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1. 发明申请

WO2016014968A1 VARIANT THIOESTERASES AND METHODS OF USE 审中-公开
标题翻译：各种各样的药物和使用方法
公开(公告)号：WO2016014968A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042044
申请日：2015-07-24
申请人： SOLAZYME, INC. , BHAT, Riyaz
发明人： BHAT, Riyaz , DAVIS, David , FRANKLIN, Scott , MOSELEY, Jeffrey L.
IPC分类号： C12N9/16 , C12N15/82 , C12P7/64
CPC分类号： C12P7/6463 , C12N9/16 , C12N15/8247 , C12Y301/02014
摘要： The present invention relates to variant thioesterases and their use in plants, e.g., to increase enzymatic activity and to promote increased production of mid-chain length fatty acids (e.g., 8 to 14 carbons) and at desired ratios. Further disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods described herein.
摘要翻译：本发明涉及变体硫酯酶及其在植物中的用途，例如增加酶活性并促进中链长度脂肪酸（例如8至14个碳）的增加和所需比例的生产。本文进一步公开的是通过制备新型甘油三酯油然后化学改性油来制造可再生化学品的方法。还公开了含有C8，C10，C12或C14脂肪酸链长度的油，并且可用作本文所述方法中的原料。

2. 发明申请

WO2014089514A1 GENETICALLY ENGINEERED MICROBIAL STRAINS INCLUDING CHLORELLA PROTOTHECOIDES LIPID PATHWAY GENES 审中-公开
标题翻译：遗传工程微生物菌株，包括氯霉素原生质体脂肪道路基因
公开(公告)号：WO2014089514A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073718
申请日：2013-12-06
申请人： SOLAZYME, INC.
发明人： FRANKLIN, Scott , BRUBAKER, Shane , RUDENKO, George N. , BHAT, Riyaz , SHOA-AZAR, Matthew , SOMANCHI, Aravind , EWING, Aren
IPC分类号： C12N15/31 , C12N15/79 , C12N1/13 , C12P7/64
CPC分类号： C12P7/6463 , C12N15/52
摘要： Genetically engineered microbial, e.g., Chlorella protothecoides , cells producing microbial oils are useful as a food additive and a source of renewable fuels and industrial chemicals. Lipid biosynthesis genes for Auxenochlorella protethecoides are disclosed that are useful for increasing lipid production and altering fatty acid and triacylglycerol profiles in recombinant microrganisms including cells of the genus Auxenochlorella or Prototheca.
摘要翻译：基因工程微生物，例如原型小球藻，产生微生物油的细胞可用作食品添加剂和可再生燃料和工业化学品的来源。本发明公开了用于增加油类生物合成的脂质体生物合成基因，其可用于增加脂质生产和改变重组微生物（包括欧洲绿叶藻或原生动物）的重组微生物中的脂肪酸和三酰甘油轮廓。

3. 发明申请

WO2012106560A9 TAILORED OILS PRODUCED FROM RECOMBINANT OLEAGINOUS MICROORGANISMS 审中-公开
公开(公告)号：WO2012106560A9
公开(公告)日：2012-08-09
申请号：PCT/US2012/023696
申请日：2012-02-02
申请人： SOLAZYME, INC. , FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey , RAKITSKY, Walt , ZHAO, Xinhua , BHAT, Riyaz
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , WEE, Janice , RUDENKO, George , MOSELEY, Jeffrey , RAKITSKY, Walt , ZHAO, Xinhua , BHAT, Riyaz
IPC分类号： C12P7/64 , C12N1/13
摘要： Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.

4. 发明申请

WO2016164495A1 OLEAGINOUS MICROALGAE HAVING AN LPAAT ABLATION 审中-公开
标题翻译：具有LPAAT消融的OLEAGINOUS MICROALGAE
公开(公告)号：WO2016164495A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026265
申请日：2016-04-06
申请人： SOLAZYME, INC.
发明人： FRANKLIN, Scott , BHAT, Riyaz , ZHAO, Xinhua
IPC分类号： C12P7/64 , C12N1/13
CPC分类号： C12N15/52 , A23L33/115 , C11C1/002 , C12N1/12 , C12N9/1029 , C12N9/1288 , C12P7/64 , C12Y203/01023 , C12Y203/01051 , C12Y203/01199 , C12Y207/08 , C12Y207/08002
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, lysophosphatidic acid acyltransferase, ketoacyl-CoA reductase, hydroxyacyl-CoA dehydratase, and/or enoyl-CoA reductase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
摘要翻译：重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。基因操作包括编码硬脂酰-ACP去饱和酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶，溶血磷脂酰基转移酶，酮酰基-CoA还原酶，羟基酰基-CoA脱水酶和/或烯酰辅酶A还原酶的那些。所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。脂肪酸分布可以富集中链型，或者油可富含饱和不饱和饱和型甘油三酸酯。

5. 发明申请

WO2015051319A2 TAILORED OILS 审中-公开
标题翻译：定制油
公开(公告)号：WO2015051319A2
公开(公告)日：2015-04-09
申请号：PCT/US2014/059161
申请日：2014-10-03
申请人： SOLAZYME, INC.
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , RUDENKO, George , BHAT, Riyaz , ZHAO, Xinhua , MOSELEY, Jeffrey L.
IPC分类号： C12P7/64
CPC分类号： C12P7/64 , C11C1/002 , C11D9/00 , C12P7/6409 , C12Y203/01041 , C12Y301/02014
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
摘要翻译：使用重组DNA技术来生产产油甘油三酯油的含油重组细胞，所述甘油三酯油具有期望的脂肪酸谱和区域特异性或立体特异性谱。操作的基因包括编码硬脂酰-ACP去饱和酶，Δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮脂酰-ACP合酶和溶血磷脂酸酰基转移酶的基因。所产生的油可具有增强的氧化或热稳定性，或可用作油炸油，起酥油，卷入起酥油，脂肪回火，替代可可脂，作为润滑剂或作为各种化学工艺的原料。脂肪酸谱可以在中链谱上富集，或者油可以富含饱和 - 不饱和饱和型甘油三酯。

6. 发明申请

WO2013158938A1 TAILORED OILS 审中-公开
标题翻译：定制油
公开(公告)号：WO2013158938A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037261
申请日：2013-04-18
申请人： SOLAZYME, INC.
发明人： FRANKLIN, Scott , SOMANCHI, Aravind , RUDENKO, George , BHAT, Riyaz , ZHAO, Xinhua , BOND, Risha , RAKITSKY, Walter , MARANGONI, Alejandro , BRAKSMAYER, Diza
IPC分类号： C12P7/64
CPC分类号： C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
摘要： Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsatturated-saturated type.
摘要翻译：重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。基因操作包括编码硬脂酰-ACP脱氧酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶和溶血磷脂酰基转移酶的那些。所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。脂肪酸分布可以富集于中链轮廓，或者油可以富集饱和不饱和饱和型甘油三酸酯。

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