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1. 发明申请

WO2011088211A3 SAMPLING DEVICE INTERFACES 审中-公开
标题翻译：采样设备接口
公开(公告)号：WO2011088211A3
公开(公告)日：2011-12-01
申请号：PCT/US2011021131
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS INC , CHICKERING DONALD E , DAVIS SHAWN , HAGHGOOIE RAMIN , BERNSTEIN HOWARD , LEVINSON DOUGLAS A
发明人： CHICKERING DONALD E , DAVIS SHAWN , HAGHGOOIE RAMIN , BERNSTEIN HOWARD , LEVINSON DOUGLAS A
IPC分类号： A61B5/151
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是自包含的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。在一些情况下，该装置可以与外部设备接口以确定包含在装置内或由装置收集的流体中的分析物。例如，该装置可以安装或接合在外部支架上，该装置可以包括用于将流体输送出装置的端口，该装置可包括询问包含在装置内的流体等的窗口。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

2. 发明申请

WO2011065972A3 PATIENT-ENACTED SAMPLING TECHNIQUE 审中-公开
标题翻译：患者采集采样技术
公开(公告)号：WO2011065972A3
公开(公告)日：2011-09-22
申请号：PCT/US2010003045
申请日：2010-11-24
申请人： SEVENTH SENSE BIOSYSTEMS INC , LEVINSON DOUGLAS A , BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , HAGHGOOIE RAMIN
发明人： LEVINSON DOUGLAS A , BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , HAGHGOOIE RAMIN
IPC分类号： A61M5/32 , A61B5/145 , A61B5/151 , A61B5/154 , A61B5/155 , A61B5/157
CPC分类号： A61B5/150984 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/74 , A61B10/0045 , A61B2010/008 , Y02A90/26
摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.
摘要翻译：本发明总体上涉及用于从主体取样流体的系统和方法。流体可以是任何合适的体液，例如血液或间质液。在某些情况下，受试者是患者。受试者可以具有可以应用于受试者的皮肤（例如受试者或其他人）的装置，并且该装置能够获得流体样本。流体可以存储在装置中的储存器中，并且可以在任何方便的时间（例如在家中，远离保健设置等）从受试者获得流体。在一些实施例中，装置或其一部分，可以返回到临床和/或实验室设置以分析存储在装置内的流体。

3. 发明申请

WO2011053788A3 RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：适用于皮肤的相对小的装置，模块化系统及其使用方法
公开(公告)号：WO2011053788A3
公开(公告)日：2011-07-28
申请号：PCT/US2010054725
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS INC , BERNSTEIN HOWARD , CHICKERING DONALD E , LEVINSON DOUGLAS A , WALT DAVID R , DAVIS SHAWN , HAGHGOOIE RAMIN
发明人： BERNSTEIN HOWARD , CHICKERING DONALD E , LEVINSON DOUGLAS A , WALT DAVID R , DAVIS SHAWN , HAGHGOOIE RAMIN
IPC分类号： A61M5/32 , A61B5/151 , A61B5/157
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.
摘要翻译：本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。在一些方面，设备被构造和布置成具有多个模块。例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体受试者的皮肤。在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周等等，或不超过约一小时，不超过约10分钟等

4. 发明申请

WO2011053787A3 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：用于皮肤的应用以及对促动，递送和/或感知的控制的系统和方法
公开(公告)号：WO2011053787A3
公开(公告)日：2011-09-01
申请号：PCT/US2010054723
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS INC , CHICKERING DONALD E , LEVINSON DOUGLAS A , DAVIS SHAWN , HAGHOOIE RAMIN , BERNSTEIN HOWARD , WALT DAVID R
发明人： CHICKERING DONALD E , LEVINSON DOUGLAS A , DAVIS SHAWN , HAGHOOIE RAMIN , BERNSTEIN HOWARD , WALT DAVID R
IPC分类号： A61M5/32 , A61B5/151 , A61B5/155 , A61M35/00
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：在某些方面，本发明一般涉及用于施用于皮肤的系统和方法，以及对其致动，递送和/或感知的控制。例如，本发明的某些方面通常涉及用于递送和/或抽出流体或从受试者例如去往或来自皮肤和/或皮肤下方的流体的装置。在一个方面，流体的输送和/或排出至少部分被遮蔽。例如，遮蔽可以是按时间和/或通过感觉遮蔽（例如通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在激活之后自动地向皮肤和/或皮肤下方输送流体和/或从皮肤下面抽取流体的装置，例如，在输送和/或抽出流体而不需要任何额外干预的情况下。这些设备可以通过任何合适的技术来激活。在其他方面，装置可以被包含在包装中，并且当从包装中取出时，装置可以被构造和布置成当装置被施加到皮肤时能够输送和/或抽出流体，并且在一些情况下，自动和/或不需要主体或另一个人的任何进一步介入。

5. 发明申请

WO2012018486A3 RAPID DELIVERY AND/OR RECEIVING OF FLUIDS 审中-公开
标题翻译：快速输送和/或接收流体
公开(公告)号：WO2012018486A3
公开(公告)日：2012-04-12
申请号：PCT/US2011043698
申请日：2011-07-12
申请人： SEVENTH SENSE BIOSYSTEMS INC , DAVIS SHAWN , CHICKERING DONALD E , HAGHGOOIE RAMIN
发明人： DAVIS SHAWN , CHICKERING DONALD E , HAGHGOOIE RAMIN
IPC分类号： A61B5/15 , A61B5/153 , A61M5/158
CPC分类号： A61M37/0015 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150282 , A61B5/150427 , A61B5/150435 , A61B5/150503 , A61B5/150511 , A61B5/150526 , A61B5/150984 , A61B5/15113 , A61B5/15144 , A61B5/157 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , Y10T29/4998
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于从受试者例如皮肤和/或从皮肤下方递送和/或接收物质或物质例如血液的系统和方法。一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面接受或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。例如，可以从装置接收血液，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。另一方面，本发明一般涉及皮肤插入物体如微针的布置以及形成和布置皮肤插入物体的方法。本发明的其它方面涉及用于接收血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

