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1. 发明申请

WO2014006197A1 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2014006197A1
公开(公告)日：2014-01-09
申请号：PCT/EP2013/064293
申请日：2013-07-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： NAGEL, Thomas , RICHTER, René , WITT, Robert , GUENTHER, Richard
IPC分类号： A61M5/142 , A61M5/145
CPC分类号： A61M5/14212 , A61K9/0004 , A61M5/14593 , A61M2005/14268 , A61M2005/14513 , A61M2205/502
摘要： The invention relates to a drug delivery device (1), comprising a control unit (2), a drive unit (3), a pressurizing medium container (4) arranged to contain a pressurizing liquid, a drug container (5) arranged to contain a drug and a discharge nozzle (6), wherein the drive unit (3) when controlled and energized by the control unit (2) is arranged to generate a pressure gradient in the pressurizing liquid thereby propagating the pressure to the drug container (5) and at least partially displacing the drug from the drug container (5) through the discharge nozzle (6), wherein the drive unit (3) is arranged as an electro-osmotic actor (3).
摘要翻译：本发明涉及一种药物输送装置（1），其包括控制单元（2），驱动单元（3），设置成容纳加压液体的加压介质容器（4），药物容器（5）药物和排出喷嘴（6），其中当由所述控制单元（2）控制和激励时，所述驱动单元（3）被布置成在所述加压液体中产生压力梯度，从而将所述压力传播到所述药物容器（5）并且通过所述排出喷嘴（6）至少部分地将所述药物从所述药物容器（5）移位，其中所述驱动单元（3）被布置为电渗透剂（3）。

2. 发明申请

WO2014001308A1 STOPPER ARRANGEMENT FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置的停止装置
公开(公告)号：WO2014001308A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/063235
申请日：2013-06-25
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： NAGEL, Thomas , RICHTER, René , WITT, Robert , GUENTHER, Richard , GRAEFE, Martin
IPC分类号： A61M5/315
CPC分类号： A61M5/1452 , A61M5/31501 , A61M5/31511 , A61M5/31515 , A61M2205/10
摘要： The invention relates to a stopper arrangement for a drug delivery device (1), comprising a stopper (5), a linear actor (7) coupled with one end to the stopper (5) and with an opposite end to a coupling arrangement (8), wherein the stopper arrangement is configured to be disposed within a container (2) of a drug delivery device (1), wherein a shape and/or material of the stopper (5) and the coupling arrangement (8) are configured such that a first frictional force between the coupling arrangement (8) and the container (2) is lower than a frictional force between the stopper (5) and the container (2) when the linear actor (7) is contracting and that second frictional force between the coupling arrangement (8) and the container (2) is greater than the frictional force between the stopper (5) and the container (2) when the linear actor (7) is expanding.
摘要翻译：本发明涉及一种用于药物输送装置（1）的止动器装置，包括止动件（5），与止动器（5）的一端连接的线性电动机（7）和与联接装置（8）相反的一端），其中所述止动器装置构造成设置在药物输送装置（1）的容器（2）内，其中所述止动件（5）和所述联接装置（8）的形状和/或材料被构造成使得当线性电动机（7）收缩时，联接装置（8）和容器（2）之间的第一摩擦力低于止动器（5）和容器（2）之间的摩擦力，并且第二摩擦力当线性电动机（7）膨胀时，联接装置（8）和容器（2）大于止动器（5）和容器（2）之间的摩擦力。

3. 发明申请

WO2011032960A1 ARRANGEMENT FOR DETERMINING A LONGITUDINAL POSITION OF A STOPPER 审中-公开
标题翻译：用于确定停止位置的纵向位置的布置
公开(公告)号：WO2011032960A1
公开(公告)日：2011-03-24
申请号：PCT/EP2010/063514
申请日：2010-09-15
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , POMMEREAU, Christian , LIEWALD, Anke , BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
发明人： POMMEREAU, Christian , LIEWALD, Anke , BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
IPC分类号： G01D5/34 , G01F23/292
CPC分类号： A61M5/31511 , A61M5/1452 , A61M5/14566 , A61M5/168 , A61M5/1685 , A61M5/31525 , A61M5/31556 , A61M2205/3306 , A61M2205/3313 , A61M2205/3389 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6063 , A61M2205/6081 , G01D5/342 , G01F23/2921 , G06F19/00
摘要： The invention refers to an arrangement and a method for determining a longitudinal position of a stopper (4) for sealing a compartment (5) of a translucent medicament container (1) for a liquid medicament (M). The arrangement comprises a circular light source (8) and a photo sensitive sensor (7), wherein either the light source (8) or the sensor (7) is laterally arrangeable next to the medicament container (1) extending over at least part of the length of the medicament container (1), and wherein the respective other of the light source (8) and the sensor (7) is arrangeable in a circular manner around a head of the medicament container (1). The light source is arranged to emit light into the medicament container. The light is scattered by the medicament or medicament container (1) and detected by the sensor (7). The sensor (7) is connected to a processor unit for detecting the position of the stopper (4).
摘要翻译：本发明涉及一种用于确定用于密封用于液体药物（M）的半透明药物容器（1）的隔室（5）的塞子（4）的纵向位置的布置和方法。所述装置包括圆形光源（8）和光敏传感器（7），其中所述光源（8）或所述传感器（7）可以横向布置在所述药物容器（1）的旁边，所述药物容器延伸至药物容器（1）的长度，并且其中光源（8）和传感器（7）中的相应另一个可以圆形排列在药物容器（1）的头部周围。光源被布置成将光发射到药物容器中。光被药物或药物容器（1）散射并由传感器（7）检测。传感器（7）连接到用于检测止动器（4）的位置的处理器单元。

