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    • 4. 发明申请
    • NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT, WHICH ARE STABILIZED USING NATURAL GUMS, HIGHLY VISCOUS, AND STABLE OVER TIME
    • 使用天然植物油稳定使用的盐水新型水溶性乳液,超高粘度和稳定性
    • WO2013083913A3
    • 2014-06-12
    • PCT/FR2012052803
    • 2012-12-05
    • SEPPIC SA
    • MERAT EMMANUELLE
    • A61K8/73A61K8/06A61K8/81A61Q19/00
    • A61K8/8188A61K8/062A61K8/20A61K8/73A61K8/8158A61K8/92A61K2800/10A61K2800/48A61K2800/5424A61Q5/00A61Q5/002A61Q5/02A61Q17/04A61Q19/00A61Q19/10
    • The invention relates to an oil-in-water emulsion including, for 100% of the weight thereof: 5 to 55 wt % of an oil phase (P1) consisting of at least one oil and/or at least one wax; 0.06 to 4.5 wt % of at least one cross-linked anionic polyelectrolyte resulting from the polymerization of at least one monomer having a strong acid function, said monomer being partially or totally salified 2-methyl 2-[(1-oxo 2-propenyl) amino] 1-propanesulfonic acid, with at least one neutral monomer selected from the N,N-dialkyl acrylamides, wherein each of the alkyl groups comprise between one and four carbon atoms, and at least one monomer of formula (I), where R is a straight or branched alkyl radical comprising eight to twenty carbon atoms and n is a number no smaller than one and no larger than twenty, in the presence of at least one cross-linking agent; and 0.0025 to 1 wt % of xanthan gum (GX); 0.0025 to 1 wt % acacia gum (GA); 38.5 to 94.835 wt % of a cosmetically acceptable aqueous phase (P2), said aqueous phase (P) including, for 100% of the weight thereof, 1 to 10 wt % of at least one dissolved salt (S), and said composition (C1) being further characterized in that the weight ratio between the xanthan gum (GX) and the acacia gum (GA) is greater no less than 1/3 and no greater than 3/1. The invention also relates to the method for preparing such compositions, and to the use thereof in cosmetics.
    • 本发明涉及一种水包油乳液,包括其100重量%:5至55重量%的由至少一种油和/或至少一种蜡组成的油相(P1); 0.06至4.5重量%的至少一种由至少一种具有强酸功能的单体的聚合产生的交联阴离子聚电解质,所述单体部分或全部成盐2 - [(1-氧代-2-丙烯基) 氨基] -1-丙磺酸与至少一种选自N,N-二烷基丙烯酰胺的中性单体,其中每个烷基包含1-4个碳原子,和至少一种式(I)单体,其中R 在至少一种交联剂的存在下,是包含8至20个碳原子的直链或支链烷基,n是不小于1且不大于20的数; 和0.0025〜1重量%的黄原胶(GX); 0.0025至1重量%的阿拉伯树胶(GA); 38.5至94.835重量%的化妆品可接受的水相(P2),所述水相(P)对于100重量%包含1至10重量%的至少一种溶解盐(S)和所述组合物( C1)的特征还在于,黄原胶(GX)和阿拉伯树胶(GA)之间的重量比不大于1/3且不大于3/1。 本发明还涉及制备这种组合物的方法及其在化妆品中的应用。
    • 8. 发明申请
    • NOVEL METHOD FOR PRODUCING WATER-SOLUBLE COMB-SHAPED COPOLYMERS
    • 用于生产水溶性复合共聚物的新方法
    • WO2007000535A2
    • 2007-01-04
    • PCT/FR2006050452
    • 2006-05-18
    • SEPPIC SAINST CURIECENTRE NAT RECH SCIENTBRAUN OLIVIERMALLO PAULVIOVY JEAN LOUISWEBER JEREMIE
    • BRAUN OLIVIERMALLO PAULVIOVY JEAN LOUISWEBER JEREMIE
    • G01N27/44747C08F267/10
    • The invention relates to a method for producing a comb-shaped copolymer whose skeleton is of an acrylamide, acrylic acid, acryloyl aminoethanol or dimethyl acrylamide type and on which poly(N-alkyl acrylamide) or poly(N,N- 5 dialkyl acrylamide lateral segments are grafted. Said method is characterised in that it consists (a) in producing a telomer poly(N-alkyl acrylamide) or poly(N,N- dialkyl acrylamide) of formula (I) H 2 N-R 1 -Z-{CH 2 -C(R 2 )[C(=O)N(R 3 )(R 4 )]-} n -H (I) 10 by reacting in water a compound of formula (II) CH 2 =C(R 2 )-C(=O)-N(R 3 )(R 4 ) (II) with a chain limiting compound of formula (III) Z-R 1 -NH 2 ; (b) in isolating the telomer of formula (I) obtained at a stage (a); (c) in reacting in water the telomer of formula (I) obtained at stage (b) with an acid chloride of formula (IV) CH 2 =C(R 5 )-C(=O)-C l at a molar ratio (IV) / (III) equal to or less than 10 and equal to or greater than 1 in such a way that a macro monomer of formula (V) 20 CH 2 =C(R 5 )-C(=O)NH-R 1 -Z-{CH 2 -C(R 2 )[C(=O)N(R 3 )(R 4 )]-} n -H (V) is obtained; (d) in isolating the macro monomer of formula (V) obtained at stage (c); (e) in copolymerising in water the macro monomer of formula (V) isolated at stage (d) with a monomer selected from acrylamide, acrylic acid, acryloyl-aminoethanol or dimethyl-acrylamide and, if necessary, (f) in purifying the thus obtained copolymer.
