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1. 发明申请

WO2008059042A1 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS 审中-公开
标题翻译： 2-羧基噻吩衍生物作为反病毒剂
公开(公告)号：WO2008059042A1
公开(公告)日：2008-05-22
申请号：PCT/EP2007/062431
申请日：2007-11-15
申请人： SMITHKLINE BEECHAM CORPORATION , GRIMES, Richard Martin , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
发明人： GRIMES, Richard Martin , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
IPC分类号： C07D409/04 , C07D409/10 , C07D409/12
CPC分类号： C07D417/12 , C07D333/38 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2和R 3如本说明书中所定义提供其制备方法及其在HCV治疗中的应用。

2. 发明申请

WO2008043791A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2008043791A2
公开(公告)日：2008-04-17
申请号：PCT/EP2007/060779
申请日：2007-10-10
申请人： SMITHKLINE BEECHAM CORPORATION , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
发明人： HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
IPC分类号： C07D409/12 , C07D471/04 , C07D491/04 , C07D513/04 , A61K31/381 , A61K31/395 , A61P31/12
CPC分类号： C07D409/12 , C07D471/04 , C07D491/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I) : wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2和R 3如本说明书中所定义提供其制备方法及其在HCV治疗中的应用。

3. 发明申请

WO2007039146A1 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 4-羧基吡唑衍生物作为反病毒剂
公开(公告)号：WO2007039146A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/009238
申请日：2006-09-21
申请人： SMITHKLINE BEECHAM CORPORATION , BRAVI, Gianpaolo , CHEASTY, Anne Goretti , CORFIELD, John Andrew , GRIMES, Richard Martin , HARRISON, David , HARTLEY, Charles David , HOWES, Peter David , MEDHURST, Katrina Jane , MEESON, Malcolm Lees , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
发明人： BRAVI, Gianpaolo , CHEASTY, Anne Goretti , CORFIELD, John Andrew , GRIMES, Richard Martin , HARRISON, David , HARTLEY, Charles David , HOWES, Peter David , MEDHURST, Katrina Jane , MEESON, Malcolm Lees , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John , WHITE, Gemma Victoria
IPC分类号： C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10 , A61K31/41 , A61P31/12
CPC分类号： C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D493/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 , R 3 and R 4 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R 1，R 2，R 3和R 4 本说明书中定义，其制备方法及其在HCV治疗中的应用。

4. 发明申请

WO2008017688A1 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 2-羧基噻吩衍生物作为反病毒剂
公开(公告)号：WO2008017688A1
公开(公告)日：2008-02-14
申请号：PCT/EP2007/058231
申请日：2007-08-08
申请人： SMITHKLINE BEECHAM CORPORATION , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John
发明人： HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John
IPC分类号： A61K31/519 , C07D487/04 , C07D491/048 , C07D498/04 , C07D513/04 , A61K31/4353 , A61P31/12
CPC分类号： C07D487/04 , C07D491/048 , C07D498/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I) wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：其中A，R 1，R 2和R 3的式（I）化合物的抗病毒剂如说明书中所定义，提供了其制备方法及其在HCV治疗中的应用。

