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1. 发明申请

WO2013187724A1 NOVEL ANTIBODY SPECIFIC FOR CLEC14A AND USES THEREOF 审中-公开
标题翻译：特别针对CLEC14A的新型抗体及其用途
公开(公告)号：WO2013187724A1
公开(公告)日：2013-12-19
申请号：PCT/KR2013/005272
申请日：2013-06-14
申请人： SCRIPPS KOREA ANTIBODY INSTITUTE
发明人： LEE, Suk Mook , KI, Min Kyoung , JEOUNG, Mee Hyun , CHOI, Jong Rip
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
CPC分类号： C07K16/18 , A61K47/6843 , C07K7/08 , C07K14/435 , C07K14/7056 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2319/30 , G01N33/53
摘要： The present invention relates to a novel antibody specifically binding to the clec14a (C-type lectin domain family 14, member A) and uses thereof. More particularly, the present invention relates to an antibody specifically binding to the CTLD (C-type lectin like domain) of clec14a, a method for preparing the antibody, a composition for the suppression of angiogenesis, comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition for preventing or treating cancer, comprising the antibody, a method for treating cancer by administering the antibody or the composition, a composition for diagnosing cancer, comprising the antibody, a kit for diagnosing cancer comprising the compostion, a method for diagnosing cancer using the composition, a composition for the suppression of angiogenesis, comprising a material for inhibiting expression of clec14a, a kit for angiogenesis, comprising the composition, a method for suppressing angiogenesis or treating cancer, using the compostion, and the use of the CTLD of clec14a as an epitope for an antibody suppressive of angiogenesis. The antibody can effectively inhibit cle14a-mediated cancer progression.
摘要翻译：本发明涉及特异性结合clec14a（C型凝集素结构域家族14，成员A）的新型抗体及其用途。更具体地，本发明涉及与clec14a的CTLD（C型凝集素样结构域）特异性结合的抗体，该抗体的制备方法，抑制血管生成的组合物，包含该抗体的组合物，抑制血管生成的方法通过给予所述抗体或所述组合物，含有所述抗体的癌症预防或治疗用组合物，通过给予所述抗体或所述组合物来治疗癌症的方法，包含所述抗体的癌症诊断用组合物，包含所述抗体或癌症的诊断用试剂盒使用该组合物的组合物，用于诊断癌症的方法，用于抑制血管生成的组合物，包含用于抑制clec14a表达的材料，用于血管生成的试剂盒，包含该组合物，抑制血管生成或治疗癌症的方法，以及clec14a的CTLD作为抑制血管生成的抗体的表位的用途。该抗体可以有效抑制cle14a介导的癌症进展。

