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1. 发明申请

WO2008054259A1 A MEDICAL IMPLANTABLE LEAD INCLUDING A FLEXIBLE FLAT TWISTED ELONGATE BODY 审中-公开
标题翻译：一种医用植入式铅包括一个柔软的平面双向拉伸的身体
公开(公告)号：WO2008054259A1
公开(公告)日：2008-05-08
申请号：PCT/SE2006/001210
申请日：2006-10-31
申请人： ST. JUDE MEDICAL AB , STRANDBERG, Hans , NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , NILSSON, Susanne , STEGFELDT, Olof
发明人： STRANDBERG, Hans , NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , NILSSON, Susanne , STEGFELDT, Olof
IPC分类号： A61N1/05 , H01B7/08
CPC分类号： A61N1/05 , A61N1/056 , H01B7/0823
摘要： This invention relates to a medical implantable lead (101) having a proximal end (109) and a distal end (107) , and having a flexible flat elongate body (103) . The elongate body includes a layer of strip conductors extending along the length of the flat elongate body, a top insulating layer, and a bottom insulating layer. The layer of strip conductors is sealingly enclosed between the top and bottom insulating layers, and at least a major portion of the flat elongate body is twisted into an elongate helical portion having a central cavity extending longitudinally of the helical portion.
摘要翻译：本发明涉及具有近端（109）和远端（107）的医用可植入引线（101），并且具有柔性扁平细长体（103）。细长主体包括沿扁平细长体的长度延伸的条形导体层，顶部绝缘层和底部绝缘层。带状导体层被密封地封闭在顶部和底部绝缘层之间，并且扁平细长体的至少大部分被扭转成具有沿螺旋部分纵向延伸的中心空腔的细长螺旋部分。

2. 发明申请

WO2008066423A1 DEVICE AND METHOD FOR TREATING CARDIAC TISSUE OF A HEART OF A PATIENT WITH THERAPEUTIC LIGHT USING PHOTOBIOMODULATION 审中-公开
标题翻译：使用光电转换治疗患者的心脏的心脏组织的装置和方法
公开(公告)号：WO2008066423A1
公开(公告)日：2008-06-05
申请号：PCT/SE2006/001375
申请日：2006-11-30
申请人： ST. JUDE MEDICAL AB , NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , ECKERDAL, Johan
发明人： NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , ECKERDAL, Johan
IPC分类号： A61N1/05 , A61N1/36 , A61N1/362 , A61N1/372 , A61N5/06
CPC分类号： A61N1/056 , A61N1/057 , A61N1/059 , A61N1/362 , A61N5/0603 , A61N2005/0652 , A61N2005/0659
摘要： The present invention is related to treatment of cardiac tissue of a heart (16) of a patient with therapeutic light using an implantable medical device (10; 20; 30) connectable to at least one medical lead (12, 14; 22a, 22b; 40; 70; 80; 90; 100; 106) comprising electrodes (42, 44; 72; 82; 92; 102; 108) and at least one fixation means (42; 71; 81; 91; 101; 107) adapted to fixate said lead (12, 14; 22a, 22b; 40; 70; 80; 90; 100; 106) at a fixation area of the cardiac tissue. Therapeutic light is emitted towards said at least one fixation area of cardiac tissue and/or towards a contact area between the at least one electrode (42, 44; 72; 82; 92; 102; 108) and cardiac tissue using light emitting means (31, 32; 46; 74; 84; 94; 104; 109a, 109b).
摘要翻译：本发明涉及使用可连接到至少一个医用引线（12,14; 22a，22b; 22b）的可植入医疗装置（10; 20; 30）治疗患有治疗用光的患者的心脏（16）的心脏组织。包括电极（42,44; 72; 82; 92; 102; 108）和至少一个固定装置（42; 71; 81; 91; 101; 107）在所述心脏组织的固定区域处固定所述引线（12,14; 22a，22b; 40; 70; 80; 90; 100; 106）。治疗性光利用发光装置向心脏组织的所述至少一个固定区域和/或朝着至少一个电极（42,44; 72; 82; 92; 102; 108）和心脏组织之间的接触区域发射 31,32; 46; 74; 84; 94; 104; 109a，109b）。

