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1. 发明申请

WO1994002677A1 SOIL-REPELLENT FINISHING AGENT 审中-公开
标题翻译：防尘剂设备
公开(公告)号：WO1994002677A1
公开(公告)日：1994-02-03
申请号：PCT/CH1993000183
申请日：1993-07-19
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , BAUMANN, Hans-Peter , WEIBLE, Karl-Heinz
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： D06M15/41
CPC分类号： D06M13/358 , D06L4/621 , D06M15/263 , D06M15/277 , D06M15/41 , D06M15/412
摘要： The defined condensation products (P) - salts at least in some cases - from dihydroxydiphenylsulphone, formaldehyde and the defined aromatic compounds (A) in defined molar ratios make for excellent soil-repellent finishing of polyamide fiber materials, especially in combination with a fiber-reactive, colorless compound and possibly using in addition other soil-repellent finishing agents, to provide highly effective, long-lasting finishes that do not produce a distracting yellowing either upon application or with extended use.

2. 发明申请

WO1997011052A1 UREA DERIVATIVES AND THEIR USE AS ANALGESICS AND ANTIINFLAMMATORY AGENTS 审中-公开
标题翻译：尿素衍生物及其用作治疗和抗炎药物
公开(公告)号：WO1997011052A1
公开(公告)日：1997-03-27
申请号：PCT/EP1996004129
申请日：1996-09-20
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ PHARMACEUTICALS (UK) LTD. , CAMPBELL, Elizabeth, Anne , WALPOLE, Christopher, Simon, John
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ PHARMACEUTICALS (UK) LTD.
IPC分类号： C07C275/24
CPC分类号： C07C275/34 , C07C275/24 , C07C275/28 , C07C275/30
摘要： Compounds of formula (I) wherein: R1 is C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl; R2 is hydrogen or has any of the meanings given for R1; R3 is hydrogen or C1-4 alkyl and n is zero, 1 or 2, or physiologically hydrolysable and acceptable amide or salt thereof, processes for their production, their use as pharmaceuticals, e.g. as analgesics and antiinflammatory agents, and pharmaceutical compositions comprising them.
摘要翻译：式（I）的化合物，其中：R 1是C 1-4烷基，C 1-4烷氧基，卤素或三氟甲基; R2是氢或具有对R1给出的任何含义; R 3是氢或C 1-4烷基，n是0,1或2，或其生理上可水解和可接受的酰胺或其盐，它们的制备方法，它们作为药物的用途。作为止痛剂和抗炎剂，以及包含它们的药物组合物。

3. 发明申请

WO1997002285A1 MACROLIDES 审中-公开
标题翻译：大环内酯类
公开(公告)号：WO1997002285A1
公开(公告)日：1997-01-23
申请号：PCT/EP1996002952
申请日：1996-07-04
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , FEHR, Theodor , OBERER, Lukas , QUESNIAUX RYFFEL, Valerie , SANGLIER, Jean-Jacques , SCHULER, Walter , SEDRANI, Richard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07K05/062
CPC分类号： C07D491/10 , A61K38/00 , C07D309/10 , C07D309/30 , C07K5/06052 , C12R1/465
摘要： A novel class of macrolides in which i) positions 2 to 6 inclusive of the macrocyclic ring are provided by a piperidazinyl carboxylic acid residue; and/or ii) positions 7 to 9 inclusive of the macrocyclic ring are provided by an aromatic alpha -amino acid residue; and/or iii) positions 10 to 12 inclusive of the macrocyclic ring are provided by an aliphatic alpha -amino acid residue, preferably comprising two, or especially all three of the characteristic structural features i), ii) and iii), more especially a compound of formula (IX) is provided having immunosuppressant and anti-inflammatory properties and protected and ring-open forms thereof.
摘要翻译：其中i）位置2至6（包括大环）的新一类大环内酯由哌嗪基羧酸残基提供; 和/或ii）包含大环的位置7至9由芳族α-氨基酸残基提供; 和/或iii）包含大环的位置10至12由脂族α-氨基酸残基提供，优选包含两个或特别是所有三种特征结构特征i），ii）和iii），更特别地，提供具有免疫抑制剂和抗炎特性及其保护和开环形式的式（Ⅸ）化合物。

4. 发明申请

WO1996040875A1 METHODS FOR OBTAINING COMPOSITIONS ENRICHED FOR HEMATOPOIETIC STEM CELLS AND ANTIBODIES FOR USE THEREIN 审中-公开
标题翻译：用于获得用于HEMATOPOIETIC STEM细胞的组合物和用于其的抗体的方法
公开(公告)号：WO1996040875A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002463
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , HILL, Beth, Louise , ROZLER, Elen , CHEN, Benjamin, P.
IPC分类号： C12N05/08
CPC分类号： C12N5/0647 , A61K35/28 , C07K16/28 , Y10S530/809
摘要： A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions obtained thereby and reagents for use therein are also provided.
摘要翻译：通过使用新型干细胞标记物对干细胞进行富集来提供获得人类造血干细胞的方法。还提供了由此获得的组合物和其中使用的试剂。

