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1. 发明申请

WO2005010153A2 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗体及其用途
公开(公告)号：WO2005010153A2
公开(公告)日：2005-02-03
申请号：PCT/US2004021002
申请日：2004-06-30
申请人： SAVIENT PHARMACEUTICALS INC , PLAKSIN DANIEL , LEVANON AVIGDOR , SZANTON ESTHER , HAGAY YOCHEVED , BEN-LEVY RACHEL , NISGAV YAEL , SZRAJBER TALI , KANFI YARIV
发明人： PLAKSIN DANIEL , LEVANON AVIGDOR , SZANTON ESTHER , HAGAY YOCHEVED , BEN-LEVY RACHEL , NISGAV YAEL , SZRAJBER TALI , KANFI YARIV
IPC分类号： C07K16/00 , C07K16/28 , C12N
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/005 , C07K16/2896 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2319/00
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.
摘要翻译：本发明提供了结合癌细胞的抗体或其片段，并且在生理现象如细胞转移和转移中是重要的。还提供了使用其抗体片段的治疗和诊断方法和组合物。根据本发明的方法和组合物可用于靶向治疗剂以及用于诸如癌症（包括肿瘤生长和转移，白血病，自身免疫疾病和炎症性疾病）的疾病的诊断，预后，分期和治疗。还提供了具有用于互补结合的不同抗原结合结构域的免疫球蛋白结合结构域的文库，其中文库仅在重链CDR3中具有多样性。

2. 发明申请

WO2005005455A3 SPECIFIC HUMAN ANTIBODIES 审中-公开
标题翻译：特异性人体抗体
公开(公告)号：WO2005005455A3
公开(公告)日：2006-02-16
申请号：PCT/US2004021099
申请日：2004-06-30
申请人： BIO TECHNOLOGY GENERAL ISRAEL , LEVANON AVIGDOR , VOGEL TIKVA , PLAKSIN DANIEL , PERETZ TUVIA , AMIT BOAZ , COOPERMAN LENA , HAGAY YOCHEVED , SZANTON ESTHER , KANFI YARIV , BEN-LEVY RACHEL , SZRAJBER TALI
发明人： LEVANON AVIGDOR , VOGEL TIKVA , PLAKSIN DANIEL , PERETZ TUVIA , AMIT BOAZ , COOPERMAN LENA , HAGAY YOCHEVED , SZANTON ESTHER , KANFI YARIV , BEN-LEVY RACHEL , SZRAJBER TALI
IPC分类号： A61K47/48 , C07K16/06 , C07K16/28 , C07K16/36 , C07K16/44 , A61K39/395
CPC分类号： C07K16/36 , A61K47/6809 , A61K47/6849 , C07K16/2896 , C07K16/44 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2319/00
摘要： The present invention provides antibodies that bind an epitope of PSGL-1 comprising the motif D-X-Y-D, wherein X represents any amino acid or the covalent linkage between D and Y, and Y is sulfated, which antibody can be complexed with one or more copies of an agent. The antibodies of the invention can be used in a method of inducing antibody-dependent cell cytotoxicity and/or stimulating natural killer (NK) cells or T cells. In addition, by administering these antibodies to a patient in need thereof, a method of inducing cell death is provided. A method of preventing infection by a virus (e.g., HIV) by administering to a patient in need thereof an antibody of the present invention is also provided. The present invention also provides a method of introducing an agent into a cell that expresses sulfated PSGL-1 by coupling or complexing an agent to an antibody of the present invention and administering the complex to the cell. Finally, the present invention provides methods of diagnosis, prognosis and staging using the present antibodies.
摘要翻译：本发明提供了结合包含基序DXYD的PSGL-1的表位的抗体，其中X表示任何氨基酸或D和Y之间的共价键，Y被硫酸化，该抗体可以与一个或多个拷贝的剂。本发明的抗体可用于诱导抗体依赖性细胞毒性和/或刺激天然杀伤（NK）细胞或T细胞的方法。另外，通过向有需要的患者施用这些抗体，提供诱导细胞死亡的方法。还提供了通过向有需要的患者施用本发明的抗体来预防病毒感染（例如HIV）的方法。本发明还提供了通过将试剂偶联或络合到本发明的抗体并将该复合物给予细胞而将试剂引入到表达硫酸化PSGL-1的细胞中的方法。最后，本发明提供使用本发明的抗体进行诊断，预后和分期的方法。

3. 发明申请

WO2004003166A3 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗体及其用途
公开(公告)号：WO2004003166A3
公开(公告)日：2005-03-10
申请号：PCT/US0320602
申请日：2003-06-30
申请人： SAVIENT PHARMACEUTICALS INC
发明人： LEVANON AVIGDOR , BEN-LEVY RACHEL , PLAKSIN DANIEL , SZANTON ESTHER , HAGAI YOCHEVED , HOCH MAR-CHAIM HAGIT
IPC分类号： G01N33/53 , A61K39/395 , A61K51/00 , A61P9/10 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P43/00 , C07K7/00 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/02 , C07H21/04 , C07K16/00 , C12N5/06 , C12N5/16 , C12P21/00 , G01N33/574
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/622
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and are important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic, prognostic or staging methods and compositions using such antibodies or fragments thereof are also provided. The methods and compositions according to the present invention can be used in diagnosis of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, autoimmune disease, and inflammatory disease.
摘要翻译：本发明提供了结合癌细胞的抗体或其片段，并且在生理现象如细胞转移和转移中是重要的。还提供了使用这种抗体或其片段的治疗和诊断，预后或分期方法和组合物。根据本发明的方法和组合物可以用于诸如癌症的疾病的诊断和治疗，包括肿瘤生长和转移，白血病，自身免疫性疾病和炎性疾病。

