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1. 发明申请

WO2011091324A3 METHODS OF GENERATING ZINC FINGER NUCLEASES HAVING ALTERED ACTIVITY 审中-公开
标题翻译：产生具有改变活性的锌指指核的方法
公开(公告)号：WO2011091324A3
公开(公告)日：2011-12-22
申请号：PCT/US2011022154
申请日：2011-01-21
申请人： SCRIPPS RESEARCH INST , BARBAS CARLOS F , GUO JING
发明人： BARBAS CARLOS F , GUO JING
IPC分类号： C12Q1/34 , C12N9/14 , C12N15/55
CPC分类号： C12N15/1034 , C07K14/4703 , C12N9/22 , C12N15/1086 , G01N2333/922
摘要： Provided herein are zinc linger nucleases having altered, arid in particular, improved catalytic activity and methods of generating such nucleases. Accordingly, there are provided methods for identifying improved catalytic activity of a ZFN by expressing a mutated zinc finger nuclease in a cell containing a reporter construct with a toxic gene, and a zinc finger nuclease cleavage site that is recognized by the ZFN. Survival of the cell is positively correlated with catalytic activity of the ZFN; thus, libraries of mutated ZFKs may be selected for altered catalytic activity based on relative survival rates, Methods of using identified ZFNs are also provided.
摘要翻译：本文提供了具有改变，特别是改进的催化活性和产生这种核酸酶的方法的锌连环核酸酶。因此，提供了通过在含有具有毒性基因的报道构建体的细胞中表达突变的锌指核酸酶以及通过ZFN识别的锌指核酸酶切割位点来鉴定ZFN的改善的催化活性的方法。细胞存活与ZFN的催化活性呈正相关; 因此，可以基于相对存活率选择突变的ZFK文库以改变催化活性，还提供使用鉴定的ZFN的方法。

2. 发明申请

WO2011091324A8 METHODS OF GENERATING ZINC FINGER NUCLEASES HAVING ALTERED ACTIVITY 审中-公开
标题翻译：产生具有改变活性的锌指指核的方法
公开(公告)号：WO2011091324A8
公开(公告)日：2012-08-30
申请号：PCT/US2011022154
申请日：2011-01-21
申请人： SCRIPPS RESEARCH INST , BARBAS III CARLOS F , GUO JING
发明人： BARBAS III CARLOS F , GUO JING
IPC分类号： C12Q1/34 , C12N9/14 , C12N15/55
CPC分类号： C12N15/1034 , C07K14/4703 , C12N9/22 , C12N15/1086 , G01N2333/922
摘要： Provided herein are zinc linger nucleases having altered, arid in particular, improved catalytic activity and methods of generating such nucleases. Accordingly, there are provided methods for identifying improved catalytic activity of a ZFN by expressing a mutated zinc finger nuclease in a cell containing a reporter construct with a toxic gene, and a zinc finger nuclease cleavage site that is recognized by the ZFN. Survival of the cell is positively correlated with catalytic activity of the ZFN; thus, libraries of mutated ZFKs may be selected for altered catalytic activity based on relative survival rates, Methods of using identified ZFNs are also provided.
摘要翻译：本文提供了具有改变，特别是改进的催化活性和产生这种核酸酶的方法的锌连环核酸酶。因此，提供了通过在含有具有毒性基因的报道构建体的细胞中表达突变的锌指核酸酶以及通过ZFN识别的锌指核酸酶切割位点来鉴定ZFN的改善的催化活性的方法。细胞存活与ZFN的催化活性呈正相关; 因此，可以基于相对存活率选择突变的ZFK文库以改变催化活性，还提供使用鉴定的ZFN的方法。

3. 发明申请

WO2012061723A3 CELL-BASED MODELS OF NEURODEGENERATIVE DISEASE 审中-公开
标题翻译：基于细胞的神经病变疾病模型
公开(公告)号：WO2012061723A3
公开(公告)日：2014-04-10
申请号：PCT/US2011059360
申请日：2011-11-04
申请人： UNIV PENNSYLVANIA , BRUNDEN KURT R , LEE VIRGINIA M Y , TROJANOWSKI JOHN Q , LUK KELVIN C , GUO JING , VOLPICELLI-DALEY LAURA
发明人： BRUNDEN KURT R , LEE VIRGINIA M Y , TROJANOWSKI JOHN Q , LUK KELVIN C , GUO JING , VOLPICELLI-DALEY LAURA
IPC分类号： C12N5/00
CPC分类号： G01N33/6896 , G01N33/5058
摘要： The present invention relates to a cell-based model useful for identifying molecules that modify intracellular pathways of α-synuclein and tau aggregation and degradation.
摘要翻译：本发明涉及可用于鉴定修饰α-突触核蛋白的细胞内途径和tau聚集和降解的分子的基于细胞的模型。