    • 本发明涉及一种生产梳形共聚物的方法,其骨架为丙烯酰胺,丙烯酸,丙烯酰氨基乙醇或二甲基丙烯酰胺型,其上聚(N-烷基丙烯酰胺)或聚(N,N- 5二烷基丙烯酰胺侧面 所述方法的特征在于:(a)在制备式(I)H 2/2的聚酯聚(N-烷基丙烯酰胺)或聚(N,N-二烷基丙烯酰胺) NR 1 -Z- {CH 2 -C(R 2 )[C(= O)N(R 3 ) - C(= O)NH-R 1 -Z- {CH 2 -C(R 2 ) C(= O)N(R 3)(R 4)] - } n -H(V) (d)分离在阶段(c)中获得的式(Ⅴ)的大分子单体; (e)在水中共聚在阶段(d)分离的式(V)的大分子单体与选自丙烯酰胺,丙烯酸,丙烯酰基 - 氨基乙醇或二甲基 - 丙烯酰胺的单体,如果需要,(f)纯化由此 得到的共聚物。
    • 9. 发明申请
    • IMMUNITY ADJUVANT CONTAINING A COMPLEXED METAL CATION AND VACCINE CONTAINING SAME
    • 含有金属复合物和含有其的疫苗的免疫调节剂
    • WO02080840A3
    • 2003-01-03
    • PCT/FR0201057
    • 2002-03-27
    • SEPPIC SATROUVE GERARDDUPUIS LAURENT
    • TROUVE GERARDDUPUIS LAURENT
    • A61K39/002A61K9/00A61K9/113A61K39/02A61K39/12A61K39/39A61K47/36A61P31/04A61P31/12A61P33/00C08K5/06C08K5/10C08L91/00C08L101/02
    • A61K39/39A61K9/0019A61K9/113A61K47/36A61K2039/55555
    • The invention relates to a composition comprising a fatty phase and a non-null quantity of an organometallic gel obtained by complexing an anionic polymer or a mixture of different anionic polymers with a multivalent metal cation or a mixture of different metal cations. Said composition is preferably in the form of an emulsion, the continuous phase of which is the fatty phase and the dispersed phase is the multivalent metal cation-anionic polymer gel complex. The invention also relates to the method for preparing the emulsion consisting in: preparing an aqueous suspension containing at least one insoluble multivalent cation salt, at least one water-soluble anionic polymer and optionally at least one hydrophilic surfactant; emulsifying the suspension thus prepared, with an oil phase containing optionally one lipophilic surfactant; if necessary, solubilising the insoluble multivalent cation salt by modifying the pH of the emulsion; optionally adding an excess of multivalent cation; and neutralising the final emulsion obtained. The invention also relates to the vaccine containing said composition.
    • 本发明涉及一种组合物,其包含通过使阴离子聚合物或不同阴离子聚合物的混合物与多价金属阳离子或不同金属阳离子的混合物络合而获得的脂肪相和非无效量的有机金属凝胶。 所述组合物优选为乳液形式,其连续相为脂肪相,分散相为多价金属阳离子 - 阴离子聚合物凝胶复合物。 本发明还涉及制备乳液的方法,其包括:制备含有至少一种不溶性多价阳离子盐,至少一种水溶性阴离子聚合物和任选的至少一种亲水性表面活性剂的水性悬浮液; 乳化由此制备的悬浮液,其中油相含有任选的一种亲脂性表面活性剂; 如果需要,通过改变乳液的pH来溶解不溶性多价阳离子盐; 任选地加入过量的多价阳离子; 并中和得到的最终乳液。 本发明还涉及含有所述组合物的疫苗。