5. 发明申请

WO1996034849A1 TETRALINES BEARING A PHENYL SUBSTITUANT ON THE AROMATIC RING AND THEIR USE IN THE TREATMENT OF EPILEPSY, STROKE AND BRAIN OR SPINAL TRAUMA 审中-公开
标题翻译：支撑在芳环上的苯并噻唑类替代物及其在治疗癫痫，脑脊髓和脊髓损伤中的应用
公开(公告)号：WO1996034849A1
公开(公告)日：1996-11-07
申请号：PCT/EP1996001841
申请日：1996-05-03
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SWOBODA, Robert
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C07C217/54
CPC分类号： C07D295/073 , C07C211/42 , C07C215/64 , C07C217/74 , C07C237/48 , C07C255/58 , C07C2602/10 , C07D295/033
摘要： Compounds of formula (I) wherein R1 and R2, independently, are hydrogen (C1-4)alkyl, (C1-4)alkoxy, (C1-4)alkylthio, halogen, trifluoromethyl, trifluoromethoxy, cyano, (C2-5)alkanoyl, (C1-4)alkylsulfonyl or sulfamoyl; R3 is hydrogen, hydroxy, (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, (C2-5)alkanoyl, carbamoyl, (C1-4)alkylsulfonyloxy or trifluoromethylsulfonyloxy; and R4 and R5, independently, are hydrogen, (C1-4)alkyl, hydroxy(C2-4)alkyl or phenyl(C1-4)alkyl, or form together with the nitrogen atom to which they are attached a pyrrolidinyl, piperidino or piperazinyl group, in free base or acid addition salt form. Compounds according to formula (I) are useful in the treatment of epilepsy, stroke and brain or spinal trauma.
摘要翻译：式（I）化合物其中R 1和R 2独立地是氢（C 1-4）烷基，（C 1-4）烷氧基，（C 1-4）烷硫基，卤素，三氟甲基，三氟甲氧基，氰基，（C 2-5）烷酰基，（C 1-4）烷基磺酰基或氨磺酰基; R3是氢，羟基，（C1-4）烷基，（C1-4）烷氧基，卤素，氰基，（C2-5）烷酰基，氨基甲酰基，（C1-4）烷基磺酰氧基或三氟甲基磺酰氧基; 并且R 4和R 5独立地为氢，（C 1-4）烷基，羟基（C 2-4）烷基或苯基（C 1-4）烷基，或与它们所连接的氮原子一起形成吡咯烷基，哌啶子基或哌嗪基，游离碱或酸加成盐形式。根据式（I）的化合物可用于治疗癫痫，中风和脑或脊髓损伤。

6. 发明申请

WO1996029420A1 PLANTS RESISTANT TO TOSPOVIRUSES 审中-公开
标题翻译：植物抗病毒
公开(公告)号：WO1996029420A1
公开(公告)日：1996-09-26
申请号：PCT/EP1996001271
申请日：1996-03-22
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , DE HAAN, Petrus, Theodorus
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/82
CPC分类号： C12N15/8283
摘要： The present invention provides, inter alia, a recombinant polynucleotide, comprising a transcriptional regulatory region and a region contiguous therewith and under the transcriptional control thereof, wherein the contiguous region comprises the sequence depicted in SEQ ID No. 1 or a sequence complementary thereto or a part of the sequence or complement, characterized in that the sequence, complement or part is modified (i) by removal therefrom of translational-start encoding codons, or mutation of such codons so that they do not encode translational start or stop codons; or (ii) by insertion or deletion of nucleotides 3' of the translational start encoding codon so that the translational reading frame of the thus encoded RNA is different to that of the unmodified sequence, complement or part. The modified sequence, complement or part is capable of conferring upon plants resistance or tolerance to tospoviruses - typified by TSWV.
摘要翻译：本发明尤其提供了一种重组多核苷酸，其包含转录调节区和与其连续的区域及其转录控制，其中连续区包含SEQ ID No.1所示的序列或其互补序列或序列或补体的一部分，其特征在于修饰序列，补体或部分（i）通过从其中除去翻译起始编码密码子或这种密码子的突变，使得它们不编码翻译起始或终止密码子; 或（ii）通过插入或缺失翻译起始编码密码子的核苷酸3'，使得如此编码的RNA的翻译阅读框与未修饰的序列，补体或部分的翻译读框不同。修饰的序列，补体或部分能够赋予植物对烟草病毒的抗性或耐受性，以TSWV为代表。

