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1. 发明申请

WO2009086136A3 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：WO2009086136A3
公开(公告)日：2010-04-15
申请号：PCT/US2008087728
申请日：2008-12-19
申请人： SARTORIUS STEDIM NORTH AMERICA , CUTTING JONATHAN , GAY ISABELLE , LEE ERIC K , VOUTE NICOLAS
发明人： CUTTING JONATHAN , GAY ISABELLE , LEE ERIC K , VOUTE NICOLAS
IPC分类号： A01N1/02 , A61J1/05 , B65D81/38 , F25D3/00
CPC分类号： A01N1/02 , A01N1/0263
摘要： A system for using freezing, storing and thawing biopharmaceutical materials which includes a holder and a container for holding biopharmaceutical materials therein. The holder has a cavity and the container is received in the cavity. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior cradle having a bottom and edges extending from the bottom. The cradle bounds the cavity. An outer rim is connected to the cradle and separated from the cavity. The bottom includes an inner surface facing the cavity receiving the container and an outer surface. The outer surface of the bottom is recessed relative to an outer surface of the outer rim.
摘要翻译：一种用于使用冷冻，储存和解冻生物药物材料的系统，其包括用于在其中保持生物药物材料的保持器和容器。保持器具有空腔并且容器容纳在空腔中。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括具有底部的内部支架和从底部延伸的边缘。摇篮限定了空腔。外缘连接到支架并与空腔分离。底部包括面向容纳容器的空腔的内表面和外表面。底部的外表面相对于外缘的外表面凹陷。

2. 发明申请

WO2010036552A3 SYSTEMS AND METHODS FOR STORING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于储存生物材料的系统和方法
公开(公告)号：WO2010036552A3
公开(公告)日：2010-06-17
申请号：PCT/US2009057241
申请日：2009-09-17
申请人： SARTORIUS STEDIM NORTH AMERICA , VOUTE NICOLAS , CUTTING JONATHAN , GAY ISABELLE
发明人： VOUTE NICOLAS , CUTTING JONATHAN , GAY ISABELLE
IPC分类号： A61J1/05 , A61J1/16
CPC分类号： A01N1/0263
摘要： A system for use in storing biopharmaceutical materials includes a holder and a container for holding biopharmaceutical materials therein. The container includes a storage portion and a sampling portion connected to each other by a connecting portion. The holder has a storage cavity receiving the storage portion and a sampling cavity receiving the sampling portion. The holder includes a first portion and second portion. The container is received between the first portion and the second portion to connect the container to the holder. The holder includes an interior storage cradle bounding the storage cavity of the holder. The holder includes an interior sampling cradle bounding the sampling cavity. The sampling cradle is separated from the storage cradle and connected to the storage cradle by a passage receiving the connecting portion connecting the storage portion to the sampling portion. An outer rim of the holder is connected to the cradle and separated from the cavity.
摘要翻译：用于储存生物药物材料的系统包括保持器和用于在其中保持生物药物材料的容器。容器包括通过连接部分彼此连接的存储部分和采样部分。保持器具有容纳存储部的存储空间和接收采样部的采样腔。保持器包括第一部分和第二部分。容器容纳在第一部分和第二部分之间，以将容器连接到保持器。保持器包括限定保持器的存储腔的内部存储支架。支架包括一个限定采样腔的内部采样支架。采样托架与存储托架分离，并通过接收将存储部分连接到采样部分的连接部分的通道连接到存储支架。保持器的外缘连接到支架并与空腔分离。

3. 发明申请

WO2011063381A3 SYSTEMS AND METHODS FOR USE IN FREEZING, THAWING, AND STORING BIOPHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于冷冻，治疗和储存生物材料的系统和方法
公开(公告)号：WO2011063381A3
公开(公告)日：2015-10-08
申请号：PCT/US2010057752
申请日：2010-11-23
申请人： SARTORIUS STEDIM NORTH AMERICA INC , CUTTING JONATHAN , GAY ISABELLE , REIF OSCAR WERNER
发明人： CUTTING JONATHAN , GAY ISABELLE , REIF OSCAR WERNER
IPC分类号： A61J1/16
CPC分类号： A61J1/165 , A01N1/0252 , A01N1/0257 , A01N1/0273 , B01F5/10 , B01F11/0008 , B01F11/0082 , B01F15/0074 , B01F15/065 , B01F2015/061 , B65D81/3825
摘要： A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity.
摘要翻译：一种用于冷冻，解冻，运输或储存生物药物材料的系统，其包括容器，保持器和多个传热构件。容器构造成在其中容纳生物药物材料。保持器具有用于容纳容器的空腔，并且包括限定空腔的内表面。多个凹穴接触容器的外表面并被容纳在空腔中。多个口袋中的每个口袋都包括袋腔。传热构件主动地控制容纳在容器中的生物药物的温度并被容纳在口腔中。