6. 发明申请

WO2012149134A1 DEVICES AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
标题翻译：用于收集和/或处理血液或其他体液的装置和方法
公开(公告)号：WO2012149134A1
公开(公告)日：2012-11-01
申请号：PCT/US2012035173
申请日：2012-04-26
申请人： SEVENTH SENSE BIOSYSTEMS INC , BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , GONG PING , HORTON KRISTIN , JAMES SCOTT
发明人： BERNSTEIN HOWARD , CHICKERING DONALD E , DAVIS SHAWN , GONG PING , HORTON KRISTIN , JAMES SCOTT
IPC分类号： A61B5/15 , A61B5/145 , A61B5/151 , A61B10/00 , G01N27/30
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present application directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood.
摘要翻译：本申请涉及使用包括物质转移组分（其可以包含例如一个或多个微针）和将血液引导到基质上的装置从例如皮肤接收血液的装置和方法，例如，用于吸收血液。

7. 发明申请

WO2007070852A3 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PARENTERAL ADMINISTRATION 审中-公开
标题翻译：用于制备基于颗粒的药物制剂用于肠胃外给药的过程
公开(公告)号：WO2007070852A3
公开(公告)日：2007-11-01
申请号：PCT/US2006062094
申请日：2006-12-14
申请人： ACUSPHERE INC , ALTREUTER DAVID , BERNSTEIN HOWARD , BRITO LUIS , BRITO SHAINA , CARNEIRO OLINDA C , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , NARASIMHAN SRIDHAR , PANDIT NAMRATA , STRAUB JULIE A
发明人： ALTREUTER DAVID , BERNSTEIN HOWARD , BRITO LUIS , BRITO SHAINA , CARNEIRO OLINDA C , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , NARASIMHAN SRIDHAR , PANDIT NAMRATA , STRAUB JULIE A
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K9/19
摘要： A method is provided for making a parenteral dosage form of a pharmaceutical agent which Includes (a) providing particles of a pharmaceutical agent; (b) blending the particles with particles of at least one bulking agent to form a first powder blend, which does not include a surfactant; (c) milling the first powder blend to form a milled blend which comprises microparticles or nanopartides of the pharmaceutical agent; and (d) reconstituting the milled blend with a liquid vehicle, which includes at least one surfactant, for parenteral administration. A method also is provided which includes (a) providing particles of a pharmaceutical agent; (b) blending these particles with particles of an excipient to form a first blend; and (c) milling the first blend to form a milled blend that includes microparticles or tianopartÊcles, which exhibits a greater dispersibility, wettability, and suspcndability as compared to the particles of step (a) or the first blend.
摘要翻译：提供了用于制备药剂的肠胃外剂型的方法，其包括（a）提供药剂颗粒; （b）将所述颗粒与至少一种填充剂的颗粒共混以形成不包含表面活性剂的第一粉末混合物; （c）研磨第一粉末混合物以形成包含药剂的微粒或纳米粒子的研磨混合物; 和（d）用含有至少一种表面活性剂的液体载体重新配制经碾磨的混合物用于肠胃外给药。还提供了一种方法，其包括（a）提供药剂颗粒; （b）将这些颗粒与赋形剂颗粒混合以形成第一混合物; 和（c）研磨第一种共混物以形成包含微粒或天鹅绒的研磨混合物，与步骤（a）或第一种混合物的颗粒相比，该混合物显示出更大的分散性，润湿性和可悬浮性。

8. 发明申请

WO2007070851A3 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PULMONARY OR NASAL ADMINISTRATION 审中-公开
标题翻译：制造用于肺部或鼻腔给药的基于颗粒的药物制剂的过程
公开(公告)号：WO2007070851A3
公开(公告)日：2007-09-20
申请号：PCT/US2006062093
申请日：2006-12-14
申请人： ACUSPHERE INC , BERNSTEIN HOWARD , BRITO SHAINA , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , STRAUB JULIE A
发明人： BERNSTEIN HOWARD , BRITO SHAINA , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , STRAUB JULIE A
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/0073 , A61K9/143 , A61K9/145
摘要： Dry powder pharmaceutical formulations for pulmonary or nasal administration are made to provide an improved respired dose. These formulations may be blends of milled blends and may include a phospholipid, alone or Ên combination with other excipient materials. In one case, the process includes the steps of (a) providing particles which comprise a pharmaceutical agent; (b) blending the particles with particles of at least one first excipient to form a first powder blend; (c) railling the first powder blend to form a milled blend which comprises microparticies or nanoparticles of the pharmaceutical agent; and (d) blending the milled blend with particles of a second excipient to form a blended dry powder blend pharmaceutical formulation suitable for pulmonary or nasal administration.
摘要翻译：制备用于肺或鼻给药的干粉药物制剂以提供改善的呼吸剂量。这些制剂可以是研磨混合物的混合物，并且可以包括磷脂，单独或与其他赋形剂材料组合。在一种情况下，该方法包括以下步骤：（a）提供包含药剂的颗粒; （b）将所述颗粒与至少一种第一赋形剂的颗粒混合以形成第一粉末混合物; （c）将第一种粉末混合物进行研磨以形成包含药剂的微粒或纳米颗粒的研磨混合物; （d）将研磨后的混合物与第二种赋形剂的颗粒混合以形成适用于肺部或鼻部给药的混合干粉混合药物制剂。

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