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1. 发明申请

WO2009118473A3 AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME 审中-公开
标题翻译： AZETIDINE衍生化合物，其制备方法及其治疗用途
公开(公告)号：WO2009118473A3
公开(公告)日：2009-11-19
申请号：PCT/FR2009000214
申请日：2009-02-27
申请人： SANOFI AVENTIS , AUGER FLORIAN , BERNARDELLI PATRICK , EVEN LUC , SABUCO JEAN-FRANCOIS , TERRIER CORINNE
发明人： AUGER FLORIAN , BERNARDELLI PATRICK , EVEN LUC , SABUCO JEAN-FRANCOIS , TERRIER CORINNE
IPC分类号： C07D205/04 , A61K31/40 , A61P3/10 , A61P25/28 , A61P35/00 , C07D405/12
CPC分类号： C07D205/04 , C07D405/12
摘要： The invention relates to compounds having formula (I) in which: R represents a (C1-C6)alkyl group, a halo(C1-C6)alkyl group; R1 represents a hydrogen atom, a (C1-C6)alkyl group; R2 represents (i) a (C1-C6)alkyl group substituted by one or more groups selected from the hydroxy group, the (C1-C6)alkoxy group and optionally substituted by a halo(C1-C6)alkyl group, (ii) a heterocycle group optionally substituted by one or more hydroxy groups, a (C1-C6)alkoxy group, a hydroxy(C1-C6)alkyl group, (iii) a heterocycle(C1-C6)alkyl group optionally substituted by one or more hydroxy groups; R3 and R4 each represent a phenyl group optionally substituted by one or more atoms or groups selected from a hydrogen atom, a halogen, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy or cyano; Y represents a hydrogen atom, a halogen, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group, a (C1-C6)alkylS(O)p or cyano; and p is between 0 and 2; said compounds taking the form of a base or an acid addition salt. The invention also relates to the preparation method thereof and to the therapeutic use of same.
摘要翻译：本发明涉及具有式（I）的化合物，其中：R表示（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基; R1表示氢原子，（C1-C6）烷基; R 2表示（i）被一个或多个选自羟基，（C 1 -C 6）烷氧基和任选被卤代（C 1 -C 6）烷基取代的基团取代的（C 1 -C 6）烷基，（ii）任选被一个或多个羟基取代的杂环基团，（C 1 -C 6）烷氧基，羟基（C 1 -C 6）烷基，（iii）任选被一个或多个羟基取代的杂环（C 1 -C 6）烷基组; R 3和R 4各自表示任选被一个或多个选自氢原子，卤素，（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基，（C 1 -C 6）烷基，）烷氧基，卤代（C 1 -C 6）烷氧基或氰基; Y表示氢原子，卤素，（C1-C6）烷基，卤代（C1-C6）烷基，（C1-C6）烷氧基，卤代（C1-C6）烷氧基，（C1 -C 6）烷基S（O）p或氰基; p在0和2之间; 所述化合物为碱或酸加成盐的形式。本发明还涉及其制备方法及其治疗用途。

2. 发明申请

WO2008145839A8 TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES AND TRIAZOLOPYRIMIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译：三唑酰胺羧酰胺衍生物和三唑基吡啶羧酰胺衍生物，其制备方法及其治疗方法
公开(公告)号：WO2008145839A8
公开(公告)日：2009-11-19
申请号：PCT/FR2008000532
申请日：2008-04-16
申请人： SANOFI AVENTIS , EVEN LUC , HOORNAERT CHRISTIAN
发明人： EVEN LUC , HOORNAERT CHRISTIAN
IPC分类号： C07D471/04 , A61K31/4439 , A61P37/00 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to the triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives of general formula (I) in which: A and X are, independently of one another, a nitrogen atom or a CH group; R1 is an NR3R4 group, in which R3 and R4 form, with the nitrogen atom which bears them, a heterocyclic group comprising 3 to 7 ring members that may incorporate an oxygen or sulphur atom, an NR group or an NR'-CO group, wherein said ring is optionally substituted with one or more groups selected from a halogen atom or a (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl or halo(C1- C6)alkoxy group, R2 is an aryl group, optionally substituted with one or more groups selected from a halogen atom or a methyl, trifluoromethyl, methoxy or trifluoromethoxy group. Process for the preparation thereof and therapeutic use thereof.
摘要翻译：本发明涉及三唑并吡啶甲酰胺衍生物和通式（I）的三唑并嘧啶甲酰胺衍生物，其中：A和X彼此独立地为氮原子或CH基团; R 1是NR 3 R 4基团，其中R 3和R 4与带有它们的氮原子一起形成含有3至7个可以引入氧或硫原子的环成员，NR基团或NR'-CO基团的杂环基，其中所述环任选被一个或多个选自卤素原子或（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，卤代（C 1 -C 6）烷基或卤代（C 1 -C 6）烷氧基的基团取代，R 2 是任选被一个或多个选自卤素原子或甲基，三氟甲基，甲氧基或三氟甲氧基的基团取代的芳基。其制备方法及其治疗用途。

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