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1. 发明申请

WO2011117506A2 ADJUVANT DILUENTS FOR LIVE VACCINES FOR PIG DISEASES 审中-公开
标题翻译：用于皮肤疾病的活疫苗的补充剂
公开(公告)号：WO2011117506A2
公开(公告)日：2011-09-29
申请号：PCT/FR2011050514
申请日：2011-03-15
申请人： SEPPIC SA , BERTRAND FRANCOIS , DEVILLE SEBASTIEN , DUPUIS LAURENT
发明人： BERTRAND FRANCOIS , DEVILLE SEBASTIEN , DUPUIS LAURENT
IPC分类号： A61K39/39
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2770/10034 , C12N2770/10051
摘要： The invention relates to a method for preparing an injectable vaccine composition intended to combat porcine reproductive and respiratory syndrome (PRRS), comprising at least a step (a) in which a live vaccine is mixed extemporaneously with an adjuvant diluent. The invention is characterised in that the adjuvant diluent is an oil-in-water-type emulsion or an oil-in-water-type microemulsion or an aqueous solution comprising water and at least one mineral salt selected from aluminium hydroxide, cerium nitrate, zinc sulphate, colloidal iron hydroxide or calcium chloride, divalent or trivalent metal salts or sympathomimetic compounds.
摘要翻译：本发明涉及一种制备用于对抗猪繁殖与呼吸综合征（PRRS）的可注射疫苗组合物的方法，该方法至少包括一种步骤（a），其中活疫苗与佐剂稀释剂同时混合。本发明的特征在于助剂稀释剂是水包油型乳剂或水包油型微乳液或包含水和至少一种选自氢氧化铝，硝酸铈，锌硫酸盐，胶体氢氧化铁或氯化钙，二价或三价金属盐或拟交替物。

2. 发明申请

WO2009053601A3 METHOD FOR PREPARING A VACCINE COMPOSITION COMPRISING AT LEAST ONE ANTIGEN AND AT LEAST ONE ADJUVANT 审中-公开
标题翻译：一种制备包含至少一种抗原和至少一种佐剂的疫苗组合物的方法
公开(公告)号：WO2009053601A3
公开(公告)日：2009-06-25
申请号：PCT/FR2008051807
申请日：2008-10-06
申请人： SEPPIC SA , DUPUIS LAURENT , GAUCHERON JEROME , BRAUN OLIVIER
发明人： DUPUIS LAURENT , GAUCHERON JEROME , BRAUN OLIVIER
IPC分类号： A61K9/00 , A61K9/127 , A61K47/32 , A61K47/44
CPC分类号： A61K9/127 , A61K9/0019 , A61K47/32 , A61K47/44
摘要： Method for preparing a vaccine, comprising - a step a) of preparing an adjuvant composition by dispersing, in a physiologically acceptable aqueous solution, at least one inverse latex or a powder of polymer resulting from the atomization of said inverse latex; - a step b) of mixing the composition obtained in step a) into an antigenic medium, intended to form a vaccine composition.
摘要翻译：制备疫苗的方法，包括 - 步骤a）：通过在生理学上可接受的水溶液中分散至少一种反相胶乳或由所述反相胶乳雾化得到的聚合物粉末来制备佐剂组合物; - 将步骤a）中获得的组合物混合到旨在形成疫苗组合物的抗原性介质中的步骤b）。

3. 发明申请

WO02080840A3 IMMUNITY ADJUVANT CONTAINING A COMPLEXED METAL CATION AND VACCINE CONTAINING SAME 审中-公开
标题翻译：含有金属复合物和含有其的疫苗的免疫调节剂
公开(公告)号：WO02080840A3
公开(公告)日：2003-01-03
申请号：PCT/FR0201057
申请日：2002-03-27
申请人： SEPPIC SA , TROUVE GERARD , DUPUIS LAURENT
发明人： TROUVE GERARD , DUPUIS LAURENT
IPC分类号： A61K39/002 , A61K9/00 , A61K9/113 , A61K39/02 , A61K39/12 , A61K39/39 , A61K47/36 , A61P31/04 , A61P31/12 , A61P33/00 , C08K5/06 , C08K5/10 , C08L91/00 , C08L101/02
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/113 , A61K47/36 , A61K2039/55555
摘要： The invention relates to a composition comprising a fatty phase and a non-null quantity of an organometallic gel obtained by complexing an anionic polymer or a mixture of different anionic polymers with a multivalent metal cation or a mixture of different metal cations. Said composition is preferably in the form of an emulsion, the continuous phase of which is the fatty phase and the dispersed phase is the multivalent metal cation-anionic polymer gel complex. The invention also relates to the method for preparing the emulsion consisting in: preparing an aqueous suspension containing at least one insoluble multivalent cation salt, at least one water-soluble anionic polymer and optionally at least one hydrophilic surfactant; emulsifying the suspension thus prepared, with an oil phase containing optionally one lipophilic surfactant; if necessary, solubilising the insoluble multivalent cation salt by modifying the pH of the emulsion; optionally adding an excess of multivalent cation; and neutralising the final emulsion obtained. The invention also relates to the vaccine containing said composition.
摘要翻译：本发明涉及一种组合物，其包含通过使阴离子聚合物或不同阴离子聚合物的混合物与多价金属阳离子或不同金属阳离子的混合物络合而获得的脂肪相和非无效量的有机金属凝胶。所述组合物优选为乳液形式，其连续相为脂肪相，分散相为多价金属阳离子 - 阴离子聚合物凝胶复合物。本发明还涉及制备乳液的方法，其包括：制备含有至少一种不溶性多价阳离子盐，至少一种水溶性阴离子聚合物和任选的至少一种亲水性表面活性剂的水性悬浮液; 乳化由此制备的悬浮液，其中油相含有任选的一种亲脂性表面活性剂; 如果需要，通过改变乳液的pH来溶解不溶性多价阳离子盐; 任选地加入过量的多价阳离子; 并中和得到的最终乳液。本发明还涉及含有所述组合物的疫苗。

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