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    • 7. 发明申请
    • OSTEOPROTEGERIN VARIANT PROTEINS
    • OSTEOPROTEGERIN变种蛋白
    • WO2006063390A1
    • 2006-06-22
    • PCT/AU2005/001877
    • 2005-12-13
    • EVOGENIX LTDROBERTS, AnthonyKOPSIDAS, GeorgeCOIA, GregorySLEIGH, MerilynBATORI, Vincent
    • ROBERTS, AnthonyKOPSIDAS, GeorgeCOIA, GregorySLEIGH, MerilynBATORI, Vincent
    • C07K14/715A61K38/17A61P19/10
    • C07K14/70578
    • The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduce binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic acids which encode these OVPs are also provided. Recombinant vectors and host cells expressing these OVPs are also encompassed as are methods of producing recombinant OVPs. The present invention also relates to compositions comprising these OVPs, and to methods of treating bone diseases characterised by increased bone turnover and/or loss. The OVPs of the invention are useful for preventing bone resorption and may be used to treat any condition resulting in abnormal bone turnover or bone loss such as osteoporosis, hypercalcemia, Paget's disease of bone, multiple myeloma, bone cancer and bone loss due to rheumatoid arthritis or osteomyelitis, and the like.
    • 本发明涉及当与野生型骨保护素相比时,其表现出降低其配体TRAIL的结合亲和力的新型骨保护素变体蛋白(OVPs)。 还提供了编码这些OVP的核酸。 重组载体和表达这些OVP的宿主细胞也包括在生产重组OVP的方法中。 本发明还涉及包含这些OVP的组合物,以及治疗以增加的骨转换和/或损失为特征的骨疾病的方法。 本发明的OVP可用于预防骨吸收,并且可用于治疗导致异常骨转换或骨丢失的任何病症,例如骨质疏松症,高钙血症,骨的佩吉特氏病,多发性骨髓瘤,骨癌和由类风湿性关节炎引起的骨丢失 或骨髓炎等。
    • 8. 发明申请
    • A FIRE ALARM MODULE
    • 一个消防报警模块
    • WO2003012759A1
    • 2003-02-13
    • PCT/GB2002/003447
    • 2002-07-26
    • COMPUTIONICS LIMITEDFOSTER, AndrewROBERTS, Anthony
    • FOSTER, AndrewROBERTS, Anthony
    • G08B25/00
    • G08B26/008G08B3/10
    • A fire alarm system comprises one or more fire alarm addressable modules (3), which interface with a fire alarm loop (1) along which data and power may be transmitted, and a voice alarm system comprising one or more amplifiers (6) connected to respective speakers (7) for transmitting voice alarm messages. The or each fire alarm module comprises a message store (22), means for interfacing with an amplifier (6) of the voice alarm system, means for interfacing with the fire alarm loop (1) and means for interpreting signals from the loop (1) and for selecting an appropriate message for transmission from the message store (22).
    • 火灾报警系统包括一个或多个火灾报警可寻址模块(3),其与可以传输数据和功率的火灾报警回路(1)接口,以及语音报警系统,包括一个或多个连接到 用于发送语音报警消息的各个扬声器(7)。 该火灾报警模块或每个火灾报警模块包括消息存储器(22),用于与语音报警系统的放大器(6)进行接口的装置,用于与火警报警回路(1)进行接口的装置和用于解释来自回路(1) )并且用于从消息存储(22)中选择用于发送的适当消息。