4. 发明申请

WO2011026738A1 MEDICAMENT CONTAINER 审中-公开
标题翻译：药物容器
公开(公告)号：WO2011026738A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/062155
申请日：2010-08-20
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , NAGEL, Thomas , RICHTER, René , WITT, Robert
发明人： NAGEL, Thomas , RICHTER, René , WITT, Robert
IPC分类号： A61M5/148 , A61M5/24 , A61M5/28 , A61J1/06 , A61M5/00
CPC分类号： A61M5/148 , A61J1/067 , A61M5/282 , A61M5/30 , A61M2005/3128
摘要： The invention relates to a medicament container (2), comprising a bag (3) with an outlet (4), the bag (3) compressible by a compression means (6), the bag (3) having an inner surface arranged to stick when subjected to the compression means (6). The invention also refers to an arrangement (1) for administering a liquid medicament (M) comprising the medicament container (2) and a compression means (6) for locally compressing the bag (3).
摘要翻译：本发明涉及一种药物容器（2），其包括具有出口（4）的袋子（3），所述袋子（3）由压缩装置（6）压缩，所述袋子（3）具有布置成粘贴的内表面当受到压缩装置（6）时。本发明还涉及一种用于施用包含药物容器（2）的液体药物（M）和用于局部压缩袋（3）的压缩装置（6）的装置（1）。

5. 发明申请

WO2011006919A1 INJECTION ARRANGEMENT 审中-公开
标题翻译：注射装置
公开(公告)号：WO2011006919A1
公开(公告)日：2011-01-20
申请号：PCT/EP2010/060120
申请日：2010-07-14
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
发明人： BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
IPC分类号： F04B23/02 , F04B43/12
CPC分类号： F04B43/1253 , F04B23/028
摘要： The invention relates to a pump unit (2), replaceably attachable to a reusable backend (3) of an injection arrangement (1) for delivering a liquid medicament, the pump unit (2) comprising a medicament inlet (2.1), a medicament outlet (2.2) and a peristaltic pump for delivering the liquid medicament from the inlet (2.1) to the outlet (2.2), the peristaltic pump comprising a pump rotor (2.3) and a pump hose (2.4), the pump hose (2.4) partially arranged around the pump rotor (2.3), the pump rotor (2.3) having protrusions (2.5) for engaging the pump hose (2.4), wherein a fixing side (2.6) of the pump unit (2) facing a reusable backend (3) when attached has a recess (2.7) in the shape of a circular arc for allowing a correspondingly shaped stop (3.1) protruding from the reusable backend (3) to enter into the pump unit (2) so as to support the pump hose (2.4) from an outer side opposite the pump rotor (2.3) thus allowing the protrusions (2.5) to locally squeeze the pump hose (2.4) against the stop (3.1) when attached to the reusable backend (3).
摘要翻译：本发明涉及一种可更换地附接到用于输送液体药物的注射装置（1）的可重复使用的后端（3）的泵单元（2），所述泵单元（2）包括药物入口（2.1），药物出口（2.2）和用于将液体药物从入口（2.1）输送到出口（2.2）的蠕动泵，蠕动泵包括泵转子（2.3）和泵软管（2.4），泵软管（2.4）部分地所述泵转子（2.3）具有用于接合所述泵管（2.4）的突出部（2.5），其中所述泵单元（2）的面向可重复使用的后端（3）的固定侧（2.6）当安装有具有圆弧形状的凹部（2.7），以允许从可重复使用的后端（3）突出的相应形状的止动件（3.1）进入泵单元（2），以便支撑泵软管（2.4 ）从泵转子（2.3）的外侧开始，从而允许突起（2.5）将泵软管（2.4）局部地挤压在泵 e连接到可重用后端（3）时停止（3.1）。

