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1. 发明申请

WO2004024757A2 MODIFIED PNA MOLECULES 审中-公开
标题翻译：修饰的PNA分子
公开(公告)号：WO2004024757A2
公开(公告)日：2004-03-25
申请号：PCT/DK0300588
申请日：2003-09-11
申请人： SANTARIS PHARMA AS , RASMUSSEN PALLE , FRANDSEN NIELS MONTANO , NYBORG MARLENE , RASMUSSEN FRANK WINTHER , HAMZAVI RAMIN , NIELSEN PETER EIGILD , KJAERULFF SOEREN
发明人： RASMUSSEN PALLE , FRANDSEN NIELS MONTANO , NYBORG MARLENE , RASMUSSEN FRANK WINTHER , HAMZAVI RAMIN , NIELSEN PETER EIGILD , KJAERULFF SOEREN
IPC分类号： C07H21/00 , C07K14/00
CPC分类号： C07H21/00
摘要： The present invention concerns novel drugs for use in combating various diseases. More particularly the invention concerns peptide nucleic acid (PNA) drugs, which are optionally modified in order to obtain novel PNA molecules with cell-specific delivery.
摘要翻译：本发明涉及用于对抗各种疾病的新药。更具体地说，本发明涉及肽核酸（PNA）药物，其为了获得具有细胞特异性递送的新型PNA分子而任选进行修饰。

2. 发明申请

WO2010006615A3 METHOD AND KIT FOR ASSESSING VIABLE CELLS 审中-公开
标题翻译：用于评估可变细胞的方法和工具包
公开(公告)号：WO2010006615A3
公开(公告)日：2010-06-10
申请号：PCT/DK2009050173
申请日：2009-07-13
申请人： CHEMOMETEC AS , SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , KJAERULFF SOEREN
发明人： SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , KJAERULFF SOEREN
IPC分类号： A01N1/02 , G01N15/14 , G01N21/64 , G01N33/50
CPC分类号： G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途）。本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。

3. 发明申请

WO2010006616A2 METHOD AND KIT FOR EXAMINATION OF CELLS USING N-(9-ACRIDINYL)MALEIMIDE (NAM) OR USING 7-DIETHYLAMINO-3-((4'-(IODOACETYL)AMINO)PHENYL)-4-METHYLCOUMARIN (CPI) 审中-公开
标题翻译：使用N-（9-亚甲基苯基）马来酰亚胺（NAM）或使用7-二乙氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基橙AR呤（CPI）的细胞检测细胞的方法和试剂盒
公开(公告)号：WO2010006616A2
公开(公告)日：2010-01-21
申请号：PCT/DK2009050174
申请日：2009-07-13
申请人： CHEMOMETEC AS , SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , KJAERULFF SOEREN
发明人： SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , KJAERULFF SOEREN
IPC分类号： G01N1/30 , A61K51/12 , C07K1/36 , G01N33/50 , G01N33/80
CPC分类号： G01N1/30 , C07K1/13 , G01N33/5005 , G01N33/502
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3- ((4'-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4'- (iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4'-(iodoacetyl)amino)phenyl)-4- methylcoumarin (CPI). The invention further relates to compositions used in methods for analyzing cells.
摘要翻译：本发明提供了用于分析细胞的简单，快速的方法和程序，在细胞的定量和定性评估之后。本发明涉及N-（9-吖啶基）马来酰亚胺（NAM）或使用7-二乙氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）特别是在其与完整（例如，活的）细胞中以高浓度存在的物质（例如，含硫物质）反应时可检测到，而不是在非完整（例如死亡）细胞中。本发明还涉及NAM或7-二乙氨基-3 - （（4'-（碘乙酰基）氨基）苯基）-4-甲基香豆素（CPI）的用途，特别是可通过其与存在于完整的和/或不完整的细胞。此外，本发明涉及与使用NAM或使用7-二乙氨基-3 - （（4' - （碘乙酰基）氨基）苯基）-4-甲基香豆素（ CPI）。本发明还涉及用于分析细胞的方法中的组合物。