3. 发明申请

WO2008051122A1 A MEDICAL IMPLANTABLE LEAD 审中-公开
标题翻译：医疗可植入式
公开(公告)号：WO2008051122A1
公开(公告)日：2008-05-02
申请号：PCT/SE2006/001209
申请日：2006-10-25
申请人： ST. JUDE MEDICAL AB , NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika
发明人： NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/05 , Y10T29/49124
摘要： This invention relates to a medical implantable lead (191) comprising an elongate body (103) including a flexible insulating tube (113), and a tubular conductor layer (117) consisting of a plurality of separate strip conductors (119), which are arranged at the outer surface of said insulating tube and extend along the length thereof.
摘要翻译：本发明涉及一种包括细长体（103）的医用可植入引线（191），其包括柔性绝缘管（113），以及由多个分开的带状导体（119）组成的管状导体层（117）在所述绝缘管的外表面处并沿其长度延伸。

4. 发明申请

WO2008054260A1 TISSUE STIMULATING DEVICE AND METHOD 审中-公开
标题翻译：组织刺激装置及方法
公开(公告)号：WO2008054260A1
公开(公告)日：2008-05-08
申请号：PCT/SE2006/001211
申请日：2006-10-31
申请人： ST. JUDE MEDICAL AB , WEISSENRIEDER-NORLIN, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika
发明人： WEISSENRIEDER-NORLIN, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika
IPC分类号： A61N1/44 , A61N1/372
CPC分类号： A61N1/44 , A61N1/32 , A61N1/362
摘要： The present invention relates to a tissue stimulating device (100) that provides a biological stimulation of tissue (15). The tissue stimulation device comprises a release surface (110) adapted for arrangement adjacent to a tissue (15) to be stimulated. An agent reservoir (120) of the device (100) comprises an ionic agent (140) capable of causing a stimulation if present at sufficient high extracellular concentration close to the tissue (15). An agent releaser (130; 132; 134; 136) is provided in the device (100) for releasing a selected amount of the ionic agent (140) from the agent reservoir (120) to an outside of the release surface (110) at a stimulation occasion for stimulating the tissue (15). The ionic agent (140) will cause a temporary change in ion permeability of the tissue cell membranes and a depolarization of the tissue cells.
摘要翻译：本发明涉及提供组织（15）的生物刺激的组织刺激装置（100）。组织刺激装置包括适于布置成邻近待刺激的组织（15）的释放表面（110）。装置（100）的药剂储存器（120）包括能够在靠近组织（15）的足够高的细胞外浓度存在的情况下引起刺激的离子试剂（140）。在所述装置（100）中设置有代理商释放器（130; 132; 134; 136），用于将选定量的离子剂（140）从药剂储存器（120）释放到释放表面（110）的外部，用于刺激组织（15）的刺激场合。离子剂（140）将导致组织细胞膜的离子渗透性的暂时变化和组织细胞的去极化。

5. 发明申请

WO2010064962A1 A MEDICAL IMPLANTABLE LEAD AND A METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：医用可植入式铅及其制造方法
公开(公告)号：WO2010064962A1
公开(公告)日：2010-06-10
申请号：PCT/SE2008/000678
申请日：2008-12-02
申请人： ST. JUDE MEDICAL AB , STRANDBERG, Hans , SIVARD, Ake , BROOME, Asa , DAHLBERG, Kenneth , PELLIJEFF, Gustav , HENRIQUEZ, Leda
发明人： STRANDBERG, Hans , SIVARD, Ake , BROOME, Asa , DAHLBERG, Kenneth , PELLIJEFF, Gustav , HENRIQUEZ, Leda
IPC分类号： A61N1/08 , H01B7/04
CPC分类号： A61N1/05 , A61N1/056 , A61N1/086 , A61N1/3718 , Y10T29/49002
摘要： The invention relates to a medical implantable lead of the kind being adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ (2) inside the body. The lead (3) comprising a fixation means (6) in a distal end, which is adapted to fixate a distal end of the lead (3) to the organ, an electrode member (6) in the distal end adapted to be in contact with tissue of the organ and receive and/or transmit electrical signals from and/or to the organ, and at least one electrically conducting coil (8, 9), which includes one or more electrically conducting helical wires (11) and which is adapted to connect the electrode member in the distal end with a monitoring and/or controlling device (1) in a proximal end of the lead. The one or more individual wires (11) of the coil comprises a wire core (12) which is provided with a surrounding electrically insulating layer (13), which in its turn is provided with a surrounding electrically conducting shield layer (14), and the coil is close-lapped such that electrically conducting shield layers of adjacent loops of the coil are in electrical contact with each other.
摘要翻译：本发明涉及一种适于植入人体或动物体内的医用可植入引线，用于监测和/或控制身体内的器官（2）。所述引线（3）包括位于远端的固定装置（6），所述固定装置适于将所述引线（3）的远端固定到所述器官，所述远端中的电极构件（6）适于接触具有器官的组织并且从器官和/或器官接收和/或传送电信号，以及包括一个或多个导电螺旋线（11）的至少一个导电线圈（8,9），并且其被适配将远端中的电极构件与引线的近端中的监视和/或控制装置（1）连接。线圈的一个或多个单独的导线（11）包括线芯（12），该芯线设置有环绕的电绝缘层（13），其又设置有环绕的导电屏蔽层（14），以及线圈被紧密地重叠，使得线圈的相邻环路的导电屏蔽层彼此电接触。