6. 发明申请

WO2010133671A1 ASSEMBLY FOR USE IN A DRUG DELIVERY DEVICE 审中-公开
标题翻译：组装用于药物递送装置
公开(公告)号：WO2010133671A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056970
申请日：2010-05-20
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
发明人： BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
IPC分类号： A61M5/148
CPC分类号： A61M5/19 , A61M5/148 , A61M5/1483 , A61M5/158 , A61M5/16813 , A61M5/282
摘要： The present invention relates to an assembly for a drug delivery device comprising a dispensing container (60) and a reservoir container (70) for holding a fluid medicinal product, wherein the dispensing container (60) and the reservoir container (70) are connected to one another and are in fluid communication, and wherein the dispensing container (60) is squeezable for dispensing a dose of the fluid medicinal product from the dispensing container (60), the dispensing container (60) being refillable with the fluid medicinal product from the reservoir container (70).
摘要翻译：本发明涉及一种用于药物输送装置的组件，其包括用于保持流体医药产品的分配容器（60）和储存容器（70），其中分配容器（60）和储存容器（70）连接到彼此流体连通，并且其中分配容器（60）可挤压用于从分配容器（60）分配一定剂量的流体医药产品，分配容器（60）可从流体药物产品储存容器（70）。

7. 发明申请

WO2010130682A1 A FLUID DRUG DELIVERY SYSTEM AND METHOD FOR MANUFACTURING A DRUG DELIVERY SYSTEM 审中-公开
标题翻译：一种用于制造药物递送系统的流体药物递送系统和方法
公开(公告)号：WO2010130682A1
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056352
申请日：2010-05-10
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
发明人： BASSO, Nils , NAGEL, Thomas , RICHTER, René , WITT, Robert
IPC分类号： A61M5/24 , A61M5/28 , A61M5/31
CPC分类号： A61M5/2425 , A61M5/282 , A61M5/3129
摘要： A fluid drug delivery system comprises a rigid shell (10) having an inner sidewall, an opening (18) and a passage (13) as well as a collapsible cartridge (20) with a distal end and a proximal end. The collapsible cartridge is arranged within the shell with its distal end being closer to the opening than the proximal end. It further comprises a first portion (14) including the proximal end and a second portion (15) including the distal end. The second portion is recoilable from the inner sidewall to urge a fluid, which comprises a drug and is contained in the collapsible cartridge, to the passage of the rigid shell. Further, the rigid shell and the collapsible cartridge are co-extruded.
摘要翻译：流体药物递送系统包括具有内侧壁的刚性壳（10），开口（18）和通道（13）以及具有远端和近端的可折叠筒（20）。可折叠的药筒布置在外壳内，其远端比近端更靠近开口。它还包括包括近端的第一部分（14）和包括远端的第二部分（15）。第二部分可从内侧壁反冲，以将包含药物并且容纳在可收缩的药筒中的流体推动到刚性壳的通道。此外，刚性壳和可折叠筒共同挤出。

8. 发明申请

WO2018083062A1 VOLUME MEASURING ARRANGEMENT 审中-公开
标题翻译：体积测量安排
公开(公告)号：WO2018083062A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077773
申请日：2017-10-30
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： RICHTER, René , WITT, Robert , GUENTHER, Richard , NAGEL, Thomas
IPC分类号： A61M5/168 , A61M5/14 , A61M5/20
摘要： In one aspect the present disclosure refers to a measuring arrangement (10; 110; 210; 310; 410; 510) for measuring of a volume change of a liquid medium (14) located inside a liquid reservoir (24), the measuring arrangement comprising: - a gas tight enclosure (20; 120; 220; 320) having an interior volume (21; 121) containing a gas reservoir (22; 122) and containing the liquid reservoir (24), wherein the liquid reservoir (24) is filled with a liquid medium (14), - a gas inlet (30; 130) in flow connection with the gas reservoir (22; 122) and extending through a boundary (19) of the gas tight enclosure (20; 120; 220; 320) to an exterior (5) of the gas tight enclosure (20; 120; 220; 320), - an outlet (42) connectable with the liquid reservoir (24) and extending through the boundary (19) of the gas tight enclosure (20; 120; 220; 320), - wherein the gas reservoir (22; 122) and the liquid reservoir (24) are hermetically separated by an impenetrable separation wall (25), and - a flow meter (28) arranged in or across the gas inlet (30; 130) to measure an ingress of a gaseous medium (15) through the inlet (30; 130) in response to a withdrawal of the liquid medium (14) from the liquid reservoir (24) through the outlet (42).
摘要翻译：在一个方面，本公开涉及用于测量位于液体储存器内的液体介质（14）的体积变化的测量装置（10; 110; 210; 310; 410; 510）（24），所述测量装置包括： - 具有包含气体储存器（22; 122）并容纳所述液体储存器（24）的内部容积（21; 121）的气密外壳（20; 120; 220; 320）其中所述液体储存器（24）填充有液体介质（14）， - 与所述气体储存器（22; 122）流动连接并且延伸穿过所述气密边界（19）的气体入口（30; 130）（20; 120; 220; 320）连接到所述气密外壳（20; 120; 220; 320）的外部（5）， - 可与所述液体储存器（24）连接并且延伸穿过所述边界（20; 120; 220; 320）的至少一部分（19），其中所述气体储存器（22; 122）和所述液体储存器（24）被不可渗透的分隔壁（25）气密地分隔开，以及 - 流量计（28）布置在气体入口（30; 响应于通过出口（42）从液体贮存器（24）中抽出液体介质（14），测量通过入口（30; 130）的气体介质（15）的进入。 >

