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1. 发明申请

WO2013071219A1 METHOD AND SYSTEM FOR MULTI-SCALE ANATOMICAL AND FUNCTIONAL MODELING OF CORONARY CIRCULATION 审中-公开
标题翻译：冠状循环的多尺度解剖学和功能建模方法与系统
公开(公告)号：WO2013071219A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064604
申请日：2012-11-12
申请人： SIEMENS CORPORATION , SHARMA, Puneet , ITU, Lucian Mihai , GEORGESCU, Bogdan , MIHALEF, Viorel , KAMEN, Ali , COMANICIU, Dorin
发明人： SHARMA, Puneet , ITU, Lucian Mihai , GEORGESCU, Bogdan , MIHALEF, Viorel , KAMEN, Ali , COMANICIU, Dorin
IPC分类号： G06F19/00
CPC分类号： G06F19/12 , G06F19/00 , G06F19/321 , G16H50/30 , G16H50/50
摘要： A method and system for multi-scale anatomical and functional modeling of coronary circulation is disclosed. A patient-specific anatomical model of coronary arteries and the heart is generated from medical image data of a patient. A multi-scale functional model of coronary circulation is generated based on the patient-specific anatomical model. Blood flow is simulated in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. Hemodynamic quantities, such as fractional flow reserve (FFR), are computed to determine a functional assessment of the stenosis, and virtual intervention simulations are performed using the multi-scale function model of coronary circulation for decision support and intervention planning.
摘要翻译：公开了一种用于冠状循环多尺度解剖和功能建模的方法和系统。冠状动脉和心脏的患者特异性解剖模型由患者的医学图像数据产生。基于患者特异性解剖模型产生冠状动脉循环的多尺度功能模型。使用冠状动脉循环的多尺度功能模型在至少一个冠状动脉的至少一个狭窄区域中模拟血流量。计算血流动力学量，例如分数流量储备（FFR），以确定狭窄的功能评估，并使用冠状动脉循环的多尺度函数模型进行虚拟干预模拟，以进行决策支持和干预计划。

2. 发明申请

WO2013138428A1 A FRAMEWORK FOR PERSONALIZATION OF CORONARY FLOW COMPUTATIONS DURING REST AND HYPEREMIA 审中-公开
标题翻译：在休息和高血压期间进行冠状动脉计算的个性化框架
公开(公告)号：WO2013138428A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/030732
申请日：2013-03-13
申请人： SIEMENS AKTIENGESELLSCHAFT , ITU, Lucian, Mihai , SHARMA, Puneet , ZHENG, Xudong , KAMEN, Ali , SUCIU, Constantin , COMANICIU, Dorin
发明人： ITU, Lucian, Mihai , SHARMA, Puneet , ZHENG, Xudong , KAMEN, Ali , SUCIU, Constantin , COMANICIU, Dorin
IPC分类号： A61B5/026 , G06F19/00 , A61B5/02 , A61B5/022 , A61B5/024
CPC分类号： G06F19/3437 , A61B5/02007 , A61B5/02028 , A61B5/021 , A61B5/022 , A61B5/024 , A61B5/026 , A61B5/055 , A61B6/032 , A61B6/481 , A61B8/0891 , G06F19/00 , G16H50/50
摘要： Embodiments relate to non-invasively determining coronary circulation parameters during a rest state and a hyperemic state for a patient. The blood flow in the coronary arteries during a hyperemic state provides a functional assessment of the patient's coronary vessel tree. Imaging techniques are used to obtain an anatomical model of the patient's coronary tree. Rest boundary conditions are computed based on non-invasive measurements taken at a rest state, and estimated hyperemic boundary conditions are computed. A feedback control system performs a simulation matching the rest state utilizing a model based on the anatomical model and a plurality of controllers, each controller relating to respective output variables of the coronary tree. The model parameters are adjusted for the output variables to be in agreement with the rest state measurements, and the hyperemic boundary conditions are accordingly adjusted. The hyperemic boundary conditions are used to compute coronary flow and coronary pressure variables.
摘要翻译：实施例涉及在休息状态和患者的充血状态期间非侵入性地确定冠状动脉循环参数。在充血状态期间冠状动脉中的血流量提供对患者冠状动脉血管树的功能评估。成像技术用于获得患者冠状动脉树的解剖模型。休息边界条件是基于在静止状态下进行的非侵入性测量计算的，并且计算估计的充血边界条件。反馈控制系统利用基于解剖模型的模型和多个控制器执行与休息状态匹配的模拟，每个控制器涉及冠状动脉树的相应输出变量。调整模型参数以使输出变量与其余状态测量一致，并相应调整充电边界条件。充血边界条件用于计算冠状动脉血流和冠状动脉压力变量。

