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1. 发明申请

WO2006102106A1 METHODS FOR MODULATED DEGENERATIVE TRANSFER LIVING POLYMERIZATION AND ISOTACTIC-ATACTIC STEREOBLOCK AND STEREOGRADIENT POLY(OLEFINS) THEREBY 审中-公开
标题翻译：用于调节退化转移活性聚合和等规偶合立体锁定和立构聚（烯烃）的方法
公开(公告)号：WO2006102106A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/009767
申请日：2006-03-17
申请人： SITA, Lawrence, R. , HARNEY, Matthew, B. , ZHANG, Yonghui
发明人： SITA, Lawrence, R. , HARNEY, Matthew, B. , ZHANG, Yonghui
IPC分类号： C08F110/06 , C08F210/06
CPC分类号： C08L53/00 , C08F210/14 , C08F297/04 , C08F297/06 , C08F297/08 , C08F297/083 , C08F297/086 , C08L53/02 , C08L2207/14 , Y10T428/298 , C08L2666/02 , C08F2500/15
摘要： Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures.
摘要翻译：用于调节的退化转移活性聚合和全同立构无规立构嵌段和立体定向聚（烯烃）的方法摘要公开了一种制备具有基本均匀微结构的多嵌段立体嵌段聚烯烃的方法。该方法包括使齐格勒 - 纳塔预催化剂与助催化剂和烯烃接触以使烯烃聚合并形成第一立体嵌段，加入改变聚合的立构规整性的甲基供体，并使烯烃聚合形成第二立体嵌段。本发明的方法允许生产具有可预见的已知类型的立体异构体结合度的聚（烯烃）。该方法可以生产各种聚烯烃微结构，范围从立体嵌段到立体定向聚（烯烃）和具有完全全同立构到完全无规立构微结构的聚（烯烃）。

2. 发明申请

WO2006102119A2 METHODS FOR MODULATED DEGENERATIVE TRANSFER LIVING POLYMERIZATION AND ISOTACTIC-ATACTIC STEREOBLOCK AND STEREOGRADIENT POLY(OLEFINS) THEREBY 审中-公开
标题翻译：用于调节变性转移聚合和等位基因的立体异构体和立体聚合物（烯烃）的方法
公开(公告)号：WO2006102119A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/009793
申请日：2006-03-17
申请人： SITA, Lawrence, R. , HARNEY, Matthew, B. , ZHANG, Yonghui
发明人： SITA, Lawrence, R. , HARNEY, Matthew, B. , ZHANG, Yonghui
IPC分类号： C08L67/02
CPC分类号： C08F110/06 , C08F4/65908 , C08F10/00 , C08F110/14 , C08F293/005 , C08F297/08 , C08F297/083 , C08F4/6592 , C08F2500/15
摘要： Methods for modulated degenerative transfer living polymerization and isotactic-atactic stereoblock and stereogradient poly(olefins) thereby Abstract A method of producing a multiblock, stereoblock polyolefin having substantially uniform microstructure is disclosed. The method includes contacting a Ziegler-Natta pre-catalyst with a co-catalyst and an olefin to polymerize the olefin and form a first stereoblock, adding a methyl donator that changes the stereoregularity of the polymerization, and polymerizing the olefin to form a second stereoblock. The methods of the present invention allow for the production of poly(olefin)s having predictable degrees of incorporation of stereoerrors of a known type. The methods allows for the production of a variety of poly(olefin) microstructures, ranging from stereoblock to stereogradient poly(olefin)s and poly(olefin)s having fully isotactic to fully atactic microstructures.
摘要翻译：本发明公开了一种制备具有基本一致的微观结构的多嵌段立体嵌段聚烯烃的方法，其中所述方法包括调节退化转移活性聚合和全同立构立构嵌段和立体聚合的聚（烯烃）的方法。该方法包括使齐格勒 - 纳塔预催化剂与助催化剂和烯烃接触以使烯烃聚合并形成第一个立体嵌段，加入改变聚合的立构规整性的甲基供体，并使烯烃聚合形成第二个立体嵌段。本发明的方法允许生产具有已知类型的立体错误的可预测掺入程度的聚（烯烃）。该方法允许生产各种聚（烯烃）微观结构，范围从立体嵌段到立体梯度聚（烯烃）和具有完全全同立构的聚（烯烃）完全无规立构微结构。