9. 发明申请

WO2018083056A1 VOLUME MEASURING ARRANGEMENT 审中-公开
标题翻译：体积测量安排
公开(公告)号：WO2018083056A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077735
申请日：2017-10-30
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： RICHTER, René , WITT, Robert , GUENTHER, Richard , NAGEL, Thomas
IPC分类号： A61M5/14 , A61M5/168 , A61M5/24
摘要： The present invention relates in one aspect to a measuring arrangement (10; 110; 210) for measuring a volume occupied by a liquid medium (14) inside a liquid reservoir (24), the measuring arrangement comprising:• - a container (20; 120) having an interior volume (21; 121) containing a gas reservoir (22; 122) filled with a gaseous medium and containing a liquid reservoir (24) filled with a liquid medium (14), • - wherein the gas reservoir (22; 122) and the liquid reservoir (24) are hermetically separated by an impenetrable separation wall (25) • - a volume modulator (30) to induce a volume change of the gas reservoir (22; 122), • - a pressure sensor (28) arranged inside the gas reservoir (22; 122) to measure a pressure change of the gaseous medium in response to the volume change of the gas reservoir (22; 122), and • - a controller (40) connectable to the pressure sensor (28), wherein the controller (40) is configured to calculate the volume of the liquid reservoir (24) on the basis of the pressure change and the volume change
摘要翻译：一方面，本发明涉及一种用于测量由液体储存器（24）内的液体介质（14）占据的体积的测量装置（10; 110; 210），该测量装置包括： - 具有内部容积（21; 121）的容器（20; 120），所述内部容积包含充满气体介质并且包含充满液体介质（14）的液体储存器（24）的气体储存器（22; 122） - 其中所述气体储存器（22; 122）和所述液体储存器（24）被不可渗透的分隔壁（25）气密地分隔开来; - 体积调节器（30），用于引起所述气体储存器（22; 122 ）， - 设置在气体储存器（22; 122）内的压力传感器（28），用于响应气体储存器（22; 122）的体积变化来测量气体介质的压力变化，以及 - 控制器（40），其可连接到所述压力传感器（28），其中所述控制器（40）被配置成计算所述液体储存器 ir（24）根据压力变化和体积变化

10. 发明申请

WO2014001310A1 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2014001310A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/063238
申请日：2013-06-25
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： NAGEL, Thomas , RICHTER, René , WITT, Robert , GUENTHER, Richard , GRAEFE, Martin
IPC分类号： A61M5/24 , A61M5/315
CPC分类号： A61M5/24 , A61M5/30 , A61M5/31511
摘要： The invention relates to a drug delivery device (1), comprising: - a case (6) for retaining drug container (2), the drug container (2) defining a cavity (3) for containing a drug, wherein a stopper (4) is slidably disposed within the container (2) so as to displace the drug through a discharge nozzle (5) on translation in a distal direction (D), - an inner magnet (14) disposable within the drug container (2) for abutting the stopper (4), - at least one outer magnet (13) disposed within the case (6) coaxially with the container (2) and slidable in an axial direction (D, P), - a trigger arrangement (15, 16) for advancing the outer magnet in a distal direction (D) on actuation, wherein the outer magnet (13) and inner magnet (14) are arranged for magnetically interacting through the drug container (2) wall such the outer magnet (13) advances the inner magnet (14) on trigger actuation.
摘要翻译：本发明涉及一种药物输送装置（1），包括： - 用于保持药物容器（2）的壳体（6），所述药物容器（2）限定用于容纳药物的空腔（3），其中塞子）可滑动地设置在所述容器（2）内，以便使所述药物沿远端方向（D）平移地通过排放喷嘴（5）移位; - 内部磁体（14），其在所述药物容器（2）所述止动件（4）， - 与所述容器（2）同轴设置并且能够沿轴向方向（D，P）滑动的至少一个外部磁体（13），所述至少一个外部磁体（13）用于在致动时在远端方向（D）推进外磁体，其中外磁体（13）和内磁体（14）被布置成用于通过药物容器（2）壁磁性相互作用，使得外磁体（13）内部磁体（14）触发启动。

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