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1. 发明申请

WO1997026017A2 PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THEIR USE IN NMR DIAGNOSTICS 审中-公开
标题翻译：全氟烷金属络合物和使用核磁共振诊断
公开(公告)号：WO1997026017A2
公开(公告)日：1997-07-24
申请号：PCT/EP1997000209
申请日：1997-01-16
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , PLATZEK, Johannes , NIEDBALLA, Ulrich , RADÜCHEL, Bernd , SCHLECKER, Wolfgang , WEINMANN, Hanns-Joachim , FRENZEL, Thomas , MISSELWITZ, Bernd , EBERT, Wolfgang
IPC分类号： A61K49/00
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention concerns new monomer perfluoroalkyl-substituted metal complexes, a process for their production, and their use in diagnostics and therapy. The compounds according to the invention to the invention are particularly suited for use as in vivo contrast agents in nuclear spin resonance tomography (MRT). They can be preferably used as blood pool agents and contrast agents for lymphography.
摘要翻译：本发明涉及新的，单体，全氟烷基取代金属络合物，它们的制备方法以及它们在诊断和治疗中的用途。本发明的化合物是如磁共振成像（MRI）的体内的造影剂是特别有用的。优选地，它可以用作血池剂和Lymphographika。

2. 发明申请

WO1996019447A1 DISUBSTITUTED P-FLUOROBENZOLSULFONAMIDES AND THEIR USE IN NMR DIAGNOSTICS 审中-公开
标题翻译：二取代P FLUORBENZOSULFONAMIDE和它们在核磁共振诊断
公开(公告)号：WO1996019447A1
公开(公告)日：1996-06-27
申请号：PCT/EP1995004825
申请日：1995-12-08
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , NIEDBALLA, Ulrich , PLATZEK, Johannes , RADÜCHEL, Bernd , FRENZEL, Thomas , BAUER, Hans
IPC分类号： C07C311/08
CPC分类号： A61K49/06 , C07C311/08
摘要： Disubstituted p-fluorobenzolsulfonamides containing a CF3 group have the general formula (I), in which Z is a CF3 group or a hydrogen atom; Y is a C1-C6 alkyl group that may be substituted by 1 to 4 hydroxy groups or interrupted by 1 to 2 oxygen atoms, a (CH2)oCOOH or (CH2)oCONR R group in which o equals 0 or 1 and R and R represent independently from each other hydrogen and a C1-C6 alkyl group optionally substituted by 1 to 4 hydroxy groups; X is a hydrogen atom or has one of the meanings given for Y; W is a C0-C6 alkylene group that may be substituted by 1 to 4 hydroxy groups or interrupted by 1 to 2 oxygen atoms; n equals 0 or 1; A is one of the rests -OH, OR , -CF3, -CH2CF3, -NH-CH2-COOH, -NH-CR (CF3)-COOH, in which R is a hydrogen atom or a straight or branched chain C1-C6 alkyl group optionally substituted by 1 to 2 hydroxy groups, provided that X stands for a hydrogen atom when Z is a CF3 group, that X has one of the meanings given for Y when Z stands for a hydrogen atom and that the optional acid groups in the molecule be present as their amides or salts with organic or inorganic bases. These compounds are useful as NMR diagnostic agents.
摘要翻译：二取代的，一CF 3 P-Fluorbenzolsulfonamide通式（I）其中Z是CF 3基团或氢原子基团的，Y代表可被1至4个羟基基团或由1至2个取代的C1-C6烷基氧原子可以被中断，一（CH 2）oCOOH-或（CH 2）OCONR <1> [R <2>组O含义数字0或1，R <1>和R <2>在独立的含义彼此的氢和任选被1至4个羟基C1-C6烷基取代的，X为氢原子或Y的给定的含义之一，W为可被1至4个羟基基团从1是取代的或由一个C 0 -C 6亚烷基 2个氧原子可被中断，n是数字0或1，A表示基团OH或<3>，-CF 3，-CH 2 CF 3，-NH-CH 2 -COOH，-NH-CR <3>（CF 3） - COOH取代的直链或者与R <3>中的氢原子的含义或一个任选地被1至2个羟基取代的（S）支链C1-C6烷基，条件是X是Wasserstoffatour当Z是X具有用于Y给出的含义中的一个的CF 3基团，条件中，当Z是氢原子，和，如果需要的话，在分子中，存在于它们的酰胺的形式或与有机或无机碱的盐的形式的酸基团是适合作为NMR诊断试剂。

