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1. 发明申请

WO2022264096A1 COMBINATION OF EXISTING DRUGS TO REPAIR THE ACTION POTENTIALS OF CELLS 审中-公开
公开(公告)号：WO2022264096A1
公开(公告)日：2022-12-22
申请号：PCT/IB2022/055624
申请日：2022-06-17
申请人： SIMULA INNOVATION
发明人： JAEGER, Karoline Horgmo , TVEITO, Aslak
IPC分类号： G01N33/487 , G16C20/50 , A61K45/06 , G01N33/48728 , G16B5/00 , G16C20/30 , G16H20/10
摘要： A process is provided for using a model to identify potential combinations of drugs to repair an action potential. A model is created for the normal state of an action potential along with a model for an abnormal state that reflects the effect of a disease or mutation on the action potential. Using a known action potential, a treated state can be generated that represents the abnormal state modified by one or more drug effects. By optimizing a formulation for a drug combination to minimize the differences between the treated state model and the normal state model, a combination of drug therapies that can potentially repair an action potential can be identified.

2. 发明申请

WO2019150328A1 METHODS FOR DETERMINING DRUG EFFECTS 审中-公开
公开(公告)号：WO2019150328A1
公开(公告)日：2019-08-08
申请号：PCT/IB2019/050840
申请日：2019-02-01
申请人： SIMULA INNOVATION
发明人： TVEITO, Aslak , WALL, Samuel , JAEGER, Karoline Horgmo
IPC分类号： G16H50/50 , G16B5/20
CPC分类号： G01N33/5061 , C12N5/0657 , G01N33/5026 , G01N33/52 , G01N33/6872 , G01N2458/30 , G01N2500/10 , G16B5/20 , G16H50/50
摘要： The present invention provides a method for determining the effect of a drug on a mature cardiomyocyte. In some embodiments, the method comprises using transmembrane voltage and/or intracellular calcium data obtained from control immature cardiomyocytes and those that have been contacted with the drug to parameterize models of immature cardiomyocytes, then applying a maturation matrix to generate a mature cardiomyocyte model. The method is useful for, among other things, predicting whether a drug may have proarrhythmic properties and for determining whether a particular drug should be administered to a patient.

3. 发明申请

WO2009156194A1 COMPUTATION OF DRUG COMPOSITION 审中-公开
标题翻译：药物组合物的计算
公开(公告)号：WO2009156194A1
公开(公告)日：2009-12-30
申请号：PCT/EP2009/053739
申请日：2009-03-30
申请人： SIMULA INNOVATION AS , TVEITO, Aslak , LINES, Glenn T.
发明人： TVEITO, Aslak , LINES, Glenn T.
IPC分类号： G06F19/00
CPC分类号： G06F19/706 , G06F19/12
摘要： The invention relates to the computing of a desired composition of a drug. A test drug is defined in terms of a number of components, where each component represents an effect to normal cells and to pathogenic cells. A drug model is accessed, and based on the drug model, the weight of each component of the test drug is determined by minimizing the difference in a predefined physiological property. The minimization is done between the normal cell after the test drug has been applied and the normal cell prior to applying the test drug, and between the pathogenic cell after the test drug has been applied and the normal cell prior to applying the test drug. The desired composition of the test drug is set as the composition defined by the weights of the components. In embodiments, the physiological property is the action potential of cardiac cells, the pathogenic cells are ischemic cells and the desired drug is an anti-arrhythmic drug.
摘要翻译：本发明涉及药物所需组合物的计算。测试药物是根据许多组分定义的，其中每个组分代表对正常细胞和致病细胞的影响。访问药物模型，并且基于药物模型，通过最小化预定的生理特性的差异来确定测试药物的每个组分的重量。在施用试验药物后的正常细胞与施用试验药物之前的正常细胞之间以及施用试验药物后的致病细胞与施用试验药物之前的正常细胞之间进行最小化。测试药物的所需组成设定为由组分重量定义的组成。在实施方案中，生理特性是心脏细胞的动作电位，致病细胞是缺血细胞，所需药物是抗心律不齐药物。

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