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1. 发明申请

WO2009115241A3 BIOREACTOR 审中-公开
标题翻译：生物反应器
公开(公告)号：WO2009115241A3
公开(公告)日：2009-11-19
申请号：PCT/EP2009001828
申请日：2009-03-13
申请人： SARTORIUS STEDIM BIOTECH GMBH , WUENN EBERHARD , GRELLER GERHARD , ADAMS THORSTEN
发明人： WUENN EBERHARD , GRELLER GERHARD , ADAMS THORSTEN
IPC分类号： C12M1/12
CPC分类号： C12M29/04 , C12M23/14 , C12M23/34 , C12M27/16 , C12M29/10 , C12M41/00
摘要： The invention relates to a bioreactor for cultivating cells having a filter bag for separating culture fluid and cells, the filter medium of the filter bag having a degree of swelling of less than 1%. The bioreactor according to the invention is characterized by a high durability of the filter bag thereof.
摘要翻译：用于培养细胞的生物反应器配备有用于分离培养液和细胞的过滤袋，其中过滤袋在水中的过滤介质的溶胀度小于1％。根据本发明的生物反应器的特征在于其滤袋的高阻力。

2. 发明申请

WO2009143925A3 FLEXIBLE BAG HAVING A MIXING DEVICE 审中-公开
标题翻译：用搅拌机软袋
公开(公告)号：WO2009143925A3
公开(公告)日：2010-03-25
申请号：PCT/EP2009002281
申请日：2009-03-27
申请人： SARTORIUS STEDIM BIOTECH GMBH , PRADEL GUENTER , GRELLER GERHARD
发明人： PRADEL GUENTER , GRELLER GERHARD
IPC分类号： B01F15/00 , B01F7/00 , B01F7/22 , C12M1/00 , C12M1/02 , F16C3/03
CPC分类号： B01F7/00633 , B01F7/00691 , B01F7/007 , B01F7/00716 , B01F7/22 , B01F15/00831 , B01F15/0085 , C12M23/14 , C12M27/02 , F16C3/03
摘要： The invention relates to a flexible bag (1) having a mixing device having a mixer shaft, the length thereof being adjustable, particularly for use as a bioreactor for cultivating microorganisms and cells.
摘要翻译：本发明涉及一种柔性袋（1）用的混合装置，所述混合器轴在它的长度可调节的，特别是用作用于培养微生物和细胞的生物反应器。

3. 发明申请

WO2009122310A3 DISPOSABLE MIXING VESSEL COMPRISING AN INTERCONNECTED MAGNETIC STIRRER 审中-公开
标题翻译：包含相互连接的磁性搅拌器的可混合混合容器
公开(公告)号：WO2009122310A3
公开(公告)日：2010-01-28
申请号：PCT/IB2009006077
申请日：2009-03-18
申请人： SARTORIUS STEDIM BIOTECH GMBH , LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
发明人： LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/18 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel (2) comprising a flexible container (4), a centrally disposed shaft (6) having first and second ends with one or more impellers (10) thereon and a magnetic element (8) associated with a first shaft end, a first flange (12) adapted to rotatably engage the first shaft end and a second flange (14) adapted to rotatably engage the second shaft end.
摘要翻译：一种一次性混合容器（2），包括柔性容器（4），中心设置的轴（6），其具有在其上的一个或多个叶轮（10）的第一和第二端以及与第一轴端相关联的磁性元件（8）适于可旋转地接合所述第一轴端的第一凸缘（12）和适于可旋转地接合所述第二轴端的第二凸缘（14）。

4. 发明申请

WO2009115926A3 METHOD OF MIXING COMPRISING AN INTERCONNECTED MAGNETIC STIRRER 审中-公开
标题翻译：混合包含互连磁电极的方法
公开(公告)号：WO2009115926A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009005467
申请日：2009-03-18
申请人： SARTORIUS STEDIM BIOTECH GMBH , LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
发明人： LUDWIG JENS , REIF OSCAR-WERNER , GRELLER GERHARD , KAHLERT WOLFGANG , PRADEL GUNTHER , BATES MICHAEL , BARBAROUX MAGALI , BAUD STEPHANE , GAY ISABELLE , CHAUSSIN SEBASTIEN
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/18 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container (4) which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft (6) with at least one impeller (10), whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element (8) of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor (24) or a sampling line (26) on the flexible container; and draining the contents of the flexible container through a drain port (18) at the bottom of the flexible container.
摘要翻译：一种混合方法，包括提供包括至少两个部件的柔性容器（4），从柔性容器外部组装部件以形成具有至少一个叶轮（10）的居中设置的磁力驱动轴（6），由此完整性保持柔性容器的一个或多个成分，填充具有居中设置的磁力驱动轴的柔性容器; 将中心设置的磁驱动轴的磁性元件（8）与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器（24）或取样管线（26）分析柔性容器的内容物; 并且通过柔性容器底部的排放口（18）排出柔性容器的内容物。