4. 发明申请

WO2008135047A3 CONTROLLABLE PROMOTERS FOR USE IN FISSION YEAST 审中-公开
标题翻译：可控制的促销商在使用YEAST
公开(公告)号：WO2008135047A3
公开(公告)日：2008-12-31
申请号：PCT/DK2008050098
申请日：2008-04-30
申请人： UNIV KOEBENHAVN , KJAERULFF SOEREN
发明人： KJAERULFF SOEREN
IPC分类号： C12N15/81 , C12N15/72
CPC分类号： C12N15/81 , C12N15/72
摘要： The present invention relates to a nucleic acid comprising a chimeric nmt::lacO promoter that allows control of gene expression in fission yeast. Hence, a gene controlled by the promoter can be turned on and off. Such promoter is useful for protein expression in fission yeast and also for biological studies in fission yeast. Other aspects of theinvention are vectorsand a kit comprising the vectorsand a method of inducing synthesis of a pre-determined RNA, said pre-determined RNA being under the control of the chimeric nmt::lacO promoter.
摘要翻译：本发明涉及包含允许控制裂殖酵母中基因表达的嵌合nmt :: lacO启动子的核酸。因此，可以开启和关闭由启动子控制的基因。这种启动子可用于裂殖酵母中的蛋白质表达，也可用于裂殖酵母中的生物学研究。本发明的其它方面是载体和包含载体的试剂盒和诱导预定RNA合成的方法，所述预定RNA处于嵌合nmt :: lacO启动子的控制之下。

5. 发明申请

WO2010045949A3 APPARATUS AND METHODS FOR ANALYSING FLUORESCENT PARTICLES 审中-公开
标题翻译：用于分析荧光颗粒的装置和方法
公开(公告)号：WO2010045949A3
公开(公告)日：2010-07-01
申请号：PCT/DK2009050278
申请日：2009-10-21
申请人： CHEMOMETEC AS , KJAERULFF SOEREN , SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , RAVN FRANS , GLENSBJERG MARTIN
发明人： KJAERULFF SOEREN , SKINDERSOE METTE ELENA , SOERENSEN HELLE FROBOESE , RAVN FRANS , GLENSBJERG MARTIN
IPC分类号： G01N21/64 , C12N15/00 , G01N1/30 , G01N33/50 , G01N33/58 , G02B21/06 , G02B27/09
CPC分类号： G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
摘要： According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
摘要翻译：根据本发明的实施例，公开了一种从样品中检测荧光的装置。所述装置包括：样品布置在其上的样品平面;至少包括用于照射样品的光源的激发光单元;以及检测单元，其至少包括具有至少100,000个有源检测元件的检测器，以检测来自例子。

6. 发明申请

WO2007137586A3 RANDOM INSERTION OF PEPTIDES 审中-公开
标题翻译：随体插入肽
公开(公告)号：WO2007137586A3
公开(公告)日：2008-02-28
申请号：PCT/DK2007000256
申请日：2007-05-30
申请人： PHARMEXA AS , LYNGSOE CHRISTINA , KJAERULFF SOEREN , MUELLER SVEN , BRATT TOMAS , DEGAN FLORENCE DAL
发明人： LYNGSOE CHRISTINA , KJAERULFF SOEREN , MUELLER SVEN , BRATT TOMAS , DEGAN FLORENCE DAL
IPC分类号： C12N15/09 , A61K39/00 , A61K39/385 , C07K14/82 , C07K19/00
CPC分类号： C12N15/1044 , A61K39/00 , A61K39/0008 , A61K39/0011
摘要： The invention provides for a random insertional mutagensis and screening method for the reliable and efficient identification and preparation of functional protein variants which have an improved phenotype when compared to the protein from which they are derived. The method involved the random insertion of a polyamino acid into a selected protein scaffold, to prepare a library of protein variants, and selection of those variants which present the desired functional characterisitics, such as solubility and/or the ability to trigger an immunogenic response.
摘要翻译：本发明提供了随机插入突变和筛选方法，用于可靠和有效地鉴定和制备与其衍生的蛋白质相比具有改善的表型的功能性蛋白质变体。该方法涉及将聚氨基酸随机插入选定的蛋白质支架中，以制备蛋白质变体文库，以及选择呈现所需功能特征的那些变体，例如溶解度和/或触发免疫原性反应的能力。

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