5. 发明申请

WO2009046098A1 NOVEL CYCLIC BORONATE INHIBITORS OF HCV REPLICATION 审中-公开
标题翻译： HCV循环新型循环抑制剂
公开(公告)号：WO2009046098A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078439
申请日：2008-10-01
申请人： SMITHKLINE BEECHAM CORPORATION , ANACOR PHARMACEUTICALS, INC. , FAN, Dazhong , JARVEST, Richard Lewis , LAZARIDES, Linos , LI, Qun , LI, Xianfeng , LIU, Yang , LIAO, Liang , MORDAUNT, Jacqueline Elizabeth , NI, Zhi-jie , PLATTNER, Jacob , QIAN, Xuelei , SLATER, Martin John , WHITE, Gemma Victoria , ZHANG, Yong Kang
发明人： FAN, Dazhong , JARVEST, Richard Lewis , LAZARIDES, Linos , LI, Qun , LI, Xianfeng , LIU, Yang , LIAO, Liang , MORDAUNT, Jacqueline Elizabeth , NI, Zhi-jie , PLATTNER, Jacob , QIAN, Xuelei , SLATER, Martin John , WHITE, Gemma Victoria , ZHANG, Yong Kang
IPC分类号： A61K31/69 , C07F5/02 , C07K5/08 , A61P31/14
CPC分类号： C07F7/10 , A61K31/69 , A61K38/05 , A61K38/21 , C07F5/025 , C07F7/1844 , C07K5/0821 , A61K2300/00
摘要： Compounds of formula (I) or a salt thereof are provided; wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 8 , R 20 , R 30 , Y, Z and n are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicaments for treating viral infection, especially HCV infection are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：提供式（I）化合物或其盐; 其中R 1，R 2，R 3，R 4，R 6，R 8，R 20，R 30，Y，Z和n如说明书中所定义。还公开了化合物作为药物的用途，以及用于制备用于治疗病毒感染的药物，特别是HCV感染。本发明还包括制备这些化合物及其药物制剂的方法。

6. 发明申请

WO2009000818A1 3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译：作为丙型肝炎病毒抑制剂的3-羰基亚氨基二羟基-2-羧酸
公开(公告)号：WO2009000818A1
公开(公告)日：2008-12-31
申请号：PCT/EP2008/057984
申请日：2008-06-24
申请人： SMITHKLINE BEECHAM CORPORATION , HARRISON, David , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SLATER, Martin John
发明人： HARRISON, David , HARTLEY, Charles David , MORDAUNT, Jacqueline Elizabeth , SLATER, Martin John
IPC分类号： C07D487/04 , A61K31/381 , A61K31/519 , A61P31/12
CPC分类号： C07D487/02 , C07D333/36 , C07D403/10 , C07D487/12
摘要： The present invention relates to novel 2-carboxy thiophene compounds of the formula (I): and salts thereof, to pharmaceutical compositions containing them and their use in medicine, as anti-viral agents. Specifically, the present invention relates to compounds as inhibitors of Hepatitis C Virus (HCV) replication.
摘要翻译：本发明涉及式（I）的新型2-羧基噻吩化合物及其盐，其含有它们的药物组合物及其在医药中的用途作为抗病毒剂。具体地，本发明涉及作为丙型肝炎病毒（HCV）复制抑制剂的化合物。

7. 发明申请

WO2008125599A1 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 2-羧基噻吩衍生物作为反病毒剂
公开(公告)号：WO2008125599A1
公开(公告)日：2008-10-23
申请号：PCT/EP2008/054381
申请日：2008-04-10
申请人： SMITHKLINE BEECHAM CORPORATION , HARRISON, David , HOWES, Peter David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John
发明人： HARRISON, David , HOWES, Peter David , MORDAUNT, Jacqueline Elizabeth , SHAH, Pritom , SLATER, Martin John
IPC分类号： C07D409/10 , C07D417/10 , A61K31/381 , A61P31/12
CPC分类号： C07D417/10 , C07D409/10
摘要： Anti-viral agents of compounds of Formula (I) : wherein A, R x , R y , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译：式（I）化合物的抗病毒剂：其中A，R x，R y，R 2和R 3 本说明书中定义，其制备方法及其在HCV治疗中的应用。

