cerebral capillaries and venules and ring-like lesions in the brain. The method comprises detection of at least one specific SNP (rs2073342, rs2233860 or rs8019343) and SNPs which are in linkage disequilibrium therewith. The invention further relates to diagnostic and research kits for use in diagnosing a genetic predisposition or susceptibility for cerebral malaria and to the use of adrenal cortical steroid, inhibitors of tyrosinkinase and anti-ECP Ig in the treatment of cerebral malaria.
摘要翻译：本发明涉及用于诊断脑疟疾的遗传易感性或易感性的体外方法，其特征在于在脑毛细血管中寄生的红细胞（PRBC）和非PRBCs（NPRBC）的螯合的疟原虫感染的严重状况，以及大脑中的小静脉和环状病变。该方法包括检测至少一种特异性SNP（rs2073342，rs2233860或rs8019343）和与其连锁不平衡的SNP。本发明还涉及用于诊断脑疟疾遗传倾向或易感性的诊断和研究试剂盒，以及在治疗脑疟疾中使用肾上腺皮质类固醇，酪氨酸激酶抑制剂和抗ECP Ig的方法。

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