4. 发明申请

WO2011139754A3 ELECTRONIC GATE ENHANCEMENT OF SCHOTTKY JUNCTION SOLAR CELLS 审中-公开
标题翻译：肖特连接太阳能电池的电子门增强
公开(公告)号：WO2011139754A3
公开(公告)日：2012-02-02
申请号：PCT/US2011034107
申请日：2011-04-27
申请人： UNIV FLORIDA , RINZLER ANDREW GABRIEL , WADHWA POOJA , GUO JING , SEOL GYUNGSEON
发明人： RINZLER ANDREW GABRIEL , WADHWA POOJA , GUO JING , SEOL GYUNGSEON
IPC分类号： H01L31/07 , H01L31/0224 , H01L31/042
CPC分类号： H01L31/022433 , H01L31/07 , Y02E10/50
摘要： Various systems and methods are provided for Schottky junction solar cells. In one embodiment, a solar cell includes a mesh layer formed on a semiconductor layer and an ionic layer formed on the mesh layer. The ionic layer seeps through the mesh layer and directly contacts the semiconductor layer. In another embodiment, a solar cell includes a first mesh layer formed on a semiconductor layer, a first metallization layer coupled to the first mesh layer, a second high surface area electrically conducting electrode coupled to the first metallization layer by a gate voltage, and an ionic layer in electrical communication with the first mesh layer and the second high surface area electrically conducting electrode. In another embodiment, a solar cell includes a grid layer formed on a semiconductor layer and an ionic layer in electrical communication with the grid layer and the semiconductor layer.
摘要翻译：为肖特基结太阳能电池提供了各种系统和方法。在一个实施例中，太阳能电池包括形成在半导体层上的网格层和形成在网格层上的离子层。离子层渗透网格层并直接接触半导体层。在另一个实施例中，太阳能电池包括形成在半导体层上的第一网格层，耦合到第一网格层的第一金属化层，通过栅极电压耦合到第一金属化层的第二高表面积导电电极，以及离子层与第一网格层和第二高表面积导电电极电连通。在另一实施例中，太阳能电池包括形成在半导体层上的栅格层和与栅格层和半导体层电连通的离子层。

5. 发明申请

WO2012177532A2 NH3 OXIDIZER GAS DISTRIBUTOR 审中-公开
标题翻译： NH3氧化剂气体分配器
公开(公告)号：WO2012177532A2
公开(公告)日：2012-12-27
申请号：PCT/US2012042870
申请日：2012-06-18
申请人： HONEYWELL INT INC , GUO JING , WARREN MATTHEW
发明人： GUO JING , WARREN MATTHEW
IPC分类号： B01J19/24 , B01J12/00 , B01J23/75
CPC分类号： B01J8/025 , B01J8/0278 , B01J2208/00911 , B01J2208/0092 , C01B21/28
摘要： Ammonia oxidizers are disclosed that can include gas distributors and distribution rings to improve the distribution of the flow of a gas feedstream across a catalyst bed in the ammonia oxidizer. The gas distributors include circular plates that have holes through which the gas feedstream is distributed across the catalyst bed. In some examples, the gas distributors also have a sidewall. The distribution rings are attached to the inner wall of the ammonia oxidizer at a predetermined distance below the gas distributor.
摘要翻译：公开了氨氧化剂，其可以包括气体分配器和分配环，以改善气体进料流在氨氧化器中的催化剂床上的分布。气体分配器包括具有孔的圆形板，气体进料流穿过该孔分布在催化剂床上。在一些示例中，气体分配器也具有侧壁。分配环在气体分布器下方预定距离处附接到氨氧化剂的内壁。

6. 发明申请

WO2005122293A3 FORMATION OF ORDERED THIN FILMS OF ORGANICS ON METAL OXIDE SURFACES 审中-公开
标题翻译：在金属氧化物表面形成有机薄膜
公开(公告)号：WO2005122293A3
公开(公告)日：2008-04-03
申请号：PCT/US2005020143
申请日：2005-06-08
申请人： UNIV PRINCETON , HANSON ERIC , SCHWARTZ JEFFREY , KOCH NORBERT , GUO JING , HILL IAN , MC DERMOTT JOE
发明人： HANSON ERIC , SCHWARTZ JEFFREY , KOCH NORBERT , GUO JING , HILL IAN , MC DERMOTT JOE
IPC分类号： H01L51/00 , H01L29/08 , H01L51/05 , H01L51/10 , H01L51/30 , H01L51/40 , H01L51/42 , H01L51/44 , H01L51/46 , H01L51/48 , H01L51/50 , H01L51/52 , H01L51/54 , H01L51/56
CPC分类号： H01L51/0036 , B82Y10/00 , B82Y30/00 , H01L51/0012 , H01L51/0037 , H01L51/0051 , H01L51/0062 , H01L51/0545 , H01L51/5088 , Y02E10/549
摘要： Provided herein is a method for altering an electronic property of a structure comprising an oxide surface or an oxide surface in electronic communication with the structure, the method comprising providing a covalently-bound film comprising at least one organic acid residue on a portion of the oxide surface so that at least one of the following properties of the structure is modified: (a) the charge carrier injection barrier properties; (b) the charge conductivity properties; (c) the charge transport properties; (d) the work function properties; (e) the sub-threshold slope; and (f) the threshold voltage.
摘要翻译：本文提供了一种用于改变包括与该结构电子连通的氧化物表面或氧化物表面的结构的电子性质的方法，所述方法包括提供共价键合的膜，其在氧化物的一部分上包含至少一个有机酸残基表面，使得结构的以下性质中的至少一个被修饰：（a）电荷载流子注入阻挡性; （b）电荷导电性; （c）电荷输送性质; （d）工作功能属性; （e）子阈值斜率; 和（f）阈值电压。

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