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1. 发明申请

WO2005120595A2 IN SITU HARDENING PASTE, ITS MANUFACTURING AND USE 审中-公开
标题翻译：在SITU硬化膏，其制造和使用
公开(公告)号：WO2005120595A2
公开(公告)日：2005-12-22
申请号：PCT/EP2005/006204
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , POMPE, Cornelius
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , POMPE, Cornelius
IPC分类号： A61L27/00
CPC分类号： A61L27/46 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/30062 , A61F2002/30583 , A61F2002/30766 , A61F2210/0004 , A61F2210/0085 , A61F2310/00293 , A61L27/446 , A61L27/48 , A61L27/502 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the filed' of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.
摘要翻译：开发了含有有机或无机填充材料，生物可降解聚合物和水溶性聚合物增塑剂的原位硬化浆料作为在组织再生领域具有支架特性的活性剂的递送系统。硬化浆料足够机械稳定，可用作骨和软骨替代基质。所有组分都是完全生物相容的，优选是生物可再吸收的并经过非肠道应用的认证。肽和蛋白质的持续释放可以通过组合物和工艺设计来调节。本发明包括一种药物组合物，其包含本发明的糊剂，并且涉及所述糊剂用于制备用于骨增大，用于治疗骨缺损，用于治疗退行性和创伤性椎间盘疾病，用于治疗骨骼的药物组合物的用途开裂或用于窦底抬高。

2. 发明申请

WO2005120454A2 COMPOSITE MATERIAL FOR USE AS PROTEIN CARRIER 审中-公开
标题翻译：用作蛋白载体的复合材料
公开(公告)号：WO2005120454A2
公开(公告)日：2005-12-22
申请号：PCT/EP2005/006206
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas
IPC分类号： A61K9/00
CPC分类号： A61L27/54 , A61L27/26 , A61L27/42 , A61L2300/252 , A61L2300/414 , A61L2300/602
摘要： The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein / peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.
摘要翻译：本发明涉及在体内具有骨诱导和骨传导性质的材料，其包含优选含有磷酸钙的陶瓷载体，以及活性剂，优选骨诱导蛋白/肽或药物和聚合物，其中活性剂均匀地涂覆在载体上和聚合物内，其优选是可降解聚合物。所述聚合物调节活性剂的释放动力学并保护其免受降解以延长体内半衰期。此外，本发明涉及一种在体内生产具有骨诱导和骨传导性质的材料的方法。

3. 发明申请

WO2005089829A3 COATED IMPLANTS, THEIR MANUFACTURING AND USE THEREOF 审中-公开
公开(公告)号：WO2005089829A3
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002506
申请日：2005-03-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , SCHIMKAT, Bernd , WIEDENMANN-SCHLEMBACH, Karin
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , SCHIMKAT, Bernd , WIEDENMANN-SCHLEMBACH, Karin
IPC分类号： B65B55/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container. Moreover said packaging container relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device Furthermore, the present invention encompasses a coated device, preferably an implant, obtainable by a method according to the present invention. The present invention also relates to the use of said method of coating devices for improving the homogeneous distribution of the coating on the device. Finally, the present invention relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device.

4. 发明申请

WO2008000488A1 BIOMATERIAL CONTAINING DEGRADATION STABILIZED POLYMER 审中-公开
标题翻译：含生物降解稳定聚合物
公开(公告)号：WO2008000488A1
公开(公告)日：2008-01-03
申请号：PCT/EP2007/005752
申请日：2007-06-28
申请人： SCIL TECHNOLOGY GMBH , FRIESS, Wolfgang , HELLERBRAND, Klaus , HERBERG, Samuel , POMPE, Cornelius , SCHUETZ, Andreas , SIEDLER, Michael
发明人： FRIESS, Wolfgang , HELLERBRAND, Klaus , HERBERG, Samuel , POMPE, Cornelius , SCHUETZ, Andreas , SIEDLER, Michael
IPC分类号： A61L27/58 , A61L27/50
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.
摘要翻译：本发明涉及包含水结合剂的聚合物基材料，而水结合剂以足以化学和/或物理吸收和/或吸附水的量存在以防止聚合物降解。它还涉及包含增塑剂或有机溶剂的聚合物基材料以及包含第二聚合物和/或活性剂的材料的多组分材料或复合材料。此外，本发明涉及制备包含材料的聚合物的方法和用于制备用于治疗骨，软骨和/或牙周缺陷的药物组合物的材料的用途。本发明还包括使用聚合物材料的试剂盒。此外，本发明包括水粘合剂用于抑制包含材料的聚合物的水诱导降解的用途，用于在包含聚合物的材料中诱导血块稳定性并增加包含材料的聚合物的储存稳定性，其中水结合剂在施加材料之前不被去除。

5. 发明申请

WO2007068489A2 A MOLDABLE BIOMATERIAL FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的可塑生物材料
公开(公告)号：WO2007068489A2
公开(公告)日：2007-06-21
申请号：PCT/EP2006/012082
申请日：2006-12-14
申请人： SCIL TECHNOLOGY GMBH , SIEDLER, Michael , HELLERBRAND, Klaus , SCHUETZ, Andreas , KRUEGER, Sabrina
发明人： SIEDLER, Michael , HELLERBRAND, Klaus , SCHUETZ, Andreas , KRUEGER, Sabrina
IPC分类号： A61L27/12 , A61L27/56
CPC分类号： A61L27/56 , A61L27/58
摘要： The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and/or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.
摘要翻译：本发明涉及一种可模制生物材料，其包括颗粒状固体多孔材料和可生物降解的糊料。糊状材料和颗粒状固体多孔材料形成可用于骨的更换或增加的基质。在各种实施方案中，基质具有高的结构完整性，其在植入塌陷成无定形无孔团块之后不立即或不久，在植入后保持其孔隙度，在植入后显示双相降解和/或具有良好的耐洗涤性当它被施加到湿开放的植入部位时。活性剂可以掺入本发明的可模制生物材料中，例如骨生长因子。还提供了套件，植入物，制造方法以及药用。