2. 发明申请

WO2015130115A1 NOVEL ANTIBODY SPECIFIC FOR TSPAN8 AND USES THEREOF 审中-公开
标题翻译： TSPAN8的新型抗体特异性及其用途
公开(公告)号：WO2015130115A1
公开(公告)日：2015-09-03
申请号：PCT/KR2015/001905
申请日：2015-02-27
申请人： SCRIPPS KOREA ANTIBODY INSTITUTE
发明人： LEE, Sukmook , KIM, Taek-Keun , PARK, Chang Sik , JEOUNG, Mee Hyun , KI, Min Kyoung , LEE, Woo Ran , GO, Nam Kyung , CHOI, Jong Rip
IPC分类号： C07K16/28 , C07K14/705 , C12N15/63 , A61K47/48 , A61P35/00 , G01N33/574
CPC分类号： C07K16/28 , A61K2039/505 , C07K14/705 , C07K2317/622 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to a novel antibody specifically binding to the TSPAN8 (tetraspanin 8) and uses thereof. More particularly, the present invention relates to an antibody specifically binding to the LEL (large extracellular loop) of TSPAN8, a method for preparing the antibody, a composition for the suppression of cancer and/or cancer metastasis comprising the antibody, a method for suppressing cancer and/or cancer metastasis by administering the antibody or the composition, a composition for preventing or treating cancer and/or cancer metastasis comprising the antibody, a method for preventing or treating cancer and/or cancer metastasis by administering the antibody or the composition, a composition for diagnosing cancer and/or cancer metastasis comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for diagnosing cancer using the composition, a composition for the suppression of cancer and/or cancer metastasis comprising a material for inhibiting expression of TSPAN8, a kit for cancer and/or cancer metastasis comprising the composition, a method for suppressing cancer and/or cancer metastasis or treating cancer using the composition, and the use of the LEL of TSPAN8 as an epitope for an antibody suppressive of cancer and/or cancer metastasis.
摘要翻译：本发明涉及特异性结合TSPAN8（tetraspanin 8）的新型抗体及其应用。更具体地，本发明涉及特异性结合TSPAN8的LEL（大细胞外环）的抗体，制备抗体的方法，用于抑制癌症和/或癌转移的组合物，其包含抗体，抑制方法通过施用抗体或组合物，用于预防或治疗包含该抗体的癌症和/或癌症转移的组合物，通过施用该抗体或该组合物来预防或治疗癌症和/或癌症转移的方法的癌症和/或癌症转移，用于诊断包括该抗体的癌症和/或癌症转移的组合物，用于诊断癌症的试剂盒，其包含该组合物，使用该组合物诊断癌症的方法，用于抑制癌症和/或癌症转移的组合物，其包含抑制表达的材料的TSPAN8，一种用于癌症和/或癌症转移的试剂盒，其包含该组合物，一种用于支持的方法使用该组合物制备癌症和/或癌症转移或治疗癌症，以及使用TSPAN8的LEL作为抑制癌症和/或癌症转移的抗体的表位。

3. 发明申请

WO2013187556A1 NOVEL ANTIBODY SPECIFIC FOR CLEC14A AND USES THEREOF 审中-公开
标题翻译： CLEC14A的新型抗体特异性及其用途
公开(公告)号：WO2013187556A1
公开(公告)日：2013-12-19
申请号：PCT/KR2012/008618
申请日：2012-10-19
申请人： SCRIPPS KOREA ANTIBODY INSTITUTE
发明人： LEE, Suk Mook , KI, Min Kyoung , JEOUNG, Mee Hyun , CHOI, Jong Rip
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61P35/00
CPC分类号： C07K16/18 , A61K47/6843 , C07K7/08 , C07K14/435 , C07K14/7056 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2319/30 , G01N33/53
摘要： The present invention relates to a novel antibody specifically binding to the clec14a (C-type lectin domain family 14, member A) and uses thereof. More particularly, the present invention relates to an antibody specifically binding to the CTLD (C-type lectin like domain) of clec14a, a method for preparing the antibody, a composition for the suppression of angiogenesis, comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition for preventing or treating cancer, comprising the antibody, a method for treating cancer by administering the antibody or the composition, a composition for diagnosing cancer, comprising the antibody, a kit for diagnosing cancer comprising the compostion, a method for diagnosing cancer using the composition, a composition for the suppression of angiogenesis, comprising a material for inhibiting expression of clec14a, a kit for angiogenesis, comprising the composition, a method for suppressing angiogenesis or treating cancer, using the compostion, and the use of the CTLD of clec14a as an epitope for an antibody suppressive of angiogenesis. The antibody can effectively inhibit cle14a-mediated cancer progression.
摘要翻译：本发明涉及与clec14a（C型凝集素结构域家族14，成员A）特异性结合的新型抗体及其应用。更具体地，本发明涉及特异性结合clec14a的CTLD（C型凝集素样结构域）的抗体，制备抗体的方法，用于抑制血管生成的组合物，其包含该抗体，抑制血管发生的方法通过施用抗体或组合物，包含该抗体的预防或治疗癌症的组合物，通过施用该抗体或该组合物来治疗癌症的方法，用于诊断癌症的组合物，其包含该抗体，用于诊断癌症的试剂盒，组合物，使用该组合物诊断癌症的方法，用于抑制血管生成的组合物，包含抑制clec14a表达的材料，用于血管生成的试剂盒，其包含所述组合物，抑制血管生成或治疗癌症的方法，使用所述组合，以及将clec14a的CTLD用作抑制血管发生的抗体的表位。抗体可以有效抑制cle14a介导的癌症进展。

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