6. 发明申请

WO2008105691A1 DEVICE AND METHOD FOR DETECTING A MYOCARDIAL INFARCTION AND TREATING THE MYOCARDIAL INFARCTION USING THERAPEUTIC LIGHT 审中-公开
标题翻译：用于检测心肌梗塞并使用治疗光治疗心肌梗塞的装置和方法
公开(公告)号：WO2008105691A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000194
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , NORLIN, Anna , HENRIQUEZ, Leda , STRANDERBERG, Hans , HARSTROM, Eva , SJOGREN, Mikael , NAESLUND, Anneika , ECKERDAL, Johan
发明人： NORLIN, Anna , HENRIQUEZ, Leda , STRANDERBERG, Hans , HARSTROM, Eva , SJOGREN, Mikael , NAESLUND, Anneika , ECKERDAL, Johan
IPC分类号： A61N1/37 , A61N1/08 , A61N5/06
CPC分类号： A61N1/36521 , A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61B5/7239 , A61N1/36557 , A61N1/3702 , A61N5/0601 , A61N2005/063 , A61N2005/0652 , A61N2005/0659 , A61N2005/067
摘要： An implantable medical device (10; 20; 30) and a method are disclosed for treating cardiac tissue of a heart (16) of a patient with therapeutic light. A myocardial infarction is detected and a location the myocardial infarction is identified. A therapy session is initiated by selectively activate one or more of a plurality of light emitting means (31, 32a, 32b; 54, 57a, 57b, 57c, 57d) arranged in at least one medical lead (12, 14; 22a, 22b; 50) connectable to the implantable medical device (10; 20;30) to emit therapeutic light towards a detected location of a myocardial infarction at detection of an occurrence of a myocardial infarction.
摘要翻译：公开了一种用于治疗具有治疗光的患者的心脏（16）的心脏组织的可植入医疗装置（10; 20; 30）和方法。检测到心肌梗塞，并确定心肌梗死的位置。通过选择性地激活布置在至少一个医用引线（12,14; 22a，22b）中的多个发光装置（31,32a，32b; 54,57a，57b，57c，57d）中的一个或多个 ; 50），其可连接到所述可植入医疗装置（10; 20; 30），以在检测到心肌梗死的发生时朝向心肌梗塞的检测位置发射治疗光。

7. 发明申请

WO2010114433A1 AN IMPLANTABLE MRI COMPATIBLE MEDICAL LEAD WITH A ROTATABLE CONTROL MEMBER 审中-公开
标题翻译：可植入MRI兼容医疗引导与可旋转的控制成员
公开(公告)号：WO2010114433A1
公开(公告)日：2010-10-07
申请号：PCT/SE2009/000480
申请日：2009-10-30
申请人： ST. JUDE MEDICAL AB , OLSEN, Linn , FORSLUND, Michael , DJURLING, Henrik , FORSSTRÖM, Patrik , HENRIQUEZ, Leda , DAHLBERG, Kenneth , STEGFELDT, Olof , SIVARD, Åke
发明人： FORSLUND, Michael , DJURLING, Henrik , FORSSTRÖM, Patrik , HENRIQUEZ, Leda , DAHLBERG, Kenneth , STEGFELDT, Olof , SIVARD, Åke
IPC分类号： A61N1/05 , A61N1/16
CPC分类号： A61N1/057 , A61N1/3752
摘要： The invention relates to a medical implantable lead of the kind being adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body. The lead comprises at a distal end a combined fixation means and electrode member in form of a helix (4), which is connected to a rotatable tubular torque transferring member (9) being in its turn connected to a rotatable control member (8) at a proximal end of the lead, and which is rotatable in relation to the lead and extendable out from the distal end, by rotation of the control member and the tubular torque transferring member, to be able to fixate the distal end of the lead to the organ by being screwed into the tissue The helix is electrically connected to a connector (7) at the proximal end by means of at least one electrically conducting wire (14) formed as an electrically conducting coil (11), which is separate from the tubular torque transferring member (9) and unrotatable in relation to the lead and which comprises one or more individual wires, each comprising an electrically conducting wire core (15) and a surrounding electrically insulating layer (16), wherein the rotatable control member (8) is rotatable within the connector (7).
摘要翻译：本发明涉及一种适于植入人体或动物体内的用于监测和/或控制体内器官的医用可植入引线。引线包括在远端处的组合的固定装置和螺旋形（4）形式的电极构件，其连接到可旋转的管状扭矩传递构件（9），该可转动的管状扭矩传递构件（9）又与可旋转的控制构件（8）连接，引线的近端，并且其可以相对于引线旋转并且可以通过控制构件和管状扭矩传递构件的旋转从远端延伸出来，以便能够将引线的远端固定到通过螺纹连接到组织中的螺旋线通过形成为导电线圈（11）的至少一个导电线（14）在近端处电连接到连接器（7），所述导电线（14）与管状体转矩传递构件（9），并且相对于引线不可旋转，并且其包括一个或多个单独的导线，每个导线包括导电导线芯（15）和周围的电绝缘层（16），其中所述旋转体控制构件（8）可在连接器（7）内旋转。