5. 发明申请

WO2009103450A3 BIOREACTOR 审中-公开
标题翻译：生物反应器
公开(公告)号：WO2009103450A3
公开(公告)日：2010-04-01
申请号：PCT/EP2009000961
申请日：2009-02-12
申请人： SARTORIUS STEDIM BIOTECH GMBH , REIF OSCAR-WERNER , VAN DEN BOOGAARD JUERGEN , GRELLER GERHARD , LUDWIG JENS
发明人： REIF OSCAR-WERNER , VAN DEN BOOGAARD JUERGEN , GRELLER GERHARD , LUDWIG JENS
IPC分类号： C12M1/02
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： The invention relates to a bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) on the inside (9) of the container (2), a drive (4) that can be connected to the shaft (5) and is disposed outside the container (2), wherein the shaft (5) is supported in the shaft housing (3) by way of at least one ball bearing (23) and is sealed with respect to the shaft housing (3) by way of at least one seal (11, 20), wherein the seal (11, 20) is configured as a radial shaft seal ring (28) having two dry sealing lips (30, 31) that are successively disposed on the shaft (5) in the longitudinal direction of the shaft (5).
摘要翻译：（生物反应器（1）包括容器（2），一轴壳体（3），用于通过一个壁执行的轴（5）（7），在所述内部（9）的容器（2）与轴（5）关联的搅拌器布置6），（容器2），与轴（5）连接的驱动器的外部（4），支撑在轴（5）在轴壳体（3）通过至少一个滚珠轴承（23）和（通过至少一个密封件 11，20）相对于所述轴壳体（3），其中，所述密封件（11，20）布置为径向轴密封带有两个环（28）（在轴5）一个在另一个后面的纵向方向上，在所述轴（5）干laufbaren密封唇（30密封，31）形成。

6. 发明申请

WO2010145735A2 CONTAINER WITH A SENSOR ADAPTER 审中-公开
标题翻译：用传感器器容器
公开(公告)号：WO2010145735A2
公开(公告)日：2010-12-23
申请号：PCT/EP2010002808
申请日：2010-05-07
申请人： SARTORIUS STEDIM BIOTECH GMBH , BAUMFALK REINHARD , KAHLERT WOLFGANG , GRELLER GERHARD
发明人： BAUMFALK REINHARD , KAHLERT WOLFGANG , GRELLER GERHARD
IPC分类号： G01D11/30
CPC分类号： G01D11/30 , C21C5/527 , C21C5/565 , C22B1/005 , C22B7/006 , C22B19/30 , Y02P10/216 , Y02P10/234
摘要： The invention relates to a container with a sensor adapter for accommodating a sensor arrangement for measuring at least one parameter of media contained in an inner space of the container, wherein the sensor adapter is arranged at the wall to the inner space of the container and comprises a receiving opening, which is accessible from the outside, of a receiving channel, the boundaries of which facing the inner space of the container for adapting the sensor arrangement. According to the invention, the receiving channel of the sensor adapter comprises towards the inner space of the container at least one boundary surface formed by a membrane, by which the medium or media to be measured are supplied to the sensor arrangement.
摘要翻译：容器与传感器适配器，用于接收一个传感器装置，用于测量包含在容器内部的媒体，其中所述传感器适配器被布置在壁到所述容器内部的至少一个参数，并朝向内部容器的外部可访问的接收开口有界接收信道，用于适配所述传感器装置，其中，所述朝向至少接收传感器适配器的信道向容器内部通过，通过该传感器装置，或者介质将被测量可以被供给的膜形成的边界表面。

