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1. 发明申请

WO2002059599A2 SYSTEM AND METHOD FOR IN VITRO ANALYSIS OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的体外分析系统和方法
公开(公告)号：WO2002059599A2
公开(公告)日：2002-08-01
申请号：PCT/US2002/002223
申请日：2002-01-25
申请人： SMITHKLINE BEECHAM CORPORATION , WALKER, Dwight, Sherod , PATRICK, Mark, Austin
发明人： WALKER, Dwight, Sherod , PATRICK, Mark, Austin
IPC分类号： G01N33/487
CPC分类号： G01N21/05 , G01N21/31
摘要： A system and method for in vitro analysis of therapeutic agents comprising a reservoir adapted to hold a therapeutic agent, a first flow cell having a first cell chamber adapted to receive at least a first sample of the therapeutic agent, a second flow cell having a second cell chamber adapted to receive at least a second sample of the therapeutic agent, the first flow cell having a first path length (b e ') and the second flow cell having a second path length (b e "), the first path length being substantially equal to a sensitivity factor (f) x b e ", a membrane chamber having a biological cell membrane therein adapted to receive at least a third sample of the therapeutic agent, the membrane chamber being further adapted to detect the membrane potential of the biological cell membrane; and spectroscopic detection means for detecting the spectral characteristics of the first and second therapeutic agent samples.
摘要翻译：一种用于体外分析治疗剂的系统和方法，所述治疗剂包括适于保持治疗剂的储存器，具有适于接收所述治疗剂的至少第一样品的第一细胞室的第一流动池，具有第二流体池所述第一流动池具有第一路径长度（be'），所述第二流动池具有第二路径长度（be“），所述第一路径长度基本相等对于敏感性因子（f）x为“，具有其中适于接收至少第三样品的治疗剂的生物细胞膜的膜室，所述膜室还适于检测所述生物细胞膜的膜电位; 以及用于检测第一和第二治疗剂样品的光谱特性的光谱检测装置。

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