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    • 1. 发明申请
    • PRE-PACKED, SEALED RADIAL FLOW CHROMATOGRAPHY COLUMN
    • 预包装,密封的径向流动色谱柱
    • WO2018081474A1
    • 2018-05-03
    • PCT/US2017/058613
    • 2017-10-26
    • SEPRAGEN CORPORATION
    • SAXENA, RenuZUFFI, DavidSAXENA, Vinit
    • B01D15/08B01D15/18B01D15/20B01D15/22B01D15/32G01N30/02G01N30/38
    • Provided herein in some embodiments is a column including a housing assembly and a cartridge assembly. The housing assembly can include a housing top, a housing bottom, and a housing siding. The housing siding can be fixedly coupled to the housing top and the housing bottom forming hermetic seals therebetween. The cartridge assembly can include a cartridge top, an outer frit, and an inner frit disposed within the outer frit. A toroidal space can defined by the cartridge top, the outer frit, the inner frit, and the housing bottom. The toroidal space can be configured to hold a stationary phase for radial flow column chromatography. Also provided herein in some embodiments is a process including assembling the cartridge assembly, assembling the housing assembly about the cartridge assembly, and pressure testing the column. In some embodiments, the process can further include charging the toroidal space with a stationary phase.
    • 这里在一些实施例中提供了一种包括壳体组件和筒组件的柱。 壳体组件可以包括壳体顶部,壳体底部和壳体侧壁。 壳体侧壁可以固定地联接到壳体顶部和壳体底部,从而在其间形成气密密封。 盒组件可以包括盒顶部,外部玻璃料和设置在外部玻璃料内的内部玻璃料。 环形空间可由盒顶部,外部玻璃料,内部玻璃料和外壳底部限定。 环形空间可以配置为保持径向流动柱色谱的固定相。 本文在一些实施例中还提供了一种方法,包括组装所述筒组件,将所述外壳组件组装在所述筒组件周围,以及对所述柱进行压力测试。 在一些实施例中,该过程可以进一步包括以固定相充电环形空间。