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1. 发明申请

WO2008082803A3 ABLATION CATHETER THERMALL MEDIATED CATHETER BODY 审中-公开
标题翻译：吸引管热介质导管体
公开(公告)号：WO2008082803A3
公开(公告)日：2008-08-21
申请号：PCT/US2007084690
申请日：2007-11-14
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , CAO HONG , GUO XIAOPING , SHAI ISAAC , YANG MICHAEL , BELHE KEDAR RAVINDRA , THAO CHOU
发明人： PAUL SAURAV , CAO HONG , GUO XIAOPING , SHAI ISAAC , YANG MICHAEL , BELHE KEDAR RAVINDRA , THAO CHOU
IPC分类号： A61B18/04
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00357
摘要： An ablation catheter (10) is provided for ablating internal tissue of a patient. The catheter includes a distal end that is adapted to be inserted into a body cavity relative to a desired location therein (e.g., within the heart). An ablation electrode (22) is connected relative to the distal end of the catheter (10) for providing ablation energy to patient tissue. A heat sink (40) is provided that is in thermal contact with the ablation electrode (22). The heat sink (40), in addition to being in thermal contact with the ablation electrode (22), is electrically isolated from the ablation electrode (22). This allows the heat sink (40) to conduct heat away from the ablation electrode (22) without dissipating electrical energy from the electrode (22). In this regard, the heat sink (40) may prevent build-up of excess heat within the electrode (22) that may result in blood coagulation and/or tissue charring.
摘要翻译：提供消融导管（10），用于烧蚀患者的内部组织。该导管包括适于相对于其中的期望位置（例如，在心脏内）插入体腔中的远端。消融电极（22）相对于导管（10）的远端连接，用于向患者组织提供消融能量。提供与消融电极（22）热接触的散热器（40）。除了与消融电极（22）热接触之外，散热器（40）与消融电极（22）电隔离。这允许散热器（40）将热量从消融电极（22）导出，而不会从电极（22）中消散电能。在这方面，散热器（40）可防止可能导致血液凝固和/或组织烧焦的电极（22）内的过多热量的累积。

2. 发明申请

WO2007067939A3 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067939A3
公开(公告)日：2007-12-21
申请号：PCT/US2006061712
申请日：2006-12-06
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG , THAO CHOU
发明人： PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG , THAO CHOU
IPC分类号： G01R19/00 , A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

3. 发明申请

WO2008083112A3 CONTACT-SENSITIVE PRESSURE-SENSITIVE CONDUCTIVE COMPOSITE ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：接触感应敏感导电复合电极及其脱模方法
公开(公告)号：WO2008083112A3
公开(公告)日：2008-09-04
申请号：PCT/US2007088680
申请日：2007-12-21
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , THAO CHOU , PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG
发明人： THAO CHOU , PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00577 , A61B2018/00702 , A61B2090/064
摘要： A catheter assembly for pressure-sensitive control of ablation treatment is disclosed. The assembly includes a conductive element, an electrode, and a pressure sensitive conductive composite member positioned between the conductive element and the electrode. At least one of the conductive pin, the pressure sensitive conductive composite element and the ablation electrode are moveable to create an engagement position and a non-engagement position. In the engagement position, the elements are electrically coupled such that ablation energy may be delivered from the conductive pin to the ablation electrode via the pressure sensitive conductive composite element. In the non-engagement position, the elements are electrically decoupled such that ablation energy is not delivered to the ablation electrode. A related method for pressure-sensitive control of ablation is also disclosed.
摘要翻译：公开了一种用于消融治疗的压敏控制的导管组件。组件包括导电元件，电极和定位在导电元件和电极之间的压敏导电复合元件。导电针，压敏导电复合元件和消融电极中的至少一个可移动以产生接合位置和非接合位置。在接合位置，元件被电耦合，使得消融能量可以经由压敏导电复合元件从导电引脚传送到消融电极。在非接合位置，元件被电去耦合，使得消融能量不被输送到消融电极。还公开了一种用于消融的压敏控制的相关方法。

4. 发明申请

WO2007067941A3 ASSESSMENT OF ELECTRODE COUPLING FOR TISSUE ABLATION 审中-公开
公开(公告)号：WO2007067941A3
公开(公告)日：2008-11-20
申请号：PCT/US2006061714
申请日：2006-12-06
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG , THAO CHOU
发明人： PAUL SAURAV , BELHE KEDAR RAVINDRA , CAO HONG , THAO CHOU
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