6. 发明申请

WO2008040556A1 DRIED RECONSTITUTED VESICLE FORMATION FOR PHARMACEUTICAL APPLICATION 审中-公开
标题翻译：用于药物应用的干燥重建的VESICLE形成
公开(公告)号：WO2008040556A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/008659
申请日：2007-10-05
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SCHUETZ, Andreas , SIGL, Rainer
发明人： HELLERBRAND, Klaus , SCHUETZ, Andreas , SIGL, Rainer
IPC分类号： A61K9/127 , A61K47/18 , C07K14/51 , A61K38/18
CPC分类号： A61K38/1875 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K9/1272 , A61K9/19 , A61K35/35 , A61K38/18
摘要： The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.
摘要翻译：本发明涉及含有一种或多种治疗剂（例如亲水性蛋白质）的干重建泡囊（DRV）组合物及其基于水的制剂。更具体地说，本发明涉及包含至少一种脂质和融合促进剂的DRV，其在重建后形成包封活性剂在水相中的大的多层脂质体。

7. 发明申请

WO2004024199A1 METAL IMPLANT COATED UNDER REDUCED OXYGEN CONCENTRATION WITH OSTEOINDUCTIVE PROTEIN 审中-公开
标题翻译：金属植入物与氧化蛋白质的还原氧化浓度
公开(公告)号：WO2004024199A1
公开(公告)日：2004-03-25
申请号：PCT/EP2003/007439
申请日：2003-07-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , BEAUCAMP, Nicola , KOHNERT, Ulrich
发明人： HELLERBRAND, Klaus , BEAUCAMP, Nicola , KOHNERT, Ulrich
IPC分类号： A61L27/04
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触，（c ）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂覆载体，其中步骤（b）至（d）在减少的氧浓度下进行。本发明还包括可通过本发明的方法获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

8. 发明申请

WO2008040557A1 A SPINAL NUCLEUS PULPOSUS IMPLANT 审中-公开
标题翻译：脊髓NUCLEUS PULPOSUS植入物
公开(公告)号：WO2008040557A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/008660
申请日：2007-10-05
申请人： SCIL TECHNOLOGY GMBH , DONY, Carola , HELLERBRAND, Klaus , HUSTERT, Elisabeth , PIPPIG, Susanne , SIGL, Rainer
发明人： DONY, Carola , HELLERBRAND, Klaus , HUSTERT, Elisabeth , PIPPIG, Susanne , SIGL, Rainer
IPC分类号： A61K9/127 , A61K38/18 , A61K9/00
CPC分类号： A61K38/1875 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K9/1272 , A61K9/19 , A61K35/35 , A61K38/18
摘要： The present invention relates to a spinal nucleus pulposus implant for use in the treatment of the intervertebral disc and in particular, to the use of a CD-RAP protein therefore.
摘要翻译：本发明涉及用于治疗椎间盘的脊髓髓核植入物，特别涉及使用CD-RAP蛋白。

9. 发明申请

WO2011134979A2 STABLE MIA/CD-RAP FORMULATION 审中-公开
标题翻译：稳定的MIA / CD-RAP配方
公开(公告)号：WO2011134979A2
公开(公告)日：2011-11-03
申请号：PCT/EP2011/056622
申请日：2011-04-27
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIGL, Rainer
发明人： HELLERBRAND, Klaus , SIGL, Rainer
IPC分类号： C07K14/78 , A61K9/00 , A61K38/18
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/0024 , A61K38/00 , A61K47/22 , A61K47/24 , C07K14/4703 , C07K14/78
摘要： The present invention relates to stable aqueous formulations comprising at least 5 mg/mL CD-RAP and a charged amino acid, said amino acid preferably having a net charge at a pH between about 6 and 8. The ingredients of the formulation preferably provide stability over repeated freeze-thaw cycles. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory disorders, preferably osteoarthritis. Furthermore, a kit comprising the formulation of the invention is provided.
摘要翻译：本发明涉及包含至少5mg / mL CD-RAP和带电荷氨基酸的稳定含水制剂，所述氨基酸优选在pH为约6至8之间具有净电荷。制剂的成分优选提供比反复冻融循环。在优选的方面，制剂用于治疗，优选用于治疗炎症性疾病，优选骨关节炎。此外，提供了包含本发明制剂的试剂盒。

10. 发明申请

WO2003043673A1 DEVICE HAVING OSTEOINDUCTIVE AND OSTEOCONDUCTIVE PROPERTIES 审中-公开
标题翻译：具有磁化和磁性特性的器件
公开(公告)号：WO2003043673A1
公开(公告)日：2003-05-30
申请号：PCT/EP2002/003463
申请日：2002-03-27
申请人： SCIL BIOMEDICALS GMBH , KOHNERT, Ulrich , PÖHLING, Sylke , HELLERBRAND, Klaus , HAPPERSBERGER, Peter
发明人： KOHNERT, Ulrich , PÖHLING, Sylke , HELLERBRAND, Klaus , HAPPERSBERGER, Peter
IPC分类号： A61L27/34
CPC分类号： A61L27/227 , A61L24/02 , A61L24/108 , A61L27/12 , A61L27/34
摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
摘要翻译：本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中所述载体均匀地涂覆有所述蛋白质。此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，并且涉及所述装置用于制备用于骨增大的药物组合物用于治疗骨缺损的用途用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

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