3. 发明申请

WO2004017938A2 NITROFURANTOIN CONTROLLED RELEASE DOSAGE FORM 审中-公开
标题翻译： NITROFURANTOIN控释释药剂型
公开(公告)号：WO2004017938A2
公开(公告)日：2004-03-04
申请号：PCT/IB2003/003517
申请日：2003-08-25
申请人： RANBAXY LABORATORIES LIMITED , SHARMA, Puneet , KUMAR, Pananchukunnath, Manoj , NAGAPRASAD, Vishnubhotla , ROY, Sunilendu, Bhushan , MALIK, Rajiv
发明人： SHARMA, Puneet , KUMAR, Pananchukunnath, Manoj , NAGAPRASAD, Vishnubhotla , ROY, Sunilendu, Bhushan , MALIK, Rajiv
IPC分类号： A61K9/00
CPC分类号： A61K9/4808 , A61K9/2027 , A61K9/2054 , A61K9/5084 , A61K31/4178
摘要： The present invention generally relates to controlled release dosage forms which provide immediate release and sustained release of nitrofurantoin, and processes for their preparation. The controlled release dosage form includes a sustained release portion and an immediate release portion. The sustained release portion includes nitrofurantoin and one or more pH dependent hydrophilic polymers. The immediate release portion includes nitrofurantoin.
摘要翻译：本发明一般涉及提供呋喃妥因立即释放和持续释放的控释剂型及其制备方法。控释剂型包括持续释放部分和立即释放部分。持续释放部分包括呋喃妥因和一种或多种pH依赖性亲水性聚合物。即时释放部分包括呋喃妥因。

4. 发明申请

WO2012162047A2 SYSTEM AND METHOD OF IMPROVED GROUP COLLABORATION 审中-公开
标题翻译：改进集团合作的制度与方法
公开(公告)号：WO2012162047A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/038073
申请日：2012-05-16
申请人： SHARMA, Puneet
发明人： SHARMA, Puneet
CPC分类号： G06Q10/10
摘要： Technologies are described herein for delivering continuous high performance using a multi¬ stage group perspective collaboration system. In one aspect, a processor presents a user interface through which users of a group can collaborate with one another. A first perspective from a user of the group is received at a first stage of maturation. The first perspective is then presented as a first stage thread to the group for collaboration. The system determines whether an elevation condition has been met to elevate the first stage thread to a second stage of maturation. Upon determining that the elevation condition has been met, the system determines whether content similar to content associated with the first stage thread exists. Upon determining that content similar to content associated with the first stage thread does not exist, the system elevates the first stage thread from the first stage of maturation to the second stage of maturation.
摘要翻译：技术在这里被描述为使用多级组透视协作系统提供连续的高性能。在一个方面，处理器呈现用户界面，组中的用户可以通过该界面彼此协作。在成熟的第一阶段接收来自组的用户的第一透视图。然后将第一个视角作为第一阶段的线索呈现给该组进行协作。系统确定是否满足升高条件以将第一级线程升高到第二级成熟阶段。在确定已经满足高程条件时，系统确定是否存在与第一级线程相关联的内容类似的内容。在确定与第一阶段线程相关联的内容类似的内容不存在时，系统将第一阶段线程从第一成熟阶段升高到第二阶段成熟。