7. 发明申请

WO2010063372A3 CLOSURE FOR A CONTAINER 审中-公开
标题翻译：关闭而在容器
公开(公告)号：WO2010063372A3
公开(公告)日：2010-07-29
申请号：PCT/EP2009008176
申请日：2009-11-17
申请人： SARTORIUS STEDIM BIOTECH GMBH , REIF OSCAR-WERNER , FATHERAZI SHAHMIR , GRELLER GERHARD , BATES MICHAEL , BARBAROUX MAGALI
发明人： REIF OSCAR-WERNER , FATHERAZI SHAHMIR , GRELLER GERHARD , BATES MICHAEL , BARBAROUX MAGALI
IPC分类号： B65D47/24 , F16K3/26
CPC分类号： B65D75/5877 , B01J19/0053 , B01J19/2415 , B01L3/523 , B01L2300/049 , B01L2300/0672 , C12M23/26 , C12M23/28 , C12M23/38
摘要： The present invention relates to a closure for a container. The closure according to the invention comprises no dead space, ensures favorable media flow, and comprises a high level of safety. The closure according to the invention comprises a top part (1) that can be connected to the container, having an opening (2) and comprising an outer hollow body (3) and an inner hollow body (4) disposed coaxially to the same and forming an intermediate space. The opening (2) of the closure according to the invention can be closed by a tang (5), wherein the tang (5) is coaxially received by retaining devices (6) in a base (7) shaped as a hollow body. The upper part of the base (7) can be longitudinally displaced in the intermediate space of the container for opening the opening (2). By limiting the longitudinal displacement of the base (7) by locking devices (8, 9), unintended opening of the closure by completely removing the base (7) is prevented. The closure according to the invention allows inlet and outlet of media into and out of a container, wherein the closure can receive further container devices.
摘要翻译：本发明涉及一种用于容器的封闭件。根据本发明应该包含没有死空间的封闭，保证良好的舆论导向，具有较高的安全性。根据本发明的封闭包括具有外中空体的容器，可连接到具有开口（2）（1）的上部（3）和一个同轴的内这一点，形成中空体的间隙（4）。根据本发明的封闭件（2）的开口可以通过（5），在同轴的空心体形状的下部分（7）的溶液中加入所述心轴（5）通过保持装置（6）的心轴被关闭。的下部（7）离开纵向移动用于打开在从容器的间隙的开口（2）的上部。通过锁定装置限制所述下部分（7）的纵方向位移（8,9）是通过下部部分（7）可预防的全部撤出封闭的无意开放。本发明的封闭件允许介质供给和排出，并从一个容器，封闭件可以包括另外的容器的装置。

8. 发明申请

WO2015022099A1 RECEPTACLE COMPRISING A SHAFT HOUSING 审中-公开
标题翻译：有外壳容器
公开(公告)号：WO2015022099A1
公开(公告)日：2015-02-19
申请号：PCT/EP2014061025
申请日：2014-05-28
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： SEITZ REINER , SALZMANN RAINER , REGEN THOMAS , HIELSCHER MATTHIAS , HUSEMANN BERNWARD , ZEUCH STEFAN , HUSEMANN UTE , GRELLER GERHARD
IPC分类号： C12M1/00 , B01F7/00 , B01F15/00 , C12M1/06 , F16C33/00
CPC分类号： B01F7/00683 , B01F15/00441 , B01F15/00707 , B01F15/0085 , B01F2015/00084 , B01F2015/0011 , C12M23/26 , C12M23/28 , C12M27/02 , C12M37/04 , F16C19/545 , F16C33/76 , F16J15/002
摘要： The invention relates to a receptacle comprising a shaft housing for guiding a shaft through a wall into the receptacle interior, the shaft being mounted in the shaft housing via a shaft guide part by way of ball bearings and being sealed relative to the shaft housing by means of seals. The invention is characterized in that: the shaft housing has the form of an annular cap towards the receptacle interior and has an inner wall spaced apart from the outer wall, said inner wall being connected to the outer wall of the shaft housing via an inner end face facing the receptacle interior; the shaft guide part, at its end facing the receptacle interior, has an outer surface which defines a gap relative to the inner wall of the shaft housing; the shaft guide part has an annular wall spaced apart from and parallel to its outer surface, which annular wall extends over the free end of the inner wall of the shaft housing in the form of a cap; the annular wall is sealed in relation to the inner wall of the shaft housing on the one end and in relation to the outer wall of the shaft housing on the other end by at least one seal each; and the shaft guide part is mounted in the shaft housing by means of a first ball bearing in the form of a radial ball bearing and by means of a second ball bearing in the form of an axial ball bearing.
摘要翻译：本发明涉及一种具有用于通过在所述容器内部的壁，其中，所述轴安装有经由球轴承在轴壳体中的波导管部分，并通过密封件相对于所述轴壳体密封携带的轴的轴壳体的容器。本发明的特征在于，所述轴壳体被构造为环状的盖到容器内部，并从外壁，它通过表面连接面对容器内部的内面与轴壳体的外壁的内壁间隔开，即在其端部的导波部面对的所述容器内端具有形成相对于所述轴壳体的内壁中的间隙的外表面，该波导部分隔开并平行于它的外表面中的环形壁，其接合在所述轴壳体帽状的内壁的自由端，以及抵靠轴壳体的一方面内壁环形壁和通过在每种情况下对轴壳体的外壁密封另一方面至少一个密封件，并且经由第一球在轴壳体中的波导管部轴承作为径向 usgebildetes球轴承，并经由第二推力球轴承设计为滚珠轴承支承。

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