3. 发明申请

WO2009135225A1 MULTI-PRODUCT-MULTI-CHANNEL PAYMENT PLATFORM SYSTEM AND METHOD 审中-公开
标题翻译：多产品多通道支付平台系统及方法
公开(公告)号：WO2009135225A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042757
申请日：2009-05-04
申请人： CASHEDGE, INC. , PANTHAKI, Behram , BHAGAVATULA, Krishna , BOWMAN, Richard , BHATIA, Vishal , PARIAL, Diya , ALI, Nash , SUNDERJI, Amir , SOKOLIC, Jeremy , ZHANG, Yonghui
发明人： PANTHAKI, Behram , BHAGAVATULA, Krishna , BOWMAN, Richard , BHATIA, Vishal , PARIAL, Diya , ALI, Nash , SUNDERJI, Amir , SOKOLIC, Jeremy , ZHANG, Yonghui
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q20/10 , G06Q20/40
摘要： Described herein is a multi-product-multi-channel payment platform system and apparatus that extends the capability of current online banking/funds-transfer systems Different types of financial accounts are modeled in a financial management system to enable types of online, electronic funds transfer transaction that were not previously possible. Among novel elements of the system and apparatus disclosed is the enablement of real-time application of rules to different types of financial accounts and/or products across channels, such as how much money may be deposited or withdrawn in a period of time.
摘要翻译：这里描述的是一种多产品多渠道支付平台系统和装置，其扩展了当前网上银行/资金转移系统的能力。不同类型的金融账户被建立在财务管理系统中，以实现类型的在线电子资金转账以前没有可能的交易。所公开的系统和装置的新颖元素是能够将规则实时地应用于跨渠道的不同类型的财务账户和/或产品，例如在一段时间内可以存入或撤回多少钱。

4. 发明申请

WO2008128056A1 BISPHOSPHONATE COMPOUNDS AND METHODS WITH ENHANCED POTENCY FOR MULTIPLE TARGETS INCLUDING FPPS, GGPPS, AND DPPS 审中-公开
标题翻译：双膦酸盐化合物和具有增强靶点的方法，包括FPPS，GGPPS和DPPS
公开(公告)号：WO2008128056A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/060051
申请日：2008-04-11
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , OLDFIELD, Eric , ZHANG, Yonghui
发明人： OLDFIELD, Eric , ZHANG, Yonghui
IPC分类号： C07F9/576 , C07F9/6503
CPC分类号： C07F9/3865 , C07F9/386 , C07F9/3873 , C07F9/5414 , C07F9/581 , C07F9/587 , C07F9/65061 , C07F9/65517 , C07F9/655345 , C07F9/65583 , C07F9/6561 , C07F9/723 , G01N33/5011
摘要： The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.
摘要翻译：本公开尤其提供了新的双膦酸盐化合物以及制备和使用这些化合物的方法。在某些实施方案中，本发明的化合物包括能够选择性抑制法呢基二磷酸合成酶（FPPS），香叶基香叶基二磷酸合成酶（GGPPS）和癸酰焦磷酸合酶（DPPS）中的一种或多种的双膦酸盐。在优选的实施方案中，本发明的化合物能够选择性地抑制FPPS，GGPPS和DPPS中的两种或更多种。在实施方案中，本发明的化合物和方法表现出优异的活性水平，例如在抗癌情境，免疫刺激背景和其他情况下，其在若干情况下超过前一代二膦酸药物的活性水平达数量级。在实施方案中，本发明提供了与研究和治疗应用相关的化合物和方法，例如用于肿瘤或癌细胞生长抑制，Gammadelta T细胞的活化，与甲羟戊酸代谢途径相关的某些酶的抑制，骨吸收疾病，癌症，免疫疾病，免疫治疗和传染病。

5. 发明申请

WO2006039721A2 BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES 审中-公开
标题翻译：双膦酸盐化合物和骨质疏松症，癌症，骨骼疼痛，免疫缺陷病毒和感染性疾病的方法
公开(公告)号：WO2006039721A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/036425
申请日：2005-10-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , SANDERS, John M. , SONG, Yongcheng , CHAN, Julian M. W. , OLDFIELD, Eric , ZHANG, Yonghui
发明人： SANDERS, John M. , SONG, Yongcheng , CHAN, Julian M. W. , OLDFIELD, Eric , ZHANG, Yonghui
IPC分类号： H05B33/04 , H05B33/00
CPC分类号： C07F9/3873 , C07F9/581 , C07F9/582 , C07F9/60 , C07F9/62 , C07F9/65061 , C07F9/65583
摘要： Bishosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.
摘要翻译：公开了二膦酸盐化合物及其制备和应用的相关方法，包括吡啶鎓-1-基，喹啉鎓-1-基和相关化合物。在功能测定的上下文中公开了化合物的活性，例如