5. 发明申请

WO2006062623A1 DETERMINING HIGHEST WORKLOADS FOR NODES IN AN OVERLAY NETWORK 审中-公开
标题翻译：确定覆盖网络中的节点的最高工作负载
公开(公告)号：WO2006062623A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/039257
申请日：2005-10-31
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L. P. , BASU, Sujoy , BANERJEE, Sujata , SHARMA, Puneet , LEE, Sung-Ju
发明人： BASU, Sujoy , BANERJEE, Sujata , SHARMA, Puneet , LEE, Sung-Ju
IPC分类号： H04L29/08 , H04L29/06
CPC分类号： H04L67/104 , H04L45/02 , H04L45/26 , H04L67/1002 , H04L67/1008 , H04L67/1029 , H04L67/1093 , H04L67/16
摘要： Nodes (130) in a network (210) are operable to provide an information service. A set of the nodes having a highest workload are identified by routing a list of workloads (712) for the nodes through the network (210) to a final destination (701). Each node receiving the list (712) determines whether to include a workload of a respective node in the list (712).
摘要翻译：网络（210）中的节点（130）可操作以提供信息服务。通过将通过网络（210）的节点的工作负载（712）的列表路由到最终目的地（701）来识别具有最高工作负荷的一组节点。接收列表（712）的每个节点确定是否在列表中包括相应节点的工作负荷（712）。

6. 发明申请

WO2020214173A1 HEURISTIC-BASED SD-WAN ROUTE RECONFIGURATION 审中-公开
公开(公告)号：WO2020214173A1
公开(公告)日：2020-10-22
申请号：PCT/US2019/028058
申请日：2019-04-18
申请人： HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP , ZAD TOOTAGHAJ, Diman , SHARMA, Puneet , AHMED, Faraz
发明人： ZAD TOOTAGHAJ, Diman , SHARMA, Puneet , AHMED, Faraz
IPC分类号： H04L12/721 , H04L12/715 , H04L12/801 , H04L12/24
摘要： An example network orchestrator includes processing circuitry and a memory. The memory includes instructions that cause the network orchestrator to receive network probe information including delay times of network probes associated with a set of flows between devices. The instructions further cause the network orchestrator to generate a correlation matrix including correlations representing shared congested links between pairs of flows. The instructions further cause the network orchestrator to for each flow of the set of flows, determine a routing solution optimized for the each flow and select a total minimum cost solution from the determined routing solutions.

7. 发明申请

WO2013137875A1 ALLOCATING BANDWIDTH IN A NETWORK 审中-公开
标题翻译：在网络中分配带宽
公开(公告)号：WO2013137875A1
公开(公告)日：2013-09-19
申请号：PCT/US2012/029109
申请日：2012-03-14
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , TOURRILHES, Jean , WEBB, Kevin Christopher , BANERJEE, Sujata , MOGUL, Jeffrey Clifford , SHARMA, Puneet , YALAGANDULA, Praveen
发明人： TOURRILHES, Jean , WEBB, Kevin Christopher , BANERJEE, Sujata , MOGUL, Jeffrey Clifford , SHARMA, Puneet , YALAGANDULA, Praveen
IPC分类号： H04L12/28
CPC分类号： H04L47/783 , H04L12/462 , H04L47/12 , H04L47/748 , H04L47/762 , H04L47/822
摘要： Allocating bandwidth in a network (100) may include reducing initial bandwidth allocations for each tenant on a link (113) such that a sum of the bandwidth allocations is equal to or less than a capacity of the link and distributing a residual of the initial bandwidth allocations to at least one under-allocated link (114).
摘要翻译：在网络（100）中分配带宽可以包括减少链路（113）上的每个租户的初始带宽分配，使得带宽分配的总和等于或小于链路的容量并且分配初始带宽的剩余至少分配一个未分配的链路（114）。