7. 发明申请

WO1996003419A1 TETRACYCLIC TRITERPENES 审中-公开
标题翻译：三元TRITERPENES
公开(公告)号：WO1996003419A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002913
申请日：1995-07-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , HIESTAND, Peter , NAEF, Reto , NAEGELI, Hans-Ulrich , OBERER, Lukas , REVESZ, Laszlo , ROTH, Hans-Jörg
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07J09/00
CPC分类号： C07J9/00 , C07J1/0014 , C07J7/002 , C07J51/00
摘要： Dammara compounds have immunosuppressant and anti-inflammatory activity and are useful as pharmaceuticals, particularly for use as immunosuppressant and anti-inflammatory agents. 17 alpha dammara compounds are novel and are included per se, for example the compound of formula (IC) [(17 alpha )-23-(E)-dammara-20,23-dien-3 beta ,25-diol], which may be obtained from the flour of the shoots of the Palmyrah palm, Borassus flabellifer L. In addition processes for the synthesis of this and other dammara compounds and intermediates thereof are described.
摘要翻译：达马拉化合物具有免疫抑制剂和抗炎活性，并且可用作药物，特别是用作免疫抑制剂和抗炎剂。 17种阿米巴马拉化合物是新型的，并且本身包括，例如式（IC）[（17α）-23-（E）-dammara-20,23-dien-3β，25-二醇]的化合物，其可从Palmyrah棕榈，Borassus flabellifer L的芽的面粉中获得。另外还描述了用于合成这种和其他dammara化合物及其中间体的方法。

8. 发明申请

WO1995030683A1 ADENOSINE DERIVATIVES 审中-公开
标题翻译：制备2-O-烷基腺苷衍生物的方法
公开(公告)号：WO1995030683A1
公开(公告)日：1995-11-16
申请号：PCT/US1995005802
申请日：1995-05-09
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , GADIENT, Fulvio , MANGOLD, Bonnie, L., K. , FOZARD, John, R. , PRASHAD, Mahavir , KAPA, Prasad, K.
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C07H19/167
CPC分类号： C07H19/16
摘要： Compounds of formula (I), wherein R1 is one of a number of significances, including cycloalkyl and hydroxycycloalkyl; R2 is hydrogen, (C1-4)alkyl, amino, (C3-5)cycloalkyl or halogen with an atomic number of 9 to 35, and R3 is (C1-4)alkyl, are useful as analgesic agents. Compounds of formula (I) wherein R1 is hydroxy alkyl are new. The compounds of formula (I) may be produced by alkylation in the 2' position in the presence of tetrabutylammonium hydrogen sulfate and a non-polar solvent.
摘要翻译：式（I）的化合物，其中R 1是许多意义之一，包括环烷基和羟基环烷基; R2为氢，（C1-4）烷基，氨基，（C3-5）环烷基或原子序数为9〜35的卤素，R3为（C1-4）烷基，可用作止痛剂。其中R1是羟基烷基的式（Ⅰ）化合物是新的。式（I）化合物可以通过在四丁基硫酸氢铵和非极性溶剂的存在下在2'位上进行烷基化来制备。

9. 发明申请

WO1995025812A3 ASSAYS FOR IMMUNOSUPPRESSANTS 审中-公开
公开(公告)号：WO1995025812A3
公开(公告)日：1995-09-28
申请号：PCT/EP1995001009
申请日：1995-03-17
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , BAUMANN, Goetz , DI PADOVA, Franco, E. , WENNER, Peter
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12Q01/68

10. 发明申请

WO1995024479A1 NOVEL THIOL PROTEASE INHIBITOR 审中-公开
标题翻译：新型THIOL PROTEASE抑制剂
公开(公告)号：WO1995024479A1
公开(公告)日：1995-09-14
申请号：PCT/EP1995000881
申请日：1995-03-09
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , BRUNKE, Karen, Joan , CHAN, Victor, Jack , DELUCA-FLAHERTY, Camille, Renee , SCARAFIA, Liliana, Estela, Cristina
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12N15/12
CPC分类号： C07K14/8139 , A01N63/02 , C12N15/8286 , Y02A40/162 , Y10S47/11
摘要： A novel inhibitor peptide (designated virgiferin) of thiol proteases is isolated from Diabrotica virgifera. The DNA encoding virgiferin and modified virgiferin peptides are claimed. These sequences may be cloned into vectors and used to transform plants thus conferring reduced susceptibility to damage by plant pests that have thiol proteases as digestive enzymes including insects and nematodes and particularly Coleopteran insects.
摘要翻译：从Diabrotica virgifera中分离出一种新的抑制剂肽（称为virgiferin）硫醇蛋白酶。要求编码virgiferin和修饰的virgiferin肽的DNA。这些序列可以被克隆到载体中并用于转化植物，从而赋予具有硫代蛋白酶作为包括昆虫和线虫以及特别是鞘翅目昆虫的消化酶的植物害虫的损害易感性。

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