8. 发明申请

WO2010071493A1 IMPLANTABLE ELECTRODE LEAD WITH SWITCHING UNIT ADAPTED FOR SWITCHING ELECTRODE LEAD BETWEEN NORMAL PACING MODE AND LOCAL PACING MODE DURING MRI 审中-公开
标题翻译：具有切换电极的可切换电极引线，适用于在MRI期间切换正常模式和本地模式之间的电极引线
公开(公告)号：WO2010071493A1
公开(公告)日：2010-06-24
申请号：PCT/SE2008/000728
申请日：2008-12-19
申请人： ST.JUDE MEDICAL AB , SIVARD, Ake , PELLIJEFF, Gustav , STRANDBERG, Hans , HENRIQUEZ, Leda , BROOME, Asa , DAHLBERG, Kenneth
发明人： SIVARD, Ake , PELLIJEFF, Gustav , STRANDBERG, Hans , HENRIQUEZ, Leda , BROOME, Asa , DAHLBERG, Kenneth
IPC分类号： A61N1/05 , A61N1/16 , A61N1/37 , G01R33/28
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3688 , A61N1/3718
摘要： Implantable electrode lead for tissue stimulation adapted to be attached to an implantable tissue stimulator provided with a pulse generator, the electrode lead comprises at least two stimulation electrodes to apply stimulation pulses to said tissue and arranged close to the distal end of the electrode lead, and at least two electrical conductors to connect said electrodes to said pulse generator. The electrode lead further comprises a switching unit arranged close to the distal end of the electrode lead and adapted to switch the electrode lead between a local pacing mode and a normal pacing mode, the switching unit being controlled by a mode control signal. Further, a pacing module is arranged close to the distal end of the electrode lead and in relation to the switching unit and being connectable to said at least two stimulation electrodes, the pacing module includes a pulse generating unit to generate stimulating pulses to be applied to the tissue by said stimulation electrodes. When the electrode lead is in the local pacing mode the electrical conductors are disconnected from said stimulation electrodes which instead are connected to the pacing module, and when the electrode lead is in the normal pacing mode the electrical conductors are connected to the stimulation electrodes.
摘要翻译：用于组织刺激的可植入电极引线，适于附接到设置有脉冲发生器的可植入组织刺激器，所述电极引线包括至少两个刺激电极，以将刺激脉冲施加到所述组织并靠近电极引线的远端布置;以及至少两个电导体，用于将所述电极连接到所述脉冲发生器。所述电极引线还包括切换单元，所述切换单元布置成靠近所述电极引线的远端并且适于在局部起搏模式和正常起搏模式之间切换所述电极引线，所述开关单元由模式控制信号控制。此外，起搏模块靠近电极引线的远端设置，并且相对于开关单元设置并且可连接到所述至少两个刺激电极，所述起搏模块包括脉冲产生单元，用于产生刺激脉冲以施加到所述刺激电极的组织。当电极引线处于局部起搏模式时，电导体与所述刺激电极断开，代替地连接到起搏模块，并且当电极引线处于正常起搏模式时，电导体连接到刺激电极。

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