4. 发明申请

WO2012131306A8 PHARMACEUTICAL PREPARATION 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2012131306A8
公开(公告)日：2013-10-24
申请号：PCT/GB2012000291
申请日：2012-03-29
申请人： FERRING BV , COTTINGHAM IAN , PLAKSIN DANIEL , AHARANOV JENNY
发明人： COTTINGHAM IAN , PLAKSIN DANIEL , AHARANOV JENNY
IPC分类号： A61K47/48 , A61P15/08
CPC分类号： A61K47/48215 , A61K47/60
摘要： Preparations including poly (ethylene glycol) modified recombinant hCG (r hCG).
摘要翻译：制备包括聚（乙二醇）修饰的重组hCG（r hCG）。

5. 发明申请

WO2009063307A8 INFLAMMATORY ACTIVITY DETECTION METHOD USING IL-6 审中-公开
标题翻译：使用IL-6的炎症活动检测方法
公开(公告)号：WO2009063307A8
公开(公告)日：2009-09-17
申请号：PCT/IB2008003063
申请日：2008-11-14
申请人： BIO TECHNOLOGY GENERAL ISRAEL , PLAKSIN DANIEL
发明人： PLAKSIN DANIEL
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2333/5412
摘要： Inflammatory activity contaminating a medical device or biologic agent can greatly affect both its safety and its efficacy. Disclosed are methods of detecting inflammatory activity in a test sample by administering the test sample to an animal and detecting the level of a pro-inflammatory cytokine or other cell-derived mediator of inflammation. Elevated levels of pro-inflammatory cytokines such as IL-1, IL-6, TNF-a, or IFN-?, or of other cell-derived mediators of inflammation such as lysosome granules, histamine, IL-8, leukotriene B4, nitric oxide, or prostaglandin E2 (PGE2), indicate that the test sample has inflammatory activity. The inflammatory activity may be due to any pro-inflammatory factor, such as a bacterial endotoxin (e.g., a lipopolysaccharide) or a non-endotoxin pyrogen (e.g., a Streptococcal mucopeptide).
摘要翻译：污染医疗器械或生物制剂的炎症活动可能会严重影响其安全性和疗效。公开了通过将测试样品给予动物并检测促炎细胞因子或其他细胞衍生的炎症介质的水平来检测测试样品中的炎症活性的方法。促炎细胞因子如IL-1，IL-6，TNF-α或IFN-γ或其他细胞衍生的炎症介质如溶酶体颗粒，组胺，IL-8，白三烯B4，一氧化氮氧化物或前列腺素E2（PGE2）表明测试样品具有炎性活性。炎性活性可能是由于任何促炎因子如细菌内毒素（例如脂多糖）或非内毒素热原（例如链球菌粘肽）造成的。

6. 发明申请

WO2009063307A3 INFLAMMATORY ACTIVITY DETECTION METHOD USING IL-6 审中-公开
标题翻译：使用IL-6的炎症活性检测方法
公开(公告)号：WO2009063307A3
公开(公告)日：2009-11-05
申请号：PCT/IB2008003063
申请日：2008-11-14
申请人： BIO TECHNOLOGY GENERAL ISRAEL , PLAKSIN DANIEL
发明人： PLAKSIN DANIEL
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2333/5412
摘要： Inflammatory activity contaminating a medical device or biologic agent can greatly affect both its safety and its efficacy. Disclosed are methods of detecting inflammatory activity in a test sample by administering the test sample to an animal and detecting the level of a pro-inflammatory cytokine or other cell-derived mediator of inflammation. Elevated levels of pro-inflammatory cytokines such as IL-1, IL-6, TNF-a, or IFN-?, or of other cell-derived mediators of inflammation such as lysosome granules, histamine, IL-8, leukotriene B4, nitric oxide, or prostaglandin E2 (PGE2), indicate that the test sample has inflammatory activity. The inflammatory activity may be due to any pro-inflammatory factor, such as a bacterial endotoxin (e.g., a lipopolysaccharide) or a non-endotoxin pyrogen (e.g., a Streptococcal mucopeptide).
摘要翻译：污染医疗器械或生物制剂的炎症活动可能会极大地影响其安全性及其功效。公开了通过向动物施用测试样品并检测促炎细胞因子或其他细胞来源的炎症介质的水平来检测测试样品中的炎症活性的方法。炎症细胞因子如IL-1，IL-6，TNF-α或IFN-γ或其它细胞来源的炎症介质如溶酶体颗粒，组胺，IL-8，白三烯B4，硝酸氧化物或前列腺素E2（PGE2），表明测试样品具有炎症活性。炎症活性可能是由于任何促炎因子，例如细菌内毒素（例如脂多糖）或非内毒素热原（例如链球菌粘肽）。

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