3. 发明申请

WO1997030969A1 PHARMACEUTICAL AGENTS CONTAINING PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THE USE THEREOF IN TUMOUR THERAPY AND INTERVENTIONAL RADIOLOGY 审中-公开
标题翻译：制药含肿瘤治疗和介入放射学全氟烷金属络合物使用
公开(公告)号：WO1997030969A1
公开(公告)日：1997-08-28
申请号：PCT/EP1997000684
申请日：1997-02-14
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , PLATZEK, Johannes , NIEDBALLA, Ulrich , RADÜCHEL, Bernd , SCHLECKER, Wolfgang , WEINMANN, Hanns-Joachim , FRENZEL, Thomas
IPC分类号： C07C229/06
CPC分类号： C07D295/26 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K49/06 , C07D257/02 , A61K2300/00
摘要： The invention relates to pharmaceutical agents containing perfluoroalkylated metal complexes of the general formula (I) RF-L-A and the use thereof in tumour therapy and interventional radiology, in which formula RF is a perfluorinated, straight-chain or branched carbon chain with the formula -CnF2nX, in which X is a terminal fluorine, chlorine, bromine, iodine or hydrogen atom and n represents the numbers 4-30, L is a binding group, and A is a metal complex or the salts thereof of organic and/or inorganic bases or amino acids or amino acid amides. L and A are defined in detail in the description.
摘要翻译：本发明涉及药物组合物包含通式（I），RF-LA，以及它们在肿瘤治疗和介入放射学用途，其中R f是全氟化的，直链或支链碳链与式-CnF2nX，在X的终端的全氟烷基化的金属络合物表示氟，氯，溴，碘或氢原子，n代表数字4-30，L为连接基团，并且a是金属配合物或有机和/或无机碱或氨基酸或氨基酸酰胺，L及其盐和A在本说明书中更详细地限定。

4. 发明申请

WO1997002051A2 CASCADE POLYMER COMPLEXES 审中-公开
标题翻译： CASCADE聚合物复合，方法用于生产和制药含
公开(公告)号：WO1997002051A2
公开(公告)日：1997-01-23
申请号：PCT/EP1996002671
申请日：1996-06-20
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , SCHMITT-WILLICH, Heribert , PLATZEK, Johannes , RADÜCHEL, Bernd , MÜHLER, Andreas , FRENZEL, Thomas
IPC分类号： A61K49/00
CPC分类号： C07D487/08 , A61K49/04 , A61K49/085 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001 , Y10S424/16
摘要： The disclosure pertains to cascade polymer complexes containing the following: a) complex-forming ligands of general formula (I), in which A is a nitrogen-containing cascade nucleus of basic multiplicity a; X and Y independently of one another stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y; Z and W independently of one another stand for cascade reproduction units of reproduction multiplicity z or w; K is the remainder of a complex forming agent; a stands for a number between 2 and 12; x, y, z and w independently of one another stand for numbers between 1 and 4, a condition being that at least two reproduction units are different and that the product of the multiplicities obeys the expression 16
摘要翻译：级联聚合物复合物包含：a）形成络合物的通式（I），其中A是碱多个一个的sticksvotffhaltigen级联核的配位体，X和Y独立地为直接键或分别再现多个x和y的级联再现单元，Z和W独立地彼此，再现多重Z或W的级联再现单元的，K是基团络合剂，支架为数字2〜12，X，Y，Z和W彼此独立地编号1〜4中，其前提是至少两个再现单元是不同的，且为多重的产物，16

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