4. 发明申请

WO2013000544A3 BIOREACTOR CONTAINER AND INTEGRITY CHECK METHOD FOR BIOREACTOR CONTAINERS 审中-公开
标题翻译：生物反应器罐和完整性测试程序容器生物反应器
公开(公告)号：WO2013000544A3
公开(公告)日：2013-04-04
申请号：PCT/EP2012002541
申请日：2012-06-15
申请人： SARTORIUS STEDIM BIOTECH GMBH , DAHLBERG MARTIN , GAY ISABELLE , BOETTCHER LARS , OBERMANN STEFAN , SANDROCK RAINER
发明人： DAHLBERG MARTIN , GAY ISABELLE , BOETTCHER LARS , OBERMANN STEFAN , SANDROCK RAINER
IPC分类号： A61J1/10 , A61J1/16 , B32B1/02 , B32B3/30 , B32B5/02 , B32B27/12 , G01M3/32
CPC分类号： C12M23/14 , A61J1/10 , A61J1/16 , B32B1/02 , B32B3/30 , B32B5/022 , B32B5/024 , B32B5/18 , B32B2307/726 , B32B2307/7265 , C12M23/02 , C12M23/26 , F04C2270/0421 , G01M3/04 , G01M3/22 , G01M3/3218 , G01M3/3272
摘要： One embodiment of the invention relates to a bioreactor container which comprises: walls that are flexible at least in sections and at least one container opening, the walls of the bioreactor container having a fluid-tight inner layer and the walls of the bioreactor container having an outer layer that is permeable to fluids or structured in at least sections thereof. The invention further relates to a method for checking the integrity of the bioreactor container.
摘要翻译：本发明的一个方面涉及一种生物反应器容器，包括： - 至少部分柔性的壁，以及 - 至少一个容器开口，其特征在于，所述生物反应器容器的壁具有流体密封的内层和所述生物反应器容器的壁具有至少部分流体可渗透的或结构化的外层，以及用于测试的方法生物反应容器的完整性。

5. 发明申请

WO2009122310A3 DISPOSABLE MIXING VESSEL COMPRISING AN INTERCONNECTED MAGNETIC STIRRER 审中-公开
标题翻译：包含相互连接的磁性搅拌器的可混合混合容器
公开(公告)号：WO2009122310A3
公开(公告)日：2010-01-28
申请号：PCT/IB2009006077
申请日：2009-03-18
申请人： SARTORIUS STEDIM BIOTECH GMBH , LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
发明人： LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/18 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel (2) comprising a flexible container (4), a centrally disposed shaft (6) having first and second ends with one or more impellers (10) thereon and a magnetic element (8) associated with a first shaft end, a first flange (12) adapted to rotatably engage the first shaft end and a second flange (14) adapted to rotatably engage the second shaft end.
摘要翻译：一种一次性混合容器（2），包括柔性容器（4），中心设置的轴（6），其具有在其上的一个或多个叶轮（10）的第一和第二端以及与第一轴端相关联的磁性元件（8）适于可旋转地接合所述第一轴端的第一凸缘（12）和适于可旋转地接合所述第二轴端的第二凸缘（14）。

6. 发明申请

WO2009115926A3 METHOD OF MIXING COMPRISING AN INTERCONNECTED MAGNETIC STIRRER 审中-公开
标题翻译：混合包含互连磁电极的方法
公开(公告)号：WO2009115926A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009005467
申请日：2009-03-18
申请人： SARTORIUS STEDIM BIOTECH GMBH , LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
发明人： LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/18 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container (4) which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft (6) with at least one impeller (10), whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element (8) of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor (24) or a sampling line (26) on the flexible container; and draining the contents of the flexible container through a drain port (18) at the bottom of the flexible container.
摘要翻译：一种混合方法，包括提供包括至少两个部件的柔性容器（4），从柔性容器外部组装部件以形成具有至少一个叶轮（10）的居中设置的磁力驱动轴（6），由此完整性保持柔性容器的一个或多个成分，填充具有居中设置的磁力驱动轴的柔性容器; 将中心设置的磁驱动轴的磁性元件（8）与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器（24）或取样管线（26）分析柔性容器的内容物; 并且通过柔性容器底部的排放口（18）排出柔性容器的内容物。

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