8. 发明申请

WO2004076415A1 1- (HETERO)AROYL-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS ANTI.VIRAL AGENTS 审中-公开
标题翻译：用作抗病毒剂的1-（异噻唑）亚油酰基吡咯烷-2-羧酸衍生物
公开(公告)号：WO2004076415A1
公开(公告)日：2004-09-10
申请号：PCT/EP2004/002021
申请日：2004-02-25
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , BURTON, George , HOWES, Peter David , KIESOW, Terence John , KU, Thomas, W. , SHAH, Pritom , SLATER, Martin John
发明人： BRAVI, Gianpaolo , BURTON, George , HOWES, Peter David , KIESOW, Terence John , KU, Thomas, W. , SHAH, Pritom , SLATER, Martin John
IPC分类号： C07D207/16
CPC分类号： C07D417/04 , C07D207/16
摘要： Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents SOnRa; n is 1 or 2; Ra represents optionally substituted C1-6alkyl or aryl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的抗病毒剂，其中：A表示羟基; D表示芳基或杂芳基; E表示氢，C 1-6烷基，芳基，杂芳基或杂环基; G代表SOnRa; n为1或2; R a表示任选取代的C 1-6烷基或芳基; J表示C 1-6烷基，杂环基烷基，芳烷基或杂芳基烷基; 及其盐，溶剂化物和酯; 条件是当A被酯化形成-OR时，其中R选自直链或支链烷基，芳烷基，芳氧基烷基或芳基，则R不是叔丁基; 提供了其制备方法及其在HCV治疗中的使用方法。

9. 发明申请

WO2005103045A1 ACYL DIHYDRO PYRROLE DERIVATIVES AS HCV INHIBITORS 审中-公开
公开(公告)号：WO2005103045A1
公开(公告)日：2005-11-03
申请号：PCT/EP2005/004270
申请日：2005-04-20
申请人： GLAXO GROUP LIMITED , HAIGH, David , SLATER, Martin John
发明人： HAIGH, David , SLATER, Martin John
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： Novel anti-viral agents of Formula (I) in which: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C 1-6 alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or C 1-6 alkyl optionally substituted by one or more substituents selected from halo, OR 1 , SR 1 , C(O)NR 2 R 3 , CO 2 H, C(O)R 4 , CO 2 R 4 , NR 2 R 3 , NHC(O)R 4 , NHCO 2 R 4 , NHC(O)NR 5 R 6 , SO 2 NR 5 R 6 , SO 2 R 4 , nitro, cyano, aryl, heteroaryl and heterocyclyl; R 1 represents hydrogen, C 1-6 alkyl, arylalkyl, or heteroarylalkyl; R 2 and R 3 are independently selected from hydrogen, C 1-6 alkyl, aryl and heteroaryl; or R 2 and R 3 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R 4 is selected from the group consisting of C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R 5 and R 6 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and J represents C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert -butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒剂，其中：A表示羟基; D表示芳基或杂芳基; E表示氢，C 1-6烷基，芳基，杂芳基或杂环基; G表示氢或任选被一个或多个选自卤素，OR 1，SR 1，C（O）NR 2 R 3，CO 2 H，C（O）R 4的取代基取代的C 1-6烷基，CO 2 R 4，NR 2 R 3，NHC（O）R 4，NHCO 2 R 4，NHC（O）NR 5 R 6，SO 2 NR 5 R 6 SO 2 R 4，硝基，氰基，芳基，杂芳基和杂环基; R 1表示氢，C 1-6烷基，芳烷基或杂芳基烷基; R 2和R 3独立地选自氢，C 1-6烷基，芳基和杂芳基; 或R 2和R 3与它们所连接的氮原子一起形成5或6元饱和的环状基团; R 4选自C 1-6烷基，芳基，杂芳基，芳烷基和杂芳基烷基; R 5和R 6独立地选自氢，C 1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; 或R 5和R 6与它们所连接的氮原子一起形成5或6元饱和环状基团; 并且J表示C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 及其盐，溶剂化物和酯; 条件是当A被酯化形成-OR时，其中R选自直链或支链烷基，芳烷基，芳氧基烷基或芳基，则R不是叔丁基; 提供其制备方法，包含它们的药物组合物，以及在HCV治疗中使用它们的方法。

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