5. 发明申请

WO2008083122A3 PRESSURE-SENSITIVE CONDUCTIVE COMPOSITE ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：压敏导电性复合电极及消融方法
公开(公告)号：WO2008083122A3
公开(公告)日：2008-09-18
申请号：PCT/US2007088723
申请日：2007-12-21
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BELHE KEDAR RAVINDRA , THAO CHOU , CAO HONG
发明人： PAUL SAURAV , BELHE KEDAR RAVINDRA , THAO CHOU , CAO HONG
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00791 , A61B2018/1437 , A61B2090/064 , A61B2090/065 , A61B2218/002
摘要： The present invention is directed to ablation devices and methods utilizing pressure sensitive conductive composites, such as quantum tunneling composites, or other contact-sensitive, conductive polymers. The materials provide for electrodes and methods capable of differentiating between a soft and a hard push. The present invention thus provides an electrode for delivering selective electrical energy for ablation that may be varied based upon the pressure exerted on the surface area of the targeted tissue.
摘要翻译：本发明涉及利用压敏导电复合材料（例如量子隧穿复合材料）或其他接触敏感的导电聚合物的消融设备和方法。这些材料提供了能够区分软推和硬推的电极和方法。因此，本发明提供了用于传递选择性电能以用于消融的电极，其可以基于施加在目标组织的表面区域上的压力而变化。

6. 发明申请

WO2007002004A2 ABLATION CATHETER WITH FLUID DISTRIBUTION STRUCTURES 审中-公开
标题翻译：具有流体分布结构的吸引管
公开(公告)号：WO2007002004A2
公开(公告)日：2007-01-04
申请号：PCT/US2006023854
申请日：2006-06-19
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , CAO HONG , THAO CHOU , BELHE KEDAR RAVINDRA , PAUL SAURAV , STANGENES TODD
发明人： CAO HONG , THAO CHOU , BELHE KEDAR RAVINDRA , PAUL SAURAV , STANGENES TODD
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00375 , A61B2018/1472
摘要： An ablation catheter (22) has improved fluid distribution structures. An ablation section at a distal end (12) of the catheter (22) is designed to provide a more uniform fluid flow emanating from the catheter (22). By creating a uniform fluid flow, a more uniform tissue lesion results and the possibility of charring the tissue is reduced. A combination of mesh material (142) layers, porous materials (354), and dispersion channels or openings (346) are used to achieve the uniform flow. The amount of fluid used as a virtual electrode to ablate the tissue is greatly reduced with the present invention. Further, the catheter (22) may be used to create a single, uniform linear lesion by successive application of energy to adjacent portions of the ablation section, thus reducing the power required to create the desired lesion.
摘要翻译：消融导管（22）具有改进的流体分布结构。在导管（22）的远端（12）处的消融部分被设计成提供从导管（22）发出的更均匀的流体流。通过产生均匀的流体流动，会产生更均匀的组织损伤，并且减少了烧结组织的可能性。使用网状材料（142）层，多孔材料（354）和分散通道或开口（346）的组合来实现均匀的流动。用于消融组织的虚拟电极的流体量大大减少。此外，导管（22）可以用于通过将能量连续施加到消融部分的相邻部分来产生单一的均匀的线性损伤，从而减少产生所需损伤所需的功率。

7. 发明申请

WO2007016123A3 MULTIPOLAR, VIRTUAL-ELECTRODE CATHETER WITH AT LEAST ONE SURFACE ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：具有至少一个表面电极的多电极，虚拟电极导体和用于吸收的方法
公开(公告)号：WO2007016123A3
公开(公告)日：2007-04-12
申请号：PCT/US2006028912
申请日：2006-07-26
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BELHE KEDAR RAVINDRA
发明人： PAUL SAURAV , BELHE KEDAR RAVINDRA
IPC分类号： A61B18/00
CPC分类号： A61B18/1492 , A61B2018/1472
摘要： Virtual-electrode catheters (10, 12) and methods for using such virtual-electrode catheters (10, 12) are disclosed. For example, bipolar (10) and multipolar (12), virtual electrode catheters having at least one internal electrode (16) and at least one surface electrode (20), and methods of using these catheters for treatment of cardiac arrhythmias are disclosed. The catheters may comprise a catheter body (14) with an internal lumen (18) extending within it and adapted to flowingly receive a conductive fluid (34). An exit feature defining a flow path from the internal lumen (18) to the catheter's outer surface may exist through a sidewall (30) of the catheter body. A conductor (16) is mounted within the internal lumen (18) adjacent to the exit feature and is adapted to deliver treatment energy to the tissue via the conductive fluid (34). At least one surface electrode (20) is mounted on the outer surface of the catheter body adjacent to the exit feature.
摘要翻译：公开了虚拟电极导管（10,12）和使用这种虚拟电极导管（10,12）的方法。例如，公开了具有至少一个内部电极（16）和至少一个表面电极（20）的双极（10）和多极（12）虚拟电极导管以及使用这些导管治疗心律失常的方法。导管可以包括导管本体（14），其内部腔（18）在其内延伸并适于流动地接纳导电流体（34）。限定从内腔（18）到导管的外表面的流动路径的出口特征可以通过导管主体的侧壁（30）存在。导体（16）安装在邻近出口特征的内腔（18）内，并且适于经由导电流体（34）将治疗能量递送至组织。至少一个表面电极（20）安装在导管主体的与出口特征相邻的外表面上。