8. 发明申请

WO2011153168A1 PHARMACEUTICAL COMPOSITIONS OF IBUPROFEN AND AN H2 RECEPTOR ANTAGONIST 审中-公开
标题翻译： IBUPROFEN和H2受体拮抗剂的药物组合物
公开(公告)号：WO2011153168A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038622
申请日：2011-05-31
申请人： HORIZON PHARMA USA, INC. , TIDMARSH, George , SHARMA, Puneet , DUNCAN, Iain
发明人： TIDMARSH, George , SHARMA, Puneet , DUNCAN, Iain
IPC分类号： A61P29/00
CPC分类号： A61K9/4808 , A61K9/00 , A61K9/209 , A61K31/192 , A61K31/426 , A61M35/00 , A61K2300/00
摘要： Pharmaceutical compositions of a H2 receptor antagonist and ibuprofen are provided herein. The compositions comprise, e.g., a core and a shell separated by a barrier layer, bilayered or trilayered compositions, or liquid formulations. Also provided are methods of making the pharmaceutical compositions, and methods of treatment comprising administering the pharmaceutical compositions. Also provided is a method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which a pharmaceutical composition comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of an H2RA, such as famotidine, is administered three times per day.
摘要翻译：本文提供H2受体拮抗剂和布洛芬的药物组合物。组合物包括例如由阻隔层，双层或三层组合物或液体制剂分离的芯和壳。还提供了制备药物组合物的方法和包括给予药物组合物的治疗方法。还提供了向需要布洛芬治疗的受试者施用布洛芬的方法，其中包含治疗有效量的布洛芬和治疗有效量的例如法莫替丁的H2RA的药物组合物每次施用三次天。

9. 发明申请

WO2008091957A2 PHARMACEUTICAL COMPOSITIONS CONTAINING FAMOTIDINE AND IBUPROFEN AND HAVING IMPROVED CONTENT UNIFORMITY 审中-公开
标题翻译：含有FAMOTIDINE和IBUPROFEN的药物组合物，具有改善的内容均匀性
公开(公告)号：WO2008091957A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051816
申请日：2008-01-23
申请人： HORIZON THERAPEUTICS, INC. , SHARMA, Puneet
发明人： SHARMA, Puneet
IPC分类号： A61K31/192 , A61K31/426 , A61K9/50 , A61K9/16
CPC分类号： A61K9/2081 , A61K9/14 , A61K9/5078 , A61K31/192 , A61K31/426 , A61K2300/00
摘要： The invention provides pharmaceutical compositions containing ibuprofen in combination with a second pharmaceutically active ingredient, such as famotidine. The invention also provides unit dosage forms containing ibuprofen and famotidine. Such unit dosage forms have significantly improved content uniformity.
摘要翻译：本发明提供含有布洛芬与第二种药物活性成分如法莫替丁组合的药物组合物。本发明还提供含有布洛芬和法莫替丁的单位剂型。这种单位剂型具有显着改善的含量均匀性。

10. 发明申请

WO2008011426A2 METHODS AND MEDICAMENTS FOR ADMINISTRATION OF IBUPROFEN 审中-公开
标题翻译： IBUPROFEN的施用方法和药物
公开(公告)号：WO2008011426A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/073716
申请日：2007-07-17
申请人： HORIZON THERAPEUTICS, INC. , TIDMARSH, George , GOLOMBIK, Barry L. , SHARMA, Puneet
发明人： TIDMARSH, George , GOLOMBIK, Barry L. , SHARMA, Puneet
IPC分类号： A61K31/426 , A61K31/192
CPC分类号： A61K31/192 , A61K31/426 , A61K2300/00
摘要： A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine is administered three times per day.
摘要翻译：提供将布洛芬给予需要布洛芬治疗的受试者的方法，其中包含治疗有效量的布洛芬和治疗有效量的法莫替丁的口服剂型每天施用三次。

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