6. 发明申请

WO2011044505A2 ENZYME INHIBITING COMPOUNDS AND METHODS 审中-公开
标题翻译：酶抑制化合物和方法
公开(公告)号：WO2011044505A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/052049
申请日：2010-10-08
申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , OLDFIELD, Eric , WANG, Ke , WANG, Weixue , ZHANG, Yonghui
发明人： OLDFIELD, Eric , WANG, Ke , WANG, Weixue , ZHANG, Yonghui
IPC分类号： C07F9/09 , C07F9/40 , A61K31/6615 , A61K31/663 , A61P31/04
CPC分类号： C07F9/65502 , A61K31/6615 , A61K31/663 , C07F9/098 , C07F9/141 , C07F9/1411 , C07F9/142 , C07F9/143 , C07F9/581 , C07F9/582 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/481
摘要： The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.
摘要翻译：本发明提供了用于研究罗氏途径和治疗细菌感染或寄生虫感染的化合物，组合物和方法。寄生虫感染可能是原生动物感染，如疟疾。化合物和组合物也可以用作抗生素，例如杀死细菌或寄生虫，或抑制细菌或寄生虫生长。本发明还提供类异戊二烯生物合成酶的抑制剂，以及抑制类异戊二烯生物合成酶活性的方法。化合物可以是例如结合异戊二烯生物合成酶的Fe4S4簇的独特Fe的炔或烯。

7. 发明申请

WO2014089226A1 ANTIBACTERIAL COMPOUNDS TARGETING ISOPRENOID BIOSYNTHESIS 审中-公开
标题翻译：抗真菌化合物对异丙酚生物合成
公开(公告)号：WO2014089226A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073148
申请日：2013-12-04
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ZHU, Wei , LINDERT, Steffen , ZHANG, Yonghui , SINKO, William , LI, Kai , MCCAMMON, James Andrew , OLDFIELD, Eric
发明人： ZHU, Wei , LINDERT, Steffen , ZHANG, Yonghui , SINKO, William , LI, Kai , MCCAMMON, James Andrew , OLDFIELD, Eric
IPC分类号： C07C257/18 , C07D403/12 , C07D403/14 , C07H15/203 , A61K31/4178 , A61K31/551 , A61K31/7034 , A61P31/04
CPC分类号： C07H15/26 , A61K31/167 , A61K31/4178 , A61K31/43 , A61K31/4439 , A61K31/506 , A61K31/551 , A61K31/7034 , A61K31/7056 , C07D209/08 , C07D233/24 , C07D239/06 , C07D239/28 , C07D243/04 , C07H15/203
摘要： With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug targets such as UPPS and FPPS by interacting with binding pockets, thereby preventing enzyme function. Compounds described herein are also active against Staphylococcus aureus (MIC90 ~0.25 µg/mL), can potently synergize with methicillin (fractional inhibitory concentration index = 0.25), and are protective in a mouse infection model. The invention therefore provides numerous compounds for anti-bacterial treatments and for restoring sensitivity to drugs such as methicillin, using combination therapies.
摘要翻译：随着抗生素如甲氧西林的抗药性上升，需要新药。本发明提供了通过与结合袋相互作用来抑制细胞药物靶标如UPPS和FPPS的小分子，从而防止酶功能。本文所述的化合物对金黄色葡萄球菌（MIC90〜0.25μg/ mL）也具有活性，可以与甲氧西林（分数抑制浓度指数= 0.25）有效协同，并且在小鼠感染模型中是保护性的。因此，本发明提供了许多用于抗菌处理的化合物，并且使用联合疗法来恢复药物如甲氧西林的敏感性。

8. 发明申请

WO2007109585A2 BISPHOSPHONATE COMPOUNDS AND METHODS 审中-公开
标题翻译：二磷酸盐化合物和方法
公开(公告)号：WO2007109585A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/064239
申请日：2007-03-16
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , OLDFIELD, Eric , SONG, Yongcheng , ZHANG, Yonghui , SANDERS, John M.
发明人： OLDFIELD, Eric , SONG, Yongcheng , ZHANG, Yonghui , SANDERS, John M.
IPC分类号： A61K31/663
CPC分类号： C07F9/4037 , C07F9/3843 , C07F9/3856 , C07F9/3865 , C07F9/3869 , C07F9/3873 , C07F9/4028 , C07F9/404 , C07F9/4046 , C07F9/5414 , C07F9/5728 , C07F9/581 , C07F9/65061 , C07F9/655345 , C07F9/655363 , C07F9/723
摘要： The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.
摘要翻译：本发明尤其提供新的双膦酸盐化合物及其制备和使用方法。在实施方案中，本发明提供了与研究和治疗应用相关的化合物和方法，例如用于肿瘤细胞生长抑制，Gammadelta T细胞的活化，法呢基二磷酸（FPPS）和/或十一烷基二磷酸合成酶的抑制，骨吸收疾病，癌症，免疫疾病，免疫治疗和传染病。关于某些实施方案，令人惊奇的进步是认识到某些结构特征可以显着增强化合物的活性。例如，当位于二膦酸盐部分附近时，特定的阳离子物质例如鏻，锍和钍部分的存在可以有助于所需的功能活性。在非含氮双膦酸盐的其它实施方案中，提供了三联苯基和苄基双膦酸盐化合物和方法。还提供了进一步的变化。

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