8. 发明申请

WO2008083311A3 PRESSURE-SENSITIVE CONDUCTIVE COMPOSITE CONTACT SENSOR AND METHOD FOR CONTACT SENSING 审中-公开
标题翻译：压敏导电复合接触传感器和接触感测方法
公开(公告)号：WO2008083311A3
公开(公告)日：2008-10-09
申请号：PCT/US2007089099
申请日：2007-12-28
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , BELHE KEDAR RAVINDRA , PAUL SAURAV
发明人： BELHE KEDAR RAVINDRA , PAUL SAURAV
IPC分类号： A61B19/00
CPC分类号： A61B18/1492 , A61B5/6885 , A61B2018/00083 , A61B2018/00577 , A61B2018/00875 , A61B2018/00988 , A61B2090/064 , A61B2090/065 , A61B2562/0209 , A61M25/00 , A61M2025/0002 , G01L1/20
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了用于评估导管组件和组织之间的接触的导管组件。该组件包括导管轴和压敏导电复合构件，其电阻随着施加到导管组件的压力而变化。该组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量装置以测量电阻，阻抗和/或其它电特性。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量端子之间的变化。可选地，该组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料相关的制造方法。

9. 发明申请

WO2007047360A3 DYNAMIC CONTACT ASSESSMENT FOR ELECTRODE CATHETERS 审中-公开
标题翻译：电极导体动态接触评估
公开(公告)号：WO2007047360A3
公开(公告)日：2009-04-23
申请号：PCT/US2006039881
申请日：2006-10-13
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , CHOU THAO , BELHE KEDAR RAVINDRA , HEIMBECHER REED R
发明人： PAUL SAURAV , CHOU THAO , BELHE KEDAR RAVINDRA , HEIMBECHER REED R
IPC分类号： A61B18/18
CPC分类号： A61B5/036 , A61B5/061 , A61B5/6885 , A61B18/1492 , A61B2018/00351 , A61B2090/065
摘要： An electrode catheter and a method for assessing catheter-tissue contact for tissue ablation are disclosed. An exemplary electrode catheter comprises a flexible catheter shaft. At least one piezoelectric sensor is oriented coaxial to the flexible catheter shaft. The at least one piezoelectric sensor is responsive to movement of the flexible catheter shaft by generating electrical signals corresponding to the amount of movement. The system may also include an output device electrically connected to the at least one piezoelectric sensor. The output device receives the electrical signals for dynamically assessing a level of contact between the flexible catheter shaft and a moving tissue. In another exemplary embodiment, the system may be implemented in a hydrodynamic environment.
摘要翻译：公开了电极导管和用于评估用于组织消融的导管 - 组织接触的方法。示例性电极导管包括柔性导管轴。至少一个压电传感器与柔性导管轴同轴地定向。至少一个压电传感器通过产生对应于移动量的电信号来响应柔性导管轴的移动。该系统还可以包括电连接到至少一个压电传感器的输出装置。输出装置接收用于动态评估柔性导管轴和移动组织之间的接触程度的电信号。在另一个示例性实施例中，系统可以在流体动力学环境中实现。

10. 发明申请

WO2007024785A3 MULTIPOLAR, MULTI-LUMEN, VIRTUAL-ELECTRODE CATHETER WITH AT LEAST ONE SURFACE ELECTRODE AND METHOD FOR ABLATION 审中-公开
标题翻译：具有多个单面表面电极的多层，多层，虚拟电极导体和方法
公开(公告)号：WO2007024785A3
公开(公告)日：2009-04-23
申请号：PCT/US2006032615
申请日：2006-08-21
申请人： ST JUDE MEDICAL ATRIAL FIBRILL , PAUL SAURAV , BELHE KEDAR RAVINDRA
发明人： PAUL SAURAV , BELHE KEDAR RAVINDRA
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： Multipolar, multi lumen, virtual-electrode catheters (10I) and methods for treatment (e.g., treatment of cardiac arrhythmias) with such catheters (10I) are disclosed. The catheters (10I) have at least two internal lumens (14, 16), and at least one internal, flexible electrode (18) rides in each internal lumen. The flexible electrodes (18) carry treatment energy (e.g., radiofrequency energy). The energy exits the catheters (10I) via at least one exit feature (e.g., slots, portholes (26), or micro pores). The methods for treatment include operating the catheters (10I) in different modes depending upon location and type of treatment to be performed. The treatment energy delivered by one of the internal, flexible electrodes (18) may be directed to the other internal, flexible electrode (20); or the energy delivered by one or both of the internal, flexible electrodes (18, 20) may be directed to one or more surface electrodes (22).
摘要翻译：公开了使用这种导管（10I）的多极，多腔，虚拟电极导管（10I）和用于治疗（例如治疗心律失常的方法）的方法。导管（10I）具有至少两个内部腔（14,16），并且至少一个内部柔性电极（18）骑在每个内腔中。柔性电极（18）承载处理能量（例如，射频能量）。能量通过至少一个出口特征（例如，狭槽，孔口（26）或微孔）离开导管（10I）。治疗方法包括根据要进行的治疗的位置和类型以不同的模式操作导管（10I）。由内部柔性电极（18）之一传递的处理能量可以被引导到另一个内部柔性电极（20）; 或者由一个或两个内部柔性电极（18,20）传送的能量可以被引导到一个或多个表面电极（22）。

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